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AR001041A1 - Procedimiento para preparar clorhidrato de 1-(2'-desoxi-2'2'-difluoro-d-ribofuranosil)-4-aminopirimidin-2-ona - Google Patents

Procedimiento para preparar clorhidrato de 1-(2'-desoxi-2'2'-difluoro-d-ribofuranosil)-4-aminopirimidin-2-ona

Info

Publication number
AR001041A1
AR001041A1 AR33407495A AR33407495A AR001041A1 AR 001041 A1 AR001041 A1 AR 001041A1 AR 33407495 A AR33407495 A AR 33407495A AR 33407495 A AR33407495 A AR 33407495A AR 001041 A1 AR001041 A1 AR 001041A1
Authority
AR
Argentina
Prior art keywords
ribofuranosyl
deoxy
difluoro
hydrochloride
prepare
Prior art date
Application number
AR33407495A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23397211&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR001041(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR001041A1 publication Critical patent/AR001041A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se proporciona un procedimiento para preparar clorhidrato de 1-(2-desoxi-2,2-difluoro-D-ribofuranosil)-4-aminopiridin-2-ona clorhidratode gemcitabina de fórmula (I), separando los grupos benzoilo de bloqueo de compuestos debeta-1-(2-desoxi-2,2-difluoro-3,5-di-O-benzoil-D-ribofuranosil)-4- aminopirimidina-2-ona en presencia de cantidades catalíticas de alquilaminas,enun medio solvente de metanol o etanol, bajo exclusión de agua. El clorhidrato gemcitabina se recuperatratando la solución formada con ácido clorhídrico y unantisolvente.
AR33407495A 1994-12-13 1995-11-01 Procedimiento para preparar clorhidrato de 1-(2'-desoxi-2'2'-difluoro-d-ribofuranosil)-4-aminopirimidin-2-ona AR001041A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/355,372 US5637688A (en) 1994-12-13 1994-12-13 Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride

Publications (1)

Publication Number Publication Date
AR001041A1 true AR001041A1 (es) 1997-09-24

Family

ID=23397211

Family Applications (1)

Application Number Title Priority Date Filing Date
AR33407495A AR001041A1 (es) 1994-12-13 1995-11-01 Procedimiento para preparar clorhidrato de 1-(2'-desoxi-2'2'-difluoro-d-ribofuranosil)-4-aminopirimidin-2-ona

Country Status (31)

Country Link
US (2) US5637688A (es)
EP (1) EP0719788B1 (es)
JP (1) JPH10510806A (es)
KR (1) KR100424991B1 (es)
CN (1) CN1047177C (es)
AR (1) AR001041A1 (es)
AT (1) ATE179986T1 (es)
AU (1) AU689674B2 (es)
BG (1) BG62738B1 (es)
BR (1) BR9509979A (es)
CO (1) CO4520286A1 (es)
CZ (1) CZ290941B6 (es)
DE (1) DE69509624T2 (es)
DK (1) DK0719788T3 (es)
ES (1) ES2130542T3 (es)
GR (1) GR3030265T3 (es)
HU (1) HU219021B (es)
IL (1) IL115852A (es)
MY (1) MY112488A (es)
NO (1) NO306783B1 (es)
NZ (1) NZ296476A (es)
PE (1) PE49296A1 (es)
PL (1) PL181732B1 (es)
RO (1) RO117327B1 (es)
RU (1) RU2154648C2 (es)
SI (1) SI0719788T1 (es)
TW (1) TW379226B (es)
UA (1) UA48152C2 (es)
WO (1) WO1996018637A1 (es)
YU (1) YU49314B (es)
ZA (1) ZA959320B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5637688A (en) * 1994-12-13 1997-06-10 Eli Lilly And Company Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride
EP0870506A1 (en) * 1997-04-11 1998-10-14 Eli Lilly And Company Compositions comprising a cryptophycin compound in combination with a synchronizing or activating agent for treating cancer
AU756762B2 (en) * 1997-12-22 2003-01-23 Schering Corporation Combination of benzocycloheptapyridine compounds and antineoplastic drugs for treating proliferative diseases
US6376470B1 (en) 1999-09-23 2002-04-23 Enzon, Inc. Polymer conjugates of ara-C and ara-C derivatives
AU2001296558A1 (en) * 2000-10-03 2002-04-15 Oncopharmaceutical, Inc. Inhibitors of angiogenesis and tumor growth for local and systemic administration
WO2005014010A1 (en) * 2003-07-24 2005-02-17 Eli Lilly And Company Pharmaceutical composition comprising gemcitabine and cyclodextrines
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
EP1812457A1 (en) * 2004-07-30 2007-08-01 Pharmaessentia Corp. STEREOSELECTIVE SYNTHESIS OF ß-NUCLEOSIDES
WO2006070985A1 (en) * 2004-12-30 2006-07-06 Hanmi Pharm. Co., Ltd. METHOD FOR THE PREPARATION OF 2#-DEOXY-2#,2#-DIFLUOROCYTIDINE
MX2007010316A (es) * 2005-03-04 2008-02-19 Dabur Pharma Ltd Intermediario de 21-desoxi, 21,21-difluoro-d-ribofuranosil nucleosidos enriquecidos en (-anomero y proceso para prepararlo.
WO2006095359A1 (en) * 2005-03-10 2006-09-14 Sms Pharmaceuticals Limited Synthesis of 2-deoxy-2, 2-di fluoro-d-ribo furanose-3, 5 di(4-methy/4-nitro-chloro)benzoate and its conversion to gemcitabine hydrochloride thereof
TWI368621B (en) * 2005-05-02 2012-07-21 Leyoung Biotech Co Ltd Stereoselective synthesis of β-nucleosides
CN100391966C (zh) * 2005-06-17 2008-06-04 华东师范大学 一种2’-脱氧-2’，2’-二氟-胞苷合成的方法
EP1940859A1 (en) * 2005-10-28 2008-07-09 Arch Pharmalabs Limited An improved process for preparation of gemcitabine hydrochloride
KR101259637B1 (ko) * 2005-12-14 2013-04-30 주식회사종근당 1-(2´-데옥시-2´,2´-디플루오로-디-리보푸라노실)-4-아미노피리미딘-2-온또는 그의 염산염의 제조방법
US20090069354A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched gemcitabine
JO2778B1 (en) 2007-10-16 2014-03-15 ايساي انك Certain vehicles, installations and methods
TWI415858B (zh) * 2007-11-06 2013-11-21 Pharmaessentia Corp β－核苷之新穎合成技術
IT1393062B1 (it) * 2008-10-23 2012-04-11 Prime Europ Therapeuticals Procedimento per la preparazione di gemcitabina cloridrato
AU2010234641B2 (en) * 2009-04-06 2016-04-21 Otsuka Pharmaceutical Co., Ltd. Combination of decitabine with cytidine deaminase inhibitor and use thereof in the treatment of cancer
AU2010234562B2 (en) * 2009-04-06 2016-05-12 Otsuka Pharmaceutical Co., Ltd. Combination of cytidine-based antineoplastic drugs with cytidine deaminase inhibitor and use thereof in the treatment of cancer
US8609631B2 (en) 2009-04-06 2013-12-17 Eisai Inc. Compositions and methods for treating cancer
AR076262A1 (es) * 2009-04-06 2011-06-01 Eisai Inc Derivados heterociclicos de diazepin-2-ona, composiciones farmaceuticas y sus usos en el tratamiento del cancer
CN101525361B (zh) * 2009-04-21 2010-11-17 济南圣鲁金药物技术开发有限公司 基于吉西他滨结构的前药及其合成方法及应用
CN102414216B (zh) * 2009-05-15 2015-01-21 德鲁塔负富莱制药股份有限公司 1-(2’-氰基-2’-脱氧-β-D-阿拉伯呋喃糖基)胞嘧啶一盐酸盐的稳定型结晶
CN101628927B (zh) * 2009-08-07 2012-10-10 卡硼瑞（北京）科技有限公司 以1,3,5-三-O-苯甲酰基-α-D-呋喃核糖为原料立体选择性制备β-二氟胞苷盐酸盐的方法
CN102453064B (zh) * 2011-06-30 2014-07-09 江苏豪森药业股份有限公司 制备吉西他滨盐酸盐的方法
CN102659884B (zh) * 2012-04-23 2014-07-02 南京臣功制药股份有限公司 盐酸吉西他滨的提纯方法
CN103224541B (zh) * 2013-04-27 2015-07-01 江苏豪森药业股份有限公司 吉西他滨α-异构体转化回收工艺
CN104402945A (zh) * 2014-11-27 2015-03-11 苏州乔纳森新材料科技有限公司 一种3-脱氧-1,2-o-异丙叉-d-呋喃木糖的合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3817978A (en) * 1971-06-16 1974-06-18 Syntex Inc 4-fluoro nucleosides and sugar intermediates, and methods of preparing
JPS5924999B2 (ja) * 1978-06-10 1984-06-13 富山化学工業株式会社 新規な５−フルオロ−２′−デオキシ−β−ウリジン誘導体の製造法
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
IL77133A (en) * 1984-12-04 1991-01-31 Lilly Co Eli Antineoplastic pharmaceutical compositions containing pentofuranoside derivatives,some new such compounds and their preparation
US5223608A (en) * 1987-08-28 1993-06-29 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
AU4134793A (en) * 1992-06-22 1993-12-23 Eli Lilly And Company 2'-deoxy-2',2'-difluoro(2,6,8-substituted) purine nucleosides having anti-viral and anti-cancer activity and intermediates
FI932871A (fi) * 1992-06-22 1993-12-23 Lilly Co Eli Stereoselektiv anjonglykosylationsprocess
UA41261C2 (uk) * 1992-06-22 2001-09-17 Елі Ліллі Енд Компані Спосіб одержання збагачених бета-аномером нуклеозидів
IL106840A (en) * 1992-09-01 1998-09-24 Lilly Co Eli Process for basic anatomization of pentopornosyl nucleosides
US5637688A (en) * 1994-12-13 1997-06-10 Eli Lilly And Company Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride

Also Published As

Publication number Publication date
DE69509624D1 (de) 1999-06-17
AU689674B2 (en) 1998-04-02
MX9704322A (es) 1997-09-30
GR3030265T3 (en) 1999-08-31
BG101591A (en) 1998-03-31
YU70895A (sh) 1998-09-18
PL321046A1 (en) 1997-11-24
EP0719788B1 (en) 1999-05-12
RU2154648C2 (ru) 2000-08-20
US5808048A (en) 1998-09-15
KR100424991B1 (ko) 2004-05-20
CN1047177C (zh) 1999-12-08
RO117327B1 (ro) 2002-01-30
JPH10510806A (ja) 1998-10-20
IL115852A0 (en) 1996-01-31
US5637688A (en) 1997-06-10
EP0719788A3 (en) 1996-09-25
NO306783B1 (no) 1999-12-20
DK0719788T3 (da) 1999-11-01
MY112488A (en) 2001-06-30
CZ290941B6 (cs) 2002-11-13
NO972679D0 (no) 1997-06-11
TW379226B (en) 2000-01-11
HUT77929A (hu) 1998-11-30
ATE179986T1 (de) 1999-05-15
PL181732B1 (en) 2001-09-28
NZ296476A (en) 1998-12-23
CZ179897A3 (en) 1997-09-17
WO1996018637A1 (en) 1996-06-20
PE49296A1 (es) 1996-11-21
CO4520286A1 (es) 1997-10-15
CN1169728A (zh) 1998-01-07
SI0719788T1 (en) 1999-10-31
EP0719788A2 (en) 1996-07-03
YU49314B (sh) 2005-06-10
UA48152C2 (uk) 2002-08-15
HU219021B (hu) 2001-01-29
AU4110196A (en) 1996-07-03
IL115852A (en) 1999-09-22
ES2130542T3 (es) 1999-07-01
BG62738B1 (bg) 2000-06-30
DE69509624T2 (de) 1999-10-07
NO972679L (no) 1997-06-11
ZA959320B (en) 1997-05-05
BR9509979A (pt) 1998-06-09

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