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DE69227624D1 - Methoden und vorrichtungen zu verbesserten electrochemi-lumineszenznachweisen - Google Patents

Methoden und vorrichtungen zu verbesserten electrochemi-lumineszenznachweisen

Info

Publication number
DE69227624D1
DE69227624D1 DE69227624T DE69227624T DE69227624D1 DE 69227624 D1 DE69227624 D1 DE 69227624D1 DE 69227624 T DE69227624 T DE 69227624T DE 69227624 T DE69227624 T DE 69227624T DE 69227624 D1 DE69227624 D1 DE 69227624D1
Authority
DE
Germany
Prior art keywords
electrochemiluminescence
working electrode
analyte
interest
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69227624T
Other languages
English (en)
Other versions
DE69227624T2 (de
Inventor
John Leland
Haresh Shah
John Kenten
Jack Goodman
George Lowke
Gary Blackburn
Richard Massey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioveris Corp
Original Assignee
IGEN Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IGEN Inc filed Critical IGEN Inc
Publication of DE69227624D1 publication Critical patent/DE69227624D1/de
Application granted granted Critical
Publication of DE69227624T2 publication Critical patent/DE69227624T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
    • G01N21/69—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence specially adapted for fluids, e.g. molten metal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/30—Electrochemically active labels

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69227624T 1991-02-06 1992-02-05 Methoden und vorrichtungen zu verbesserten electrochemi-lumineszenznachweisen Expired - Lifetime DE69227624T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US65242791A 1991-02-06 1991-02-06
US82726992A 1992-02-03 1992-02-03
US82727092A 1992-02-03 1992-02-03
PCT/US1992/000992 WO1992014139A1 (en) 1991-02-06 1992-02-05 Methods and apparatus for improved luminescence assays

Publications (2)

Publication Number Publication Date
DE69227624D1 true DE69227624D1 (de) 1998-12-24
DE69227624T2 DE69227624T2 (de) 1999-07-08

Family

ID=27417877

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69233703T Expired - Lifetime DE69233703T2 (de) 1991-02-06 1992-02-05 Verfahren und Vorrichtung für verbesserte Lumineszenztests
DE69227624T Expired - Lifetime DE69227624T2 (de) 1991-02-06 1992-02-05 Methoden und vorrichtungen zu verbesserten electrochemi-lumineszenznachweisen
DE69233675T Expired - Lifetime DE69233675T2 (de) 1991-02-06 1992-02-05 Verfahren und Vorrichtung zur Lumineszenzbestimmungen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69233703T Expired - Lifetime DE69233703T2 (de) 1991-02-06 1992-02-05 Verfahren und Vorrichtung für verbesserte Lumineszenztests

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69233675T Expired - Lifetime DE69233675T2 (de) 1991-02-06 1992-02-05 Verfahren und Vorrichtung zur Lumineszenzbestimmungen

Country Status (17)

Country Link
EP (3) EP0877252B1 (de)
JP (2) JP3061416B2 (de)
KR (1) KR100226231B1 (de)
CN (2) CN1495425A (de)
AT (2) ATE173542T1 (de)
AU (1) AU668085B2 (de)
CA (1) CA2103674C (de)
DE (3) DE69233703T2 (de)
DK (2) DK0877252T3 (de)
ES (3) ES2281119T3 (de)
GR (1) GR3029446T3 (de)
HK (3) HK1017970A1 (de)
IE (1) IE69060B1 (de)
IL (1) IL100867A (de)
NZ (1) NZ241537A (de)
TW (1) TW316291B (de)
WO (1) WO1992014139A1 (de)

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IE920380A1 (en) 1992-08-12
DK0877252T3 (da) 2007-05-07
JP3061416B2 (ja) 2000-07-10
ES2291407T3 (es) 2008-03-01
ES2281119T3 (es) 2007-09-16
GR3029446T3 (en) 1999-05-28
ATE173542T1 (de) 1998-12-15
DE69233703D1 (de) 2007-09-06
HK1017970A1 (en) 1999-12-03
EP0570518A4 (en) 1994-05-18
EP1286164A3 (de) 2003-10-22
ES2126591T3 (es) 1999-04-01
CN1094593C (zh) 2002-11-20
IL100867A0 (en) 1992-11-15
EP1286164A2 (de) 2003-02-26
NZ241537A (en) 1993-06-25
JP3182515B2 (ja) 2001-07-03
HK1015878A1 (en) 1999-10-22
CA2103674C (en) 2002-04-09
DE69233675D1 (de) 2007-02-22
AU668085B2 (en) 1996-04-26
DE69233703T2 (de) 2008-05-29
JPH11148901A (ja) 1999-06-02
JPH06509412A (ja) 1994-10-20
AU1420692A (en) 1992-09-07
HK1066059A1 (en) 2005-03-11
EP0570518A1 (de) 1993-11-24
TW316291B (de) 1997-09-21
CN1495425A (zh) 2004-05-12
DK0570518T3 (da) 1999-08-02
IE69060B1 (en) 1996-08-07
EP0570518B1 (de) 1998-11-18
DE69233675T2 (de) 2007-11-15
WO1992014139A1 (en) 1992-08-20
KR100226231B1 (ko) 1999-10-15
EP0877252B1 (de) 2007-01-10
CN1064945A (zh) 1992-09-30
EP0877252A3 (de) 1999-02-17
EP0877252A2 (de) 1998-11-11
IL100867A (en) 1995-12-08
EP1286164B1 (de) 2007-07-25
ATE368224T1 (de) 2007-08-15
CA2103674A1 (en) 1992-08-07
DE69227624T2 (de) 1999-07-08

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