DK0685487T3 - Fremgangsmåde til fremstilling af et 16beta-methylsteroid og nogle intermediære - Google Patents

Fremgangsmåde til fremstilling af et 16beta-methylsteroid og nogle intermediære

Info

Publication number: DK0685487T3
Authority: DK; Denmark
Prior art keywords: give; alpha; methyl; oxo; beta
Prior art date: 1994-06-02

Application number

DK95401273.8T

Other languages

Danish (da)

English (en)

Inventor

Michel Vivat

Catherine Geurts

Original Assignee

Roussel Uclaf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-06-02

Filing date

1995-06-01

Publication date

1998-04-20

1995-06-01 Application filed by Roussel Uclaf filed Critical Roussel Uclaf

1998-04-20 Application granted granted Critical

1998-04-20 Publication of DK0685487T3 publication Critical patent/DK0685487T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
- C07J7/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16
- C07J7/0055—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Toxicology (AREA)
Steroid Compounds (AREA)

DK95401273.8T 1994-06-02 1995-06-01 Fremgangsmåde til fremstilling af et 16beta-methylsteroid og nogle intermediære DK0685487T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9406743A FR2720747B1 (fr)	1994-06-02	1994-06-02	Nouveau procédé de préparation d'un stéroïde 16béta-méthyl et nouveaux intermédiaires.

Publications (1)

Publication Number	Publication Date
DK0685487T3 true DK0685487T3 (da)	1998-04-20

Family

ID=9463797

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95401273.8T DK0685487T3 (da)	1994-06-02	1995-06-01	Fremgangsmåde til fremstilling af et 16beta-methylsteroid og nogle intermediære

Country Status (20)

Country	Link
US (3)	US5596108A (de)
EP (1)	EP0685487B1 (de)
JP (1)	JP3950489B2 (de)
KR (1)	KR100369766B1 (de)
CN (3)	CN100379753C (de)
AT (1)	ATE157669T1 (de)
AU (1)	AU689564B2 (de)
CA (1)	CA2150738C (de)
DE (1)	DE69500643T2 (de)
DK (1)	DK0685487T3 (de)
ES (1)	ES2106623T3 (de)
FI (1)	FI114397B (de)
FR (1)	FR2720747B1 (de)
GR (1)	GR3024626T3 (de)
HK (1)	HK1098760A1 (de)
HU (1)	HU219490B (de)
RU (1)	RU2151774C1 (de)
TW (1)	TW427997B (de)
UA (1)	UA48107C2 (de)
ZA (1)	ZA954453B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10014847A1 (de)	2000-03-24	2001-10-04	Gsf Forschungszentrum Umwelt	Verfahren und Vorrichtung zum Nachweis von Verbindungen in einem Gasstrom
CN100408025C (zh) *	2006-11-24	2008-08-06	上海医药(集团)有限公司	倍他米松β-11物的自乳化组合物及其制备方法和应用
KR101778603B1 (ko)	2009-08-13	2017-09-14	마리누스 파마슈티컬스	3α-히드록시, 3β-메틸-5α-프레그난-20-온 (가낙솔론)의 제조 방법
CN101851264B (zh) *	2010-03-12	2011-08-10	广西万德药业股份有限公司	一种具有16-β-甲基甾体类药物中间体的制备方法
CN103819495B (zh) *	2014-02-28	2016-08-17	上海新华联制药有限公司	倍他米松中间体的制备方法
CN107286216A (zh) *	2016-03-31	2017-10-24	天津金耀集团有限公司	具有多个烯烃甾体化合物的制备方法
CN105693802B (zh) *	2016-04-12	2017-08-25	湖南新合新生物医药有限公司	16β‑甲基甾族化合物的制备方法
CN106866777B (zh) *	2017-04-12	2019-05-24	杭州弘任医药科技有限公司	苯甲孕酮的制备方法
IT201800009683A1 (it) *	2018-10-22	2020-04-22	Ind Chimica Srl	Processo per la preparazione di 3α-idrossi-5α-pregnan-20-one (brexanolone)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2703799A (en) *	1954-05-12	1955-03-08	Searle & Co	9alpha-halo-11-oxo-16alpha, 17alpha-epoxyprogesterones
US2705711A (en) *	1954-09-24	1955-04-05	Searle & Co	9beta, 11beta; 16alpha, 17alpha-bisepoxyprogesterone
GB805497A (en) *	1955-07-13	1958-12-10	Glaxo Lab Ltd	Steroid intermediates for the preparation of adreno-cortical hormones
DE1041043B (de) *	1955-07-13	1958-10-16	Nat Res Dev	Verfahren zur Herstellung von 17ª‡-Hydroxy-16-halogenallopregnanen
US2951857A (en) *	1956-03-13	1960-09-06	Searle & Co	11-oxygenated 16-halo-17-hydroxy-progesterones
US3219674A (en) *	1959-03-11	1965-11-23	Syntex Corp	15-dehydro-16 methyl steroids and process for the production thereof
US3761498A (en) *	1971-06-05	1973-09-25	Plurichemie Anstalt	New process of preparation of steroids
EP0263569B1 (de) *	1986-10-10	1992-12-09	Roussel-Uclaf	9-Alpha-Hydroxysteroide, Verfahren zu ihrer Herstellung und Verfahren zur Herstellung der entsprechenden 9(11)-Dehydro-Derivate.
HU198736B (en) *	1986-12-29	1989-11-28	Gyogyszerkutato Intezet	Process for producing 16-dehydro-20-oxopregnane derivatives

1994
- 1994-06-02 FR FR9406743A patent/FR2720747B1/fr not_active Expired - Fee Related
1995
- 1995-05-15 TW TW084104785A patent/TW427997B/zh not_active IP Right Cessation
- 1995-05-18 US US08/444,229 patent/US5596108A/en not_active Expired - Lifetime
- 1995-05-31 JP JP15546595A patent/JP3950489B2/ja not_active Expired - Fee Related
- 1995-05-31 ZA ZA954453A patent/ZA954453B/xx unknown
- 1995-06-01 HU HU9501595A patent/HU219490B/hu not_active IP Right Cessation
- 1995-06-01 CN CNB200610054918XA patent/CN100379753C/zh not_active Expired - Fee Related
- 1995-06-01 DK DK95401273.8T patent/DK0685487T3/da active
- 1995-06-01 ES ES95401273T patent/ES2106623T3/es not_active Expired - Lifetime
- 1995-06-01 CA CA002150738A patent/CA2150738C/fr not_active Expired - Fee Related
- 1995-06-01 RU RU95108877/04A patent/RU2151774C1/ru not_active IP Right Cessation
- 1995-06-01 UA UA95062622A patent/UA48107C2/uk unknown
- 1995-06-01 AT AT95401273T patent/ATE157669T1/de active
- 1995-06-01 DE DE69500643T patent/DE69500643T2/de not_active Expired - Lifetime
- 1995-06-01 AU AU20442/95A patent/AU689564B2/en not_active Ceased
- 1995-06-01 EP EP95401273A patent/EP0685487B1/de not_active Expired - Lifetime
- 1995-06-01 CN CN95106623A patent/CN1057303C/zh not_active Expired - Fee Related
- 1995-06-01 KR KR1019950014481A patent/KR100369766B1/ko not_active IP Right Cessation
- 1995-06-02 FI FI952718A patent/FI114397B/fi not_active IP Right Cessation
1996
- 1996-09-13 US US08/710,198 patent/US5795982A/en not_active Expired - Lifetime
1997
- 1997-09-04 GR GR970402264T patent/GR3024626T3/el unknown
1998
- 1998-04-22 US US09/064,576 patent/US6117994A/en not_active Expired - Lifetime
- 1998-11-04 CN CNB981237525A patent/CN1252081C/zh not_active Expired - Fee Related
2007
- 2007-02-23 HK HK07102100A patent/HK1098760A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
HUT71801A (en)	1996-02-28
US5795982A (en)	1998-08-18
CA2150738C (fr)	2006-04-18
EP0685487A1 (de)	1995-12-06
CN1118351A (zh)	1996-03-13
ZA954453B (en)	1996-05-31
CN100379753C (zh)	2008-04-09
RU95108877A (ru)	1997-05-10
CN1057303C (zh)	2000-10-11
US5596108A (en)	1997-01-21
UA48107C2 (uk)	2002-08-15
CN1220996A (zh)	1999-06-30
ATE157669T1 (de)	1997-09-15
HU219490B (hu)	2001-04-28
DE69500643D1 (de)	1997-10-09
FR2720747B1 (fr)	1996-07-12
DE69500643T2 (de)	1998-01-08
AU689564B2 (en)	1998-04-02
CA2150738A1 (fr)	1995-12-03
JPH08169897A (ja)	1996-07-02
FR2720747A1 (fr)	1995-12-08
JP3950489B2 (ja)	2007-08-01
AU2044295A (en)	1995-12-14
KR100369766B1 (ko)	2003-12-11
GR3024626T3 (en)	1997-12-31
CN1252081C (zh)	2006-04-19
FI952718A (fi)	1995-12-03
US6117994A (en)	2000-09-12
TW427997B (en)	2001-04-01
KR960000915A (ko)	1996-01-25
CN1821263A (zh)	2006-08-23
HU9501595D0 (en)	1995-07-28
EP0685487B1 (de)	1997-09-03
RU2151774C1 (ru)	2000-06-27
FI952718A0 (fi)	1995-06-02
ES2106623T3 (es)	1997-11-01
FI114397B (fi)	2004-10-15
HK1098760A1 (en)	2007-07-27

Publication	Publication Date	Title
HK1098760A1 (en)	2007-07-27	An intermediate for the preperation of a 16 beta-methyl steroid
KR860005832A (ko)	1986-08-13	위치 10에 치환된 스테로이드의 제조방법
GR3018330T3 (en)	1996-03-31	O-methyl derivatives of azithromycin A, process and intermediates for their preparation, and use thereof in the preparation of pharmaceuticals.
ATE284895T1 (de)	2005-01-15	Neuroaktive steroide der androstan- und pregnanreihe
DK0669001T3 (da)	1998-05-04	Bestemmelse af peptidmotiver på MHC-molekyler
AU2939984A (en)	1984-12-20	1-alkyl-androsta-1, 4-diene-3, 17-diones
DK256380A (da)	1980-12-16	Fremgangsmaade til fremstilling af 5!deoxy-5-fluoruridin
DK630988D0 (da)	1988-11-11	Fremgangsmaade til fremstilling af delta1,4-3-keto-21-hemiester-steroider
ATE15047T1 (de)	1985-09-15	Galactopyranoside verbindungen, verfahren zu ihrer herstellung und ihre verwendung als antigene oder immunadsorbentien.
UA40574C2 (uk)	2001-08-15	Похідні 17,20-епоксипрегнану, спосіб їх одержання, спосіб одержання похідних кортизону і проміжні сполуки
DE69812079D1 (de)	2003-04-17	Verfahren zur herstellung eines buthylthuio-isochinolinderivates und zwischenprodukte dafür
DK572081A (da)	1982-06-24	Fremgangsmaade til fremstilling af 11beta-,21-dihydroxy-2!-methyl-5!-betah-1,4-pregnadieno (16,17-d)-oxazol-3,20-dion
FI913699A0 (fi)	1991-08-02	Menetelmä farmaseuttisesti käyttökelpoisten 4'-epi-4'-aminoantrasykliinien valmistamiseksi sekä menetelmässä käytettävät välituotteet
DE59800127D1 (de)	2000-05-25	9 Alpha-Hydroxy-8 Alpha-estra-1,3,5(10)-triene und Verfahren zu deren Herstellung
RO95696A2 (ro)	1988-10-30	Derivati de 1,1-oxibis(4n-benzamido) bnzen si procedeu de preparare al acestora
FR2442857A1 (fr)	1980-06-27	Nouveau steroide de la serie du pregnane et son procede de preparation
NZ333837A (en)	2000-05-26	estrene steroids for inducing hypothalamic effects
NO944999D0 (no)	1994-12-23	Fremgangsmåte for steroide peracylglykosider
DK542085A (da)	1985-11-22	Fremgangsmaade til fremstilling af en cholesterolsynteseinhibitor
FR2307920A1 (fr)	1976-11-12	Dispositif d'equipement sanitaire reversible