DE69940753D1 - Verfahren zur Einführung von heterologischen Zellen in Fische - Google Patents
Verfahren zur Einführung von heterologischen Zellen in FischeInfo
- Publication number
- DE69940753D1 DE69940753D1 DE69940753T DE69940753T DE69940753D1 DE 69940753 D1 DE69940753 D1 DE 69940753D1 DE 69940753 T DE69940753 T DE 69940753T DE 69940753 T DE69940753 T DE 69940753T DE 69940753 D1 DE69940753 D1 DE 69940753D1
- Authority
- DE
- Germany
- Prior art keywords
- cells
- fish
- methods
- useful
- heterologous cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 5
- 241000251468 Actinopterygii Species 0.000 title abstract 3
- 238000004458 analytical method Methods 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0058—Antibodies
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
- A61K49/0043—Fluorescein, used in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/40—Fish
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/4603—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates from fish
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Food Science & Technology (AREA)
- Environmental Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- General Engineering & Computer Science (AREA)
- Rheumatology (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11046498P | 1998-12-01 | 1998-12-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69940753D1 true DE69940753D1 (de) | 2009-05-28 |
Family
ID=22333153
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69940753T Expired - Lifetime DE69940753D1 (de) | 1998-12-01 | 1999-11-30 | Verfahren zur Einführung von heterologischen Zellen in Fische |
| DE69935999T Expired - Lifetime DE69935999T2 (de) | 1998-12-01 | 1999-11-30 | Methoden zur introduktion heterologer zellen in fische |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69935999T Expired - Lifetime DE69935999T2 (de) | 1998-12-01 | 1999-11-30 | Methoden zur introduktion heterologer zellen in fische |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US6761876B2 (de) |
| EP (1) | EP1135531B1 (de) |
| JP (1) | JP4522587B2 (de) |
| AT (2) | ATE428928T1 (de) |
| AU (1) | AU776246B2 (de) |
| CA (1) | CA2352568A1 (de) |
| DE (2) | DE69940753D1 (de) |
| ES (2) | ES2286908T3 (de) |
| WO (1) | WO2000032822A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69940753D1 (de) | 1998-12-01 | 2009-05-28 | Phylonix Pharmaceuticals Inc | Verfahren zur Einführung von heterologischen Zellen in Fische |
| CA2494310A1 (en) * | 2002-08-01 | 2004-02-12 | Immunomedics, Inc. | Alpha-fetoprotein immu31 antibodies and fusion proteins and methods of use thereof |
| GB0228093D0 (en) * | 2002-12-02 | 2003-01-08 | Daniolabs Ltd | Disease models and uses thereof |
| US20070044168A1 (en) * | 2005-07-12 | 2007-02-22 | Northwestern University | Transplantable tumor model |
| JP5893563B2 (ja) | 2009-10-07 | 2016-03-23 | ケレシス・イーエイチエフＫｅｒｅｃｉｓ Ｅｈｆ | 創傷ケア及び／又は他の組織治癒適用のための骨格材料 |
| JP5875010B2 (ja) * | 2012-10-24 | 2016-03-02 | 国立大学法人三重大学 | 異種細胞移植モデル動物の作製方法 |
| CN105121657A (zh) * | 2012-12-02 | 2015-12-02 | 生物医学核心有限公司 | 有关癌症发展及对治疗的反应的快速预测 |
| KR101508356B1 (ko) | 2013-05-06 | 2015-04-06 | 광주과학기술원 | 제브라피시 인간 종양 이종이식 모델을 이용한 항암제 스크리닝 방법 |
| US10543287B2 (en) | 2013-07-10 | 2020-01-28 | The General Hospital Corporation | Immune-compromised zebrafish |
| EA038321B1 (ru) | 2014-11-06 | 2021-08-09 | Е.И. Дюпон Де Немур Энд Компани | Опосредуемая пептидом доставка направляемой рнк эндонуклеазы в клетки |
| US11179480B2 (en) | 2014-12-22 | 2021-11-23 | Dana-Farber Cancer Institute, Inc. | In vivo methods for identifying cancer-associated immunotherapy targets |
| JP6622007B2 (ja) * | 2015-05-29 | 2019-12-18 | オリンパス株式会社 | 細胞評価方法 |
| KR102686073B1 (ko) | 2015-10-14 | 2024-07-17 | 엑스-써마 인코포레이티드 | 얼음 결정 형성을 감소시키기 위한 조성물 및 방법 |
| EP3387134B1 (de) | 2015-12-11 | 2020-10-14 | Danisco US Inc. | Verfahren und zusammensetzungen für verbesserte nukleasevermittelte genommodifizierung und verringerte off-target-nebenwirkungen |
| EP3708665A1 (de) | 2015-12-18 | 2020-09-16 | Danisco US Inc. | Verfahren und zusammensetzungen zur t-rna-basierten guide-rna-expression |
| CN108967358A (zh) * | 2018-05-31 | 2018-12-11 | 上海交通大学医学院附属瑞金医院 | 一种斑马鱼fl肿瘤模型的构建方法及其应用 |
| CN112452362B (zh) * | 2020-09-25 | 2021-09-21 | 中山大学 | 一种无泵固定斑马鱼微流体芯片系统及其制备方法与应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5399992A (en) | 1977-02-10 | 1978-08-31 | Hitachi Ltd | Water quality fluctuation detector |
| ZA793568B (en) | 1978-07-26 | 1981-02-25 | Duphar Int Res | Algicidal composition |
| GB2080948B (en) | 1980-08-04 | 1983-09-21 | Euratom | Apparatus and method for measuring the toxicity of pollutants to aquatic living organisms |
| US4816392A (en) | 1984-10-02 | 1989-03-28 | Research Corporation Of The University Of Hawaii | Rapid stick test for detection of ciguatoxin and other polyether toxins from tissues |
| US5510099A (en) | 1987-05-01 | 1996-04-23 | Stratagene | Mutagenesis testing using transgenic non-human animals carrying test DNA sequences |
| DE3801476A1 (de) | 1988-01-20 | 1989-08-03 | Henkel Kgaa | Zusammensetzungen zur befreiung festgesetzter bohrgestaenge |
| US5190920A (en) | 1990-09-24 | 1993-03-02 | W. R. Grace & Co.-Conn. | Method for using synthetic analogs of thrombospondin for inhibiting metastasis activity |
| US5326692B1 (en) | 1992-05-13 | 1996-04-30 | Molecular Probes Inc | Fluorescent microparticles with controllable enhanced stokes shift |
| US5658751A (en) | 1993-04-13 | 1997-08-19 | Molecular Probes, Inc. | Substituted unsymmetrical cyanine dyes with selected permeability |
| EP0703990A4 (de) | 1993-04-30 | 1997-09-24 | Lxr Biotechnology Inc | Verfahren zur erkennung potentiell therapeutisch wirksamer mittel und dafur verwendbare zellinien |
| US5565187A (en) | 1993-06-01 | 1996-10-15 | Zikria; Bashir | Methods for studying capillary circulation using fish fry and tadpoles |
| US5491084A (en) | 1993-09-10 | 1996-02-13 | The Trustees Of Columbia University In The City Of New York | Uses of green-fluorescent protein |
| DE4401868C1 (de) | 1994-01-22 | 1995-02-16 | Lobbe Xenex Gmbh | Mikrobielles Verfahren zum Nachweis von Schadstoffen |
| WO1996003034A1 (en) | 1994-07-27 | 1996-02-08 | Massachusetts Institute Of Technology | Method for retroviral vector insertion in fish |
| FR2728790B1 (fr) | 1994-12-29 | 1997-01-24 | Cird Galderma | Composition modulant l'apoptose comprenant du methonial ou tout facteur influencant le taux intracellulaire de methonial |
| EP0854923A2 (de) * | 1995-08-09 | 1998-07-29 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Isolierte nukleinsäuremolekulen an zu wenden als leukemiamarker und in brustkrebs prognosis |
| US5932418A (en) * | 1996-04-08 | 1999-08-03 | Naiad Systems, Inc. | Fish embryo screening test for genotoxic agents using three different developmental life stages |
| GB9615202D0 (en) | 1996-07-19 | 1996-09-04 | Smithkline Beecham Plc | Pharmaceuticals |
| GB9701245D0 (en) | 1997-01-22 | 1997-03-12 | Eisai Co Ltd | Method of screening compounds |
| DE19726597C1 (de) | 1997-06-23 | 1998-11-19 | Wengler Georg S | Verfahren zur Herstellung von monoklonalen Antikörper |
| EP1826560B1 (de) | 1998-12-01 | 2009-04-15 | Phylonix Pharmaceuticals Inc. | Verfahren zur Einführung von heterologischen Zellen in Fische |
| DE69940753D1 (de) | 1998-12-01 | 2009-05-28 | Phylonix Pharmaceuticals Inc | Verfahren zur Einführung von heterologischen Zellen in Fische |
-
1999
- 1999-11-30 DE DE69940753T patent/DE69940753D1/de not_active Expired - Lifetime
- 1999-11-30 ES ES99965950T patent/ES2286908T3/es not_active Expired - Lifetime
- 1999-11-30 AU AU21612/00A patent/AU776246B2/en not_active Ceased
- 1999-11-30 WO PCT/US1999/028416 patent/WO2000032822A1/en active IP Right Grant
- 1999-11-30 AT AT07008609T patent/ATE428928T1/de not_active IP Right Cessation
- 1999-11-30 CA CA002352568A patent/CA2352568A1/en not_active Abandoned
- 1999-11-30 US US09/451,489 patent/US6761876B2/en not_active Expired - Lifetime
- 1999-11-30 AT AT99965950T patent/ATE361469T1/de not_active IP Right Cessation
- 1999-11-30 JP JP2000585453A patent/JP4522587B2/ja not_active Expired - Fee Related
- 1999-11-30 EP EP99965950A patent/EP1135531B1/de not_active Expired - Lifetime
- 1999-11-30 ES ES07008609T patent/ES2325285T3/es not_active Expired - Lifetime
- 1999-11-30 DE DE69935999T patent/DE69935999T2/de not_active Expired - Lifetime
-
2004
- 2004-01-27 US US10/766,134 patent/US7408095B2/en not_active Expired - Fee Related
-
2006
- 2006-12-21 US US11/614,853 patent/US7838726B2/en not_active Expired - Fee Related
-
2010
- 2010-11-22 US US12/951,767 patent/US20110286973A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2161200A (en) | 2000-06-19 |
| DE69935999T2 (de) | 2008-01-10 |
| EP1135531A1 (de) | 2001-09-26 |
| US20020061291A1 (en) | 2002-05-23 |
| ATE428928T1 (de) | 2009-05-15 |
| CA2352568A1 (en) | 2000-06-08 |
| ES2325285T3 (es) | 2009-08-31 |
| ATE361469T1 (de) | 2007-05-15 |
| US7408095B2 (en) | 2008-08-05 |
| ES2286908T3 (es) | 2007-12-01 |
| WO2000032822A1 (en) | 2000-06-08 |
| AU776246B2 (en) | 2004-09-02 |
| DE69935999D1 (de) | 2007-06-14 |
| JP2002531104A (ja) | 2002-09-24 |
| US20040185431A1 (en) | 2004-09-23 |
| US20110286973A1 (en) | 2011-11-24 |
| US7838726B2 (en) | 2010-11-23 |
| EP1135531B1 (de) | 2007-05-02 |
| US6761876B2 (en) | 2004-07-13 |
| US20070130632A1 (en) | 2007-06-07 |
| EP1135531A4 (de) | 2005-03-09 |
| JP4522587B2 (ja) | 2010-08-11 |
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| 8364 | No opposition during term of opposition | ||
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