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DK0612745T3 - Fremgangsmåde til fremstilling af 1,2,3,4,10,14b-hexahydro-2-methyl-dibenzo[c,f]pyrazino[1,2-a]azepin og salte deraf - Google Patents

Fremgangsmåde til fremstilling af 1,2,3,4,10,14b-hexahydro-2-methyl-dibenzo[c,f]pyrazino[1,2-a]azepin og salte deraf

Info

Publication number
DK0612745T3
DK0612745T3 DK94101043T DK94101043T DK0612745T3 DK 0612745 T3 DK0612745 T3 DK 0612745T3 DK 94101043 T DK94101043 T DK 94101043T DK 94101043 T DK94101043 T DK 94101043T DK 0612745 T3 DK0612745 T3 DK 0612745T3
Authority
DK
Denmark
Prior art keywords
pyrazino
azepine
hexahydro
preparation
dibenzo
Prior art date
Application number
DK94101043T
Other languages
English (en)
Inventor
Lothar Dr Kisielowski-Ruppert
Johann Peter Dr Dipl Moersdorf
Ingomar Dr Dipl Chem Grafe
Kurt-Henning Dr Ahrens
Original Assignee
Heumann Pharma Gmbh & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heumann Pharma Gmbh & Co filed Critical Heumann Pharma Gmbh & Co
Application granted granted Critical
Publication of DK0612745T3 publication Critical patent/DK0612745T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/04Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reaction of ammonia or amines with olefin oxides or halohydrins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/30Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK94101043T 1993-02-24 1994-01-25 Fremgangsmåde til fremstilling af 1,2,3,4,10,14b-hexahydro-2-methyl-dibenzo[c,f]pyrazino[1,2-a]azepin og salte deraf DK0612745T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4305659A DE4305659A1 (de) 1993-02-24 1993-02-24 Verfahren zur Herstellung von 1,2,3,4,10,14b-Hexahydro-2-methyl-dibenzo[c,f]pyrazino[1,2-a]azepin und seiner Salze

Publications (1)

Publication Number Publication Date
DK0612745T3 true DK0612745T3 (da) 1999-08-16

Family

ID=6481214

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94101043T DK0612745T3 (da) 1993-02-24 1994-01-25 Fremgangsmåde til fremstilling af 1,2,3,4,10,14b-hexahydro-2-methyl-dibenzo[c,f]pyrazino[1,2-a]azepin og salte deraf

Country Status (6)

Country Link
EP (1) EP0612745B1 (da)
JP (1) JP3364519B2 (da)
AT (1) ATE174335T1 (da)
DE (2) DE4305659A1 (da)
DK (1) DK0612745T3 (da)
ES (1) ES2124802T3 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102558075A (zh) 2004-12-03 2012-07-11 先灵公司 作为cb1拮抗剂的取代哌嗪
AR059021A1 (es) 2006-01-18 2008-03-05 Schering Corp Moduladores de receptores cannabinoides
BRPI0814806A2 (pt) 2007-06-28 2015-02-03 Intervet Int Bv Pirazinas substituídas como antagonistas de cb1
CN117777144A (zh) * 2023-12-26 2024-03-29 仁和堂药业有限公司 一种盐酸米安色林新晶型ⅱ及其制备方法
CN117777146A (zh) * 2023-12-29 2024-03-29 仁和堂药业有限公司 一种盐酸米安色林一水合物新晶型ⅰ及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL179906C (nl) * 1974-02-09 1986-12-01 Akzo Nv Werkwijze voor het bereiden van 1,2,3,4,10,14b-hexahydrodibenzo(c,f)pyrazino (1,2-a)azepine derivaten.

Also Published As

Publication number Publication date
EP0612745A1 (de) 1994-08-31
ES2124802T3 (es) 1999-02-16
DE59407418D1 (de) 1999-01-21
JPH06312988A (ja) 1994-11-08
JP3364519B2 (ja) 2003-01-08
EP0612745B1 (de) 1998-12-09
ATE174335T1 (de) 1998-12-15
DE4305659A1 (de) 1994-08-25

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