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WO2002099379A3 - Breast homing peptides and methods of identifying same using aminopeptidase p - Google Patents

Breast homing peptides and methods of identifying same using aminopeptidase p Download PDF

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Publication number
WO2002099379A3
WO2002099379A3 PCT/US2002/016462 US0216462W WO02099379A3 WO 2002099379 A3 WO2002099379 A3 WO 2002099379A3 US 0216462 W US0216462 W US 0216462W WO 02099379 A3 WO02099379 A3 WO 02099379A3
Authority
WO
WIPO (PCT)
Prior art keywords
aminopeptidase
methods
breast
homing peptides
identifying same
Prior art date
Application number
PCT/US2002/016462
Other languages
French (fr)
Other versions
WO2002099379A2 (en
Inventor
Erkki Ruoslahti
Markus Essler
Original Assignee
Burnham Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Burnham Inst filed Critical Burnham Inst
Priority to AU2002310106A priority Critical patent/AU2002310106A1/en
Publication of WO2002099379A2 publication Critical patent/WO2002099379A2/en
Publication of WO2002099379A3 publication Critical patent/WO2002099379A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides a method of directing a moiety to breast vasculature in a subject by administering to the subject a conjugate which contains a moiety linked to a homing molecule that selectively homes to breast vasculature, whereby the moiety is directed to breast vasculature. In one embodiment, the homing molecule is a peptide containing the amino acid sequence PGPEGAG (SEQ ID NO: 1), or a peptidomimetic thereof.
PCT/US2002/016462 2001-06-01 2002-05-21 Breast homing peptides and methods of identifying same using aminopeptidase p WO2002099379A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002310106A AU2002310106A1 (en) 2001-06-01 2002-05-21 Breast homing peptides and methods of identifying same using aminopeptidase p

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87234201A 2001-06-01 2001-06-01
US09/872,342 2001-06-01

Publications (2)

Publication Number Publication Date
WO2002099379A2 WO2002099379A2 (en) 2002-12-12
WO2002099379A3 true WO2002099379A3 (en) 2003-07-03

Family

ID=25359386

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/016462 WO2002099379A2 (en) 2001-06-01 2002-05-21 Breast homing peptides and methods of identifying same using aminopeptidase p

Country Status (2)

Country Link
AU (1) AU2002310106A1 (en)
WO (1) WO2002099379A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004104575A2 (en) * 2003-05-23 2004-12-02 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with x-prolyl aminopeptidase 2 (xpnpep2)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0478101A2 (en) * 1990-09-24 1992-04-01 W.R. Grace & Co.-Conn. Therapeutic use of peptides having thrombospondin-like activity
WO1993022338A1 (en) * 1992-05-05 1993-11-11 Rijksuniversiteit Leiden Peptides of human papilloma virus for use in human t cell response inducing compositions
US5641497A (en) * 1992-05-22 1997-06-24 Children's Hospital Of Philadelphia Gastrointestinal defensins, cDNA sequences and method for the production and use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0478101A2 (en) * 1990-09-24 1992-04-01 W.R. Grace & Co.-Conn. Therapeutic use of peptides having thrombospondin-like activity
WO1993022338A1 (en) * 1992-05-05 1993-11-11 Rijksuniversiteit Leiden Peptides of human papilloma virus for use in human t cell response inducing compositions
US5641497A (en) * 1992-05-22 1997-06-24 Children's Hospital Of Philadelphia Gastrointestinal defensins, cDNA sequences and method for the production and use thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FINK J.K. ET AL.: "Human microtubule-associated protein 1a (MAP1A) gene: genomic organization, cDNA sequence and developmental- and tissue-specific expression", GENOMICS, vol. 35, no. 3, 1 August 1996 (1996-08-01), pages 577 - 585, XP002960780 *
REDENBACH M. ET AL.: "A set of ordered cosmids and a detailed genetic and physical map for the 8Mb streptomyces coelicolor A3(2) chromosome", MOL. MICROBIOL., vol. 21, no. 1, July 1996 (1996-07-01), pages 77 - 96, XP002907946 *
RUOSLAHTI E.: "Targeting tumor vasculature with homing peptides from phage display", SEMIN. CANCER BIOL., vol. 10, no. 6, December 2000 (2000-12-01), pages 435 - 442, XP002963317 *

Also Published As

Publication number Publication date
WO2002099379A2 (en) 2002-12-12
AU2002310106A1 (en) 2002-12-16

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