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DK0853484T3 - Hidtil ukendte MU-opioid-receptorligander: agonister og antagonister - Google Patents

Hidtil ukendte MU-opioid-receptorligander: agonister og antagonister

Info

Publication number
DK0853484T3
DK0853484T3 DK96919169T DK96919169T DK0853484T3 DK 0853484 T3 DK0853484 T3 DK 0853484T3 DK 96919169 T DK96919169 T DK 96919169T DK 96919169 T DK96919169 T DK 96919169T DK 0853484 T3 DK0853484 T3 DK 0853484T3
Authority
DK
Denmark
Prior art keywords
trp
seq
xaa
tyr
phe
Prior art date
Application number
DK96919169T
Other languages
English (en)
Inventor
T Dooley Colette
A Houghten Richard
Original Assignee
Torrey Pines Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torrey Pines Inst filed Critical Torrey Pines Inst
Application granted granted Critical
Publication of DK0853484T3 publication Critical patent/DK0853484T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DK96919169T 1995-06-07 1996-06-06 Hidtil ukendte MU-opioid-receptorligander: agonister og antagonister DK0853484T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47643895A 1995-06-07 1995-06-07
PCT/US1996/009321 WO1996040208A1 (en) 1995-06-07 1996-06-06 Novel mu opioid receptor ligands: agonists and antagonists

Publications (1)

Publication Number Publication Date
DK0853484T3 true DK0853484T3 (da) 2003-01-20

Family

ID=23891841

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96919169T DK0853484T3 (da) 1995-06-07 1996-06-06 Hidtil ukendte MU-opioid-receptorligander: agonister og antagonister

Country Status (8)

Country Link
EP (1) EP0853484B1 (da)
AT (1) ATE223927T1 (da)
AU (1) AU707245B2 (da)
CA (1) CA2223428A1 (da)
DE (1) DE69623635T2 (da)
DK (1) DK0853484T3 (da)
ES (1) ES2180781T3 (da)
WO (1) WO1996040208A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5885958A (en) * 1997-03-25 1999-03-23 Administrators Of The Tulane Educational Fund Mu-opiate receptor peptides
TW460478B (en) * 1997-08-15 2001-10-21 Chugai Pharmaceutical Co Ltd Phenethylamine derivatives
WO1999065932A1 (en) * 1998-06-18 1999-12-23 Sepracor, Inc. Tetrapeptides, analogs and peptidomimetics which bind selectively mammalian opioid receptors
TW509699B (en) 1998-09-24 2002-11-11 Chugau Pharmaceutical Co Ltd Ethylamine derivatives
PL349354A1 (en) 1999-01-28 2002-07-15 Chugai Pharmaceutical Co Ltd Substituted phenethylamine derivatives
US7115664B2 (en) 2000-03-16 2006-10-03 Sepracor Inc. Peptidomimetic ligands for cellular receptors and ion channels
AU2001296994A1 (en) * 2000-10-06 2002-04-15 Regents Of The University Of California Nmda receptor channel blocker with neuroprotective activity
JP5166423B2 (ja) 2006-10-17 2013-03-21 レヴァ メディカル、 インコーポレイテッド Ｎ−置換モノマーおよびポリマー

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2090171A1 (en) * 1993-02-23 1994-08-24 Peter W. Schiller Opioid receptor antagonists, their synthesis and use as analgesic and immunosuppressive compounds
IS4261A (is) * 1994-02-21 1995-08-22 Astra Aktiebolag Nýir peptíð-ópíóíðar til meðhöndlunar á verkjum og notkun þeirra

Also Published As

Publication number Publication date
EP0853484A1 (en) 1998-07-22
ATE223927T1 (de) 2002-09-15
DE69623635T2 (de) 2003-05-08
CA2223428A1 (en) 1996-12-19
AU707245B2 (en) 1999-07-08
EP0853484A4 (en) 1999-11-03
AU6157696A (en) 1996-12-30
ES2180781T3 (es) 2003-02-16
EP0853484B1 (en) 2002-09-11
DE69623635D1 (de) 2002-10-17
WO1996040208A1 (en) 1996-12-19

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