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ES2023760A6 - Procedimiento para la preparacion de derivados benzotiazinicos. - Google Patents

Procedimiento para la preparacion de derivados benzotiazinicos.

Info

Publication number
ES2023760A6
ES2023760A6 ES9002075A ES9002075A ES2023760A6 ES 2023760 A6 ES2023760 A6 ES 2023760A6 ES 9002075 A ES9002075 A ES 9002075A ES 9002075 A ES9002075 A ES 9002075A ES 2023760 A6 ES2023760 A6 ES 2023760A6
Authority
ES
Spain
Prior art keywords
medicines
intermediates
synthesis
preparation
benzothiazine derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES9002075A
Other languages
English (en)
Inventor
Baro Jose Miguel Ribalta
Constansa Jordi Frigola
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Publication of ES2023760A6 publication Critical patent/ES2023760A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPRACION DE DERIVADOS BENZOTIAZINICOS. COMPRENDE LA REACCION DE UN COMPUESTO DE FORMULA GENERAL III CON UN COMPUESTO DE FORMULA GENERAL IV OBTENIENDOSE COMPUESTOS DE FORMULA GENERAL I EN LA CUAL: RBS1 REPRESENTA UN RADICAL ALQUILO INFERIOR (DE UNO A CUATRO ATOMOS DE CARBONO), UN RADICAL FENILO O UN RADICAL BENCILO. LA REACCION SE EFECTUA A TEMPERATURAS COMPRENDIDAS ENTRE -5GC Y DE 30GC, DURNATE UN TIEMPO COMPRENDIDO ENTRE 1 HORA Y 5 HORAS. LOS COMPUESTOS OBTENIDOS SON UTILES COMO MEDICAMENTOS O COMO INTERMEDIOS DE SINTESIS DE MEDICAMENTOS.
ES9002075A 1989-08-04 1990-08-01 Procedimiento para la preparacion de derivados benzotiazinicos. Expired - Lifetime ES2023760A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8910537A FR2650589A1 (fr) 1989-08-04 1989-08-04 Derives benzothiaziniques, leur preparation et leurs applications comme medicaments ou comme intermediaires de synthese de medicaments

Publications (1)

Publication Number Publication Date
ES2023760A6 true ES2023760A6 (es) 1992-02-01

Family

ID=9384485

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9002075A Expired - Lifetime ES2023760A6 (es) 1989-08-04 1990-08-01 Procedimiento para la preparacion de derivados benzotiazinicos.

Country Status (16)

Country Link
US (1) US5132304A (es)
EP (1) EP0412014A1 (es)
JP (1) JP2566843B2 (es)
KR (1) KR950009827B1 (es)
CA (1) CA2022460A1 (es)
CZ (1) CZ277710B6 (es)
DD (1) DD296920A5 (es)
ES (1) ES2023760A6 (es)
FR (1) FR2650589A1 (es)
HU (1) HU210064B (es)
PL (1) PL164340B1 (es)
PT (1) PT94904A (es)
RO (1) RO107657B1 (es)
RU (1) RU2032679C1 (es)
YU (1) YU47562B (es)
ZA (1) ZA905995B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2053395A1 (es) * 1992-11-16 1994-07-16 S A L V A T Lab Sa "4-cinnamoiloxi-2-metil-n-(2-piridil)-2h-1,2-benzotiazina-3-carboxamida 1,1-dioxido, procedimiento para la obtencion del mismo y nuevos intermedios utilizados en su preparacion.

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703073A (en) * 1995-04-19 1997-12-30 Nitromed, Inc. Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
AU763000B2 (en) * 1998-10-30 2003-07-10 Nicox S.A. Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3925371A (en) * 1974-09-23 1975-12-09 Mcneilab Inc Benzothiazine-1,1-dioxides
US3923801A (en) * 1974-09-23 1975-12-02 Mcneilab Inc Oxazinobenzothiazine 6,6-dioxides
US3900470A (en) * 1974-09-23 1975-08-19 Mcneilab Inc Esters of benzothiazine-1,1-dioxides derivatives
US4623486A (en) * 1985-05-29 1986-11-18 Pfizer Inc. [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity
FR2597103B1 (fr) * 1986-04-15 1988-12-16 Provesan Sa Procede de preparation de derives d'oxazinobenzothiazine 6,6-dioxyde

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2053395A1 (es) * 1992-11-16 1994-07-16 S A L V A T Lab Sa "4-cinnamoiloxi-2-metil-n-(2-piridil)-2h-1,2-benzotiazina-3-carboxamida 1,1-dioxido, procedimiento para la obtencion del mismo y nuevos intermedios utilizados en su preparacion.

Also Published As

Publication number Publication date
PL286340A1 (en) 1992-01-13
JPH0366687A (ja) 1991-03-22
RU2032679C1 (ru) 1995-04-10
CA2022460A1 (fr) 1991-02-05
CZ277710B6 (en) 1993-03-17
FR2650589A1 (fr) 1991-02-08
RO107657B1 (ro) 1993-12-30
CS384690A3 (en) 1992-08-12
JP2566843B2 (ja) 1996-12-25
YU47562B (sh) 1995-10-03
HU210064B (en) 1995-01-30
HU904885D0 (en) 1991-01-28
FR2650589B1 (es) 1994-04-22
DD296920A5 (de) 1991-12-19
YU150690A (sh) 1992-09-07
EP0412014A1 (fr) 1991-02-06
US5132304A (en) 1992-07-21
KR910004614A (ko) 1991-03-29
PT94904A (pt) 1991-04-18
PL164340B1 (pl) 1994-07-29
KR950009827B1 (ko) 1995-08-29
ZA905995B (en) 1991-07-31
HUT58733A (en) 1992-03-30

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