DK0630368T3 - Antivirale nukleosidanaloge - Google Patents
Antivirale nukleosidanalogeInfo
- Publication number
- DK0630368T3 DK0630368T3 DK93905536T DK93905536T DK0630368T3 DK 0630368 T3 DK0630368 T3 DK 0630368T3 DK 93905536 T DK93905536 T DK 93905536T DK 93905536 T DK93905536 T DK 93905536T DK 0630368 T3 DK0630368 T3 DK 0630368T3
- Authority
- DK
- Denmark
- Prior art keywords
- nucleoside analogues
- antiviral nucleoside
- substituted
- benzimidazole base
- hepatitis
- Prior art date
Links
- 230000000840 anti-viral effect Effects 0.000 title abstract 2
- 229940127073 nucleoside analogue Drugs 0.000 title abstract 2
- 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 241000701022 Cytomegalovirus Species 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 208000002672 hepatitis B Diseases 0.000 abstract 1
- 241001529453 unidentified herpesvirus Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929205071A GB9205071D0 (en) | 1992-03-09 | 1992-03-09 | Therapeutic nucleosides |
PCT/GB1993/000479 WO1993018009A1 (en) | 1992-03-09 | 1993-03-08 | Antiviral nucleoside analogues |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0630368T3 true DK0630368T3 (da) | 1999-06-07 |
Family
ID=10711750
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK93905536T DK0630368T3 (da) | 1992-03-09 | 1993-03-08 | Antivirale nukleosidanaloge |
Country Status (20)
Country | Link |
---|---|
US (1) | US5534535A (de) |
EP (1) | EP0630368B1 (de) |
JP (1) | JP3450854B2 (de) |
KR (2) | KR950700887A (de) |
AT (1) | ATE170846T1 (de) |
AU (1) | AU672597B2 (de) |
CA (1) | CA2131693A1 (de) |
CZ (1) | CZ209494A3 (de) |
DE (1) | DE69320945T2 (de) |
DK (1) | DK0630368T3 (de) |
ES (1) | ES2123048T3 (de) |
FI (1) | FI944134A (de) |
GB (1) | GB9205071D0 (de) |
HU (1) | HUT68445A (de) |
IL (1) | IL104976A (de) |
NZ (1) | NZ249554A (de) |
RU (1) | RU2141952C1 (de) |
TW (1) | TW366339B (de) |
WO (1) | WO1993018009A1 (de) |
ZA (1) | ZA931647B (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9205071D0 (en) * | 1992-03-09 | 1992-04-22 | Wellcome Found | Therapeutic nucleosides |
GB9413724D0 (en) * | 1994-07-07 | 1994-08-24 | Wellcome Found | Therapeutic nucleosides |
AU3692895A (en) * | 1994-09-09 | 1996-03-27 | Regents Of The University Of Michigan, The | Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring |
US5811073A (en) * | 1995-06-19 | 1998-09-22 | President And Fellows Of Harvard College | Method for radioisotopic detection and localization of inflammation in a host |
US5912356A (en) * | 1995-09-11 | 1999-06-15 | Glaxo Wellcome Inc. | Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring |
GB9600142D0 (en) * | 1996-01-05 | 1996-03-06 | Wellcome Found | Chemical compounds |
GB9600143D0 (en) | 1996-01-05 | 1996-03-06 | Wellcome Found | Therapeutic compounds |
CA2280761A1 (en) | 1997-02-13 | 1998-08-20 | Stanley Dawes Chamberlain | Benzimidazole derivatives |
SK284810B6 (sk) * | 1997-05-13 | 2005-12-01 | Lonza Ag | Spôsob výroby (1S,4R)- alebo (1R,4S)-4-(2-amino-6-chlór-9-H- purín-9-yl)-2-cyklopentén-1-metanolu |
TR199903053T2 (xx) | 1997-06-10 | 2000-11-21 | Glaxo Group Limited | Benzimidazol t�revleri. |
US6455506B1 (en) | 1997-07-30 | 2002-09-24 | Smithkline Beecham Corporation | Lyxofuranosyl benzimidazoles as antiviral agents |
US6514979B1 (en) | 1999-03-03 | 2003-02-04 | University Of Maryland Biotechnology Institute | Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor |
GB0008939D0 (en) | 2000-04-11 | 2000-05-31 | Glaxo Group Ltd | Process for preparing substituted benzimidazole compounds |
BR0110023A (pt) | 2000-04-13 | 2003-12-30 | Pharmasset Ltd | Derivados de nucleosìdeo 3'-ou-2' substituìdos para tratamento de infecções por vìrus da hepatite |
TW200831081A (en) | 2006-12-25 | 2008-08-01 | Kyorin Seiyaku Kk | Glucokinase activator |
EP2540726B1 (de) | 2007-08-02 | 2019-10-09 | Millennium Pharmaceuticals, Inc. | Zwischenprodukte zur Synthese von E1-aktivitätsaktivierenden Enzymhemmern |
PT2275414E (pt) | 2008-04-28 | 2015-09-09 | Teijin Pharma Ltd | Derivado de amida do ácido ciclopentacrílico |
US11499722B2 (en) * | 2020-04-30 | 2022-11-15 | Bsh Home Appliances Corporation | Household cooking appliance having an oven door with an interior camera |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4996308A (en) * | 1988-03-25 | 1991-02-26 | Merrell Dow Pharmaceuticals Inc. | Derivatives with unsaturated substitutions for the 5'-hydroxymethyl group |
ZA894534B (en) * | 1988-06-20 | 1990-03-28 | Merrell Dow Pharma | Novel neplanocin derivatives |
GB8826205D0 (en) * | 1988-11-09 | 1988-12-14 | Wellcome Found | Heterocyclic compounds |
GB8926417D0 (en) * | 1989-11-22 | 1990-01-10 | Wellcome Found | Heterocyclic compounds |
MY104575A (en) * | 1989-12-22 | 1994-04-30 | The Wellcome Foundation Ltd | Therapeutic nucleosides. |
US5248672A (en) * | 1990-11-01 | 1993-09-28 | The Regents Of The University Of Michigan | Polysubstituted benzimidazole nucleosides as antiviral agents |
GB9205071D0 (en) * | 1992-03-09 | 1992-04-22 | Wellcome Found | Therapeutic nucleosides |
-
1992
- 1992-03-09 GB GB929205071A patent/GB9205071D0/en active Pending
-
1993
- 1993-03-08 DE DE69320945T patent/DE69320945T2/de not_active Expired - Fee Related
- 1993-03-08 EP EP93905536A patent/EP0630368B1/de not_active Expired - Lifetime
- 1993-03-08 HU HU9402582A patent/HUT68445A/hu unknown
- 1993-03-08 AU AU36432/93A patent/AU672597B2/en not_active Ceased
- 1993-03-08 WO PCT/GB1993/000479 patent/WO1993018009A1/en active IP Right Grant
- 1993-03-08 JP JP51547193A patent/JP3450854B2/ja not_active Expired - Fee Related
- 1993-03-08 CZ CZ942094A patent/CZ209494A3/cs unknown
- 1993-03-08 IL IL10497693A patent/IL104976A/en not_active IP Right Cessation
- 1993-03-08 ES ES93905536T patent/ES2123048T3/es not_active Expired - Lifetime
- 1993-03-08 ZA ZA931647A patent/ZA931647B/xx unknown
- 1993-03-08 RU RU94043771A patent/RU2141952C1/ru active
- 1993-03-08 CA CA002131693A patent/CA2131693A1/en not_active Abandoned
- 1993-03-08 AT AT93905536T patent/ATE170846T1/de not_active IP Right Cessation
- 1993-03-08 DK DK93905536T patent/DK0630368T3/da active
- 1993-03-08 NZ NZ249554A patent/NZ249554A/en unknown
- 1993-05-27 TW TW082104263A patent/TW366339B/zh active
-
1994
- 1994-09-08 FI FI944134A patent/FI944134A/fi unknown
- 1994-09-09 KR KR1019940703149A patent/KR950700887A/ko not_active Application Discontinuation
- 1994-09-09 US US08/304,006 patent/US5534535A/en not_active Expired - Lifetime
-
1995
- 1995-09-11 KR KR1019970701554A patent/KR970705547A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
RU94043771A (ru) | 1996-08-10 |
DE69320945T2 (de) | 1999-02-04 |
IL104976A0 (en) | 1993-07-08 |
NZ249554A (en) | 1996-05-28 |
US5534535A (en) | 1996-07-09 |
FI944134A0 (fi) | 1994-09-08 |
KR970705547A (ko) | 1997-10-09 |
ZA931647B (en) | 1994-09-08 |
EP0630368A1 (de) | 1994-12-28 |
CA2131693A1 (en) | 1993-09-16 |
EP0630368B1 (de) | 1998-09-09 |
KR950700887A (ko) | 1995-02-20 |
AU672597B2 (en) | 1996-10-10 |
CZ209494A3 (en) | 1995-11-15 |
ATE170846T1 (de) | 1998-09-15 |
RU2141952C1 (ru) | 1999-11-27 |
ES2123048T3 (es) | 1999-01-01 |
JPH07506816A (ja) | 1995-07-27 |
WO1993018009A1 (en) | 1993-09-16 |
HU9402582D0 (en) | 1994-11-28 |
JP3450854B2 (ja) | 2003-09-29 |
AU3643293A (en) | 1993-10-05 |
GB9205071D0 (en) | 1992-04-22 |
IL104976A (en) | 1998-10-30 |
HUT68445A (en) | 1995-06-28 |
FI944134A (fi) | 1994-11-07 |
TW366339B (en) | 1999-08-11 |
DE69320945D1 (de) | 1998-10-15 |
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