DK0942899T3 - Fremgangsmåde til fremstilling af metoprolol. - Google Patents

Fremgangsmåde til fremstilling af metoprolol.

Info

Publication number: DK0942899T3
Authority: DK; Denmark
Prior art keywords: metoprolol; preparation
Prior art date: 1996-11-20

Application number

DK97913641T

Other languages

English (en)

Inventor

Sven Palmer

Michael Sidenqvist

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-20

Filing date

1997-11-18

Publication date

2003-06-02

1997-11-18 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2003-06-02 Application granted granted Critical

2003-06-02 Publication of DK0942899T3 publication Critical patent/DK0942899T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/04—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reaction of ammonia or amines with olefin oxides or halohydrins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Hematology (AREA)
Diabetes (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Epoxy Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK97913641T 1996-11-20 1997-11-18 Fremgangsmåde til fremstilling af metoprolol. DK0942899T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9604253A SE9604253D0 (sv)	1996-11-20	1996-11-20	New manufacturing process metoprolol
PCT/SE1997/001926 WO1998022426A1 (en)	1996-11-20	1997-11-18	New manufacturing process of metoprolol

Publications (1)

Publication Number	Publication Date
DK0942899T3 true DK0942899T3 (da)	2003-06-02

Family

ID=20404680

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97913641T DK0942899T3 (da)	1996-11-20	1997-11-18	Fremgangsmåde til fremstilling af metoprolol.

Country Status (36)

Country	Link
US (1)	US6252113B1 (da)
EP (1)	EP0942899B1 (da)
JP (1)	JP4039640B2 (da)
KR (1)	KR100544560B1 (da)
CN (1)	CN1128786C (da)
AR (1)	AR010069A1 (da)
AT (1)	ATE234273T1 (da)
AU (1)	AU728270B2 (da)
BR (1)	BR9713370A (da)
CA (1)	CA2269941A1 (da)
CZ (1)	CZ174499A3 (da)
DE (1)	DE69719788T2 (da)
DK (1)	DK0942899T3 (da)
EE (1)	EE03761B1 (da)
EG (1)	EG21158A (da)
ES (1)	ES2193365T3 (da)
HK (1)	HK1022684A1 (da)
HU (1)	HUP0002445A3 (da)
ID (1)	ID21505A (da)
IL (1)	IL129747A (da)
IN (1)	IN187175B (da)
IS (1)	IS1964B (da)
MY (1)	MY119303A (da)
NO (1)	NO311352B1 (da)
NZ (1)	NZ335213A (da)
PL (1)	PL191392B1 (da)
PT (1)	PT942899E (da)
RU (1)	RU2210565C2 (da)
SA (1)	SA97180599B1 (da)
SE (1)	SE9604253D0 (da)
SK (1)	SK281990B6 (da)
TR (1)	TR199901115T2 (da)
TW (1)	TW412513B (da)
UA (1)	UA66769C2 (da)
WO (1)	WO1998022426A1 (da)
ZA (1)	ZA9710005B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20050107635A1 (en) *	2003-11-14	2005-05-19	Mehra Janakraj K.	Metoprolol manufacturing process
WO2007141593A2 (en) *	2005-12-23	2007-12-13	Medichem, S.A.	Process for the preparation of metoprolol and its salts
US20080107726A1 (en) *	2006-11-01	2008-05-08	Pramod Kharwade	Compositions comprising beta-adrenergic receptor antagonists and diuretics
CN101607918B (zh) *	2008-06-16	2014-02-19	北京德众万全药物技术开发有限公司	一种美托洛尔的制备方法
WO2011056929A1 (en) *	2009-11-04	2011-05-12	Massachusetts Institute Of Technology	Continuous flow synthesis of amino alcohols using microreactors
WO2011109276A1 (en)	2010-03-01	2011-09-09	Massachussets Institute Of Technology	Epoxidation catalysts
CN102381995B (zh) *	2010-08-31	2015-04-15	扬子江药业集团北京海燕药业有限公司	美托洛尔的制备方法
CN102432476A (zh) *	2010-09-29	2012-05-02	湖南康普医药研究院	一种规模化制备琥珀酸美托洛尔的方法
CN102503843B (zh) *	2011-10-28	2013-10-23	山东阿如拉药物研究开发有限公司	一种美托洛尔盐的制备方法
KR101379383B1 (ko) *	2012-03-23	2014-04-02	주식회사 알에스텍	고순도 ⒮―메토프롤롤의 제조방법
CN103980134B (zh) *	2014-05-30	2015-09-30	安徽省新星药物开发有限责任公司	一种琥珀酸s-美托洛尔的制备方法
CN105820057B (zh) *	2016-04-22	2017-09-29	上海应用技术学院	一种制备美多心安的方法
CN106543015A (zh) *	2016-11-07	2017-03-29	上海应用技术大学	一种美多心安的制备方法
CN108299279B (zh) *	2018-02-09	2021-03-23	北京梅尔森医药技术开发有限公司	取代芳基胺醇化合物及其制备方法和用途
EP3768378A4 (en)	2018-03-22	2021-11-17	InCarda Therapeutics, Inc.	INNOVATIVE METHOD OF SLOWING THE VENTRICULAR RATE
CN111018724B (zh) *	2019-12-27	2022-11-08	江西美晶科技有限公司	一种美托洛尔及其制备方法
CN112645827A (zh) *	2020-12-25	2021-04-13	浙江普洛家园药业有限公司	一种连续合成美多心安及其盐的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2011584A6 (es) *	1989-05-26	1990-01-16	Esteve Quimica Sa	Procedimiento industrial para la obtencion de una ariloxipropanolamina.
AU660984B2 (en)	1991-03-18	1995-07-13	Sepracor, Inc.	Composition and method containing optically pure (S) metoprolol

1996
- 1996-11-18 NZ NZ335213A patent/NZ335213A/en unknown
- 1996-11-20 US US08/973,144 patent/US6252113B1/en not_active Expired - Lifetime
- 1996-11-20 SE SE9604253A patent/SE9604253D0/xx unknown
1997
- 1997-10-23 TW TW086115698A patent/TW412513B/zh active
- 1997-11-06 ZA ZA9710005A patent/ZA9710005B/xx unknown
- 1997-11-12 SA SA97180599A patent/SA97180599B1/ar unknown
- 1997-11-13 IN IN3275DE1997 patent/IN187175B/en unknown
- 1997-11-18 JP JP51107298A patent/JP4039640B2/ja not_active Expired - Fee Related
- 1997-11-18 PL PL333541A patent/PL191392B1/pl not_active IP Right Cessation
- 1997-11-18 KR KR1019997004401A patent/KR100544560B1/ko not_active IP Right Cessation
- 1997-11-18 EG EG122697A patent/EG21158A/xx active
- 1997-11-18 PT PT97913641T patent/PT942899E/pt unknown
- 1997-11-18 UA UA99042412A patent/UA66769C2/uk unknown
- 1997-11-18 SK SK564-99A patent/SK281990B6/sk unknown
- 1997-11-18 IL IL12974797A patent/IL129747A/xx not_active IP Right Cessation
- 1997-11-18 ES ES97913641T patent/ES2193365T3/es not_active Expired - Lifetime
- 1997-11-18 CN CN97199796A patent/CN1128786C/zh not_active Expired - Lifetime
- 1997-11-18 WO PCT/SE1997/001926 patent/WO1998022426A1/en not_active Application Discontinuation
- 1997-11-18 DE DE69719788T patent/DE69719788T2/de not_active Expired - Fee Related
- 1997-11-18 RU RU99109477/04A patent/RU2210565C2/ru not_active IP Right Cessation
- 1997-11-18 EP EP97913641A patent/EP0942899B1/en not_active Expired - Lifetime
- 1997-11-18 TR TR1999/01115T patent/TR199901115T2/xx unknown
- 1997-11-18 AU AU50776/98A patent/AU728270B2/en not_active Ceased
- 1997-11-18 CZ CZ991744A patent/CZ174499A3/cs unknown
- 1997-11-18 ID IDW990343D patent/ID21505A/id unknown
- 1997-11-18 CA CA002269941A patent/CA2269941A1/en not_active Abandoned
- 1997-11-18 HU HU0002445A patent/HUP0002445A3/hu unknown
- 1997-11-18 BR BR9713370A patent/BR9713370A/pt not_active Application Discontinuation
- 1997-11-18 AT AT97913641T patent/ATE234273T1/de not_active IP Right Cessation
- 1997-11-18 EE EEP199900202A patent/EE03761B1/xx not_active IP Right Cessation
- 1997-11-18 DK DK97913641T patent/DK0942899T3/da active
- 1997-11-19 AR ARP970105420A patent/AR010069A1/es unknown
- 1997-11-19 MY MYPI97005544A patent/MY119303A/en unknown
1999
- 1999-04-26 IS IS5034A patent/IS1964B/is unknown
- 1999-05-19 NO NO19992401A patent/NO311352B1/no unknown
2000
- 2000-03-20 HK HK00101688A patent/HK1022684A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
IN187175B (da)	2002-02-23
NO311352B1 (no)	2001-11-19
EE9900202A (et)	1999-12-15
SE9604253D0 (sv)	1996-11-20
ATE234273T1 (de)	2003-03-15
DE69719788T2 (de)	2004-02-12
ZA9710005B (en)	1998-05-20
AU728270B2 (en)	2001-01-04
EE03761B1 (et)	2002-06-17
HUP0002445A2 (hu)	2001-08-28
SK56499A3 (en)	2000-03-13
IL129747A (en)	2003-01-12
NO992401D0 (no)	1999-05-19
ES2193365T3 (es)	2003-11-01
RU2210565C2 (ru)	2003-08-20
TR199901115T2 (xx)	1999-07-21
PL191392B1 (pl)	2006-05-31
JP4039640B2 (ja)	2008-01-30
NZ335213A (en)	2001-02-23
CN1128786C (zh)	2003-11-26
EP0942899A1 (en)	1999-09-22
JP2001503388A (ja)	2001-03-13
AU5077698A (en)	1998-06-10
UA66769C2 (uk)	2004-06-15
NO992401L (no)	1999-07-13
IL129747A0 (en)	2000-02-29
US6252113B1 (en)	2001-06-26
BR9713370A (pt)	2000-03-21
CZ174499A3 (cs)	1999-11-17
IS5034A (is)	1999-04-26
WO1998022426A1 (en)	1998-05-28
IS1964B (is)	2004-12-15
KR20000057134A (ko)	2000-09-15
TW412513B (en)	2000-11-21
SA97180599B1 (ar)	2006-03-25
EP0942899B1 (en)	2003-03-12
HUP0002445A3 (en)	2001-09-28
SK281990B6 (sk)	2001-09-11
AR010069A1 (es)	2000-05-15
EG21158A (en)	2000-12-31
DE69719788D1 (de)	2003-04-17
CA2269941A1 (en)	1998-05-28
ID21505A (id)	1999-06-17
CN1237958A (zh)	1999-12-08
MY119303A (en)	2005-04-30
PT942899E (pt)	2003-06-30
KR100544560B1 (ko)	2006-01-24
HK1022684A1 (en)	2000-08-18

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