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ATE211727T1 - 5-hydroxymethyl-2-aminotetraline als cardiovasculäre mittel - Google Patents

5-hydroxymethyl-2-aminotetraline als cardiovasculäre mittel

Info

Publication number
ATE211727T1
ATE211727T1 AT98908052T AT98908052T ATE211727T1 AT E211727 T1 ATE211727 T1 AT E211727T1 AT 98908052 T AT98908052 T AT 98908052T AT 98908052 T AT98908052 T AT 98908052T AT E211727 T1 ATE211727 T1 AT E211727T1
Authority
AT
Austria
Prior art keywords
pct
aminotetraline
hydroxymethyl
cardiovascular agents
sec
Prior art date
Application number
AT98908052T
Other languages
English (en)
Inventor
Stefania Montanari
Paolo Cavalleri
Francesco Santangelo
Francesco Marchini
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Application granted granted Critical
Publication of ATE211727T1 publication Critical patent/ATE211727T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT98908052T 1997-02-26 1998-02-04 5-hydroxymethyl-2-aminotetraline als cardiovasculäre mittel ATE211727T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97MI000414A IT1289979B1 (it) 1997-02-26 1997-02-26 5-idrossimetil-6-idrossi-2-amminotetraline attive come agenti cardiovascolari
PCT/EP1998/000589 WO1998038155A1 (en) 1997-02-26 1998-02-04 5-hydroxymethyl-2-aminotetralins as cardiovascular agents

Publications (1)

Publication Number Publication Date
ATE211727T1 true ATE211727T1 (de) 2002-01-15

Family

ID=11376182

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98908052T ATE211727T1 (de) 1997-02-26 1998-02-04 5-hydroxymethyl-2-aminotetraline als cardiovasculäre mittel

Country Status (16)

Country Link
US (1) US6063964A (de)
EP (1) EP0970042B1 (de)
JP (1) JP2001513763A (de)
KR (1) KR20000075736A (de)
AT (1) ATE211727T1 (de)
AU (1) AU733001B2 (de)
CA (1) CA2282388A1 (de)
DE (1) DE69803445T2 (de)
DK (1) DK0970042T3 (de)
ES (1) ES2169909T3 (de)
HU (1) HUP0001058A3 (de)
IT (1) IT1289979B1 (de)
NO (1) NO994104L (de)
NZ (1) NZ336680A (de)
PT (1) PT970042E (de)
WO (1) WO1998038155A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019101917A1 (en) 2017-11-24 2019-05-31 H. Lundbeck A/S New catecholamine prodrugs for use in the treatment of parkinson's disease
US11111263B2 (en) 2019-05-20 2021-09-07 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11130775B2 (en) 2019-05-20 2021-09-28 H. Lundbeck A/S Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11104697B2 (en) 2019-05-20 2021-08-31 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11168056B2 (en) 2019-05-20 2021-11-09 H. Lundbeck A/S Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2803582A1 (de) * 1978-01-27 1979-08-02 Sandoz Ag Neue tetralinderivate, ihre herstellung und verwendung
IT1271411B (it) * 1993-09-14 1997-05-28 Zambon Spa Derivati del 2-ammino-1,2,3,4-tetraidro-naftalene attivi sul sistema cardiovascolare

Also Published As

Publication number Publication date
DE69803445D1 (en) 2002-02-28
IT1289979B1 (it) 1998-10-19
HUP0001058A2 (hu) 2001-06-28
NO994104L (no) 1999-10-26
ES2169909T3 (es) 2002-07-16
ITMI970414A1 (it) 1998-08-26
KR20000075736A (ko) 2000-12-26
NO994104D0 (no) 1999-08-25
US6063964A (en) 2000-05-16
DE69803445T2 (de) 2002-08-29
AU733001B2 (en) 2001-05-03
WO1998038155A1 (en) 1998-09-03
EP0970042A1 (de) 2000-01-12
HUP0001058A3 (en) 2001-07-30
EP0970042B1 (de) 2002-01-09
NZ336680A (en) 2000-02-28
JP2001513763A (ja) 2001-09-04
CA2282388A1 (en) 1998-09-03
PT970042E (pt) 2002-06-28
DK0970042T3 (da) 2002-04-29
AU6619898A (en) 1998-09-18

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee