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DK0970042T3 - 5-hydroxymethyl-2-aminotetraliner som kardiovaskulære midler - Google Patents

5-hydroxymethyl-2-aminotetraliner som kardiovaskulære midler

Info

Publication number
DK0970042T3
DK0970042T3 DK98908052T DK98908052T DK0970042T3 DK 0970042 T3 DK0970042 T3 DK 0970042T3 DK 98908052 T DK98908052 T DK 98908052T DK 98908052 T DK98908052 T DK 98908052T DK 0970042 T3 DK0970042 T3 DK 0970042T3
Authority
DK
Denmark
Prior art keywords
pct
aminotetralins
hydroxymethyl
cardiovascular agents
sec
Prior art date
Application number
DK98908052T
Other languages
Danish (da)
English (en)
Inventor
Stefania Montanari
Paolo Cavalleri
Francesco Santangelo
Francesco Marchini
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Application granted granted Critical
Publication of DK0970042T3 publication Critical patent/DK0970042T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK98908052T 1997-02-26 1998-02-04 5-hydroxymethyl-2-aminotetraliner som kardiovaskulære midler DK0970042T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97MI000414A IT1289979B1 (it) 1997-02-26 1997-02-26 5-idrossimetil-6-idrossi-2-amminotetraline attive come agenti cardiovascolari
PCT/EP1998/000589 WO1998038155A1 (en) 1997-02-26 1998-02-04 5-hydroxymethyl-2-aminotetralins as cardiovascular agents

Publications (1)

Publication Number Publication Date
DK0970042T3 true DK0970042T3 (da) 2002-04-29

Family

ID=11376182

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98908052T DK0970042T3 (da) 1997-02-26 1998-02-04 5-hydroxymethyl-2-aminotetraliner som kardiovaskulære midler

Country Status (16)

Country Link
US (1) US6063964A (de)
EP (1) EP0970042B1 (de)
JP (1) JP2001513763A (de)
KR (1) KR20000075736A (de)
AT (1) ATE211727T1 (de)
AU (1) AU733001B2 (de)
CA (1) CA2282388A1 (de)
DE (1) DE69803445T2 (de)
DK (1) DK0970042T3 (de)
ES (1) ES2169909T3 (de)
HU (1) HUP0001058A3 (de)
IT (1) IT1289979B1 (de)
NO (1) NO994104L (de)
NZ (1) NZ336680A (de)
PT (1) PT970042E (de)
WO (1) WO1998038155A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019101917A1 (en) 2017-11-24 2019-05-31 H. Lundbeck A/S New catecholamine prodrugs for use in the treatment of parkinson's disease
US11111263B2 (en) 2019-05-20 2021-09-07 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11130775B2 (en) 2019-05-20 2021-09-28 H. Lundbeck A/S Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11104697B2 (en) 2019-05-20 2021-08-31 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11168056B2 (en) 2019-05-20 2021-11-09 H. Lundbeck A/S Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2803582A1 (de) * 1978-01-27 1979-08-02 Sandoz Ag Neue tetralinderivate, ihre herstellung und verwendung
IT1271411B (it) * 1993-09-14 1997-05-28 Zambon Spa Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare

Also Published As

Publication number Publication date
DE69803445D1 (en) 2002-02-28
IT1289979B1 (it) 1998-10-19
HUP0001058A2 (hu) 2001-06-28
NO994104L (no) 1999-10-26
ES2169909T3 (es) 2002-07-16
ITMI970414A1 (it) 1998-08-26
KR20000075736A (ko) 2000-12-26
NO994104D0 (no) 1999-08-25
US6063964A (en) 2000-05-16
DE69803445T2 (de) 2002-08-29
AU733001B2 (en) 2001-05-03
WO1998038155A1 (en) 1998-09-03
EP0970042A1 (de) 2000-01-12
HUP0001058A3 (en) 2001-07-30
EP0970042B1 (de) 2002-01-09
NZ336680A (en) 2000-02-28
JP2001513763A (ja) 2001-09-04
CA2282388A1 (en) 1998-09-03
PT970042E (pt) 2002-06-28
AU6619898A (en) 1998-09-18
ATE211727T1 (de) 2002-01-15

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