[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

DK0870050T3 - Virus, der udtrykker et toksisk protein, og producercellelinier - Google Patents

Virus, der udtrykker et toksisk protein, og producercellelinier

Info

Publication number
DK0870050T3
DK0870050T3 DK96945414T DK96945414T DK0870050T3 DK 0870050 T3 DK0870050 T3 DK 0870050T3 DK 96945414 T DK96945414 T DK 96945414T DK 96945414 T DK96945414 T DK 96945414T DK 0870050 T3 DK0870050 T3 DK 0870050T3
Authority
DK
Denmark
Prior art keywords
cell lines
producer cell
virus expressing
toxic protein
nucleic acid
Prior art date
Application number
DK96945414T
Other languages
Danish (da)
English (en)
Inventor
Nicholas J Depolo
Sybille Sauter
Joan Robbins
Douglas J Jolly
William C Manning
John E Murphy
Robert O Ii Ralston
Sunil Chada
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Application granted granted Critical
Publication of DK0870050T3 publication Critical patent/DK0870050T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20211—Vesiculovirus, e.g. vesicular stomatitis Indiana virus
    • C12N2760/20222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C12N2830/003—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor tet inducible
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/10—Vectors comprising a special translation-regulating system regulates levels of translation
    • C12N2840/105—Vectors comprising a special translation-regulating system regulates levels of translation enhancing translation

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DK96945414T 1995-12-29 1996-12-20 Virus, der udtrykker et toksisk protein, og producercellelinier DK0870050T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58055695A 1995-12-29 1995-12-29
US58055495A 1995-12-29 1995-12-29
PCT/US1996/020587 WO1997024452A2 (en) 1995-12-29 1996-12-20 Toxic-protein expressing viruses and producer cell lines

Publications (1)

Publication Number Publication Date
DK0870050T3 true DK0870050T3 (da) 2002-07-15

Family

ID=27078078

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96945414T DK0870050T3 (da) 1995-12-29 1996-12-20 Virus, der udtrykker et toksisk protein, og producercellelinier

Country Status (8)

Country Link
EP (1) EP0870050B1 (de)
JP (1) JP2000502261A (de)
AT (1) ATE219521T1 (de)
DE (1) DE69621949T2 (de)
DK (1) DK0870050T3 (de)
ES (1) ES2175184T3 (de)
PT (1) PT870050E (de)
WO (1) WO1997024452A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2337520B (en) * 1998-05-22 2000-06-14 Oxford Biomedica Ltd Delivery system
AU775679B2 (en) * 1998-08-20 2004-08-12 Cell Genesys, Inc. Use of suppressor tRNA's to regulate cytotoxicity during the production of recombinant gene products

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4963481A (en) * 1985-12-18 1990-10-16 Genetics Institute Inc Promoter system
US5512421A (en) * 1991-02-19 1996-04-30 The Regents Of The University Of California Generation, concentration and efficient transfer of VSV-G pseudotyped retroviral vectors

Also Published As

Publication number Publication date
ATE219521T1 (de) 2002-07-15
WO1997024452A2 (en) 1997-07-10
DE69621949D1 (de) 2002-08-01
EP0870050B1 (de) 2002-06-19
ES2175184T3 (es) 2002-11-16
EP0870050A2 (de) 1998-10-14
DE69621949T2 (de) 2002-09-26
PT870050E (pt) 2002-10-31
JP2000502261A (ja) 2000-02-29
WO1997024452A3 (en) 1997-11-06

Similar Documents

Publication Publication Date Title
AU1750297A (en) Humanized green fluorescent protein genes and methods
DE69128893D1 (de) Genetische veränderung von endothelzellen
PT101297A (pt) Factores mitogenicos gliais, sua preparacao e utilizacao
GB2338237A (en) In vitro peptide or protein expression library
CA2282497A1 (en) In vitro peptide or protein expression library
ES2042693T5 (es) Formulaciones de proteinas plasmaticas y recombinantes en medios de baja potencia ionica.
AU573523B2 (en) Functional human urokinase proteins
EP0804609A4 (de) NEUARTIGE AUF p53 ANSPRECHENDE GENE
ATE270337T1 (de) Materialen und methoden im zusammenhang mit bindung und präsentation von substanzen auf zelloberflächen
EP1012603A4 (de) Funktionelle fragmente des hiv-1 vpr proteins and eine methode zu seiner anwendung
NO910982D0 (no) Uratoksydase-aktivt protein, rekombinant gen som koder for det, ekspresjonsvektor, mikroorganismer og transformerteceller.
ATA192895A (de) Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen
ATE273388T1 (de) Veränderte menschliche c3-proteine
PT1025245E (pt) Criacao rapida de linhas celulares estaveis de mamifero produzindo elevados iiveis de proteinas recombinantes
PT742821E (pt) Processo de preparacao de uma biblioteca multicombinatoria de vectores de expressao de genes de anticorpos
NZ307444A (en) Polyphenol oxidase genes from lettuce and banana
FR2732346B1 (fr) Proteines mutees, codees par un gene env mute de lentivirus, fragments peptidiques inclus dans lesdites proteines, vecteurs d'expression exprimant lesdites proteines mutees et leurs applications
DK0870050T3 (da) Virus, der udtrykker et toksisk protein, og producercellelinier
AU7423391A (en) Dna constructs for the expression of proteins in the mammary gland of transgenetic mammals
DK0516647T3 (da) Polypeptider, som er involveret i biosyntesen af cobalaminer og/eller cobamider, DNA-sekvenser, som koder for disse polypep
DK0805204T3 (da) Bitestikel - specifikt receptorprotein og anvendelse heraf
ES2073451T3 (es) Vectores de clonacion y de expresion en una cepa de actinomiceto, procedimiento de transformacion de dicha cepa, cepa de actinomiceto obtenida y preparacion de proteinas.
DK0868511T3 (da) Genekspression af utrophin
KR890008166A (ko) 융합 단백질의 선택적 분해 방법
EP0846165A4 (de) Neue cystein-protease von filariiden nematoden, nuklöeinsäuremoleküle und ihre verwendungen