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ATE135721T1 - Verfahren zur herstellung vernetzter polyamine - Google Patents

Verfahren zur herstellung vernetzter polyamine

Info

Publication number
ATE135721T1
ATE135721T1 AT91915184T AT91915184T ATE135721T1 AT E135721 T1 ATE135721 T1 AT E135721T1 AT 91915184 T AT91915184 T AT 91915184T AT 91915184 T AT91915184 T AT 91915184T AT E135721 T1 ATE135721 T1 AT E135721T1
Authority
AT
Austria
Prior art keywords
producing cross
linked polyamine
linked
cross
polyamines
Prior art date
Application number
AT91915184T
Other languages
English (en)
Inventor
Samuel Joseph Tremont
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Application granted granted Critical
Publication of ATE135721T1 publication Critical patent/ATE135721T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • C08G73/0213—Preparatory process
    • C08G73/0226—Quaternisation of polyalkylene(poly)amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S525/00—Synthetic resins or natural rubbers -- part of the class 520 series
    • Y10S525/923—Aminoplast having terminal ethylenic unsaturation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Phenolic Resins Or Amino Resins (AREA)
AT91915184T 1990-07-26 1991-07-22 Verfahren zur herstellung vernetzter polyamine ATE135721T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55804190A 1990-07-26 1990-07-26

Publications (1)

Publication Number Publication Date
ATE135721T1 true ATE135721T1 (de) 1996-04-15

Family

ID=24227945

Family Applications (2)

Application Number Title Priority Date Filing Date
AT91915184T ATE135721T1 (de) 1990-07-26 1991-07-22 Verfahren zur herstellung vernetzter polyamine
AT91913230T ATE104154T1 (de) 1990-07-26 1991-07-22 Arzneimittel freisetzendes polymeres system.

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT91913230T ATE104154T1 (de) 1990-07-26 1991-07-22 Arzneimittel freisetzendes polymeres system.

Country Status (15)

Country Link
US (5) US5827925A (de)
EP (2) EP0540580B1 (de)
JP (2) JP2611073B2 (de)
AT (2) ATE135721T1 (de)
AU (2) AU8285991A (de)
CA (2) CA2086527A1 (de)
DE (2) DE69101710T2 (de)
DK (2) DK0540670T3 (de)
ES (2) ES2084825T3 (de)
GR (1) GR3019804T3 (de)
IE (1) IE912630A1 (de)
NZ (1) NZ239133A (de)
PT (1) PT98442B (de)
WO (2) WO1992001477A1 (de)
ZA (1) ZA915892B (de)

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ATE135721T1 (de) * 1990-07-26 1996-04-15 Monsanto Co Verfahren zur herstellung vernetzter polyamine
JPH06239931A (ja) * 1992-12-14 1994-08-30 Monsanto Co ポリ（第２アミン）とその製造方法
US5559193A (en) * 1993-12-20 1996-09-24 Monsanto Company Controlled functional density polyamines and method for preparation thereof
US5691422A (en) * 1994-03-07 1997-11-25 Exxon Chemical Patents Inc. Saturated polyolefins having terminal aldehyde or hydroxy substituents and derivatives thereof
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US6890524B1 (en) 1997-04-04 2005-05-10 Monsanto Company Hydrolyzable delivery system using cross-linked polymeric resins as vehicles
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WO1998044951A2 (en) * 1997-04-04 1998-10-15 Monsanto Company Hydrolysable delivery system using cross-linked polymeric resins as vehicles
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EP3494974B1 (de) 2011-07-08 2023-10-18 The University of North Carolina at Chapel Hill Metall-bisphosphonat-nanopartikel zur krebstherapie sowie bildgebung und zur behandlung von knochenerkrankungen
JP6590802B2 (ja) 2013-11-06 2019-10-16 ザ ユニバーシティ オブ シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ 化学療法用薬剤、核酸及び光増感剤の送達又は共送達のためのナノスケール輸送体
US10806694B2 (en) 2014-10-14 2020-10-20 The University Of Chicago Nanoparticles for photodynamic therapy, X-ray induced photodynamic therapy, radiotherapy, radiodynamic therapy, chemotherapy, immunotherapy, and any combination thereof
CN110731961A (zh) 2014-10-14 2020-01-31 芝加哥大学 金属有机框架、药物制剂及其在制备药物中的用途
JP7090034B2 (ja) 2016-05-20 2022-06-23 ザ ユニバーシティ オブ シカゴ 化学療法、標的療法、光線力学療法、免疫療法及びそれらの任意の組み合わせのためのナノ粒子
EP3555280A4 (de) 2016-12-19 2020-09-09 The Regents of The University of California Auf duales enzym reagierende peptide
EP3554548A4 (de) 2016-12-19 2020-08-19 The Regents of The University of California Nicht brechbare tablettenformulierungen
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Also Published As

Publication number Publication date
US5676939A (en) 1997-10-14
CA2085366A1 (en) 1992-01-27
EP0540580A1 (de) 1993-05-12
DE69118188D1 (de) 1996-04-25
EP0540670A1 (de) 1993-05-12
NZ239133A (en) 1993-10-26
CA2085366C (en) 2001-06-12
EP0540670B1 (de) 1996-03-20
DK0540580T3 (da) 1994-05-16
DE69101710D1 (de) 1994-05-19
ES2084825T3 (es) 1996-05-16
ZA915892B (en) 1992-09-30
DK0540670T3 (da) 1996-04-29
US5474767A (en) 1995-12-12
WO1992001477A1 (en) 1992-02-06
JP2611073B2 (ja) 1997-05-21
DE69118188T2 (de) 1996-10-31
JPH05508680A (ja) 1993-12-02
EP0540580B1 (de) 1994-04-13
JPH06502391A (ja) 1994-03-17
AU8285991A (en) 1992-02-18
WO1992001730A1 (en) 1992-02-06
IE912630A1 (en) 1992-01-29
GR3019804T3 (en) 1996-07-31
ES2053333T3 (es) 1994-07-16
US5827925A (en) 1998-10-27
PT98442A (pt) 1992-06-30
ATE104154T1 (de) 1994-04-15
DE69101710T2 (de) 1994-08-18
AU8418891A (en) 1992-02-18
US5795567A (en) 1998-08-18
CA2086527A1 (en) 1992-01-27
US5693319A (en) 1997-12-02
PT98442B (pt) 1999-01-29

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