DK0540580T3 - Polymert lægemiddelafgivelsessystem - Google Patents
Polymert lægemiddelafgivelsessystemInfo
- Publication number
- DK0540580T3 DK0540580T3 DK91913230.8T DK91913230T DK0540580T3 DK 0540580 T3 DK0540580 T3 DK 0540580T3 DK 91913230 T DK91913230 T DK 91913230T DK 0540580 T3 DK0540580 T3 DK 0540580T3
- Authority
- DK
- Denmark
- Prior art keywords
- drug delivery
- delivery system
- polymeric drug
- polyamines
- polymeric
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/02—Polyamines
- C08G73/0206—Polyalkylene(poly)amines
- C08G73/0213—Preparatory process
- C08G73/0226—Quaternisation of polyalkylene(poly)amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/02—Polyamines
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S525/00—Synthetic resins or natural rubbers -- part of the class 520 series
- Y10S525/923—Aminoplast having terminal ethylenic unsaturation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Phenolic Resins Or Amino Resins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55804190A | 1990-07-26 | 1990-07-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0540580T3 true DK0540580T3 (da) | 1994-05-16 |
Family
ID=24227945
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91915184.5T DK0540670T3 (da) | 1990-07-26 | 1991-07-22 | Fremgangsmåde til fremstilling af tværbundne polyaminer |
| DK91913230.8T DK0540580T3 (da) | 1990-07-26 | 1991-07-22 | Polymert lægemiddelafgivelsessystem |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91915184.5T DK0540670T3 (da) | 1990-07-26 | 1991-07-22 | Fremgangsmåde til fremstilling af tværbundne polyaminer |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US5827925A (da) |
| EP (2) | EP0540580B1 (da) |
| JP (2) | JP2611073B2 (da) |
| AT (2) | ATE135721T1 (da) |
| AU (2) | AU8285991A (da) |
| CA (2) | CA2086527A1 (da) |
| DE (2) | DE69101710T2 (da) |
| DK (2) | DK0540670T3 (da) |
| ES (2) | ES2084825T3 (da) |
| GR (1) | GR3019804T3 (da) |
| IE (1) | IE912630A1 (da) |
| NZ (1) | NZ239133A (da) |
| PT (1) | PT98442B (da) |
| WO (2) | WO1992001477A1 (da) |
| ZA (1) | ZA915892B (da) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE135721T1 (de) * | 1990-07-26 | 1996-04-15 | Monsanto Co | Verfahren zur herstellung vernetzter polyamine |
| JPH06239931A (ja) * | 1992-12-14 | 1994-08-30 | Monsanto Co | ポリ（第２アミン）とその製造方法 |
| US5559193A (en) * | 1993-12-20 | 1996-09-24 | Monsanto Company | Controlled functional density polyamines and method for preparation thereof |
| US5691422A (en) * | 1994-03-07 | 1997-11-25 | Exxon Chemical Patents Inc. | Saturated polyolefins having terminal aldehyde or hydroxy substituents and derivatives thereof |
| US5674950A (en) * | 1994-03-07 | 1997-10-07 | Exxon Chemical Patents Inc. | Polymers having terminal hydroxyl aldehyde, or alkylamino substitutents and derivatives thereof |
| US6890524B1 (en) | 1997-04-04 | 2005-05-10 | Monsanto Company | Hydrolyzable delivery system using cross-linked polymeric resins as vehicles |
| US6413945B1 (en) * | 1997-04-04 | 2002-07-02 | Pharmacia Corporation | Gastro-specific prodrugs |
| US6030959A (en) * | 1997-04-04 | 2000-02-29 | Monsanto Company | Gastro-specific prodrugs |
| WO1998044952A1 (en) * | 1997-04-04 | 1998-10-15 | Monsanto Company | pH-SELECTIVE DELIVERY SYSTEM USING CROSS-LINKED POLYMERIC RESINS AS VEHICLES |
| WO1998044951A2 (en) * | 1997-04-04 | 1998-10-15 | Monsanto Company | Hydrolysable delivery system using cross-linked polymeric resins as vehicles |
| CN1414902A (zh) | 1999-12-28 | 2003-04-30 | 金伯利-克拉克环球有限公司 | 硬质表面用受控释放抗菌擦 |
| WO2001047403A1 (en) | 1999-12-28 | 2001-07-05 | Kimberly-Clark Worldwide, Inc. | Use-dependent indicator system for absorbent articles |
| US6315987B1 (en) * | 2000-05-10 | 2001-11-13 | Isp Investments Inc. | Polymeric delivery and release systems for oral care actives |
| US7097181B2 (en) * | 2001-11-02 | 2006-08-29 | Outrigger, Inc. | Angular handle assembly for wheeled luggage |
| EP1501352B1 (en) * | 2001-12-14 | 2015-02-18 | The University Of Wyoming | Controlled release of oxycodone |
| GB0222522D0 (en) | 2002-09-27 | 2002-11-06 | Controlled Therapeutics Sct | Water-swellable polymers |
| RS51707B (sr) * | 2002-12-12 | 2011-10-31 | Nycomed Gmbh. | Kombinacija leka sastavljena od r, r - formoterola i ciklezonida |
| EP1626748B1 (en) * | 2003-05-13 | 2012-07-11 | Medtronic, Inc. | Moisture curable materials for delivery of agents, methods, and medical devices |
| GB0417401D0 (en) | 2004-08-05 | 2004-09-08 | Controlled Therapeutics Sct | Stabilised prostaglandin composition |
| JP5021621B2 (ja) | 2005-04-13 | 2012-09-12 | アスション ファーマ エー／エス | 皮膚の結合組織病を治療するためのβ−２アドレナリン受容体作動薬 |
| US8367096B2 (en) * | 2005-07-19 | 2013-02-05 | Boston Scientific Scimed, Inc. | Polymers having covalently bound therapeutic agents |
| US20090317335A1 (en) * | 2006-04-20 | 2009-12-24 | Wenbin Lin | Hybrid Nanomaterials as Multimodal Imaging Contrast Agents |
| GB0613333D0 (en) | 2006-07-05 | 2006-08-16 | Controlled Therapeutics Sct | Hydrophilic polyurethane compositions |
| GB0613638D0 (en) | 2006-07-08 | 2006-08-16 | Controlled Therapeutics Sct | Polyurethane elastomers |
| MX2009001534A (es) * | 2006-08-10 | 2009-04-08 | Us Gov Health & Human Serv | Preparacion de (r,r)-fenoterol y analogos de (r,r)- o (r,s)-fenoterol y su uso en el tratamiento de insuficiencia cardiaca congestiva. |
| GB0620685D0 (en) | 2006-10-18 | 2006-11-29 | Controlled Therapeutics Sct | Bioresorbable polymers |
| MX2009008170A (es) * | 2007-01-31 | 2009-08-12 | Allergan Inc | Nuevos biomateriales para la distribucion de farmaco ocular y metodo para hacerlos y utilizarlos. |
| US20110135571A1 (en) * | 2008-02-22 | 2011-06-09 | Wenbin Lin | Hybrid nanoparticles as anti-cancer therapeutic agents and dual therapeutic/imaging contrast agents |
| US8945527B2 (en) * | 2008-04-25 | 2015-02-03 | The University Of North Carolina At Chapel Hill | Degradable compounds and methods of use thereof, particularly with particle replication in non-wetting templates |
| US20130203675A1 (en) | 2010-09-16 | 2013-08-08 | Joseph M. DeSimone | Asymmetric biofunctional silyl monomers and particles thereof as prodrugs and delivery vehicles for pharmaceutical, chemical and biological agents |
| EP3494974B1 (en) | 2011-07-08 | 2023-10-18 | The University of North Carolina at Chapel Hill | Metal bisphosphonate nanoparticles for anti-cancer therapy and imaging and for treating bone disorders |
| JP6590802B2 (ja) | 2013-11-06 | 2019-10-16 | ザ ユニバーシティ オブ シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ | 化学療法用薬剤、核酸及び光増感剤の送達又は共送達のためのナノスケール輸送体 |
| US10806694B2 (en) | 2014-10-14 | 2020-10-20 | The University Of Chicago | Nanoparticles for photodynamic therapy, X-ray induced photodynamic therapy, radiotherapy, radiodynamic therapy, chemotherapy, immunotherapy, and any combination thereof |
| CN110731961A (zh) | 2014-10-14 | 2020-01-31 | 芝加哥大学 | 金属有机框架、药物制剂及其在制备药物中的用途 |
| JP7090034B2 (ja) | 2016-05-20 | 2022-06-23 | ザ ユニバーシティ オブ シカゴ | 化学療法、標的療法、光線力学療法、免疫療法及びそれらの任意の組み合わせのためのナノ粒子 |
| EP3555280A4 (en) | 2016-12-19 | 2020-09-09 | The Regents of The University of California | PEPTIDES SENSITIVE TO TWO ENZYMES |
| EP3554548A4 (en) | 2016-12-19 | 2020-08-19 | The Regents of The University of California | NON-CRUSHABLE PILL FORMULATIONS |
| IL269506B2 (en) | 2017-03-22 | 2024-04-01 | Genentech Inc | Hyaluronic acid cross-linked hydrogel preparations and methods |
| WO2019028250A1 (en) | 2017-08-02 | 2019-02-07 | The University Of Chicago | NOMOGENEOUS ORGANOMETALLIC ORGANOMETRIC ORGANOMETRIC LAYERS FOR X-RAY INDUCED PHOTODYNAMIC THERAPY, RADIOTHERAPY, RODIODYNAMIC THERAPY, CHEMOTHERAPY, IMMUNOTHERAPY, AND ANY COMBINATION THEREOF |
| CA3030416A1 (en) | 2018-01-18 | 2019-07-18 | Research Triangle Institute | Polyamine phosphorus dendrimer materials for carbon dioxide capture |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2923662A (en) * | 1957-07-11 | 1960-02-02 | White Lab Inc | Appetite depressant resin |
| US3383426A (en) * | 1963-09-09 | 1968-05-14 | Exxon Research Engineering Co | Hydroformylation process for polymers |
| DE2060703A1 (de) * | 1970-12-10 | 1972-06-22 | Hoechst Ag | Glasklare Polyamide |
| FR2273554A1 (fr) * | 1974-06-04 | 1976-01-02 | Wellcome Found | Derives de prostaglandines et medicaments contenant ces substances |
| IT1044797B (it) * | 1974-10-15 | 1980-04-21 | Ferruti Paolo | Alti polimeri contenenti radicali prostaglandinici processo per la loro preparazione e loro impiego |
| US4068056A (en) * | 1975-03-05 | 1978-01-10 | Exxon Research And Engineering Company | Aminated polymeric additives for fuel and lubricants |
| US4292242A (en) * | 1978-12-06 | 1981-09-29 | Sri International | Production of amines |
| US4356166A (en) * | 1978-12-08 | 1982-10-26 | University Of Utah | Time-release chemical delivery system |
| JPH0323530B2 (da) * | 1979-03-21 | 1991-03-29 | Nat Res Dev | |
| US4296004A (en) * | 1979-09-10 | 1981-10-20 | Henkel Corporation | Polycyclic polyamines |
| US4297481A (en) * | 1980-02-22 | 1981-10-27 | W. R. Grace & Co. | Process of forming polymeric polyamine/amide |
| US4312965A (en) * | 1980-02-22 | 1982-01-26 | W. R. Grace & Co. | Process for forming amine/amide containing polymers |
| US4489056A (en) * | 1982-06-30 | 1984-12-18 | Merck & Co., Inc. | Acid anhydrides as rate controlling agent for the erosion of polymers which latter polymers have beneficial substances dispersed throughout their matrix or where the polymer matrix surrounds the beneficial substance |
| US4675182A (en) * | 1983-02-12 | 1987-06-23 | Bayer Aktiengesellschaft | Complexes of prostaglandins |
| US4526936A (en) * | 1983-03-18 | 1985-07-02 | W. R. Grace & Co. | Process for the preparation of polymeric amine containing products |
| US4558101A (en) * | 1983-03-18 | 1985-12-10 | W. R. Grace & Co. | Process for the preparation of polymeric amine containing products |
| US4606939A (en) * | 1983-06-22 | 1986-08-19 | The Ohio State University Research Foundation | Small particle formation |
| US4608278A (en) * | 1983-06-22 | 1986-08-26 | The Ohio State University Research Foundation | Small particule formation and encapsulation |
| US4459310A (en) * | 1983-06-27 | 1984-07-10 | G.D. Searle & Co. | Method for cholesterol lowering |
| US4543411A (en) * | 1983-11-10 | 1985-09-24 | Texaco Inc. | Process for selective preparation of secondary and tertiary amines |
| US4503217A (en) * | 1983-11-10 | 1985-03-05 | Texaco Inc. | Process for selective preparation of polymeric polyamines |
| US4795436A (en) * | 1983-11-14 | 1989-01-03 | Bio-Mimetics, Inc. | Bioadhesive composition and method of treatment therewith |
| SE457505B (sv) * | 1984-01-10 | 1989-01-09 | Lejus Medical Ab | Laminatbelagd oral farmaceutisk komposition och foerfarande foer dess framstaellning |
| US4600578A (en) * | 1984-05-11 | 1986-07-15 | Bristol-Myers Company | Method of inhibiting diarrhea |
| US4639366A (en) * | 1984-06-06 | 1987-01-27 | Merck & Co., Inc. | Polymers containing pendant acid functionalities and labile backbone bonds |
| US4765973A (en) * | 1984-06-06 | 1988-08-23 | Merck & Co., Inc. | Polymers containing pendant acid functionalities and labile backbone bonds |
| US4794199A (en) * | 1984-07-05 | 1988-12-27 | Texaco Inc. | Process for synthesis of primary amines from olefins, syngas and ammonia |
| US4663308A (en) * | 1984-07-18 | 1987-05-05 | Medical College Of Ohio | Method of use of polymers containing cross-linked azo bonds for releasing therapeutic agents into the lower gastrointestinal tract |
| DE3686275T2 (de) * | 1985-01-11 | 1993-03-18 | Teijin Ltd | Praeparate mit verzoegerter freisetzung. |
| US4548955A (en) * | 1985-02-25 | 1985-10-22 | Sogo Pharmaceutical Company Limited | Nylon capsule responding to pH |
| US4780319A (en) * | 1985-07-08 | 1988-10-25 | Merck & Co., Inc. | Organic acids as catalysts for the erosion of polymers |
| US4657984A (en) * | 1985-10-16 | 1987-04-14 | Texaco Inc. | Process for formation of dialkylaminomethylated internal olefin polymers |
| US4847250A (en) * | 1985-11-29 | 1989-07-11 | Merck & Co., Inc. | Pyroglutamic acid esters used as dermal penetration enhancers for drugs |
| US4764364A (en) * | 1986-02-25 | 1988-08-16 | S R I International | Method of preparing bioerodible polymers having pH sensitivity in the acid range and resulting product |
| US4705898A (en) * | 1986-04-04 | 1987-11-10 | Texaco Inc. | Preparation of disecondary amines from diolefins and primary amines |
| US4894226A (en) * | 1986-11-14 | 1990-01-16 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polyproline conjugation |
| IL83715A0 (en) * | 1987-08-31 | 1988-01-31 | Yeda Res & Dev | Pharmaceutical anti-protozoal compositions |
| ATE96030T1 (de) * | 1988-03-24 | 1993-11-15 | Taisho Pharmaceutical Co Ltd | Cholesterolvermindernde wirkstoffe. |
| GB8912903D0 (en) * | 1989-06-05 | 1989-07-26 | Smith Kline French Lab | Compounds |
| GB8913699D0 (en) * | 1989-06-14 | 1989-08-02 | Smith Kline French Lab | Compounds |
| DE3930696A1 (de) * | 1989-09-14 | 1991-03-28 | Hoechst Ag | Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel |
| CA2042603A1 (en) * | 1989-10-02 | 1991-04-03 | David Coates | Electrooptical liquid crystal system |
| GB8928278D0 (en) * | 1989-12-14 | 1990-02-21 | Smith Kline French Lab | Compounds |
| US5049625A (en) * | 1990-03-08 | 1991-09-17 | The Goodyear Tire & Rubber Company | Polymeric diphenyldiamines |
| CA2040996A1 (en) * | 1990-05-02 | 1991-11-03 | Robert L. Albright | Composition and method for controlling cholesterol |
| GB9010784D0 (en) * | 1990-05-14 | 1990-07-04 | Shell Int Research | Process for the preparation of a secondary amine |
| ATE135721T1 (de) * | 1990-07-26 | 1996-04-15 | Monsanto Co | Verfahren zur herstellung vernetzter polyamine |
| US5134200A (en) * | 1990-10-09 | 1992-07-28 | The Goodyear Tire & Rubber Company | Polymers containing chemically bound amine antidegradants |
| EP0534316A1 (de) * | 1991-09-21 | 1993-03-31 | Hoechst Aktiengesellschaft | Verwendung von alkylierten Polyethyleniminderivaten zur Anreicherung von Gallensäuren |
| EP0548793A3 (en) * | 1991-12-20 | 1995-11-02 | Hoechst Ag | Ethylenic-unsaturated bile acid derivatives, process for their production and preliminary processes therefor |
| JPH06239931A (ja) * | 1992-12-14 | 1994-08-30 | Monsanto Co | ポリ（第２アミン）とその製造方法 |
-
1991
- 1991-07-22 AT AT91915184T patent/ATE135721T1/de not_active IP Right Cessation
- 1991-07-22 AT AT91913230T patent/ATE104154T1/de not_active IP Right Cessation
- 1991-07-22 DE DE69101710T patent/DE69101710T2/de not_active Expired - Fee Related
- 1991-07-22 AU AU82859/91A patent/AU8285991A/en not_active Abandoned
- 1991-07-22 JP JP3513736A patent/JP2611073B2/ja not_active Expired - Fee Related
- 1991-07-22 US US07/966,171 patent/US5827925A/en not_active Expired - Fee Related
- 1991-07-22 US US07/976,990 patent/US5474767A/en not_active Expired - Fee Related
- 1991-07-22 ES ES91915184T patent/ES2084825T3/es not_active Expired - Lifetime
- 1991-07-22 EP EP91913230A patent/EP0540580B1/en not_active Expired - Lifetime
- 1991-07-22 JP JP3512692A patent/JPH06502391A/ja active Pending
- 1991-07-22 DK DK91915184.5T patent/DK0540670T3/da active
- 1991-07-22 DE DE69118188T patent/DE69118188T2/de not_active Expired - Fee Related
- 1991-07-22 CA CA002086527A patent/CA2086527A1/en not_active Abandoned
- 1991-07-22 WO PCT/US1991/005029 patent/WO1992001477A1/en active IP Right Grant
- 1991-07-22 DK DK91913230.8T patent/DK0540580T3/da active
- 1991-07-22 WO PCT/US1991/005147 patent/WO1992001730A1/en active IP Right Grant
- 1991-07-22 AU AU84188/91A patent/AU8418891A/en not_active Abandoned
- 1991-07-22 ES ES91913230T patent/ES2053333T3/es not_active Expired - Lifetime
- 1991-07-22 CA CA002085366A patent/CA2085366C/en not_active Expired - Fee Related
- 1991-07-22 EP EP91915184A patent/EP0540670B1/en not_active Expired - Lifetime
- 1991-07-25 NZ NZ239133A patent/NZ239133A/en unknown
- 1991-07-25 PT PT98442A patent/PT98442B/pt active IP Right Grant
- 1991-07-25 IE IE263091A patent/IE912630A1/en unknown
- 1991-07-26 ZA ZA915892A patent/ZA915892B/xx unknown
-
1995
- 1995-03-06 US US08/399,313 patent/US5676939A/en not_active Expired - Fee Related
- 1995-03-06 US US08/399,312 patent/US5693319A/en not_active Expired - Lifetime
- 1995-03-06 US US08/399,301 patent/US5795567A/en not_active Expired - Lifetime
-
1996
- 1996-04-30 GR GR960401190T patent/GR3019804T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5676939A (en) | 1997-10-14 |
| CA2085366A1 (en) | 1992-01-27 |
| EP0540580A1 (en) | 1993-05-12 |
| DE69118188D1 (de) | 1996-04-25 |
| EP0540670A1 (en) | 1993-05-12 |
| NZ239133A (en) | 1993-10-26 |
| CA2085366C (en) | 2001-06-12 |
| EP0540670B1 (en) | 1996-03-20 |
| DE69101710D1 (de) | 1994-05-19 |
| ES2084825T3 (es) | 1996-05-16 |
| ZA915892B (en) | 1992-09-30 |
| ATE135721T1 (de) | 1996-04-15 |
| DK0540670T3 (da) | 1996-04-29 |
| US5474767A (en) | 1995-12-12 |
| WO1992001477A1 (en) | 1992-02-06 |
| JP2611073B2 (ja) | 1997-05-21 |
| DE69118188T2 (de) | 1996-10-31 |
| JPH05508680A (ja) | 1993-12-02 |
| EP0540580B1 (en) | 1994-04-13 |
| JPH06502391A (ja) | 1994-03-17 |
| AU8285991A (en) | 1992-02-18 |
| WO1992001730A1 (en) | 1992-02-06 |
| IE912630A1 (en) | 1992-01-29 |
| GR3019804T3 (en) | 1996-07-31 |
| ES2053333T3 (es) | 1994-07-16 |
| US5827925A (en) | 1998-10-27 |
| PT98442A (pt) | 1992-06-30 |
| ATE104154T1 (de) | 1994-04-15 |
| DE69101710T2 (de) | 1994-08-18 |
| AU8418891A (en) | 1992-02-18 |
| US5795567A (en) | 1998-08-18 |
| CA2086527A1 (en) | 1992-01-27 |
| US5693319A (en) | 1997-12-02 |
| PT98442B (pt) | 1999-01-29 |
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