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DK0713490T3 - Ringstabiliserede rapamycinderivater - Google Patents

Ringstabiliserede rapamycinderivater

Info

Publication number
DK0713490T3
DK0713490T3 DK94925809.9T DK94925809T DK0713490T3 DK 0713490 T3 DK0713490 T3 DK 0713490T3 DK 94925809 T DK94925809 T DK 94925809T DK 0713490 T3 DK0713490 T3 DK 0713490T3
Authority
DK
Denmark
Prior art keywords
rapamycin derivatives
image
diseases
ring stabilized
stabilized rapamycin
Prior art date
Application number
DK94925809.9T
Other languages
Danish (da)
English (en)
Inventor
Frances Christy Nelson
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Application granted granted Critical
Publication of DK0713490T3 publication Critical patent/DK0713490T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
DK94925809.9T 1993-08-10 1994-08-10 Ringstabiliserede rapamycinderivater DK0713490T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/105,090 US5387680A (en) 1993-08-10 1993-08-10 C-22 ring stabilized rapamycin derivatives

Publications (1)

Publication Number Publication Date
DK0713490T3 true DK0713490T3 (da) 1998-05-11

Family

ID=22303982

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94925809.9T DK0713490T3 (da) 1993-08-10 1994-08-10 Ringstabiliserede rapamycinderivater

Country Status (20)

Country Link
US (1) US5387680A (ko)
EP (1) EP0713490B1 (ko)
JP (1) JPH09501436A (ko)
KR (1) KR100330799B1 (ko)
CN (1) CN1132512A (ko)
AT (1) ATE163420T1 (ko)
BR (1) BR9407236A (ko)
CA (1) CA2169277A1 (ko)
CZ (1) CZ291205B6 (ko)
DE (1) DE69408678T2 (ko)
DK (1) DK0713490T3 (ko)
ES (1) ES2115255T3 (ko)
GR (1) GR3026586T3 (ko)
HU (1) HUT74675A (ko)
NZ (1) NZ271822A (ko)
PL (1) PL178625B1 (ko)
RU (1) RU2152946C1 (ko)
SG (1) SG47977A1 (ko)
UA (1) UA45318C2 (ko)
WO (1) WO1995004738A1 (ko)

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US6984635B1 (en) 1998-02-13 2006-01-10 Board Of Trustees Of The Leland Stanford Jr. University Dimerizing agents, their production and use
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US20050002986A1 (en) * 2000-05-12 2005-01-06 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US8236048B2 (en) 2000-05-12 2012-08-07 Cordis Corporation Drug/drug delivery systems for the prevention and treatment of vascular disease
MXPA03002871A (es) * 2000-09-29 2004-12-06 Johnson & Johnson Dispositivos medicos recubiertos.
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US6613083B2 (en) * 2001-05-02 2003-09-02 Eckhard Alt Stent device and method
IL162734A0 (en) 2002-02-01 2005-11-20 Ariad Gene Therapeutics Inc Phosphorus-containing compounds & uses thereof
WO2004060283A2 (en) 2002-12-16 2004-07-22 Nitromed, Inc. Nitrosated and nitrosylated rapamycin compounds, compositions and methods of use
CA2511521C (en) 2002-12-30 2012-02-07 Angiotech International Ag Drug delivery from rapid gelling polymer composition
US7349971B2 (en) * 2004-02-05 2008-03-25 Scenera Technologies, Llc System for transmitting data utilizing multiple communication applications simultaneously in response to user request without specifying recipient's communication information
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
US7812032B2 (en) * 2006-07-25 2010-10-12 Abbott Laboratories Crystalline forms of rapamycin analogs
WO2008060546A2 (en) * 2006-11-14 2008-05-22 Ariad Pharmaceuticals, Inc. Oral formulations
US8414910B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8998846B2 (en) 2006-11-20 2015-04-07 Lutonix, Inc. Drug releasing coatings for balloon catheters
US9700704B2 (en) 2006-11-20 2017-07-11 Lutonix, Inc. Drug releasing coatings for balloon catheters
US9737640B2 (en) 2006-11-20 2017-08-22 Lutonix, Inc. Drug releasing coatings for medical devices
US8425459B2 (en) 2006-11-20 2013-04-23 Lutonix, Inc. Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
US8414525B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8414909B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US20080276935A1 (en) 2006-11-20 2008-11-13 Lixiao Wang Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
US8414526B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
US8440185B2 (en) 2006-12-26 2013-05-14 The Johns Hopkins University Compositions and methods for the treatment of immunologic disorders
WO2008083239A2 (en) 2006-12-27 2008-07-10 The Johns Hopkins University Compositions and methods for stimulating an immune response
US7989173B2 (en) 2006-12-27 2011-08-02 The Johns Hopkins University Detection and diagnosis of inflammatory disorders
EP2245165A4 (en) 2008-01-11 2011-06-01 Massachusetts Eye & Ear Infirm TRANSGENIC CONDITIONAL STOP DIMERICABLE CASPASE ANIMALS
WO2010024898A2 (en) * 2008-08-29 2010-03-04 Lutonix, Inc. Methods and apparatuses for coating balloon catheters
AU2010286351A1 (en) 2009-08-31 2012-03-15 Amplimmune, Inc. B7-H4 fusion proteins and methods of use thereof
PL2836234T3 (pl) 2012-04-12 2020-02-28 Yale University Podłoża do kontrolowanego dostarczania różnych środków farmaceutycznych
EP2934575A2 (en) 2012-12-19 2015-10-28 Amplimmune, Inc. B7-h4 specific antibodies, and compositions and methods of use thereof
US20160146806A1 (en) 2013-05-17 2016-05-26 Amplimmune, Inc. Receptors for b7-h4
US9593356B2 (en) 2013-06-11 2017-03-14 Takara Bio Usa, Inc. Protein enriched microvesicles and methods of making and using the same
WO2017041053A1 (en) 2015-09-04 2017-03-09 Yale University Polymeric bile acid nanocompositions targeting the pancreas and colon
US20190117799A1 (en) 2016-04-01 2019-04-25 The Brigham And Women's Hospital, Inc. Stimuli-responsive nanoparticles for biomedical applications
CN110035769A (zh) 2016-09-21 2019-07-19 奈斯科尔公司 针对siglec-15的抗体及其使用方法
AU2019262978B2 (en) * 2018-05-01 2023-07-13 Revolution Medicines, Inc. C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors
IL312291A (en) 2018-05-01 2024-06-01 Revolution Medicines Inc C-26-linked rapamycin analogs as MTOR inhibitors
CA3103661A1 (en) 2018-05-09 2019-11-14 Yale University Particles for spatiotemporal release of agents
US20210115378A1 (en) 2018-05-09 2021-04-22 Yale University Compositions and systems for ex vivo cell modulation and methods of use thereof
WO2021258042A1 (en) 2020-06-19 2021-12-23 Yale University Polymeric bile acid ester nanoparticles comprising an immunomodulator agent to induce antigen-specific tolerance
US20240082249A1 (en) 2022-05-25 2024-03-14 Revolution Medicines, Inc. Methods of treating cancer with an mtor inhibitor

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US5100899A (en) * 1989-06-06 1992-03-31 Roy Calne Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof
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US5169851A (en) * 1991-08-07 1992-12-08 American Home Products Corporation Rapamycin analog as immunosuppressants and antifungals
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Also Published As

Publication number Publication date
NZ271822A (en) 1998-05-27
CZ291205B6 (cs) 2003-01-15
RU2152946C1 (ru) 2000-07-20
US5387680A (en) 1995-02-07
AU7560194A (en) 1995-02-28
GR3026586T3 (en) 1998-07-31
ES2115255T3 (es) 1998-06-16
CN1132512A (zh) 1996-10-02
DE69408678D1 (de) 1998-04-02
DE69408678T2 (de) 1998-06-18
KR100330799B1 (ko) 2002-10-18
AU676086B2 (en) 1997-02-27
CZ35896A3 (en) 1996-09-11
UA45318C2 (uk) 2002-04-15
WO1995004738A1 (en) 1995-02-16
HU9600298D0 (en) 1996-04-29
HUT74675A (en) 1997-01-28
BR9407236A (pt) 1996-09-24
SG47977A1 (en) 1998-04-17
EP0713490B1 (en) 1998-02-25
PL178625B1 (pl) 2000-05-31
PL312991A1 (en) 1996-05-27
ATE163420T1 (de) 1998-03-15
CA2169277A1 (en) 1995-02-16
EP0713490A1 (en) 1996-05-29
JPH09501436A (ja) 1997-02-10

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