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ES2069303T3 - Proteinas 2b inflamatorias del macrofago humano. - Google Patents

Proteinas 2b inflamatorias del macrofago humano.

Info

Publication number
ES2069303T3
ES2069303T3 ES91913167T ES91913167T ES2069303T3 ES 2069303 T3 ES2069303 T3 ES 2069303T3 ES 91913167 T ES91913167 T ES 91913167T ES 91913167 T ES91913167 T ES 91913167T ES 2069303 T3 ES2069303 T3 ES 2069303T3
Authority
ES
Spain
Prior art keywords
mip
beta
human
macrophagus
inflammatory proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91913167T
Other languages
English (en)
Inventor
Patricia Tekamp-Olson
Carol Ann Gallegos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Application granted granted Critical
Publication of ES2069303T3 publication Critical patent/ES2069303T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

EL INTENTO DE INDENTIFICAR LA CONTRAPARTIDA HUMANA DE LA PROTEINA 2 INFLAMATORIA MACROFAGA DE LOS MURIDOS DIO COMO RESULTADO INESPERADO NO UNA SINO DOS SECUENCIAS CANDIDATAS, DESIGNADAS COMO HU-MIP-2(ALFA) Y HU-MIP-(BETA), RESPECTIVAMENTE. USANDO LAS SECUENCIAS DE DNA Y SISTEMAS RECOMBINANTES SUMINISTRADOS POR ESTA INVENCION, SE PUEDE OBTENER HU-MIP-2(BETA), UNA DE LAS DOS CONTRAPARTIDAS HUMANAS A LA MMIP-2, SUBSTANCIALMENTE LIBRE DE OTRAS PROTEINAS HUMANAS. ESTA INVENCION TAMBIEN SUMINISTRA ANTICUERPOS REACTIVOS CON POLIPEPTIDOS HU-MIP-2$(B) ASI COMO METODOS DE INMUNOENSAYO PARA DETERMINAR LA HU-MIP-2(BETA) Y SONDAS NUCLEOTIDAS PARA DETECTAR SECUENCIAS NUCLEOTIDAS QUE CODIFICAN LA HU-MIP-2(BETA) EN MUESTRAS BIOLOGICAS.
ES91913167T 1990-06-22 1991-06-24 Proteinas 2b inflamatorias del macrofago humano. Expired - Lifetime ES2069303T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54189890A 1990-06-22 1990-06-22
US71519591A 1991-06-19 1991-06-19

Publications (1)

Publication Number Publication Date
ES2069303T3 true ES2069303T3 (es) 1995-05-01

Family

ID=27066836

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91913167T Expired - Lifetime ES2069303T3 (es) 1990-06-22 1991-06-24 Proteinas 2b inflamatorias del macrofago humano.

Country Status (11)

Country Link
EP (1) EP0535150B1 (es)
JP (1) JPH06501244A (es)
AT (1) ATE118018T1 (es)
CA (1) CA2086088A1 (es)
DE (1) DE69107209T2 (es)
DK (1) DK0535150T3 (es)
ES (1) ES2069303T3 (es)
GR (1) GR3015284T3 (es)
IE (1) IE66227B1 (es)
PT (1) PT98073B (es)
WO (1) WO1992000326A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145676A (en) * 1981-09-08 1992-09-08 The Rockefeller University Method and agents for promoting wound healing
DE69131133T2 (de) * 1990-09-28 1999-12-09 Chiron Corp., Emeryville Verwendung von gro-genen und proteinen
US5504003A (en) * 1994-03-08 1996-04-02 Human Genome Sciences, Inc. Macrophage inflammatory protein-3 and -4
US6001606A (en) * 1994-03-08 1999-12-14 Human Genome Sciences, Inc. Polynucleotides encoding myeloid progenitor inhibitory factor-1 (MPIF-1) and polypeptides encoded thereby
US6488925B2 (en) 1993-12-22 2002-12-03 Human Genome Sciences, Inc. Macrophage inflammatory protein-4 (MIP-4) polypeptides
US6811773B1 (en) 1993-12-22 2004-11-02 Human Genome Sciences, Inc. Human monocyte colony inhibitory factor (M-CIF) polypeptides
US6495129B1 (en) 1994-03-08 2002-12-17 Human Genome Sciences, Inc. Methods of inhibiting hematopoietic stem cells using human myeloid progenitor inhibitory factor-1 (MPIF-1) (Ckbeta-8/MIP-3)
US6623942B2 (en) 1994-03-08 2003-09-23 Human Genome Sciences, Inc. Macrophage inflammatory protein-4 (MIP-4) polynucleotides
WO1997019173A1 (en) * 1995-11-21 1997-05-29 Smithkline Beecham Corporation Method of treating sepsis
US5981231A (en) * 1996-06-17 1999-11-09 Human Genome Sciences, Inc. Polynucleotides encoding chemokine β-15
GB0024283D0 (en) * 2000-10-04 2000-11-15 Inpharmatica Ltd Novel proteins

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68928124T2 (de) * 1988-09-02 1997-10-16 Chiron Corp., Emeryville, Calif. Makrophagenabgeleiteter entzündungsmediator(mip-2)

Also Published As

Publication number Publication date
CA2086088A1 (en) 1991-12-23
WO1992000326A1 (en) 1992-01-09
PT98073B (pt) 1998-11-30
GR3015284T3 (en) 1995-06-30
JPH06501244A (ja) 1994-02-10
ATE118018T1 (de) 1995-02-15
DK0535150T3 (da) 1995-05-15
EP0535150B1 (en) 1995-02-01
PT98073A (pt) 1992-03-31
DE69107209T2 (de) 1995-05-24
IE912193A1 (en) 1992-01-01
IE66227B1 (en) 1995-12-13
DE69107209D1 (de) 1995-03-16
EP0535150A1 (en) 1993-04-07

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