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DE69029781D1 - Anthracyclinglycosid-Derivate und Verfahren zu ihrer Herstellung - Google Patents

Anthracyclinglycosid-Derivate und Verfahren zu ihrer Herstellung

Info

Publication number
DE69029781D1
DE69029781D1 DE69029781T DE69029781T DE69029781D1 DE 69029781 D1 DE69029781 D1 DE 69029781D1 DE 69029781 T DE69029781 T DE 69029781T DE 69029781 T DE69029781 T DE 69029781T DE 69029781 D1 DE69029781 D1 DE 69029781D1
Authority
DE
Germany
Prior art keywords
preparation
hydrogen atom
glycoside derivatives
anthracycline glycoside
chem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69029781T
Other languages
English (en)
Other versions
DE69029781T2 (de
Inventor
Dae Ok Kwang
Bae Park Jeong
Sung Kim Moon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Dong A Pharmaceutical Co Ltd
Original Assignee
Microbial Chemistry Research Foundation
Dong A Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1019890015375A external-priority patent/KR0157612B1/ko
Priority claimed from KR1019900016213A external-priority patent/KR920008062A/ko
Application filed by Microbial Chemistry Research Foundation, Dong A Pharmaceutical Co Ltd filed Critical Microbial Chemistry Research Foundation
Publication of DE69029781D1 publication Critical patent/DE69029781D1/de
Application granted granted Critical
Publication of DE69029781T2 publication Critical patent/DE69029781T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE69029781T 1989-10-25 1990-10-24 Anthracyclinglycosid-Derivate und Verfahren zu ihrer Herstellung Expired - Fee Related DE69029781T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1019890015375A KR0157612B1 (ko) 1989-10-25 1989-10-25 신규 안트라사이클린 글리코사이드 유도체
KR1019900016213A KR920008062A (ko) 1990-10-13 1990-10-13 신규 안트라사이클린 클리코사이드 유도체 및 그 제조방법

Publications (2)

Publication Number Publication Date
DE69029781D1 true DE69029781D1 (de) 1997-03-06
DE69029781T2 DE69029781T2 (de) 1997-05-15

Family

ID=26628106

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69029781T Expired - Fee Related DE69029781T2 (de) 1989-10-25 1990-10-24 Anthracyclinglycosid-Derivate und Verfahren zu ihrer Herstellung

Country Status (10)

Country Link
US (1) US5220001A (de)
EP (1) EP0424899B1 (de)
JP (1) JP2806621B2 (de)
CN (1) CN1028997C (de)
AT (1) ATE148128T1 (de)
CA (1) CA2028465C (de)
DE (1) DE69029781T2 (de)
DK (1) DK0424899T3 (de)
ES (1) ES2096572T3 (de)
GR (1) GR3022702T3 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866679A (en) * 1994-06-28 1999-02-02 Merck & Co., Inc. Peptides
US6143864A (en) * 1994-06-28 2000-11-07 Merck & Co., Inc. Peptides
NZ291368A (en) * 1994-08-19 1999-04-29 Wallone Region A compound comprising a marker or a therapeutic agent linked to a ligand containing amino acids wherein the marker or agent is cleaved from the ligand to permit entry into the cell of the marker or agent, medicaments for treating tumours; diagnostic devices
CA2184956A1 (en) * 1995-09-08 1997-03-09 Tomio Takeuchi Fluorine-containing anthracycline derivatives having hydroxyl group(s) mono- or di-o-aminoalkanoylated in the sugar moiety thereof
US5998362A (en) * 1996-09-12 1999-12-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6391305B1 (en) 1997-09-10 2002-05-21 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US7425541B2 (en) * 1998-12-11 2008-09-16 Medarex, Inc. Enzyme-cleavable prodrug compounds
GB0012718D0 (en) * 2000-05-24 2000-07-19 Angeletti P Ist Richerche Bio Conjugates of aminodrugs
US7115573B2 (en) * 2000-06-14 2006-10-03 Medarex, Inc. Prodrug compounds with an isoleucine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1533151A (fr) * 1962-05-18 1968-07-19 Rhone Poulenc Sa Nouvel antibiotique et sa préparation
YU33730B (en) * 1967-04-18 1978-02-28 Farmaceutici Italia Process for preparing a novel antibiotic substance and salts thereof
FR2135221A1 (en) * 1971-05-04 1972-12-15 Farmaceutici Italia Doxorubicin 14-esters prepn - by treating 14-bromodaunomycin with a salt of the corresp acid
CA1248944A (en) * 1982-09-28 1989-01-17 Gareth J. Thomas Anthracycline glycosides
US4870058A (en) * 1982-12-20 1989-09-26 Ohio State University Research Foundation 14-Acyloxy-2'-halo-anthracycline anti-cancer antibiotics
JPH0631298B2 (ja) * 1985-12-18 1994-04-27 財団法人微生物化学研究会 新規アンスラサイクリン誘導体，抗腫瘍剤，及び製造法
JPH0742304B2 (ja) * 1986-12-05 1995-05-10 財団法人微生物化学研究会 新規なアンスラサイクリン誘導体およびその製造法
EP0335369A3 (de) * 1988-03-29 1990-03-28 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Anthracyclin-Derivate und Verfahren zu deren Herstellung

Also Published As

Publication number Publication date
CN1052865A (zh) 1991-07-10
EP0424899B1 (de) 1997-01-22
CA2028465C (en) 1999-06-08
DK0424899T3 (da) 1997-03-24
JP2806621B2 (ja) 1998-09-30
EP0424899A3 (en) 1991-09-18
ES2096572T3 (es) 1997-03-16
CA2028465A1 (en) 1991-04-26
GR3022702T3 (en) 1997-05-31
EP0424899A2 (de) 1991-05-02
ATE148128T1 (de) 1997-02-15
US5220001A (en) 1993-06-15
JPH03206095A (ja) 1991-09-09
CN1028997C (zh) 1995-06-21
DE69029781T2 (de) 1997-05-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee