DE69731835D1 - Verfahren zur herstellung von zwischenprodukten des florfenicols - Google Patents

Verfahren zur herstellung von zwischenprodukten des florfenicols

Info

Publication number: DE69731835D1
Authority: DE; Germany
Prior art keywords: florfenicols; intermediate products; producing intermediate; producing; products
Prior art date: 1996-08-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69731835T

Other languages

English (en)

Other versions

DE69731835T3 (de

DE69731835T2 (de

Inventor

C Towson

B Vashi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Sharp and Dohme LLC

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-19

Filing date

1997-08-18

Publication date

2005-01-05

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24808601&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69731835(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-08-18 Application filed by Schering Corp filed Critical Schering Corp

2005-01-05 Publication of DE69731835D1 publication Critical patent/DE69731835D1/de

2005-07-21 Application granted granted Critical

2005-07-21 Publication of DE69731835T2 publication Critical patent/DE69731835T2/de

2013-12-05 Publication of DE69731835T3 publication Critical patent/DE69731835T3/de

2017-08-19 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/28—Nitrogen atoms not forming part of a nitro radical

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DE69731835T 1996-08-19 1997-08-18 Verfahren zur herstellung von zwischenprodukten des florfenicols Expired - Lifetime DE69731835T3 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US699271		1996-08-19
US08/699,271 US5663361A (en)	1996-08-19	1996-08-19	Process for preparing intermediates to florfenicol
PCT/US1997/014205 WO1998007709A1 (en)	1996-08-19	1997-08-18	Process for preparing intermediates to florfenicol
EP97938263.7A EP0922040B2 (de)	1996-08-19	1997-08-18	Verfahren zur herstellung von zwischenprodukten des florfenicols

Publications (3)

Publication Number	Publication Date
DE69731835D1 true DE69731835D1 (de)	2005-01-05
DE69731835T2 DE69731835T2 (de)	2005-07-21
DE69731835T3 DE69731835T3 (de)	2013-12-05

Family

ID=24808601

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69731835T Expired - Lifetime DE69731835T3 (de)	1996-08-19	1997-08-18	Verfahren zur herstellung von zwischenprodukten des florfenicols

Country Status (31)

Country	Link
US (1)	US5663361A (de)
EP (1)	EP0922040B2 (de)
JP (1)	JP3274868B2 (de)
KR (1)	KR100286851B1 (de)
CN (1)	CN1097583C (de)
AR (1)	AR008298A1 (de)
AT (1)	ATE283847T1 (de)
AU (1)	AU714495B2 (de)
BR (1)	BR9711318B1 (de)
CA (1)	CA2264116C (de)
CO (1)	CO4560550A1 (de)
CZ (1)	CZ297915B6 (de)
DE (1)	DE69731835T3 (de)
DK (1)	DK0922040T3 (de)
ES (1)	ES2234026T5 (de)
HK (1)	HK1017890A1 (de)
HU (1)	HU229610B1 (de)
ID (1)	ID18047A (de)
IL (1)	IL128574A (de)
MY (1)	MY115679A (de)
NO (1)	NO312962B1 (de)
NZ (1)	NZ334111A (de)
PE (1)	PE99798A1 (de)
PL (2)	PL196454B1 (de)
PT (1)	PT922040E (de)
SI (1)	SI0922040T1 (de)
SK (1)	SK286124B6 (de)
TR (2)	TR200800474T2 (de)
TW (1)	TW381075B (de)
WO (1)	WO1998007709A1 (de)
ZA (1)	ZA977406B (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
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CN1173933C (zh) *	2001-06-01	2004-11-03	中国科学院上海有机化学研究所	一种从l型取代苯丝氨酸酯制备d－（－）－苏式1－r－取代苯基－2－二氯乙酰氨基－3－氟－1－丙醇的方法
KR20040091698A (ko) *	2002-03-08	2004-10-28	쉐링-플라우 리미티드.	신규한 플로르페니콜형 항생제
MY146351A (en) *	2003-05-29	2012-08-15	Schering Plough Ltd	Compositions for treating infection in cattle and swine
US7439268B2 (en)	2003-07-18	2008-10-21	Idexx Laboratories	Compositions containing prodrugs of florfenicol and methods of use
US20050049210A1 (en) *	2003-08-27	2005-03-03	Idexx Laboratories, Inc.	Methods for the controlled delivery of pharmacologically active compounds
US7126005B2 (en) *	2003-10-06	2006-10-24	Aurobindo Pharma Limited	Process for preparing florfenicol
CA2576589C (en)	2004-08-13	2013-11-12	Schering-Plough Ltd.	Pharmaceutical formulation comprising an antibiotic, a triazole and a corticosteroid
KR20070054691A (ko)	2004-09-23	2007-05-29	쉐링-프라우 리미티드	신규한 트리플루오로메탄설폰아미드 옥심 에테르 유도체를사용하여 동물의 기생충 방제
DE602005017419D1 (de) *	2004-11-19	2009-12-10	Schering Plough Ltd	Kontrolle von parasiten bei tieren mittels verwendung von parasitiziden 2-phenyl-3-(1h-pyrrol-2-yl) acrylonitril-derivaten
US8680154B2 (en) *	2004-12-21	2014-03-25	Intervet International B.V.	Injectable veterinary composition
JP2008545788A (ja) *	2005-06-09	2008-12-18	シェーリング−プラウ・リミテッド	Ｎ−［（フェニルオキシ）フェニル］−１，１，１−トリフルオロメタンスルホンアミドおよびｎ−［（フェニルスルファニル）フェニル）］−１，１，１−トリフルオロメタンスルホンアミド誘導体による動物中の寄生生物の制御
MX2008003188A (es) *	2005-09-07	2008-03-18	Schering Plough Ltd	Procedimiento para la preparacion de compuestos ester oxazolidina y su conversion a florfenicol.
US8119667B2 (en) *	2005-12-29	2012-02-21	Schering-Plough Animal Health Corporation	Carbonates of fenicol antibiotics
US7518017B2 (en)	2006-02-17	2009-04-14	Idexx Laboratories	Fenicol compounds and methods synthesizing 2-trifluoroacetamido-3-substituted propiophenone compounds
US20070238700A1 (en) *	2006-04-10	2007-10-11	Winzenberg Kevin N	N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
EP2091909A1 (de) *	2006-12-13	2009-08-26	Schering-Plough Ltd.	Wasserlösliche florfenicol-prodrugs und analoga
EP2102154A1 (de) *	2006-12-13	2009-09-23	Schering-Plough Ltd.	Wasserlösliche chloramphenicol- und thiamphenicol-prodrugs sowie analoga davon
AR066265A1 (es) *	2007-04-27	2009-08-05	Schering Plough Ltd	Compuestos y metodos para mejorar la solubilidad de florfenicol y antibioticos estructuralmente relacionados por medio del uso de ciclodextrinas. composicion. complejo. kit. metodo de tratamiento.
WO2008150406A1 (en) *	2007-05-30	2008-12-11	Schering-Plough Ltd.	A process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol
TWI430995B (zh)	2007-06-26	2014-03-21	Du Pont	萘異唑啉無脊椎有害動物控制劑
MX361762B (es)	2007-06-27	2018-12-17	Du Pont	Metodo de control de plagas en animales.
RU2010106607A (ru) *	2007-07-25	2011-08-27	Интервет Интернэшнл Б.В. (Nl)	Способ получения оксазолидин- и оксазолидинонаминодиолов
US7550625B2 (en) *	2007-10-19	2009-06-23	Idexx Laboratories	Esters of florfenicol
AU2008324852A1 (en) *	2007-11-09	2009-05-14	Intervet International B.V.	Fast release solid formulation, preparation and use thereof
TWI468407B (zh)	2008-02-06	2015-01-11	Du Pont	中離子農藥
JP2011529895A (ja) *	2008-07-30	2011-12-15	インターベツト・インターナシヨナル・ベー・ベー	フロルフェニコール中間体として有用なオキサゾリン保護アミノジオール化合物を調製する方法
WO2011017347A2 (en)	2009-08-05	2011-02-10	E. I. Du Pont De Nemours And Company	Mesoionic pesticides
UA107804C2 (en)	2009-08-05	2015-02-25	Du Pont	Mixtures of pesticides mezoionnyh
JP2013501059A (ja)	2009-08-05	2013-01-10	イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー	メソイオン性殺虫剤
UA110924C2 (uk)	2009-08-05	2016-03-10	Е. І. Дю Пон Де Немур Енд Компані	Мезоіонні пестициди
BRPI1002023A2 (pt)	2010-03-01	2011-10-25	Nanocore Biotecnologia S A	forma farmacêutica sólida de dissolução rápida para tratamento de infecções bacterianas
US8598087B2 (en)	2010-05-27	2013-12-03	E. I. Du Pont De Nemours And Company	Crystalline form of 4-[5-[3-chloro-5-(trifluoromethyl)phenyl]-4, 5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-0X0-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1- naph-thalenecarboxamide
WO2012087630A1 (en)	2010-12-20	2012-06-28	E.I. Du Pont De Nemours And Company	Pyridine and pyrimidine compounds for controlling invertebrate
WO2013158422A1 (en)	2012-04-17	2013-10-24	E. I. Du Pont De Nemours And Company	Heterocyclic compounds for controlling invertebrate pests
CN102911133B (zh) *	2012-10-31	2014-07-02	绍兴民生医药有限公司	(4r,5r)-2-二氯甲基-4,5-二氢-5-(4-甲砜基苯基)-4-恶唑甲醇的纯化方法
CN103254147B (zh) *	2013-04-19	2016-04-06	浙江科技学院	一种d-苏式-2-(二氯甲基)-4,5-二氢-5-[对-（甲砜基）苯基]-4-噁唑甲醇的制备方法
CN106278964B (zh) *	2016-07-31	2018-01-16	浙江润康药业有限公司	氟苯尼考的制备方法
CN106631872A (zh) *	2016-12-13	2017-05-10	浙江普洛家园药业有限公司	一种氟苯尼考类似物中间体的合成方法
CN110272856B (zh) *	2019-05-08	2022-05-03	江南大学	一种表达d-苏氨酸醛缩酶的重组菌及其构建方法与应用
CN117466787B (zh) *	2023-12-28	2024-03-22	山东国邦药业有限公司	一种氟苯尼考中间体的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2759001A (en) *	1952-03-01	1956-08-14	Parke Davis & Co	Process for the production of delta2-oxazolines
US4361557A (en) *	1980-01-28	1982-11-30	Schering Corporation	1-Aryl-2-acylamido-3-fluoro-1-propanol acylates, methods for their use as anti-bacterial agents and compositions useful therefor
EP0677511A3 (de) *	1983-06-02	1996-07-24	Zambon Spa	Zwischenprodukte zur Herstellung von 1-Phenyl-1-hydroxy-2-amino-3-fluorpropan-Derivaten.
US4876352A (en) *	1988-09-14	1989-10-24	Schering Corporation	Pressurized fluorination of hydroxy alkyl groups
EP0405104A1 (de) †	1989-05-15	1991-01-02	Schering Corporation	Verfahren zur Herstellung antibakterieller Verbindungen und Intermediate hierzu
NZ250394A (en) *	1990-10-25	1994-10-26	Schering Corp	Fluorinated and hydroxylated oxazoline compounds

1996
- 1996-08-19 US US08/699,271 patent/US5663361A/en not_active Expired - Lifetime
1997
- 1997-08-15 AR ARP970103736A patent/AR008298A1/es not_active Application Discontinuation
- 1997-08-15 CO CO97047276A patent/CO4560550A1/es unknown
- 1997-08-18 EP EP97938263.7A patent/EP0922040B2/de not_active Expired - Lifetime
- 1997-08-18 CZ CZ0054099A patent/CZ297915B6/cs not_active IP Right Cessation
- 1997-08-18 PE PE1997000728A patent/PE99798A1/es not_active Application Discontinuation
- 1997-08-18 IL IL12857497A patent/IL128574A/en not_active IP Right Cessation
- 1997-08-18 PT PT97938263T patent/PT922040E/pt unknown
- 1997-08-18 JP JP51080598A patent/JP3274868B2/ja not_active Expired - Lifetime
- 1997-08-18 MY MYPI97003778A patent/MY115679A/en unknown
- 1997-08-18 PL PL331644A patent/PL196454B1/pl not_active IP Right Cessation
- 1997-08-18 WO PCT/US1997/014205 patent/WO1998007709A1/en active Application Filing
- 1997-08-18 DK DK97938263T patent/DK0922040T3/da active
- 1997-08-18 SK SK199-99A patent/SK286124B6/sk not_active IP Right Cessation
- 1997-08-18 PL PL378741A patent/PL198553B1/pl not_active IP Right Cessation
- 1997-08-18 CN CN97198768A patent/CN1097583C/zh not_active Expired - Lifetime
- 1997-08-18 ID IDP972887A patent/ID18047A/id unknown
- 1997-08-18 NZ NZ334111A patent/NZ334111A/en not_active IP Right Cessation
- 1997-08-18 BR BRPI9711318-2A patent/BR9711318B1/pt not_active IP Right Cessation
- 1997-08-18 TR TR2008/00474T patent/TR200800474T2/xx unknown
- 1997-08-18 ES ES97938263T patent/ES2234026T5/es not_active Expired - Lifetime
- 1997-08-18 HU HU9904166A patent/HU229610B1/hu unknown
- 1997-08-18 ZA ZA9707406A patent/ZA977406B/xx unknown
- 1997-08-18 AU AU40638/97A patent/AU714495B2/en not_active Expired
- 1997-08-18 DE DE69731835T patent/DE69731835T3/de not_active Expired - Lifetime
- 1997-08-18 CA CA002264116A patent/CA2264116C/en not_active Expired - Lifetime
- 1997-08-18 AT AT97938263T patent/ATE283847T1/de active
- 1997-08-18 TR TR1999/00354T patent/TR199900354T2/xx unknown
- 1997-08-18 SI SI9730688T patent/SI0922040T1/xx unknown
- 1997-08-19 TW TW086111823A patent/TW381075B/zh not_active IP Right Cessation
1999
- 1999-02-18 NO NO19990756A patent/NO312962B1/no not_active IP Right Cessation
- 1999-02-18 KR KR1019997001290A patent/KR100286851B1/ko not_active IP Right Cessation
- 1999-07-10 HK HK99102946A patent/HK1017890A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP3274868B2 (ja)	2002-04-15
KR20000068178A (ko)	2000-11-25
EP0922040A1 (de)	1999-06-16
CA2264116C (en)	2002-07-02
CZ54099A3 (cs)	1999-07-14
HUP9904166A3 (en)	2001-11-28
ZA977406B (en)	1998-02-18
DE69731835T3 (de)	2013-12-05
SK19999A3 (en)	2000-02-14
KR100286851B1 (ko)	2001-04-16
WO1998007709A1 (en)	1998-02-26
NZ334111A (en)	1999-10-28
NO990756D0 (no)	1999-02-18
PL196454B1 (pl)	2008-01-31
US5663361A (en)	1997-09-02
HUP9904166A2 (hu)	2000-05-28
HK1017890A1 (en)	1999-12-03
DK0922040T3 (da)	2005-04-04
EP0922040B2 (de)	2013-07-17
ES2234026T5 (es)	2013-11-12
BR9711318A (pt)	1999-08-17
CZ297915B6 (cs)	2007-04-25
BR9711318B1 (pt)	2009-01-13
TR199900354T2 (xx)	1999-05-21
CN1233244A (zh)	1999-10-27
PE99798A1 (es)	1998-12-28
IL128574A (en)	2002-04-21
SI0922040T1 (en)	2005-02-28
AR008298A1 (es)	1999-12-29
SK286124B6 (sk)	2008-04-07
JP2000501424A (ja)	2000-02-08
IL128574A0 (en)	2000-01-31
EP0922040B1 (de)	2004-12-01
TW381075B (en)	2000-02-01
CN1097583C (zh)	2003-01-01
PT922040E (pt)	2005-02-28
MY115679A (en)	2003-08-30
NO990756L (no)	1999-02-18
CO4560550A1 (es)	1998-02-10
ID18047A (id)	1998-02-19
DE69731835T2 (de)	2005-07-21
AU714495B2 (en)	2000-01-06
NO312962B1 (no)	2002-07-22
PL198553B1 (pl)	2008-06-30
HU229610B1 (en)	2014-03-28
TR200800474T2 (tr)	2008-04-21
ATE283847T1 (de)	2004-12-15
AU4063897A (en)	1998-03-06
PL331644A1 (en)	1999-08-02
ES2234026T3 (es)	2005-06-16
CA2264116A1 (en)	1998-02-26

Publication	Publication Date	Title
DE69731835D1 (de)	2005-01-05	Verfahren zur herstellung von zwischenprodukten des florfenicols
DE69704964D1 (de)	2001-07-05	Verfahren zur Herstellung von Acryloxypropylsilane
DE69628712D1 (de)	2003-07-24	Verfahren zur Herstellung von Dihalogenazolopyrimidinen
DE69713022D1 (de)	2002-07-11	Verfahren zur Herstellung von Unterkleidung
DE69503400D1 (de)	1998-08-20	Verfahren zur Herstellung falznahtloser Dosen
DE69621491D1 (de)	2002-07-11	Verfahren zur Herstellung von Epsilon-Caprolactam
DE59707913D1 (de)	2002-09-12	Kontinuierliches Verfahren zur Herstellung von gamma- Aminopropyltrialkoxysilanen
DE59607656D1 (de)	2001-10-18	Verfahren zur Herstellung von Alkylhydrogenchlorsilanen
DE69703923D1 (de)	2001-02-22	Verfahren zur Herstellung von Polyester
DE69510596D1 (de)	1999-08-12	Verfahren zur Herstellung von Organooxysilane
DE59501143D1 (de)	1998-02-05	Verfahren zur Herstellung von Magnesium-hydrid
DE59608641D1 (de)	2002-03-14	Verfahren zur Herstellung von Nikotinsäureamid
DE59500545D1 (de)	1997-10-02	Verfahren zur adiabatischen Herstellung von Mononitrotoluolen
DE69735433D1 (de)	2006-05-04	Verfahren zur herstellung von substituierten pyridinen
DE69700509D1 (de)	1999-10-21	Verfahren zur Herstellung von Allylsilanen
DE69605709D1 (de)	2000-01-27	Verfahren zur kontinuierliche Herstellung von Dimethylkarbonat
DE59708227D1 (de)	2002-10-24	Verfahren zur Herstellung von feinstteiligen Kristallisationsprodukten
DE59506135D1 (de)	1999-07-15	Verfahren zur adiabatischen Herstellung von Mononitrohalogenbenzolen
DE69611331D1 (de)	2001-02-01	Verfahren zur Herstellung von S-Phenyl-L-Cystein
DE69600385D1 (de)	1998-08-06	Verfahren zur Herstellung von Aminonitropyridinen
DE69530176T2 (de)	2004-01-29	Verfahren zur Herstellung von Protein
DE69603243D1 (de)	1999-08-19	Verfahren zur Herstellung von Ethenylamiden
DE69513008D1 (de)	1999-12-02	Verfahren zur Herstellung von Hydroxyalkoxybenzophenonen
DE69607541D1 (de)	2000-05-11	Verfahren zur Herstellung von p-Bromfluorobenzol
DE59605105D1 (de)	2000-06-08	Verfahren zur Herstellung von substituierten Aminocarbonyltriazolinonen

Legal Events

Date	Code	Title	Description
2005-12-01	8363	Opposition against the patent