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DK0424232T3 - Process for the preparation of chenodesoxycholic acid - Google Patents

Process for the preparation of chenodesoxycholic acid

Info

Publication number
DK0424232T3
DK0424232T3 DK90402879.2T DK90402879T DK0424232T3 DK 0424232 T3 DK0424232 T3 DK 0424232T3 DK 90402879 T DK90402879 T DK 90402879T DK 0424232 T3 DK0424232 T3 DK 0424232T3
Authority
DK
Denmark
Prior art keywords
preparation
alpha
acid
alkali metal
oxocholanates
Prior art date
Application number
DK90402879.2T
Other languages
Danish (da)
Inventor
Emilio Crisafulli
Roberto Arosio
Vittorio Rossetti
Stefano Beratto
Armando Talamona
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8913569A external-priority patent/FR2653126B1/en
Priority claimed from FR8913570A external-priority patent/FR2653127B1/en
Priority claimed from FR8913571A external-priority patent/FR2653128B1/en
Priority claimed from FR8913572A external-priority patent/FR2653129B1/en
Application filed by Sanofi Sa filed Critical Sanofi Sa
Application granted granted Critical
Publication of DK0424232T3 publication Critical patent/DK0424232T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Improvements to the stages of the conventional process for the preparation of chenodeoxycholic and ursodeoxycholic acids, which comprise - the preparation of methyl 3 alpha ,7 alpha -diacetoxy-12 alpha -hydroxy- 5ss-cholanates by acetylation of the corresponding alkyl cholates with the stoichiometric quantity of acetic anhydride in an organic solvent in the presence of a catalytic quantity of an N,N-dialkylaniline or a 4-dialkylaminopyridine and a quantity of tertiary amine smaller than one mole per mole of starting material; - the preparation of 12-oxocholanates from alkyl 3,7-diacetate cholates by oxidation with an alkali metal hypochlorite and acetic acid in stoichiometric quantities in the presence of an alkali metal bromide and at a temperature below 40 DEG C; - the reduction of 3 alpha ,7 alpha -dihydroxy-12-oxo-5ss-cholanic acid with hydrazine and an inorganic base, the operation being carried out in an aqueous-organic solvent and by then removing the water by distillation; and - the preparation of 7-oxocholanates, intermediate products in the preparation of ursodeoxycholic acid, by oxidation of chenodeoxycholic acid with an alkali metal hypochlorite and acetic acid in stoichiometric quantities in the presence of an alkali metal bromide and at a temperature below 40 DEG C followed by an optional reduction of 3,7-dioxocholanic acid. b
DK90402879.2T 1989-10-17 1990-10-16 Process for the preparation of chenodesoxycholic acid DK0424232T3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR8913569A FR2653126B1 (en) 1989-10-17 1989-10-17 PROCESS FOR THE PREPARATION OF DIACETOXYCHOLANATES.
FR8913570A FR2653127B1 (en) 1989-10-17 1989-10-17 PROCESS FOR THE PREPARATION OF 12-OXOCHOLANATES.
FR8913571A FR2653128B1 (en) 1989-10-17 1989-10-17 PROCESS FOR THE PREPARATION OF CHENODESOXYCHOLIC ACID.
FR8913572A FR2653129B1 (en) 1989-10-17 1989-10-17 PROCESS FOR THE PREPARATION OF 7-OXOCHOLANATES.

Publications (1)

Publication Number Publication Date
DK0424232T3 true DK0424232T3 (en) 1996-06-17

Family

ID=27446720

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90402879.2T DK0424232T3 (en) 1989-10-17 1990-10-16 Process for the preparation of chenodesoxycholic acid

Country Status (7)

Country Link
EP (1) EP0424232B1 (en)
AT (1) ATE134378T1 (en)
DE (1) DE69025449T2 (en)
DK (1) DK0424232T3 (en)
ES (1) ES2086388T3 (en)
GR (1) GR3019857T3 (en)
IE (1) IE73449B1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2105500A1 (en) 2008-03-26 2009-09-30 Pharmazell GmbH New 12alpha-hydroxysteroiddehydrogenases, method for their manufacture and application thereof
CN101215311B (en) * 2008-01-10 2010-10-27 辽宁百隆生物工程有限公司 Method for producing ursodesoxycholic acid from 86% of chenodeoxycholic acid
EP2333101A1 (en) 2009-12-11 2011-06-15 PharmaZell GmbH NAD(P)+-cofactor regeneration system und its use
CN102060902A (en) * 2011-01-21 2011-05-18 郑州大学 Chenodeoxycholic acid synthesis method
ITMI20110534A1 (en) 2011-03-31 2012-10-01 Prodotti Chimici Alimentari "NEW PROCESS FOR SELECTIVE OXIDATION OF BILE ACIDS, THEIR SALTS OR DERIVATIVES"
WO2017207648A1 (en) 2016-05-31 2017-12-07 Bionice, S.L.U Process and intermediates for the preparation of obeticholic acid and derivatives thereof
EP3431486A1 (en) 2017-07-18 2019-01-23 Bionice, S.L.U. Process and intermediates for the synthesis of obeticholic acid and derivatives thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4360470A (en) * 1980-10-22 1982-11-23 Hoffmann-La Roche Inc. Process and intermediates for the synthesis of Vitamin D3 metabolites and chenodeoxycholic acid
IT1137459B (en) * 1981-04-14 1986-09-10 Erregierre Spa PRODUCTION FOR THE PREPARATION OF HIGH PURITY URSODEOXICOLIC ACID
IT1167478B (en) * 1981-07-24 1987-05-13 Carlo Scolastico URSODESOXICOLIC ACID DERIVATIVES
FR2511007A1 (en) * 1981-08-07 1983-02-11 Roussel Uclaf PROCESS FOR THE PREPARATION OF URSODESOXYCHOLIC ACID FROM 3A, 7B, 12A-TRIHYDROXYCHOLANIC ACID AND INTERMEDIATE PRODUCT USED
JPS5842878B2 (en) * 1981-12-02 1983-09-22 名糖産業株式会社 12-oxocholanic acid tosylhydrazone compound, its production method and use
JPS58155098A (en) * 1982-03-09 1983-09-14 Yakult Honsha Co Ltd Preparation of ursodeoxycholic acid by microorganism
IT1204429B (en) * 1986-01-09 1989-03-01 Blaschim Spa STEREOSELECTIVE REDUCTION IN BILIARY ACIDS

Also Published As

Publication number Publication date
DE69025449D1 (en) 1996-03-28
ES2086388T3 (en) 1996-07-01
IE73449B1 (en) 1997-06-04
GR3019857T3 (en) 1996-08-31
IE903701A1 (en) 1991-04-24
EP0424232A2 (en) 1991-04-24
DE69025449T2 (en) 1996-07-11
EP0424232A3 (en) 1992-05-20
ATE134378T1 (en) 1996-03-15
EP0424232B1 (en) 1996-02-21

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