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DK0696281T3 - Hidtil ukendte 5-pyrrolyl-2-pyridylmethylsulfinylbenzimidazolderivater - Google Patents

Hidtil ukendte 5-pyrrolyl-2-pyridylmethylsulfinylbenzimidazolderivater

Info

Publication number
DK0696281T3
DK0696281T3 DK94921865T DK94921865T DK0696281T3 DK 0696281 T3 DK0696281 T3 DK 0696281T3 DK 94921865 T DK94921865 T DK 94921865T DK 94921865 T DK94921865 T DK 94921865T DK 0696281 T3 DK0696281 T3 DK 0696281T3
Authority
DK
Denmark
Prior art keywords
pct
pyrrolyl
new
pyridylmethylsulfinylbenzimidazole
sec
Prior art date
Application number
DK94921865T
Other languages
English (en)
Inventor
Su Ung Kim
Dong Yeon Kim
Gi Ju Chung
Sung Kol Hong
Sung Jun Park
Sang Hoon Nam
Yong Suk Lee
Original Assignee
Il Yang Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Il Yang Pharm Co Ltd filed Critical Il Yang Pharm Co Ltd
Application granted granted Critical
Publication of DK0696281T3 publication Critical patent/DK0696281T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK94921865T 1994-02-28 1994-07-22 Hidtil ukendte 5-pyrrolyl-2-pyridylmethylsulfinylbenzimidazolderivater DK0696281T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1019940003833A KR0179401B1 (ko) 1994-02-28 1994-02-28 신규한 5-피롤릴-2-피리딜메틸설피닐벤즈이미다졸 유도체
PCT/KR1994/000098 WO1995023140A1 (en) 1994-02-28 1994-07-22 Novel 5-pyrrolyl-2-pyridylmethylsulfinyl benzimidazole derivatives

Publications (1)

Publication Number Publication Date
DK0696281T3 true DK0696281T3 (da) 1999-11-01

Family

ID=19378085

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94921865T DK0696281T3 (da) 1994-02-28 1994-07-22 Hidtil ukendte 5-pyrrolyl-2-pyridylmethylsulfinylbenzimidazolderivater

Country Status (17)

Country Link
US (1) US5703097A (da)
EP (1) EP0696281B1 (da)
JP (1) JP2690621B2 (da)
KR (1) KR0179401B1 (da)
CN (1) CN1048245C (da)
AT (1) ATE179976T1 (da)
AU (1) AU675564B2 (da)
BR (1) BR9406362A (da)
CA (1) CA2161542C (da)
DE (1) DE69418461T2 (da)
DK (1) DK0696281T3 (da)
ES (1) ES2132415T3 (da)
HU (1) HU220047B (da)
RU (1) RU2100358C1 (da)
TW (1) TW263499B (da)
WO (1) WO1995023140A1 (da)
ZA (1) ZA945621B (da)

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US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6489346B1 (en) * 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6051570A (en) * 1997-05-30 2000-04-18 Dr. Reddy's Research Foundation Benzimidazole derivatives as antiulcer agents, process for their preparation and pharmaceutical compositions containing them
KR100299562B1 (ko) * 1998-12-29 2001-11-22 우재영 안정성을극대화시킨5-피롤릴-2-피리딜메틸설피닐벤즈이미다졸유도체함유미세과립
US6852739B1 (en) * 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
KR100359256B1 (ko) * 1999-10-06 2002-11-04 한미약품공업 주식회사 란소프라졸의 개선된 제조방법
SG105539A1 (en) * 2002-03-01 2004-08-27 Il Yang Pharm Co Ltd Stabilized enteric-coated microgranules comprising 2-[(4-methoxy-3-methyl)-2-pyridinyl] methylsulfinyl-5-(1h-pyrrol-1-yl)-1h-benzimidazole and oral formulations comprising the microgranules
AU2003254282A1 (en) * 2002-08-01 2004-02-23 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
CA2597632C (en) * 2005-03-25 2012-05-15 Livzon Pharmaceutical Group Inc. Substituted sulfoxide compounds, methods for preparing the same and use thereof
CN101098867B (zh) * 2005-03-25 2010-08-11 丽珠医药集团股份有限公司 取代的亚砜类化合物和其制备方法及用途
KR101148399B1 (ko) * 2005-06-22 2012-05-23 일양약품주식회사 항궤양제 및 점막보호제를 함유하는 경구용 위장질환치료용 약제 조성물
WO2007075381A2 (en) * 2005-12-16 2007-07-05 Tap Pharmaceutical Products, Inc. Pharmaceutical compositions of ilaprazole
DK2046292T3 (da) * 2006-07-21 2010-06-07 Novartis Ag Formuleringer for benzimidazolylpyridylethere
US20100317689A1 (en) * 2006-09-19 2010-12-16 Garst Michael E Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety
AU2007317561A1 (en) 2006-10-27 2008-05-15 The Curators Of The University Of Missouri Compositions comprising at least one acid labile proton pump inhibiting agents, optionally other pharmaceutically active agents and methods of using same
WO2008083319A1 (en) * 2006-12-29 2008-07-10 Il Yang Pharmaceutical Company, Ltd. Solid state forms of enantiopure ilaprazole
WO2008083341A1 (en) * 2006-12-29 2008-07-10 Il Yang Pharmaceutical Company, Ltd. Crystalline forms of solvated ilaprazole
WO2008130863A2 (en) * 2007-04-11 2008-10-30 Auspex Pharmaceuticals, Inc. Substituted benzimidazoles
KR101044880B1 (ko) 2008-06-12 2011-06-28 일양약품주식회사 항궤양제 화합물의 합성에 유용한 중간체의 제조방법
CZ302548B6 (cs) * 2008-10-22 2011-07-07 Zentiva, A.S. Zpusob výroby 5-amino-2-[(4-methoxy-3-methyl-2-pyridyl)methylthio]-1H-benzimidazolu a 5-(1H-pyrrol-1-yl)-2-[(4-methoxy-3-methyl-2-pyridyl)methylthio]-1H-benzimidazolu
CN102140092B (zh) * 2010-02-03 2013-05-29 丽珠医药集团股份有限公司 艾普拉唑盐的水合物及其制备方法和用途
WO2013108068A1 (en) 2012-01-21 2013-07-25 Jubilant Life Sciences Limited Process for the preparation of 2-pyridinylmethylsulfinyl benzimidazoles, their analogs and optically active enantiomers
CN103073536B (zh) * 2013-01-17 2015-06-24 丽珠医药集团股份有限公司 一种艾普拉唑的制备方法
CN105218522B (zh) * 2014-06-25 2019-04-02 江苏奥赛康药业股份有限公司 一种右旋艾普拉唑化合物及其药物组合物
CN113045544A (zh) * 2014-09-04 2021-06-29 江苏奥赛康药业有限公司 艾普拉唑钠化合物及其药物组合物
US11628159B2 (en) 2017-01-10 2023-04-18 Eth Zurich Cell-protective compounds and their use
KR102027388B1 (ko) 2017-11-15 2019-10-01 주식회사 다산제약 고순도 일라프라졸 결정형 b의 제조방법
CN109053685B (zh) * 2018-06-22 2020-09-22 丽珠医药集团股份有限公司 一种含艾普拉唑钠的药物组合物及其制备方法
CN108685918B (zh) * 2018-06-22 2021-02-09 丽珠医药集团股份有限公司 一种含艾普拉唑或其盐的药物组合物及其制备方法
KR102250509B1 (ko) 2020-12-09 2021-05-11 유니셀랩 주식회사 새로운 일라프라졸/자일리톨 공결정
CN114163419A (zh) * 2021-12-24 2022-03-11 辰欣药业股份有限公司 一种兰索拉唑的制备方法
KR20240121004A (ko) 2023-02-01 2024-08-08 주식회사 하이플 일라프라졸의 신규한 제조방법

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GB1234058A (da) * 1968-10-21 1971-06-03
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4225431A (en) * 1978-12-28 1980-09-30 Pepsico, Inc. Process and apparatus for the treatment of aqueous waste materials
SE8300736D0 (sv) * 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
IL75400A (en) * 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
JPS6185383A (ja) * 1984-10-02 1986-04-30 Banyu Pharmaceut Co Ltd ベンズイミダゾ−ル誘導体，その製造法およびそれを含有する医薬
JPS62108879A (ja) * 1985-11-05 1987-05-20 Grelan Pharmaceut Co Ltd 置換ベンズイミダゾ−ル類
FI90544C (fi) * 1986-11-13 1994-02-25 Eisai Co Ltd Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi
KR0142815B1 (ko) * 1994-12-02 1998-07-15 정도언 신규한 5-피롤릴-6-할로게노-2피리딜메틸설피닐벤즈이미다졸 유도체

Also Published As

Publication number Publication date
JP2690621B2 (ja) 1997-12-10
HUT75123A (en) 1997-04-28
DE69418461D1 (de) 1999-06-17
HU220047B (hu) 2001-10-28
AU7239994A (en) 1995-09-11
KR0179401B1 (ko) 1999-03-20
HU9503401D0 (en) 1996-01-29
TW263499B (da) 1995-11-21
US5703097A (en) 1997-12-30
ATE179976T1 (de) 1999-05-15
EP0696281B1 (en) 1999-05-12
DE69418461T2 (de) 1999-09-09
KR950025038A (ko) 1995-09-15
EP0696281A1 (en) 1996-02-14
CN1121714A (zh) 1996-05-01
ZA945621B (en) 1995-03-07
CA2161542C (en) 1999-11-02
ES2132415T3 (es) 1999-08-16
CN1048245C (zh) 2000-01-12
RU2100358C1 (ru) 1997-12-27
JPH09503000A (ja) 1997-03-25
AU675564B2 (en) 1997-02-06
WO1995023140A1 (en) 1995-08-31
CA2161542A1 (en) 1995-08-31
BR9406362A (pt) 1996-02-13

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