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ATE238811T1 - Inhibitoren von farnesylprotein-transferase mit radiosensibilisierenden eigenschaften - Google Patents

Inhibitoren von farnesylprotein-transferase mit radiosensibilisierenden eigenschaften

Info

Publication number
ATE238811T1
ATE238811T1 AT99931229T AT99931229T ATE238811T1 AT E238811 T1 ATE238811 T1 AT E238811T1 AT 99931229 T AT99931229 T AT 99931229T AT 99931229 T AT99931229 T AT 99931229T AT E238811 T1 ATE238811 T1 AT E238811T1
Authority
AT
Austria
Prior art keywords
protein transferase
transferase inhibitors
farnesyl protein
radiosensitizing properties
radiosensitizing
Prior art date
Application number
AT99931229T
Other languages
English (en)
Inventor
Ginckel Robert Franciscus Van
Wim Joanna Floren
David William End
Walter Boudewijn Leopo Wouters
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE238811T1 publication Critical patent/ATE238811T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
AT99931229T 1998-07-06 1999-06-30 Inhibitoren von farnesylprotein-transferase mit radiosensibilisierenden eigenschaften ATE238811T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98202257 1998-07-06
EP98204330 1998-12-18
PCT/EP1999/004545 WO2000001411A1 (en) 1998-07-06 1999-06-30 Farnesyl protein transferase inhibitors with in vivo radiosensitizing properties

Publications (1)

Publication Number Publication Date
ATE238811T1 true ATE238811T1 (de) 2003-05-15

Family

ID=26150503

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99931229T ATE238811T1 (de) 1998-07-06 1999-06-30 Inhibitoren von farnesylprotein-transferase mit radiosensibilisierenden eigenschaften

Country Status (31)

Country Link
US (1) US6545020B1 (de)
EP (1) EP1094839B1 (de)
JP (1) JP4530537B2 (de)
KR (1) KR100591603B1 (de)
CN (1) CN1152716C (de)
AP (1) AP1599A (de)
AT (1) ATE238811T1 (de)
AU (1) AU762423B2 (de)
BG (1) BG64941B1 (de)
BR (1) BR9911861A (de)
CA (1) CA2336624C (de)
CZ (1) CZ300968B6 (de)
DE (1) DE69907461T2 (de)
DK (1) DK1094839T3 (de)
EA (1) EA003877B1 (de)
EE (1) EE04582B1 (de)
ES (1) ES2199579T3 (de)
HK (1) HK1034451A1 (de)
HR (1) HRP20000903A2 (de)
HU (1) HU229076B1 (de)
ID (1) ID26987A (de)
IL (2) IL140721A0 (de)
MY (1) MY126519A (de)
NO (1) NO328178B1 (de)
PL (1) PL193464B1 (de)
PT (1) PT1094839E (de)
SI (1) SI1094839T1 (de)
SK (1) SK284723B6 (de)
TR (1) TR200003879T2 (de)
TW (1) TW586937B (de)
WO (1) WO2000001411A1 (de)

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EP1255537B1 (de) * 2000-02-04 2006-04-19 Janssen Pharmaceutica N.V. Farnesyl protein transferase inhibitoren zur behandlung von brustkrebs
JO2361B1 (en) 2000-06-22 2006-12-12 جانسين فارماسيوتيكا ان. في Enaniumer 1,2-anylated quinoline inhibitor for the transporter - farnesyl
EP1322636A1 (de) 2000-09-25 2003-07-02 Janssen Pharmaceutica N.V. 6-(substituierte phenyl)methyl)chinolin- und chinazolinderivate und deren verwendung als farneyl transferase inhibitoren
EP1322644A1 (de) 2000-09-25 2003-07-02 Janssen Pharmaceutica N.V. 6-heterocyclylmethyl chinolon derivate und deren verwendung als farnesyl transferase inhibitoren
JP4911866B2 (ja) 2000-09-25 2012-04-04 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ファルネシルトランスフェラーゼ阻害剤としてのファルネシルトランスフェラーゼを阻害するキノリンおよびキナゾリン誘導体
WO2002024686A2 (en) 2000-09-25 2002-03-28 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives
US7153958B2 (en) 2000-11-21 2006-12-26 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting benzoheterocyclic derivatives
US7129356B2 (en) 2000-12-27 2006-10-31 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting 4-substituted quinoline and quinazoline derivatives
WO2002051834A1 (en) * 2000-12-27 2002-07-04 Janssen Pharmaceutica N.V. Farnesyl transferase inhibiting 4-heterocyclyl-quinoline and quinazoline derivatives
WO2003000266A1 (en) 2001-06-21 2003-01-03 Ariad Pharmaceuticals, Inc. Novel quinolines and uses thereof
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ATE336496T1 (de) 2002-04-15 2006-09-15 Janssen Pharmaceutica Nv Farnesyl transferase hemmende tricyclische quinazolinederivate substitutiert mit kohlenstoff-gebundenen imidazolen oder triazolen
AU2004295058B9 (en) * 2003-11-20 2011-06-30 Janssen Pharmaceutica N.V. 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
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WO2005089496A2 (en) * 2004-03-18 2005-09-29 The Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies
WO2005089504A2 (en) * 2004-03-18 2005-09-29 The Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies
WO2005089515A2 (en) * 2004-03-18 2005-09-29 The Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies
US20060194821A1 (en) * 2005-02-18 2006-08-31 The Brigham And Women's Hospital, Inc. Compounds inhibiting the aggregation of superoxide dismutase-1
CA2617056A1 (en) 2005-07-29 2007-02-08 Children's Hospital Medical Center Gtpase inhibitors and methods of use and crystal structure of rac-1 gtpase
AU2006331542A1 (en) 2005-12-23 2007-07-05 Link Medicine Corporation Treatment of synucleinopathies
WO2008147788A1 (en) * 2007-05-23 2008-12-04 Allergan, Inc. Therapeutic ((phenyl)imidazolyl)methylquinolinyl compounds
US8232402B2 (en) * 2008-03-12 2012-07-31 Link Medicine Corporation Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
ATE555384T1 (de) 2008-06-26 2012-05-15 Spherotec Gmbh Verfahren zum testen der reaktion von zellen auf die einwirkung von therapeutika
MX2011005096A (es) * 2008-11-13 2011-11-18 Link Medicine Corp Derivados de azaquinolinona y usos de los mismos.
US20100331363A1 (en) * 2008-11-13 2010-12-30 Link Medicine Corporation Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
US20110060005A1 (en) * 2008-11-13 2011-03-10 Link Medicine Corporation Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
WO2013166043A1 (en) 2012-05-02 2013-11-07 Children's Hospital Medical Center Rejuvenation of precursor cells
PE20151203A1 (es) 2012-10-16 2015-08-31 Janssen Pharmaceutica Nv MODULADORES DE QUINOLINILO UNIDOS A FENILO DE ROR-GAMMA-t
LT2909192T (lt) 2012-10-16 2017-07-10 Janssen Pharmaceutica Nv Su metilenu sujungti rop-gama-t chinolinilo moduliatoriai
ES2619610T3 (es) 2012-10-16 2017-06-26 Janssen Pharmaceutica Nv Moduladores de ROR-gamma-t de quinolinilo enlazado con heteroarilo
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
BR112016008215A2 (pt) 2013-10-15 2017-09-26 Janssen Pharmaceutica Nv moduladores de quinolinila ligados por alquila de roryt
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
WO2015057626A1 (en) 2013-10-15 2015-04-23 Janssen Pharmaceutica Nv QUINOLINYL MODULATORS OF RORyT
US10028503B2 (en) 2014-06-18 2018-07-24 Children's Hospital Medical Center Platelet storage methods and compositions for same
LT3277842T (lt) 2015-08-17 2019-10-25 Kura Oncology Inc Vėžio pacientų gydymo būdai farneziltransferazės inhibitoriais
WO2017184968A1 (en) 2016-04-22 2017-10-26 Kura Oncology, Inc. Methods of selecting cancer patients for treatment with farnesyltransferase inhibitors
AR110031A1 (es) 2016-11-03 2019-02-13 Kura Oncology Inc Métodos de tratamiento de pacientes con cáncer con inhibidores de farnesiltransferasa
US9956215B1 (en) 2017-02-21 2018-05-01 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
KR102138904B1 (ko) 2017-02-21 2020-07-28 쿠라 온콜로지, 인크. 파르네실트랜스퍼라제 억제제를 사용하는 암 환자의 치료 방법
AU2018313738B2 (en) 2017-08-07 2024-07-04 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
US10806730B2 (en) 2017-08-07 2020-10-20 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
WO2019113269A1 (en) 2017-12-08 2019-06-13 Kura Oncology, Inc. Methods of treating cancer patients with farnesyltransferase inhibitors
TW202031259A (zh) 2018-11-01 2020-09-01 美商庫拉腫瘤技術股份有限公司 以法尼基轉移酶(farnesyltransferase)抑制劑治療癌症之方法
US20220142983A1 (en) 2019-03-01 2022-05-12 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
WO2020190604A1 (en) 2019-03-15 2020-09-24 Kura Oncology, Inc. Methods of treating cancer patients with farnesyltransferase inhibitors
CN113795253A (zh) 2019-03-29 2021-12-14 库拉肿瘤学公司 用法呢基转移酶抑制剂治疗鳞状细胞癌的方法
WO2020205387A1 (en) 2019-04-01 2020-10-08 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
WO2020223583A1 (en) 2019-05-02 2020-11-05 Kura Oncology, Inc. Methods of treating acute myeloid leukemia with farnesyltransferase inhibitors

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US5141851A (en) * 1990-04-18 1992-08-25 Board Of Regents, The University Of Texas System Isolated farnesyl protein transferase enzyme
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CA2260216A1 (en) * 1996-07-15 1998-01-22 Bristol-Myers Squibb Company Thiadioxobenzodiazepine inhibitors of farnesyl protein transferase
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Also Published As

Publication number Publication date
PL193464B1 (pl) 2007-02-28
TW586937B (en) 2004-05-11
AU4780599A (en) 2000-01-24
AP2001002057A0 (en) 2001-03-31
EA003877B1 (ru) 2003-10-30
BG105108A (en) 2001-11-30
JP2002519389A (ja) 2002-07-02
CZ300968B6 (cs) 2009-09-30
KR20010052770A (ko) 2001-06-25
SK19862000A3 (sk) 2001-12-03
JP4530537B2 (ja) 2010-08-25
CN1311692A (zh) 2001-09-05
EP1094839A1 (de) 2001-05-02
US6545020B1 (en) 2003-04-08
BR9911861A (pt) 2001-03-20
WO2000001411A1 (en) 2000-01-13
PT1094839E (pt) 2003-09-30
SK284723B6 (sk) 2005-10-06
BG64941B1 (bg) 2006-10-31
AU762423B2 (en) 2003-06-26
CA2336624A1 (en) 2000-01-13
KR100591603B1 (ko) 2006-06-20
DE69907461D1 (de) 2003-06-05
EA200100111A1 (ru) 2001-06-25
NO20010082L (no) 2001-01-05
NO328178B1 (no) 2009-12-28
CA2336624C (en) 2008-10-21
PL347979A1 (en) 2002-05-06
CN1152716C (zh) 2004-06-09
EP1094839B1 (de) 2003-05-02
NO20010082D0 (no) 2001-01-05
IL140721A (en) 2008-11-26
TR200003879T2 (tr) 2007-01-22
AP1599A (en) 2006-04-27
EE200000794A (et) 2002-06-17
ID26987A (id) 2001-02-22
CZ20004777A3 (en) 2001-05-16
IL140721A0 (en) 2002-02-10
HUP0103689A3 (en) 2003-01-28
HU229076B1 (en) 2013-07-29
MY126519A (en) 2006-10-31
SI1094839T1 (en) 2003-12-31
DK1094839T3 (da) 2003-08-18
HK1034451A1 (en) 2001-10-26
ES2199579T3 (es) 2004-02-16
HUP0103689A2 (hu) 2002-02-28
EE04582B1 (et) 2006-02-15
HRP20000903A2 (en) 2001-12-31
DE69907461T2 (de) 2004-02-19

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