DK0555205T3 - DNA, der koder for en væstfaktor, som er specifik for epitelceller - Google Patents

DNA, der koder for en væstfaktor, som er specifik for epitelceller

Info

Publication number: DK0555205T3
Authority: DK; Denmark
Prior art keywords: cells; growth factor; protein; kgf; dna encoding
Prior art date: 1989-01-31

Application number

DK90903253T

Other languages

English (en)

Inventor

Jeffrey S Rubin

Paul W Finch

Stuart A Aaronson

Original Assignee

Jeffrey S Rubin

Paul W Finch

Stuart A Aaronson

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-01-31

Filing date

1990-01-30

Publication date

2001-03-05

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23175833&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0555205(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1990-01-30 Application filed by Jeffrey S Rubin, Paul W Finch, Stuart A Aaronson filed Critical Jeffrey S Rubin

2001-03-05 Application granted granted Critical

2001-03-05 Publication of DK0555205T3 publication Critical patent/DK0555205T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Toxicology (AREA)
Analytical Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Dermatology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)

DK90903253T 1989-01-31 1990-01-30 DNA, der koder for en væstfaktor, som er specifik for epitelceller DK0555205T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US30428189A	1989-01-31	1989-01-31
PCT/US1990/000418 WO1990008771A1 (en)	1989-01-31	1990-01-30	Dna encoding a growth factor specific for epithelial cells

Publications (1)

Publication Number	Publication Date
DK0555205T3 true DK0555205T3 (da)	2001-03-05

Family

ID=23175833

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90903253T DK0555205T3 (da)	1989-01-31	1990-01-30	DNA, der koder for en væstfaktor, som er specifik for epitelceller

Country Status (22)

Country	Link
US (8)	US5707805A (da)
EP (2)	EP0555205B1 (da)
JP (6)	JP3298874B2 (da)
KR (1)	KR950012805B1 (da)
AT (1)	ATE197800T1 (da)
AU (2)	AU647732B2 (da)
CA (2)	CA2038398C (da)
DE (2)	DE69033668T2 (da)
DK (1)	DK0555205T3 (da)
ES (1)	ES2153816T3 (da)
FI (1)	FI114711B (da)
GE (1)	GEP20022681B (da)
HU (1)	HU218090B (da)
IE (1)	IE20020188A1 (da)
LT (1)	LT3472B (da)
LU (1)	LU91237I2 (da)
LV (1)	LV10284B (da)
NL (1)	NL300230I2 (da)
NO (2)	NO308312B1 (da)
RU (1)	RU2250213C2 (da)
SG (1)	SG46699A1 (da)
WO (1)	WO1990008771A1 (da)

Families Citing this family (49)

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GEP20022681B (en)	1989-01-31	2002-04-25	Aaronson Us Stuart A	Protein KFG, Antibodies, Pharmaceutical Composition, Their Use, recombinant DNA, Cell, Method for Discoveries and Production of Proteins, Method for Stimulation of Epithelial Cells Growth
GB9203533D0 (en) *	1992-02-19	1992-04-08	Erba Carlo Spa	Use of the conjugate between a fibroblast growth factor and a saporin in treating ocular pathologies
US5965530A (en) *	1993-03-26	1999-10-12	Amgen Inc.	Therapeutic uses of keratinocyte growth factor
IL109122A (en) *	1993-03-26	2004-07-25	Amgen Inc	Use of products from a keratinocytic growth factor for the preparation of medicinal preparations
US7084119B2 (en)	1993-06-29	2006-08-01	Chiron Corporation	Truncated keratinocyte growth factor (KGF) having increased biological activity
DK0706563T3 (da) *	1993-06-29	2005-01-31	Chiron Corp	Afkortet keratonocyt-vækstfaktor (KGF) med foröget biologisk aktivetet
US6268212B1 (en)	1993-10-18	2001-07-31	Amgen Inc.	Tissue specific transgene expression
JP4422210B2 (ja) *	1994-10-13	2010-02-24	アムジエン・インコーポレーテツド	ケラチノサイト増殖因子アナログ
DK0804479T3 (da) *	1994-10-13	2007-01-29	Amgen Inc	Fremgangsmåde til behandling af diabetes mellitus ved anvendelse af KGF
PT785949E (pt) *	1994-10-13	2003-09-30	Amgen Inc	Metodo para purificar factores de crescimento de queratinocitos
US6008328A (en) *	1994-10-13	1999-12-28	Amgen Inc.	Method for purifying keratinocyte growth factors
US6818439B1 (en)	1994-12-30	2004-11-16	Chiron Corporation	Methods for administration of recombinant gene delivery vehicles for treatment of hemophilia and other disorders
US6030613A (en)	1995-01-17	2000-02-29	The Brigham And Women's Hospital, Inc.	Receptor specific transepithelial transport of therapeutics
US7232667B2 (en)	1995-02-14	2007-06-19	Human Genome Sciences, Inc.	Keratinocyte growth factor-2 polynucleotides
US6693077B1 (en)	1995-02-14	2004-02-17	Human Genome Sciences, Inc.	Keratinocyte growth factor-2
US6077692A (en)	1995-02-14	2000-06-20	Human Genome Sciences, Inc.	Keratinocyte growth factor-2
DE69637332T2 (de)	1995-10-11	2008-10-09	Novartis Vaccines and Diagnostics, Inc., Emeryville	Kombinierung von PDGF, KGF, IGF und IGFBP für Wundheilung
US6692961B1 (en)	1996-10-11	2004-02-17	Invitrogen Corporation	Defined systems for epithelial cell culture and use thereof
US6743422B1 (en)	1996-10-15	2004-06-01	Amgen, Inc.	Keratinocyte growth factor-2 products
US20030144202A1 (en) *	1996-10-15	2003-07-31	Amgen Inc.	Uses of keratinocyte growth factor-2
DE19716098A1 (de) *	1997-04-17	1998-10-22	Univ Ludwigs Albert	Fibroblasten mit einem Fremdgen enthaltende Zusammensetzung zur Behandlung von Wunden
US6228839B1 (en)	1997-12-19	2001-05-08	Emory University	Use of keratinocyte growth factor to improve oxidative status
EP1041996A4 (en)	1997-12-22	2003-05-14	Human Genome Sciences Inc	KERATINOCYTE GROWTH FACTOR-2 FORMULATIONS
US6869927B1 (en)	1997-12-22	2005-03-22	Human Genome Sciences, Inc.	Keratinocyte growth factor-2 formulations
AU762519B2 (en) *	1998-02-13	2003-06-26	Human Genome Sciences, Inc.	Therapeutic uses of keratinocyte growth factor-2
US6335317B1 (en)	1998-04-10	2002-01-01	Emory University	Use of gut-trophic growth factors to improve oxidative status
US6313103B1 (en)	1998-05-13	2001-11-06	Carrington Laboratories, Inc.	Pectic substance as a growth factor stabilizer
US5929051A (en) *	1998-05-13	1999-07-27	Carrington Laboratories, Inc.	Aloe pectins
US7022683B1 (en)	1998-05-13	2006-04-04	Carrington Laboratories, Inc.	Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation
US6372494B1 (en) *	1999-05-14	2002-04-16	Advanced Tissue Sciences, Inc.	Methods of making conditioned cell culture medium compositions
US6783546B2 (en)	1999-09-13	2004-08-31	Keraplast Technologies, Ltd.	Implantable prosthetic or tissue expanding device
US6371984B1 (en) *	1999-09-13	2002-04-16	Keraplast Technologies, Ltd.	Implantable prosthetic or tissue expanding device
US6376112B1 (en)	2000-02-11	2002-04-23	General Motors Corporation	Controlled shutdown of a fuel cell
US6395414B1 (en)	2000-02-11	2002-05-28	General Motors Corporation	Staged venting of fuel cell system during rapid shutdown
US6413662B1 (en)	2000-02-22	2002-07-02	General Motors Corporation	Fuel cell system shutdown with anode pressure control
JP2001302691A (ja) *	2000-04-17	2001-10-31	Nichirei Corp	ヒトｋｇｆに対する抗体
EP1357931A2 (en) *	2001-01-08	2003-11-05	Human Genome Sciences, Inc.	Keratinocyte growth factor-2
MXPA03007316A (es)	2001-02-19	2003-12-04	Merck Patent Gmbh	Metodo para la identificacion de epitopes de celulas t y el uso para la preparacion de moleculas con inmunogenicidad reducida.
US7494669B2 (en)	2001-02-28	2009-02-24	Carrington Laboratories, Inc.	Delivery of physiological agents with in-situ gels comprising anionic polysaccharides
AU2002326742B2 (en) *	2001-08-21	2007-05-31	Novartis Vaccines And Diagnostics, Inc.	KGF polypeptide compositions
US7202066B2 (en) *	2002-01-29	2007-04-10	Carrington Laboratories, Inc.	Combination of a growth factor and a protease enzyme
GB0206309D0 (en) *	2002-03-16	2002-05-01	Axordia Ltd	Isolated cells
WO2004019001A2 (en) *	2002-08-20	2004-03-04	Curagen Corporation	Methods for diagnosing and treatment of conditions that alter phosphate transport in mammals
EP1827483B1 (en)	2004-12-15	2014-07-02	Swedish Orphan Biovitrum AB (publ)	Therapeutic formulations of keratinocyte growth factor
US20080119433A1 (en) *	2006-07-06	2008-05-22	Aaron Thomas Tabor	Compositions and Methods for Genetic Modification of Cells Having Cosmetic Function to Enhance Cosmetic Appearance
ES2404669T3 (es) *	2007-01-05	2013-05-28	Helix Biomedix, Inc.	Péptidos bioactivos cortos para modulación celular e inmunológica
EP2454368A4 (en)	2009-07-17	2013-01-09	Aaron Thomas Tabor	COMPOSITIONS AND METHOD FOR THE GENETIC MODIFICATION OF COSMETIC FUNCTION CELLS FOR IMPROVING THE COSMETIC APPEARANCE PICTURE
EP2875359A4 (en)	2012-03-30	2015-08-19	Charles R Drew University Of Medicine And Science	COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING METABOLISM SYNDROME DISEASES
KR102277147B1 (ko) *	2017-12-13	2021-07-13	건국대학교 산학협력단	섬유아 성장인자 유래 펩타이드의 골 또는 연골 분화 촉진 용도

Family Cites Families (10)

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Publication number	Priority date	Publication date	Assignee	Title
US5096825A (en) *	1983-01-12	1992-03-17	Chiron Corporation	Gene for human epidermal growth factor and synthesis and expression thereof
US4444760A (en) *	1983-06-17	1984-04-24	Merck & Co., Inc.	Purification and characterization of a protein fibroblast growth factor
US4473679A (en)	1983-12-12	1984-09-25	Borg-Warner Chemicals, Inc.	Thermoplastic acrylic elastomers
US4743679A (en) *	1986-02-24	1988-05-10	Creative Biomolecules, Inc.	Process for producing human epidermal growth factor and analogs thereof
US4868113A (en)	1986-03-03	1989-09-19	Rorer Biotechnology, Inc.	Recombinant DNA vector encoding human endothelial cell growth factor
US4983679A (en)	1986-05-29	1991-01-08	E. I. Dupont De Nemours And Company	β-(keto or sulfonyl)esters from reaction of silylketene acetal and acyl or sulfonyl compound
IL89661A (en)	1988-03-17	1999-05-09	Novo Nordisk As	Heparin binding proteins
GEP20022681B (en)	1989-01-31	2002-04-25	Aaronson Us Stuart A	Protein KFG, Antibodies, Pharmaceutical Composition, Their Use, recombinant DNA, Cell, Method for Discoveries and Production of Proteins, Method for Stimulation of Epithelial Cells Growth
DK0706563T3 (da) *	1993-06-29	2005-01-31	Chiron Corp	Afkortet keratonocyt-vækstfaktor (KGF) med foröget biologisk aktivetet
DK0804479T3 (da)	1994-10-13	2007-01-29	Amgen Inc	Fremgangsmåde til behandling af diabetes mellitus ved anvendelse af KGF

1990
- 1990-01-30 GE GEAP1990983A patent/GEP20022681B/en unknown
- 1990-01-30 DK DK90903253T patent/DK0555205T3/da active
- 1990-01-30 RU SU5001740/13A patent/RU2250213C2/ru active
- 1990-01-30 EP EP90903253A patent/EP0555205B1/en not_active Expired - Lifetime
- 1990-01-30 DE DE69033668T patent/DE69033668T2/de not_active Expired - Lifetime
- 1990-01-30 ES ES90903253T patent/ES2153816T3/es not_active Expired - Lifetime
- 1990-01-30 WO PCT/US1990/000418 patent/WO1990008771A1/en active IP Right Grant
- 1990-01-30 AU AU50496/90A patent/AU647732B2/en not_active Expired
- 1990-01-30 JP JP50341390A patent/JP3298874B2/ja not_active Expired - Lifetime
- 1990-01-30 SG SG1996008633A patent/SG46699A1/en unknown
- 1990-01-30 EP EP00103140A patent/EP1016716A3/en not_active Withdrawn
- 1990-01-30 HU HU998/90A patent/HU218090B/hu unknown
- 1990-01-30 AT AT90903253T patent/ATE197800T1/de active
- 1990-01-31 IE IE20020188A patent/IE20020188A1/en not_active Application Discontinuation
- 1990-09-29 KR KR90702202A patent/KR950012805B1/ko not_active IP Right Cessation
1991
- 1991-03-15 CA CA002038398A patent/CA2038398C/en not_active Expired - Lifetime
- 1991-03-15 CA CA2349875A patent/CA2349875C/en not_active Expired - Lifetime
- 1991-07-30 FI FI913637A patent/FI114711B/fi active
1992
- 1992-12-23 LV LVP-92-410A patent/LV10284B/xx unknown
1993
- 1993-06-21 LT LTIP667A patent/LT3472B/lt not_active IP Right Cessation
1994
- 1994-06-28 AU AU65986/94A patent/AU684278B2/en not_active Expired
1995
- 1995-05-31 US US08/455,641 patent/US5707805A/en not_active Expired - Lifetime
- 1995-05-31 US US08/455,655 patent/US5654405A/en not_active Expired - Lifetime
- 1995-05-31 US US08/455,628 patent/US5665870A/en not_active Expired - Lifetime
- 1995-05-31 US US08/455,672 patent/US5741642A/en not_active Expired - Lifetime
- 1995-05-31 US US08/455,975 patent/US6833132B1/en not_active Expired - Lifetime
- 1995-05-31 US US08/455,620 patent/US6420531B1/en not_active Expired - Lifetime
- 1995-06-07 US US08/480,948 patent/US5731170A/en not_active Expired - Lifetime
- 1995-06-07 US US08/477,982 patent/US6709842B1/en not_active Expired - Lifetime
- 1995-12-27 JP JP7341890A patent/JP2716416B2/ja not_active Expired - Lifetime
1997
- 1997-05-16 NO NO972259A patent/NO308312B1/no not_active IP Right Cessation
- 1997-06-06 NO NO972617A patent/NO308310B1/no not_active IP Right Cessation
- 1997-10-22 JP JP09290175A patent/JP3088983B2/ja not_active Expired - Lifetime
1999
- 1999-10-06 JP JP28551799A patent/JP3802292B2/ja not_active Expired - Lifetime
2000
- 2000-10-11 JP JP2000311208A patent/JP3802329B2/ja not_active Expired - Lifetime
2006
- 2006-03-06 JP JP2006060217A patent/JP2006149407A/ja not_active Withdrawn
- 2006-04-11 DE DE200612000021 patent/DE122006000021I1/de active Pending
- 2006-04-19 NL NL300230C patent/NL300230I2/nl unknown
- 2006-04-24 LU LU91237C patent/LU91237I2/fr unknown

Also Published As

Publication number	Publication date
US5654405A (en)	1997-08-05
AU647732B2 (en)	1994-03-31
EP1016716A2 (en)	2000-07-05
JPH04504415A (ja)	1992-08-06
JP2716416B2 (ja)	1998-02-18
HUT58759A (en)	1992-03-30
FI913637A0 (fi)	1991-07-30
NO972259L (no)	1997-05-16
JP2001157594A (ja)	2001-06-12
KR950012805B1 (en)	1995-10-21
AU5049690A (en)	1990-08-24
KR910700257A (ko)	1991-03-14
JP2000102396A (ja)	2000-04-11
NO308312B1 (no)	2000-08-28
EP1016716A3 (en)	2000-07-12
HU218090B (hu)	2000-05-28
DE69033668T2 (de)	2001-04-12
ATE197800T1 (de)	2000-12-15
NO308310B1 (no)	2000-08-28
NL300230I1 (nl)	2006-07-03
GEP20022681B (en)	2002-04-25
LTIP667A (en)	1995-01-31
SG46699A1 (en)	1998-02-20
CA2349875A1 (en)	1992-09-16
CA2349875C (en)	2010-02-09
LT3472B (en)	1995-10-25
NO972259D0 (no)	1997-05-16
WO1990008771A1 (en)	1990-08-09
NO972617D0 (no)	1997-06-06
LV10284B (en)	1995-04-20
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US5741642A (en)	1998-04-21
LU91237I2 (fr)	2007-02-22
AU684278B2 (en)	1997-12-11
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US5665870A (en)	1997-09-09
US5707805A (en)	1998-01-13
JP3088983B2 (ja)	2000-09-18
DE69033668D1 (de)	2001-01-04
US5731170A (en)	1998-03-24
CA2038398A1 (en)	1992-09-16
JPH08277227A (ja)	1996-10-22
JP3802329B2 (ja)	2006-07-26
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US6833132B1 (en)	2004-12-21
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US6709842B1 (en)	2004-03-23
JPH10243800A (ja)	1998-09-14
CA2038398C (en)	2002-01-22
LV10284A (lv)	1994-10-20
ES2153816T3 (es)	2001-03-16
EP0555205B1 (en)	2000-11-29
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EP0555205A1 (en)	1993-08-18
RU2250213C2 (ru)	2005-04-20

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DK38892D0 (da)	1992-03-25	Proteinpraeparat, monoklonalt antistof fremstillet dermed, fremgangsmaade og middel til detektering, dna-sekvens og extrachromosomalt element indeholdende en saadan dna-sekvens
ES2059361T3 (es)	1994-11-16	Complejo de proteinas recombinantes que tiene actividad de factor viii:c su produccion y uso.
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ATE199095T1 (de)	2001-02-15	Heparin bindendes mitogen mit homologie zum epidermis wachstumsfaktor (egf)
HUP0002472A2 (hu)	2000-10-28	Izolált dendritikus sejtmembrán-fehérje gének
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ZHANG et al.	1990	Increased proteolytic cleavage of α1-antitrypsin (α1-proteinase inhibitor) in knee-joint synovial fluid from patients with rheumatoid arthritis
Addo-Boadu et al.	1996	Azelaic acid decreases the fibrinolytic potential of cultured human melanoma cells in vitro
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BR9808718A (pt)	2000-07-11	Polinucleotìdeo isolado, sequência de polinucleotìdeo isolado, vetor de expressão, célula cultivada, construção de dna, proteìna de fusão, polipeptìdeo isolado, processos para produzir um polipeptìdeo de convertase pró-hormÈnio humano 4, para determinar substratos de pró-hormÈnio de polipeptìdeo, para detectar, em uma amostra de teste, a presença de um modulador de atividade de polipeptìdeo de convertase pró-hormÈnio humano, e, para produzir um anticorpo para polipeptìdeo de convertase pró-hormÈnio humano 4
ATE124722T1 (de)	1995-07-15	Für das plazentaprotein 9 (pp9) kodierende cdna, ihre isolierung und verwendung.