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DK0544779T3 - Heterocykliske forbindelser og deres fremstilling og anvendelse - Google Patents

Heterocykliske forbindelser og deres fremstilling og anvendelse

Info

Publication number
DK0544779T3
DK0544779T3 DK91915629T DK91915629T DK0544779T3 DK 0544779 T3 DK0544779 T3 DK 0544779T3 DK 91915629 T DK91915629 T DK 91915629T DK 91915629 T DK91915629 T DK 91915629T DK 0544779 T3 DK0544779 T3 DK 0544779T3
Authority
DK
Denmark
Prior art keywords
preparation
compounds
heterocyclic compounds
forebrain
hippocampus
Prior art date
Application number
DK91915629T
Other languages
English (en)
Inventor
Per Sauerberg
Preben H Olesen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of DK0544779T3 publication Critical patent/DK0544779T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Lubricants (AREA)
  • Hydrogenated Pyridines (AREA)
DK91915629T 1990-08-21 1991-08-20 Heterocykliske forbindelser og deres fremstilling og anvendelse DK0544779T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK198590A DK198590D0 (da) 1990-08-21 1990-08-21 Heterocykliske forbindelser, deres fremstilling og anvendelse
PCT/DK1991/000236 WO1992003433A1 (en) 1990-08-21 1991-08-20 Heterocyclic compounds and their preparation and use

Publications (1)

Publication Number Publication Date
DK0544779T3 true DK0544779T3 (da) 1999-08-16

Family

ID=8109272

Family Applications (2)

Application Number Title Priority Date Filing Date
DK198590A DK198590D0 (da) 1990-08-21 1990-08-21 Heterocykliske forbindelser, deres fremstilling og anvendelse
DK91915629T DK0544779T3 (da) 1990-08-21 1991-08-20 Heterocykliske forbindelser og deres fremstilling og anvendelse

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK198590A DK198590D0 (da) 1990-08-21 1990-08-21 Heterocykliske forbindelser, deres fremstilling og anvendelse

Country Status (23)

Country Link
US (1) US5260314A (da)
EP (1) EP0544779B1 (da)
JP (1) JP3100160B2 (da)
KR (1) KR100247121B1 (da)
AT (1) ATE174027T1 (da)
AU (1) AU662105B2 (da)
CA (1) CA2089769C (da)
CZ (1) CZ282606B6 (da)
DE (1) DE69130570T2 (da)
DK (2) DK198590D0 (da)
ES (1) ES2124707T3 (da)
FI (1) FI930747A (da)
GR (1) GR3029289T3 (da)
HU (2) HU221433B (da)
IE (1) IE912960A1 (da)
IL (1) IL99165A (da)
NO (1) NO301883B1 (da)
NZ (1) NZ239450A (da)
PT (1) PT98736B (da)
SG (1) SG68567A1 (da)
SK (1) SK283219B6 (da)
WO (1) WO1992003433A1 (da)
ZA (1) ZA916581B (da)

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US5418240A (en) * 1990-08-21 1995-05-23 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
US5641791A (en) * 1991-08-13 1997-06-24 Novo Nordisk A.S Heterocyclic compounds and their preparation and use
WO1993014089A1 (en) * 1992-01-13 1993-07-22 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
MX9300875A (es) 1992-02-20 1993-08-31 Smithkline Beecham Plc Procedimiento para la preparacion de compuestos azabiciclicos.
AU671163B2 (en) * 1992-12-23 1996-08-15 Neurosearch A/S Alkyl substituted heterocyclic compounds
US5554626A (en) * 1992-12-23 1996-09-10 Neurosearch A/S Substituted heterocyclic compounds as dopamine-reuptake inhibitors
AU672644B2 (en) * 1992-12-23 1996-10-10 Neurosearch A/S Aryl substituted heterocyclic compounds
AU672052B2 (en) * 1992-12-23 1996-09-19 Neurosearch A/S Antidepressant and antiparkinsonian compounds
US5663182A (en) * 1993-08-19 1997-09-02 Bymaster; Franklin Porter Antipsychotic method
ATE202353T1 (de) * 1993-08-19 2001-07-15 Novo Nordisk As Antipsychotisches verfahren mit thiadiazol- und oxadiazol-derivaten
US6281232B1 (en) 1993-08-19 2001-08-28 Novo Nordisk A/S Method of treating gastrointestinal motility disorders
US6265419B1 (en) 1993-12-21 2001-07-24 Novo Nordisk A/S Method of treating gastrointestinal motility disorders
GB9409705D0 (en) * 1994-05-14 1994-07-06 Smithkline Beecham Plc Novel compounds
US5929247A (en) * 1994-10-24 1999-07-27 Eli Lilly And Company Heterocyclic compounds and their preparation and use
US5998404A (en) * 1994-10-24 1999-12-07 Eli Lilly And Company Heterocyclic compounds and their use
US5605908A (en) * 1994-10-24 1997-02-25 Eli Lilly And Company Heterocyclic compounds and their use
US5488056A (en) * 1994-10-31 1996-01-30 Eli Lilly And Company Method for treating anxiety
US5726193A (en) * 1994-10-31 1998-03-10 Eli Lilly And Company Method for treating anxiety
US5574028A (en) * 1994-10-31 1996-11-12 Eli Lilly And Company Method for treating anxiety
US5484794A (en) * 1994-11-09 1996-01-16 Eli Lilly And Company Method for treating anxiety
US5612351A (en) * 1994-11-08 1997-03-18 Novo Nordisk A/S Method of treating urinary bladder dysfunctions
TW390883B (en) * 1994-11-21 2000-05-21 Novo Nordisk As Azacyclic or azabicyclic compounds for treating diseases in the central nervous system, their preparation and pharmaceutical composition thereof
TW304167B (da) * 1995-01-30 1997-05-01 Lilly Co Eli
PE17897A1 (es) * 1995-02-17 1997-06-12 Lilly Co Eli Formulacion transdermica en parche del 3-(4-butiltio)-1,2,5-tiadiazol-3-il)-1-azabiciclo (2,2,2) octano
EP0809494A1 (en) * 1995-02-17 1997-12-03 Novo Nordisk A/S The use of heterocyclic compounds
US6040442A (en) * 1995-06-01 2000-03-21 Eli Lilly And Company Process for preparing 1,2,5-thiadiazole containing ethers
US5767280A (en) * 1995-06-01 1998-06-16 Eli Lilly And Company Process for making heterocyclic compounds
CA2233541C (en) * 1995-10-13 2002-04-30 Neurosearch A/S 8-azabicyclo[3.2.1]oct-2-ene derivatives, their preparation and use
US5852037A (en) * 1995-11-13 1998-12-22 Eli Lilly And Company Method for treating anxiety
US5889019A (en) * 1995-11-29 1999-03-30 Eli Lilly And Company Heterocyclic compounds and their use
WO1997019669A2 (en) * 1995-11-29 1997-06-05 Eli Lilly And Company Heterocyclic compounds and their use
US5998434A (en) * 1995-12-06 1999-12-07 Eli Lilly And Company Composition for treating pain
WO1997020556A1 (en) * 1995-12-07 1997-06-12 Eli Lilly And Company Method for treating pain
JP2000502716A (ja) * 1996-01-04 2000-03-07 ノボ ノルディスク アクティーゼルスカブ 高コレステロール血症及び関連する疾患を治療する方法
JP2000506871A (ja) 1996-03-19 2000-06-06 ノボ ノルディスク アクティーゼルスカブ 複素環式化合物並びにその調製及び用途
US5914338A (en) * 1996-04-02 1999-06-22 Novo Nordisk Heterocyclic compounds and their preparation and use
CA2250472A1 (en) * 1996-04-23 1997-10-30 Steven James Quimby Heterocyclic compounds
CA2252527A1 (en) * 1996-04-23 1997-10-30 Lone Jeppesen Heterocyclic compounds
US6117883A (en) * 1996-04-23 2000-09-12 Eli Lilly And Company Heterocyclic compounds
AU2679497A (en) * 1996-04-23 1997-11-12 Eli Lilly And Company Heterocyclic compounds
JP2000513712A (ja) * 1996-04-24 2000-10-17 ノボ ノルディスク アクティーゼルスカブ 複素環化合物およびその調製およびその使用
US5834458A (en) * 1996-10-09 1998-11-10 Eli Lilly And Company Heterocyclic compounds and their use
US5733912A (en) * 1997-02-19 1998-03-31 Abbott Laboratories 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
GB9805557D0 (en) * 1998-03-16 1998-05-13 Merck Sharp & Dohme A combination of therapeutic agents
DK1406900T3 (da) * 2001-07-06 2007-01-29 Neurosearch As Hidtil ukendte forbindelser, fremstilling og anvendelse deraf
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
US7678363B2 (en) * 2005-08-26 2010-03-16 Braincells Inc Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
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US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
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Also Published As

Publication number Publication date
HUT66863A (en) 1995-01-30
FI930747A0 (fi) 1993-02-19
ES2124707T3 (es) 1999-02-16
CZ24493A3 (en) 1994-01-19
JPH06500542A (ja) 1994-01-20
CA2089769C (en) 2002-10-01
SK283219B6 (sk) 2003-03-04
GR3029289T3 (en) 1999-05-28
AU8403691A (en) 1992-03-17
NO930601L (no) 1993-04-16
ZA916581B (en) 1992-05-27
DE69130570D1 (de) 1999-01-14
HU221433B (en) 2002-10-28
IL99165A0 (en) 1992-07-15
IL99165A (en) 1997-11-20
PT98736B (pt) 1999-01-29
CZ282606B6 (cs) 1997-08-13
AU662105B2 (en) 1995-08-24
SG68567A1 (en) 1999-11-16
NZ239450A (en) 1994-12-22
SK12793A3 (en) 1993-09-09
WO1992003433A1 (en) 1992-03-05
JP3100160B2 (ja) 2000-10-16
DK198590D0 (da) 1990-08-21
NO301883B1 (no) 1997-12-22
EP0544779B1 (en) 1998-12-02
DE69130570T2 (de) 1999-04-29
NO930601D0 (no) 1993-02-19
ATE174027T1 (de) 1998-12-15
HU211861A9 (en) 1995-12-28
FI930747A (fi) 1993-03-30
CA2089769A1 (en) 1992-02-22
US5260314A (en) 1993-11-09
EP0544779A1 (en) 1993-06-09
PT98736A (pt) 1992-07-31
IE912960A1 (en) 1992-02-26
KR100247121B1 (ko) 2000-08-01
HU9300464D0 (en) 1993-05-28

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