ATE157669T1 - Neues verfahren zur herstellung von einem 16-beta-steroid und neue zwischenprodukte davon - Google Patents

Neues verfahren zur herstellung von einem 16-beta-steroid und neue zwischenprodukte davon

Info

Publication number: ATE157669T1
Authority: AT; Austria
Prior art keywords: give; beta; alpha; new; producing
Prior art date: 1994-06-02

Application number

AT95401273T

Other languages

English (en)

Inventor

Catherine Geurts

Michel Vivat

Original Assignee

Roussel Uclaf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-06-02

Filing date

1995-06-01

Publication date

1997-09-15

1995-06-01 Application filed by Roussel Uclaf filed Critical Roussel Uclaf

1997-09-15 Application granted granted Critical

1997-09-15 Publication of ATE157669T1 publication Critical patent/ATE157669T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
- C07J7/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16
- C07J7/0055—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Toxicology (AREA)
Steroid Compounds (AREA)

AT95401273T 1994-06-02 1995-06-01 Neues verfahren zur herstellung von einem 16-beta-steroid und neue zwischenprodukte davon ATE157669T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9406743A FR2720747B1 (fr)	1994-06-02	1994-06-02	Nouveau procédé de préparation d'un stéroïde 16béta-méthyl et nouveaux intermédiaires.

Publications (1)

Publication Number	Publication Date
ATE157669T1 true ATE157669T1 (de)	1997-09-15

Family

ID=9463797

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95401273T ATE157669T1 (de)	1994-06-02	1995-06-01	Neues verfahren zur herstellung von einem 16-beta-steroid und neue zwischenprodukte davon

Country Status (20)

Country	Link
US (3)	US5596108A (de)
EP (1)	EP0685487B1 (de)
JP (1)	JP3950489B2 (de)
KR (1)	KR100369766B1 (de)
CN (3)	CN100379753C (de)
AT (1)	ATE157669T1 (de)
AU (1)	AU689564B2 (de)
CA (1)	CA2150738C (de)
DE (1)	DE69500643T2 (de)
DK (1)	DK0685487T3 (de)
ES (1)	ES2106623T3 (de)
FI (1)	FI114397B (de)
FR (1)	FR2720747B1 (de)
GR (1)	GR3024626T3 (de)
HK (1)	HK1098760A1 (de)
HU (1)	HU219490B (de)
RU (1)	RU2151774C1 (de)
TW (1)	TW427997B (de)
UA (1)	UA48107C2 (de)
ZA (1)	ZA954453B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10014847A1 (de)	2000-03-24	2001-10-04	Gsf Forschungszentrum Umwelt	Verfahren und Vorrichtung zum Nachweis von Verbindungen in einem Gasstrom
CN100408025C (zh) *	2006-11-24	2008-08-06	上海医药(集团)有限公司	倍他米松β-11物的自乳化组合物及其制备方法和应用
EA024269B1 (ru) *	2009-08-13	2016-09-30	ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "НоваМедика"	СПОСОБ ПОЛУЧЕНИЯ 3α-ГИДРОКСИ-3β-МЕТИЛ-5α-ПРЕГНАН-20-ОНА (ГАНАКСОЛОНА)
CN101851264B (zh) *	2010-03-12	2011-08-10	广西万德药业股份有限公司	一种具有16-β-甲基甾体类药物中间体的制备方法
CN103819495B (zh) *	2014-02-28	2016-08-17	上海新华联制药有限公司	倍他米松中间体的制备方法
CN107286216A (zh) *	2016-03-31	2017-10-24	天津金耀集团有限公司	具有多个烯烃甾体化合物的制备方法
CN105693802B (zh) *	2016-04-12	2017-08-25	湖南新合新生物医药有限公司	16β‑甲基甾族化合物的制备方法
CN106866777B (zh) *	2017-04-12	2019-05-24	杭州弘任医药科技有限公司	苯甲孕酮的制备方法
IT201800009683A1 (it) *	2018-10-22	2020-04-22	Ind Chimica Srl	Processo per la preparazione di 3α-idrossi-5α-pregnan-20-one (brexanolone)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2703799A (en) *	1954-05-12	1955-03-08	Searle & Co	9alpha-halo-11-oxo-16alpha, 17alpha-epoxyprogesterones
US2705711A (en) *	1954-09-24	1955-04-05	Searle & Co	9beta, 11beta; 16alpha, 17alpha-bisepoxyprogesterone
DE1041043B (de) *	1955-07-13	1958-10-16	Nat Res Dev	Verfahren zur Herstellung von 17ª‡-Hydroxy-16-halogenallopregnanen
GB805497A (en) *	1955-07-13	1958-12-10	Glaxo Lab Ltd	Steroid intermediates for the preparation of adreno-cortical hormones
US2951857A (en) *	1956-03-13	1960-09-06	Searle & Co	11-oxygenated 16-halo-17-hydroxy-progesterones
US3219674A (en) *	1959-03-11	1965-11-23	Syntex Corp	15-dehydro-16 methyl steroids and process for the production thereof
US3761498A (en) *	1971-06-05	1973-09-25	Plurichemie Anstalt	New process of preparation of steroids
AU607948B2 (en) *	1986-10-10	1991-03-21	Aventis Pharma S.A.	9-alpha-hydroxy steroids and process for their preparation
HU198736B (en) *	1986-12-29	1989-11-28	Gyogyszerkutato Intezet	Process for producing 16-dehydro-20-oxopregnane derivatives

1994
- 1994-06-02 FR FR9406743A patent/FR2720747B1/fr not_active Expired - Fee Related
1995
- 1995-05-15 TW TW084104785A patent/TW427997B/zh not_active IP Right Cessation
- 1995-05-18 US US08/444,229 patent/US5596108A/en not_active Expired - Lifetime
- 1995-05-31 ZA ZA954453A patent/ZA954453B/xx unknown
- 1995-05-31 JP JP15546595A patent/JP3950489B2/ja not_active Expired - Fee Related
- 1995-06-01 CA CA002150738A patent/CA2150738C/fr not_active Expired - Fee Related
- 1995-06-01 DK DK95401273.8T patent/DK0685487T3/da active
- 1995-06-01 CN CNB200610054918XA patent/CN100379753C/zh not_active Expired - Fee Related
- 1995-06-01 RU RU95108877/04A patent/RU2151774C1/ru not_active IP Right Cessation
- 1995-06-01 ES ES95401273T patent/ES2106623T3/es not_active Expired - Lifetime
- 1995-06-01 AU AU20442/95A patent/AU689564B2/en not_active Ceased
- 1995-06-01 KR KR1019950014481A patent/KR100369766B1/ko not_active IP Right Cessation
- 1995-06-01 HU HU9501595A patent/HU219490B/hu not_active IP Right Cessation
- 1995-06-01 AT AT95401273T patent/ATE157669T1/de active
- 1995-06-01 EP EP95401273A patent/EP0685487B1/de not_active Expired - Lifetime
- 1995-06-01 DE DE69500643T patent/DE69500643T2/de not_active Expired - Lifetime
- 1995-06-01 UA UA95062622A patent/UA48107C2/uk unknown
- 1995-06-01 CN CN95106623A patent/CN1057303C/zh not_active Expired - Fee Related
- 1995-06-02 FI FI952718A patent/FI114397B/fi not_active IP Right Cessation
1996
- 1996-09-13 US US08/710,198 patent/US5795982A/en not_active Expired - Lifetime
1997
- 1997-09-04 GR GR970402264T patent/GR3024626T3/el unknown
1998
- 1998-04-22 US US09/064,576 patent/US6117994A/en not_active Expired - Lifetime
- 1998-11-04 CN CNB981237525A patent/CN1252081C/zh not_active Expired - Fee Related
2007
- 2007-02-23 HK HK07102100A patent/HK1098760A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0685487A1 (de)	1995-12-06
HU219490B (hu)	2001-04-28
CN1252081C (zh)	2006-04-19
FR2720747A1 (fr)	1995-12-08
GR3024626T3 (en)	1997-12-31
CN1118351A (zh)	1996-03-13
JPH08169897A (ja)	1996-07-02
CN1220996A (zh)	1999-06-30
CN1821263A (zh)	2006-08-23
ES2106623T3 (es)	1997-11-01
CA2150738A1 (fr)	1995-12-03
FR2720747B1 (fr)	1996-07-12
EP0685487B1 (de)	1997-09-03
HUT71801A (en)	1996-02-28
FI952718A0 (fi)	1995-06-02
US5795982A (en)	1998-08-18
KR960000915A (ko)	1996-01-25
FI114397B (fi)	2004-10-15
JP3950489B2 (ja)	2007-08-01
CN1057303C (zh)	2000-10-11
US6117994A (en)	2000-09-12
DE69500643T2 (de)	1998-01-08
AU2044295A (en)	1995-12-14
KR100369766B1 (ko)	2003-12-11
US5596108A (en)	1997-01-21
DK0685487T3 (da)	1998-04-20
UA48107C2 (uk)	2002-08-15
CN100379753C (zh)	2008-04-09
FI952718A (fi)	1995-12-03
AU689564B2 (en)	1998-04-02
HU9501595D0 (en)	1995-07-28
DE69500643D1 (de)	1997-10-09
RU95108877A (ru)	1997-05-10
HK1098760A1 (en)	2007-07-27
TW427997B (en)	2001-04-01
ZA954453B (en)	1996-05-31
RU2151774C1 (ru)	2000-06-27
CA2150738C (fr)	2006-04-18

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Legal Events

Date	Code	Title	Description
1998-02-15	UEP	Publication of translation of european patent specification
2005-04-15	EEIH	Change in the person of patent owner