DK1094839T3 - Farnesylproteintransferaseinhibitorer med in vivo radiosensibiliserende egenskaber - Google Patents

Farnesylproteintransferaseinhibitorer med in vivo radiosensibiliserende egenskaber

Info

Publication number: DK1094839T3
Authority: DK; Denmark
Prior art keywords: protein transferase; transferase inhibitors; farnesyl protein; radiosensitizing properties; vivo
Prior art date: 1998-07-06

Application number

DK99931229T

Other languages

Danish (da)

English (en)

Inventor

Ginckel Robert Franciscus Van

Wim Joanna Floren

David William End

Walter Boudewijn Leopo Wouters

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-06

Filing date

1999-06-30

Publication date

2003-08-18

1999-06-30 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2003-08-18 Application granted granted Critical

2003-08-18 Publication of DK1094839T3 publication Critical patent/DK1094839T3/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Enzymes And Modification Thereof (AREA)

DK99931229T 1998-07-06 1999-06-30 Farnesylproteintransferaseinhibitorer med in vivo radiosensibiliserende egenskaber DK1094839T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP98202257		1998-07-06
EP98204330		1998-12-18
PCT/EP1999/004545 WO2000001411A1 (en)	1998-07-06	1999-06-30	Farnesyl protein transferase inhibitors with in vivo radiosensitizing properties

Publications (1)

Publication Number	Publication Date
DK1094839T3 true DK1094839T3 (da)	2003-08-18

Family

ID=26150503

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99931229T DK1094839T3 (da)	1998-07-06	1999-06-30	Farnesylproteintransferaseinhibitorer med in vivo radiosensibiliserende egenskaber

Country Status (31)

Country	Link
US (1)	US6545020B1 (tr)
EP (1)	EP1094839B1 (tr)
JP (1)	JP4530537B2 (tr)
KR (1)	KR100591603B1 (tr)
CN (1)	CN1152716C (tr)
AP (1)	AP1599A (tr)
AT (1)	ATE238811T1 (tr)
AU (1)	AU762423B2 (tr)
BG (1)	BG64941B1 (tr)
BR (1)	BR9911861A (tr)
CA (1)	CA2336624C (tr)
CZ (1)	CZ300968B6 (tr)
DE (1)	DE69907461T2 (tr)
DK (1)	DK1094839T3 (tr)
EA (1)	EA003877B1 (tr)
EE (1)	EE04582B1 (tr)
ES (1)	ES2199579T3 (tr)
HK (1)	HK1034451A1 (tr)
HR (1)	HRP20000903A2 (tr)
HU (1)	HU229076B1 (tr)
ID (1)	ID26987A (tr)
IL (2)	IL140721A0 (tr)
MY (1)	MY126519A (tr)
NO (1)	NO328178B1 (tr)
PL (1)	PL193464B1 (tr)
PT (1)	PT1094839E (tr)
SI (1)	SI1094839T1 (tr)
SK (1)	SK284723B6 (tr)
TR (1)	TR200003879T2 (tr)
TW (1)	TW586937B (tr)
WO (1)	WO2000001411A1 (tr)

Families Citing this family (58)

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IL140720A0 (en)	1998-07-06	2002-02-10	Janssen Pharmaceutica Nv	Farnesyl protein transferase inhibitors for treating arthropathies
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SI1255537T1 (sl) *	2000-02-04	2006-10-31	Janssen Pharmaceutica Nv	Inhibitorji farnezil protein transferaze za zdravljenje raka dojk
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AU2001293835A1 (en)	2000-09-25	2002-04-02	Janssen Pharmaceutica N.V.	Farnesyl transferase inhibiting 6-heterocyclylmethyl quinolinone derivatives
AU2002220559A1 (en)	2000-09-25	2002-04-02	Janssen Pharmaceutica N.V.	Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives
JP4974437B2 (ja)	2000-09-25	2012-07-11	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	ファルネシルトランスフェラーゼを阻害する６−［（置換フェニル）メチル］−キノリンおよびキナゾリン誘導体
EP1322635B1 (en)	2000-09-25	2006-03-22	Janssen Pharmaceutica N.V.	Farnesyl transferase inhibiting quinoline and quinazoline derivatives as farnesyl transferase inhibitors
US7153958B2 (en)	2000-11-21	2006-12-26	Janssen Pharmaceutica N.V.	Farnesyl transferase inhibiting benzoheterocyclic derivatives
JP4351445B2 (ja)	2000-12-27	2009-10-28	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	ファルネシルトランスフェラーゼを阻害する４−置換−キノリンおよびキナゾリン誘導体
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WO2003051880A1 (en)	2001-12-19	2003-06-26	Janssen Pharmaceutica N.V.	1,8-annelated quinoline derivatives substituted with carbon-linked triazoles as farnesyl transferase inhibitors
WO2003080058A1 (en)	2002-03-22	2003-10-02	Janssen Pharmaceutica. N.V.	Benzylimidazolyl substituted 2-quinoline and quinazoline derivatives for use as farnesyl transferase inhibitors
AU2003229688B2 (en)	2002-04-15	2009-07-30	Janssen Pharmaceutica N.V.	Farnesyl transferase inhibiting tricyclic quinazoline derivatives substituted with carbon-linked imidazoles or triazoles
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US20050272068A1 (en) *	2004-03-18	2005-12-08	The Brigham And Women's Hospital, Inc.	UCH-L1 expression and cancer therapy
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WO2005089504A2 (en) *	2004-03-18	2005-09-29	The Brigham And Women's Hospital, Inc.	Methods for the treatment of synucleinopathies
WO2005089496A2 (en) *	2004-03-18	2005-09-29	The Brigham And Women's Hospital, Inc.	Methods for the treatment of synucleinopathies
US20060194821A1 (en) *	2005-02-18	2006-08-31	The Brigham And Women's Hospital, Inc.	Compounds inhibiting the aggregation of superoxide dismutase-1
EP1920048A4 (en)	2005-07-29	2009-12-09	Childrens Hosp Medical Center	GTASE INHIBITORS AND USE METHOD AND CRYSTAL STRUCTURE OF RAC-1 GTASE
EP1968591A4 (en)	2005-12-23	2010-02-17	Link Medicine Corp	TREATMENT OF SYNUCLEINOPATHIES
US8124774B2 (en) *	2007-05-23	2012-02-28	Allergan, Inc.	Therapeutic ((phenyl)imidazolyl)methylquinolinyl compounds
US8232402B2 (en) *	2008-03-12	2012-07-31	Link Medicine Corporation	Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
ATE555384T1 (de)	2008-06-26	2012-05-15	Spherotec Gmbh	Verfahren zum testen der reaktion von zellen auf die einwirkung von therapeutika
MX2011005096A (es) *	2008-11-13	2011-11-18	Link Medicine Corp	Derivados de azaquinolinona y usos de los mismos.
US20110060005A1 (en) *	2008-11-13	2011-03-10	Link Medicine Corporation	Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
US20100331363A1 (en) *	2008-11-13	2010-12-30	Link Medicine Corporation	Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
US9980942B2 (en)	2012-05-02	2018-05-29	Children's Hospital Medical Center	Rejuvenation of precursor cells
KR20150070350A (ko)	2012-10-16	2015-06-24	얀센 파마슈티카 엔.브이.	Ror-감마-t의 페닐 결합 퀴놀리닐 조절제
JP6250686B2 (ja)	2012-10-16	2017-12-20	ヤンセンファーマシューティカエヌ．ベー．	Ｒｏｒγｔのヘテロアリール結合させたキノリニルモジュレータ
RS56283B1 (sr)	2012-10-16	2017-12-29	Janssen Pharmaceutica Nv	Metilen vezani hinolinil modulatori ror-gama-t
US9284308B2 (en)	2013-10-15	2016-03-15	Janssen Pharmaceutica Nv	Methylene linked quinolinyl modulators of RORγt
ES2742843T3 (es)	2013-10-15	2020-02-17	Janssen Pharmaceutica Nv	Moduladores de quinolinilo de ROR(gamma)t
US10555941B2 (en)	2013-10-15	2020-02-11	Janssen Pharmaceutica Nv	Alkyl linked quinolinyl modulators of RORγt
US9346782B2 (en)	2013-10-15	2016-05-24	Janssen Pharmaceutica Nv	Alkyl linked quinolinyl modulators of RORγt
US9403816B2 (en)	2013-10-15	2016-08-02	Janssen Pharmaceutica Nv	Phenyl linked quinolinyl modulators of RORγt
US9221804B2 (en)	2013-10-15	2015-12-29	Janssen Pharmaceutica Nv	Secondary alcohol quinolinyl modulators of RORγt
US9328095B2 (en)	2013-10-15	2016-05-03	Janssen Pharmaceutica Nv	Heteroaryl linked quinolinyl modulators of RORgammat
US10028503B2 (en)	2014-06-18	2018-07-24	Children's Hospital Medical Center	Platelet storage methods and compositions for same
PL3277842T3 (pl)	2015-08-17	2019-12-31	Kura Oncology, Inc.	Sposoby leczenia pacjentów z nowotworem z użyciem inhibitorów farnezylotransferazy
WO2017184968A1 (en)	2016-04-22	2017-10-26	Kura Oncology, Inc.	Methods of selecting cancer patients for treatment with farnesyltransferase inhibitors
WO2018085518A2 (en)	2016-11-03	2018-05-11	Kura Oncology, Inc.	Methods of treating cancer patients with farnesyltransferase inhibitors
WO2018156609A1 (en)	2017-02-21	2018-08-30	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
US10137121B2 (en)	2017-02-21	2018-11-27	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
WO2019032489A1 (en)	2017-08-07	2019-02-14	Kura Oncology, Inc.	METHODS OF TREATING CANCER WITH FARNESYLTRANSFERASE INHIBITORS
US10806730B2 (en)	2017-08-07	2020-10-20	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
WO2019113269A1 (en)	2017-12-08	2019-06-13	Kura Oncology, Inc.	Methods of treating cancer patients with farnesyltransferase inhibitors
SG11202104296TA (en)	2018-11-01	2021-05-28	Kura Oncology Inc	Methods of treating cancer with farnesyltransferase inhibitors
US20220142983A1 (en)	2019-03-01	2022-05-12	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
US20220143006A1 (en)	2019-03-15	2022-05-12	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
TW202043487A (zh)	2019-03-29	2020-12-01	美商庫拉腫瘤技術股份有限公司	以法尼基轉移酶(farnesyltransferase)抑制劑治療鱗狀細胞癌之方法
TW202102218A (zh)	2019-04-01	2021-01-16	美商庫拉腫瘤技術股份有限公司	以法呢基(farnesyl)轉移酶抑制劑治療癌症的方法
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1999
- 1999-06-30 CZ CZ20004777A patent/CZ300968B6/cs not_active IP Right Cessation
- 1999-06-30 WO PCT/EP1999/004545 patent/WO2000001411A1/en active IP Right Grant
- 1999-06-30 AT AT99931229T patent/ATE238811T1/de active
- 1999-06-30 BR BR9911861-0A patent/BR9911861A/pt not_active Application Discontinuation
- 1999-06-30 KR KR1020007014066A patent/KR100591603B1/ko not_active IP Right Cessation
- 1999-06-30 AU AU47805/99A patent/AU762423B2/en not_active Expired
- 1999-06-30 EA EA200100111A patent/EA003877B1/ru not_active IP Right Cessation
- 1999-06-30 ID IDW20010020A patent/ID26987A/id unknown
- 1999-06-30 PT PT99931229T patent/PT1094839E/pt unknown
- 1999-06-30 TR TR2000/03879T patent/TR200003879T2/tr unknown
- 1999-06-30 PL PL99347979A patent/PL193464B1/pl unknown
- 1999-06-30 IL IL14072199A patent/IL140721A0/xx active IP Right Grant
- 1999-06-30 EE EEP200000794A patent/EE04582B1/xx unknown
- 1999-06-30 US US09/743,130 patent/US6545020B1/en not_active Expired - Lifetime
- 1999-06-30 CN CNB998082678A patent/CN1152716C/zh not_active Expired - Lifetime
- 1999-06-30 HU HU0103689A patent/HU229076B1/hu unknown
- 1999-06-30 DE DE69907461T patent/DE69907461T2/de not_active Expired - Lifetime
- 1999-06-30 SK SK1986-2000A patent/SK284723B6/sk not_active IP Right Cessation
- 1999-06-30 EP EP99931229A patent/EP1094839B1/en not_active Expired - Lifetime
- 1999-06-30 SI SI9930332T patent/SI1094839T1/xx unknown
- 1999-06-30 AP APAP/P/2001/002057A patent/AP1599A/en active
- 1999-06-30 CA CA002336624A patent/CA2336624C/en not_active Expired - Lifetime
- 1999-06-30 DK DK99931229T patent/DK1094839T3/da active
- 1999-06-30 JP JP2000557857A patent/JP4530537B2/ja not_active Expired - Lifetime
- 1999-06-30 ES ES99931229T patent/ES2199579T3/es not_active Expired - Lifetime
- 1999-07-01 MY MYPI99002794A patent/MY126519A/en unknown
- 1999-07-05 TW TW088111346A patent/TW586937B/zh not_active IP Right Cessation
2000
- 2000-12-28 HR HR20000903A patent/HRP20000903A2/hr not_active Application Discontinuation
2001
- 2001-01-03 BG BG105108A patent/BG64941B1/bg unknown
- 2001-01-04 IL IL140721A patent/IL140721A/en not_active IP Right Cessation
- 2001-01-05 NO NO20010082A patent/NO328178B1/no not_active IP Right Cessation
- 2001-07-18 HK HK01105023A patent/HK1034451A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP4530537B2 (ja)	2010-08-25
HUP0103689A2 (hu)	2002-02-28
HUP0103689A3 (en)	2003-01-28
BR9911861A (pt)	2001-03-20
DE69907461T2 (de)	2004-02-19
NO20010082L (no)	2001-01-05
CN1152716C (zh)	2004-06-09
AU762423B2 (en)	2003-06-26
AP2001002057A0 (en)	2001-03-31
NO328178B1 (no)	2009-12-28
KR20010052770A (ko)	2001-06-25
NO20010082D0 (no)	2001-01-05
ID26987A (id)	2001-02-22
SI1094839T1 (en)	2003-12-31
DE69907461D1 (de)	2003-06-05
SK19862000A3 (sk)	2001-12-03
AP1599A (en)	2006-04-27
SK284723B6 (sk)	2005-10-06
HK1034451A1 (en)	2001-10-26
EE04582B1 (et)	2006-02-15
EA200100111A1 (ru)	2001-06-25
EA003877B1 (ru)	2003-10-30
PL193464B1 (pl)	2007-02-28
CA2336624A1 (en)	2000-01-13
CA2336624C (en)	2008-10-21
ATE238811T1 (de)	2003-05-15
EE200000794A (et)	2002-06-17
CN1311692A (zh)	2001-09-05
HRP20000903A2 (en)	2001-12-31
PT1094839E (pt)	2003-09-30
US6545020B1 (en)	2003-04-08
JP2002519389A (ja)	2002-07-02
CZ300968B6 (cs)	2009-09-30
PL347979A1 (en)	2002-05-06
KR100591603B1 (ko)	2006-06-20
MY126519A (en)	2006-10-31
TR200003879T2 (tr)	2007-01-22
CZ20004777A3 (en)	2001-05-16
EP1094839A1 (en)	2001-05-02
IL140721A (en)	2008-11-26
AU4780599A (en)	2000-01-24
WO2000001411A1 (en)	2000-01-13
IL140721A0 (en)	2002-02-10
BG64941B1 (bg)	2006-10-31
HU229076B1 (en)	2013-07-29
ES2199579T3 (es)	2004-02-16
BG105108A (en)	2001-11-30
TW586937B (en)	2004-05-11
EP1094839B1 (en)	2003-05-02

Publication	Publication Date	Title
DK1094839T3 (da)	2003-08-18	Farnesylproteintransferaseinhibitorer med in vivo radiosensibiliserende egenskaber
EE9800408A (et)	1999-06-15	Proteiinfarnesüültransferaasi inhibiitorid
IS6183A (is)	2001-11-29	Díamínóþíazol og notagildi þeirra til að hindra prótín kínasa
NO996571D0 (no)	1999-12-30	Inhibitorer for farnesyl-protein-transferase
ATE546139T1 (de)	2012-03-15	Isoprentransferase proteine inhibitoren
CY2014034I1 (el)	2016-04-13	Υποκατεστημενες 3-κυανοκινολινες ως αναστολεις κινασων πρωτεϊνης τυροσινης
EE200300085A (et)	2004-12-15	Pürasooli derivaadid ja nende kasutamine proteiini kinaasi inhibiitoritena
FI951554A (fi)	1995-10-01	Imidatsolipitoisia farnesyyliproteiinitransferaasi-inhibiittoreita
DE69924876D1 (de)	2005-05-25	Farnesyl protein transferase inhibitoren
DE60101323D1 (de)	2004-01-08	Tricyclische proteinkinasehemmer
ATE273299T1 (de)	2004-08-15	Benzpyrido cycloheptan derivate mit farnesyl protein transferase inhibierender wirkung
NO20005680D0 (no)	2000-11-10	Kombinasjoner av protein-farnesyltransferase og HMG CoA reduktase inhibitorer og anvendelse derav for behandling av cancer
NO20012961D0 (no)	2001-06-15	Trisykliske farnesylproteintransferase-inhibitorer
ATE317386T1 (de)	2006-02-15	Dihydroindol- und tetrahydrochinolinderivate
IS6358A (is)	2002-04-23	Farnasýl transferasa latar
AU3514302A (en)	2002-06-11	0ovel farnesyl protein transferase inhibitors
ATE323096T1 (de)	2006-04-15	Prenyltransferase-inhibitoren
NO20022923L (no)	2002-06-18	Inhibitorer av farnesyl-protein-transferase
FIU990312U0 (fi)	1999-07-12	Kylmäsavustus kylmälaitteissa