DK0719788T3 - Fremgangsmåde til fremstilling af 1-(2'-deoxy-2',2'-difluor-D-ribofuranosyl)-4-aminopyrimidin-2-on-hydrochlorid - Google Patents

Fremgangsmåde til fremstilling af 1-(2'-deoxy-2',2'-difluor-D-ribofuranosyl)-4-aminopyrimidin-2-on-hydrochlorid

Info

Publication number: DK0719788T3
Authority: DK; Denmark
Prior art keywords: aminopyrimidin; ribofuranosyl; deoxy; difluoro; hydrochloride
Prior art date: 1994-12-13

Application number

DK95308030T

Other languages

Danish (da)

English (en)

Inventor

Richard Alan Berglund

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-13

Filing date

1995-11-09

Publication date

1999-11-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23397211&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0719788(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-11-09 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1999-11-01 Application granted granted Critical

1999-11-01 Publication of DK0719788T3 publication Critical patent/DK0719788T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK95308030T 1994-12-13 1995-11-09 Fremgangsmåde til fremstilling af 1-(2'-deoxy-2',2'-difluor-D-ribofuranosyl)-4-aminopyrimidin-2-on-hydrochlorid DK0719788T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/355,372 US5637688A (en)	1994-12-13	1994-12-13	Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride

Publications (1)

Publication Number	Publication Date
DK0719788T3 true DK0719788T3 (da)	1999-11-01

Family

ID=23397211

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95308030T DK0719788T3 (da)	1994-12-13	1995-11-09	Fremgangsmåde til fremstilling af 1-(2'-deoxy-2',2'-difluor-D-ribofuranosyl)-4-aminopyrimidin-2-on-hydrochlorid

Country Status (31)

Country	Link
US (2)	US5637688A (es)
EP (1)	EP0719788B1 (es)
JP (1)	JPH10510806A (es)
KR (1)	KR100424991B1 (es)
CN (1)	CN1047177C (es)
AR (1)	AR001041A1 (es)
AT (1)	ATE179986T1 (es)
AU (1)	AU689674B2 (es)
BG (1)	BG62738B1 (es)
BR (1)	BR9509979A (es)
CO (1)	CO4520286A1 (es)
CZ (1)	CZ290941B6 (es)
DE (1)	DE69509624T2 (es)
DK (1)	DK0719788T3 (es)
ES (1)	ES2130542T3 (es)
GR (1)	GR3030265T3 (es)
HU (1)	HU219021B (es)
IL (1)	IL115852A (es)
MY (1)	MY112488A (es)
NO (1)	NO306783B1 (es)
NZ (1)	NZ296476A (es)
PE (1)	PE49296A1 (es)
PL (1)	PL181732B1 (es)
RO (1)	RO117327B1 (es)
RU (1)	RU2154648C2 (es)
SI (1)	SI0719788T1 (es)
TW (1)	TW379226B (es)
UA (1)	UA48152C2 (es)
WO (1)	WO1996018637A1 (es)
YU (1)	YU49314B (es)
ZA (1)	ZA959320B (es)

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US5637688A (en) *	1994-12-13	1997-06-10	Eli Lilly And Company	Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride
EP0870506A1 (en) *	1997-04-11	1998-10-14	Eli Lilly And Company	Compositions comprising a cryptophycin compound in combination with a synchronizing or activating agent for treating cancer
AU756762B2 (en) *	1997-12-22	2003-01-23	Schering Corporation	Combination of benzocycloheptapyridine compounds and antineoplastic drugs for treating proliferative diseases
US6376470B1 (en)	1999-09-23	2002-04-23	Enzon, Inc.	Polymer conjugates of ara-C and ara-C derivatives
AU2001296558A1 (en) *	2000-10-03	2002-04-15	Oncopharmaceutical, Inc.	Inhibitors of angiogenesis and tumor growth for local and systemic administration
WO2005014010A1 (en) *	2003-07-24	2005-02-17	Eli Lilly And Company	Pharmaceutical composition comprising gemcitabine and cyclodextrines
US7214791B2 (en) *	2004-07-01	2007-05-08	Shenzhen Hande Technology Co., Ltd.	Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
EP1812457A1 (en) *	2004-07-30	2007-08-01	Pharmaessentia Corp.	STEREOSELECTIVE SYNTHESIS OF ß-NUCLEOSIDES
WO2006070985A1 (en) *	2004-12-30	2006-07-06	Hanmi Pharm. Co., Ltd.	METHOD FOR THE PREPARATION OF 2&num;-DEOXY-2&num;,2&num;-DIFLUOROCYTIDINE
MX2007010316A (es) *	2005-03-04	2008-02-19	Dabur Pharma Ltd	Intermediario de 21-desoxi, 21,21-difluoro-d-ribofuranosil nucleosidos enriquecidos en (-anomero y proceso para prepararlo.
WO2006095359A1 (en) *	2005-03-10	2006-09-14	Sms Pharmaceuticals Limited	Synthesis of 2-deoxy-2, 2-di fluoro-d-ribo furanose-3, 5 di(4-methy/4-nitro-chloro)benzoate and its conversion to gemcitabine hydrochloride thereof
TWI368621B (en) *	2005-05-02	2012-07-21	Leyoung Biotech Co Ltd	Stereoselective synthesis of β-nucleosides
CN100391966C (zh) *	2005-06-17	2008-06-04	华东师范大学	一种2’-脱氧-2’，2’-二氟-胞苷合成的方法
EP1940859A1 (en) *	2005-10-28	2008-07-09	Arch Pharmalabs Limited	An improved process for preparation of gemcitabine hydrochloride
KR101259637B1 (ko) *	2005-12-14	2013-04-30	주식회사종근당	1-(2´-데옥시-2´,2´-디플루오로-디-리보푸라노실)-4-아미노피리미딘-2-온또는 그의 염산염의 제조방법
US20090069354A1 (en) *	2007-09-12	2009-03-12	Protia, Llc	Deuterium-enriched gemcitabine
JO2778B1 (en)	2007-10-16	2014-03-15	ايساي انك	Certain vehicles, installations and methods
TWI415858B (zh) *	2007-11-06	2013-11-21	Pharmaessentia Corp	β－核苷之新穎合成技術
IT1393062B1 (it) *	2008-10-23	2012-04-11	Prime Europ Therapeuticals	Procedimento per la preparazione di gemcitabina cloridrato
AU2010234641B2 (en) *	2009-04-06	2016-04-21	Otsuka Pharmaceutical Co., Ltd.	Combination of decitabine with cytidine deaminase inhibitor and use thereof in the treatment of cancer
AU2010234562B2 (en) *	2009-04-06	2016-05-12	Otsuka Pharmaceutical Co., Ltd.	Combination of cytidine-based antineoplastic drugs with cytidine deaminase inhibitor and use thereof in the treatment of cancer
US8609631B2 (en)	2009-04-06	2013-12-17	Eisai Inc.	Compositions and methods for treating cancer
AR076262A1 (es) *	2009-04-06	2011-06-01	Eisai Inc	Derivados heterociclicos de diazepin-2-ona, composiciones farmaceuticas y sus usos en el tratamiento del cancer
CN101525361B (zh) *	2009-04-21	2010-11-17	济南圣鲁金药物技术开发有限公司	基于吉西他滨结构的前药及其合成方法及应用
CN102414216B (zh) *	2009-05-15	2015-01-21	德鲁塔负富莱制药股份有限公司	1-(2’-氰基-2’-脱氧-β-D-阿拉伯呋喃糖基)胞嘧啶一盐酸盐的稳定型结晶
CN101628927B (zh) *	2009-08-07	2012-10-10	卡硼瑞（北京）科技有限公司	以1,3,5-三-O-苯甲酰基-α-D-呋喃核糖为原料立体选择性制备β-二氟胞苷盐酸盐的方法
CN102453064B (zh) *	2011-06-30	2014-07-09	江苏豪森药业股份有限公司	制备吉西他滨盐酸盐的方法
CN102659884B (zh) *	2012-04-23	2014-07-02	南京臣功制药股份有限公司	盐酸吉西他滨的提纯方法
CN103224541B (zh) *	2013-04-27	2015-07-01	江苏豪森药业股份有限公司	吉西他滨α-异构体转化回收工艺
CN104402945A (zh) *	2014-11-27	2015-03-11	苏州乔纳森新材料科技有限公司	一种3-脱氧-1,2-o-异丙叉-d-呋喃木糖的合成方法

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US3817978A (en) *	1971-06-16	1974-06-18	Syntex Inc	4-fluoro nucleosides and sugar intermediates, and methods of preparing
JPS5924999B2 (ja) *	1978-06-10	1984-06-13	富山化学工業株式会社	新規な５−フルオロ−２′−デオキシ−β−ウリジン誘導体の製造法
US4526988A (en) *	1983-03-10	1985-07-02	Eli Lilly And Company	Difluoro antivirals and intermediate therefor
IL77133A (en) *	1984-12-04	1991-01-31	Lilly Co Eli	Antineoplastic pharmaceutical compositions containing pentofuranoside derivatives,some new such compounds and their preparation
US5223608A (en) *	1987-08-28	1993-06-29	Eli Lilly And Company	Process for and intermediates of 2',2'-difluoronucleosides
US4965374A (en) *	1987-08-28	1990-10-23	Eli Lilly And Company	Process for and intermediates of 2',2'-difluoronucleosides
AU4134793A (en) *	1992-06-22	1993-12-23	Eli Lilly And Company	2'-deoxy-2',2'-difluoro(2,6,8-substituted) purine nucleosides having anti-viral and anti-cancer activity and intermediates
FI932871A (fi) *	1992-06-22	1993-12-23	Lilly Co Eli	Stereoselektiv anjonglykosylationsprocess
UA41261C2 (uk) *	1992-06-22	2001-09-17	Елі Ліллі Енд Компані	Спосіб одержання збагачених бета-аномером нуклеозидів
IL106840A (en) *	1992-09-01	1998-09-24	Lilly Co Eli	Process for basic anatomization of pentopornosyl nucleosides
US5637688A (en) *	1994-12-13	1997-06-10	Eli Lilly And Company	Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride

1994
- 1994-12-13 US US08/355,372 patent/US5637688A/en not_active Expired - Lifetime
1995
- 1995-11-01 AR AR33407495A patent/AR001041A1/es unknown
- 1995-11-02 PE PE1995283631A patent/PE49296A1/es not_active IP Right Cessation
- 1995-11-02 IL IL11585295A patent/IL115852A/xx not_active IP Right Cessation
- 1995-11-03 ZA ZA959320A patent/ZA959320B/xx unknown
- 1995-11-09 DE DE69509624T patent/DE69509624T2/de not_active Expired - Lifetime
- 1995-11-09 SI SI9530272T patent/SI0719788T1/xx unknown
- 1995-11-09 EP EP95308030A patent/EP0719788B1/en not_active Expired - Lifetime
- 1995-11-09 ES ES95308030T patent/ES2130542T3/es not_active Expired - Lifetime
- 1995-11-09 AT AT95308030T patent/ATE179986T1/de active
- 1995-11-09 DK DK95308030T patent/DK0719788T3/da active
- 1995-11-10 CO CO95053319A patent/CO4520286A1/es unknown
- 1995-11-13 YU YU70895A patent/YU49314B/sh unknown
- 1995-11-14 BR BR9509979A patent/BR9509979A/pt not_active Application Discontinuation
- 1995-11-14 NZ NZ296476A patent/NZ296476A/xx not_active IP Right Cessation
- 1995-11-14 WO PCT/US1995/014864 patent/WO1996018637A1/en active IP Right Grant
- 1995-11-14 CZ CZ19971798A patent/CZ290941B6/cs not_active IP Right Cessation
- 1995-11-14 HU HU9800673A patent/HU219021B/hu not_active IP Right Cessation
- 1995-11-14 RO RO97-01060A patent/RO117327B1/ro unknown
- 1995-11-14 CN CN95196792A patent/CN1047177C/zh not_active Expired - Fee Related
- 1995-11-14 AU AU41101/96A patent/AU689674B2/en not_active Ceased
- 1995-11-14 TW TW084112041A patent/TW379226B/zh not_active IP Right Cessation
- 1995-11-14 UA UA97062781A patent/UA48152C2/uk unknown
- 1995-11-14 KR KR1019970703880A patent/KR100424991B1/ko not_active IP Right Cessation
- 1995-11-14 RU RU97111801/04A patent/RU2154648C2/ru not_active IP Right Cessation
- 1995-11-14 PL PL95321046A patent/PL181732B1/pl unknown
- 1995-11-14 JP JP8518835A patent/JPH10510806A/ja active Pending
- 1995-11-16 MY MYPI95003490A patent/MY112488A/en unknown
1997
- 1997-04-11 US US08/837,071 patent/US5808048A/en not_active Expired - Lifetime
- 1997-06-10 BG BG101591A patent/BG62738B1/bg unknown
- 1997-06-11 NO NO972679A patent/NO306783B1/no not_active IP Right Cessation
1999
- 1999-05-19 GR GR990401358T patent/GR3030265T3/el unknown

Also Published As

Publication number	Publication date
DE69509624D1 (de)	1999-06-17
AU689674B2 (en)	1998-04-02
MX9704322A (es)	1997-09-30
AR001041A1 (es)	1997-09-24
GR3030265T3 (en)	1999-08-31
BG101591A (en)	1998-03-31
YU70895A (sh)	1998-09-18
PL321046A1 (en)	1997-11-24
EP0719788B1 (en)	1999-05-12
RU2154648C2 (ru)	2000-08-20
US5808048A (en)	1998-09-15
KR100424991B1 (ko)	2004-05-20
CN1047177C (zh)	1999-12-08
RO117327B1 (ro)	2002-01-30
JPH10510806A (ja)	1998-10-20
IL115852A0 (en)	1996-01-31
US5637688A (en)	1997-06-10
EP0719788A3 (en)	1996-09-25
NO306783B1 (no)	1999-12-20
MY112488A (en)	2001-06-30
CZ290941B6 (cs)	2002-11-13
NO972679D0 (no)	1997-06-11
TW379226B (en)	2000-01-11
HUT77929A (hu)	1998-11-30
ATE179986T1 (de)	1999-05-15
PL181732B1 (en)	2001-09-28
NZ296476A (en)	1998-12-23
CZ179897A3 (en)	1997-09-17
WO1996018637A1 (en)	1996-06-20
PE49296A1 (es)	1996-11-21
CO4520286A1 (es)	1997-10-15
CN1169728A (zh)	1998-01-07
SI0719788T1 (en)	1999-10-31
EP0719788A2 (en)	1996-07-03
YU49314B (sh)	2005-06-10
UA48152C2 (uk)	2002-08-15
HU219021B (hu)	2001-01-29
AU4110196A (en)	1996-07-03
IL115852A (en)	1999-09-22
ES2130542T3 (es)	1999-07-01
BG62738B1 (bg)	2000-06-30
DE69509624T2 (de)	1999-10-07
NO972679L (no)	1997-06-11
ZA959320B (en)	1997-05-05
BR9509979A (pt)	1998-06-09

Publication	Publication Date	Title
DK0719788T3 (da)	1999-11-01	Fremgangsmåde til fremstilling af 1-(2'-deoxy-2',2'-difluor-D-ribofuranosyl)-4-aminopyrimidin-2-on-hydrochlorid
DK0858440T3 (da)	2002-04-29	Fremgangsmåde til fremstilling af 1,1,1,3,3-pentafluorpropan
DK0775100T3 (da)	2000-11-27	Fremgangsmåde til fremstilling af trifluorethylen
DK0937055T3 (da)	2002-07-29	Fremgangsmåde til fremstilling af d,I-alfa-tocopherol
DE59507222D1 (de)	1999-12-16	Substituierte 1,2,3,4-tetrahydro-5-nitro-pyrimidine
KR960007633A (ko)	1996-03-22	고강성 프로필렌-에틸렌 블록 공중합체 조성물 및 이의 제조방법
DK0824517T3 (da)	2002-11-18	Fremgangsmåde til fremstilling af lercanidipinhydrochlorid
DK0839138T3 (da)	2004-09-27	Fremgangsmåde til fremstilling af N-substituerede 3-hydroxypyrazoler
FI971418A0 (fi)	1997-04-04	Menetelmä oligoamiinien tai polyamiinien valmistamiseksi
DK0946514T3 (da)	2003-08-25	Fremgangsmåde til fremstilling af n-substituerede 3-hydroxypyrazoler
DK0815092T3 (da)	1999-12-06	Fremgangsmåde til fremstilling af 1,2-benzisothiazolin-3-oner
DK0735043T3 (da)	1998-10-07	Fremgangsmåde til fremstilling af 2-substitueret 3,3-difluorfuran
DK0800506T3 (da)	2000-05-15	Opløsningsmiddelfri fremgangsmåde til fremstilling af 2,6-diflourbenzonitril
NO985535L (no)	1999-01-27	FremgangsmÕte for fremstilling av 1,3-alkandioler
ATE220674T1 (de)	2002-08-15	12h-dibenzo(d,g)(1,3)dioxocin derivate
DK153592A (da)	1994-06-23	Fremgangsmåde til fremstilling af 2,3,5,6-tetrachlorpyridin
FI972624A0 (fi)	1997-06-18	14alfa,17alfa-C2-sillan sisältäviä 19-norprogesteronijohdoksia
DK0783491T3 (da)	2002-01-21	Fremgangsmåde til fremstilling af 3,3,5-trichlorglutarimid
BR9510289A (pt)	1997-11-11	Monômetros de ciclohexan-1-of 3,3-dissubstituido e compostos relacionados
DK0994849T3 (da)	2002-11-25	Fremgangsmåde til fremstilling af 2,4,5-triflour-benzonitril
FI970039A0 (fi)	1997-01-03	Menetelmä 5-aryyli-2,4-dialkyyli-3H-1,2,3-triatsoli-3-tionien valmistamiseksi
FR2735103B1 (fr)	1997-08-01	Support d'elements d'echafaudages.
IT1275512B (it)	1997-08-07	Procedimento di preparazione di pirimidin-4-(3h)-oni-2,3,5,6- tetrasostituiti
ITMI940613A1 (it)	1995-10-01	Procedimento per la preparazione di 17-idrossi-1-alfa, 2-alfa - metilenepregna-4, 6-dien-3, 20-dione
KR970001333A (ko)	1997-01-24	순수한 4, 6-디클로로피리미딘의 제조방법