DE69526452D1 - Indolditerpen alkaloide - Google Patents
Indolditerpen alkaloideInfo
- Publication number
- DE69526452D1 DE69526452D1 DE69526452T DE69526452T DE69526452D1 DE 69526452 D1 DE69526452 D1 DE 69526452D1 DE 69526452 T DE69526452 T DE 69526452T DE 69526452 T DE69526452 T DE 69526452T DE 69526452 D1 DE69526452 D1 DE 69526452D1
- Authority
- DE
- Germany
- Prior art keywords
- indolditerpen
- alkaloids
- useful
- formula
- channel antagonists
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/186,197 US5541208A (en) | 1994-01-24 | 1994-01-24 | Indole diterpene alkaloid compounds |
PCT/US1995/000861 WO1995019771A1 (en) | 1994-01-24 | 1995-01-20 | Indole diterpene alkaloid compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69526452D1 true DE69526452D1 (de) | 2002-05-23 |
DE69526452T2 DE69526452T2 (de) | 2002-11-14 |
Family
ID=22684018
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69526452T Expired - Fee Related DE69526452T2 (de) | 1994-01-24 | 1995-01-20 | Indolditerpen alkaloide |
Country Status (11)
Country | Link |
---|---|
US (1) | US5541208A (de) |
EP (1) | EP0804186B1 (de) |
JP (1) | JP3689108B2 (de) |
AT (1) | ATE216233T1 (de) |
AU (1) | AU689207B2 (de) |
CA (1) | CA2181371A1 (de) |
DE (1) | DE69526452T2 (de) |
DK (1) | DK0804186T3 (de) |
ES (1) | ES2173177T3 (de) |
PT (1) | PT804186E (de) |
WO (1) | WO1995019771A1 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0912086B1 (de) * | 1995-08-08 | 2006-10-25 | University Of Alabama, Birmingham Research Foundation | Verfahren zum auffinden von arzneimitteln zur behandlung von alzheimer-krankheit |
US6160000A (en) * | 1996-12-23 | 2000-12-12 | Merck & Co., Inc. | Antidiabetic agents based on aryl and heteroarylacetic acids |
US6090839A (en) * | 1996-12-23 | 2000-07-18 | Merck & Co., Inc. | Antidiabetic agents |
ATE319440T1 (de) * | 1996-12-23 | 2006-03-15 | Merck & Co Inc | Antidiabetische mittel |
WO2003077845A2 (en) * | 2002-03-15 | 2003-09-25 | Merck & Co., Inc. | Compositions and methods for treating glaucoma and ocular hypertension |
JP2005533055A (ja) * | 2002-06-17 | 2005-11-04 | メルク エンド カムパニー インコーポレーテッド | 新規マキシkチャンネルブロッカー、その使用方法および製造方法 |
CN110872338B (zh) * | 2018-09-04 | 2021-04-09 | 中国海洋大学 | 一种吲哚二萜类化合物及其制备方法和用途 |
CN110105422B (zh) * | 2019-06-12 | 2020-03-27 | 扬州工业职业技术学院 | 一种钩藤吲哚二萜生物碱及其制备方法与应用 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4374132A (en) * | 1979-12-10 | 1983-02-15 | Sterling Drug Inc. | Plasma uric acid lowering method |
US4560558A (en) * | 1983-05-16 | 1985-12-24 | Abbott Laboratories | 3-Alkyl-8-chloro-5,6-dihydrofuro-[3,2-f]-1,2-benzisoxazole-6-carboxylic acids |
US4812447A (en) * | 1985-10-22 | 1989-03-14 | City Of Hope | Method for the treatment of nervous system degeneration |
US4960867A (en) * | 1987-10-01 | 1990-10-02 | Merck & Co., Inc. | Leiurus quinquestriatus venom peptide inhibitor of calcium activated potassium channels |
US5006512A (en) * | 1987-10-02 | 1991-04-09 | Tsuyoshi Ohnishi | Therapeutic usages of inhibitors for a potassium efflux channel |
US5006529A (en) * | 1988-05-27 | 1991-04-09 | Lever Brothers Company | Soap compositions of enhanced antimicrobial effectiveness |
US4973601A (en) * | 1988-06-01 | 1990-11-27 | The United States Of America, As Represented By The Secretary Of Agriculture | Control of insects by fungal tremorgenic mycotoxins |
US5223430A (en) * | 1988-08-04 | 1993-06-29 | American Cyanamid Company | Subspecies of micromonospora citrea which produces antibiotic ll-e19085 alpha |
JPH05331146A (ja) * | 1991-07-16 | 1993-12-14 | Tsumura & Co | 新規ジテルペンアルカロイド及びジテルペンアルカロイド類を有効成分とする心疾患治療薬 |
US5130326A (en) * | 1991-07-19 | 1992-07-14 | The United States Of America As Represented By The Secretary Of Agriculture | Sulpinine, secopenitrem B and aflatrem B antiinsectan metabolites |
US5300495A (en) * | 1991-07-19 | 1994-04-05 | The United States Of America, As Represented By The Secretary Of Agriculture | Indole antiinsectan metabolites |
US5158969A (en) * | 1991-08-21 | 1992-10-27 | Neurosearch A/S | Indole derivatives as potassium channel blockers |
WO1994009004A1 (en) * | 1992-10-22 | 1994-04-28 | The Kitasato Institute | Fo-2546 substance, its production and its use as inhibitor of acyl-coa cholesterol acyltransferase |
US5399582A (en) * | 1993-11-01 | 1995-03-21 | Merck & Co., Inc. | Antiparasitic agents |
-
1994
- 1994-01-24 US US08/186,197 patent/US5541208A/en not_active Expired - Fee Related
-
1995
- 1995-01-20 DK DK95908099T patent/DK0804186T3/da active
- 1995-01-20 AT AT95908099T patent/ATE216233T1/de not_active IP Right Cessation
- 1995-01-20 ES ES95908099T patent/ES2173177T3/es not_active Expired - Lifetime
- 1995-01-20 DE DE69526452T patent/DE69526452T2/de not_active Expired - Fee Related
- 1995-01-20 JP JP51970095A patent/JP3689108B2/ja not_active Expired - Fee Related
- 1995-01-20 EP EP95908099A patent/EP0804186B1/de not_active Expired - Lifetime
- 1995-01-20 WO PCT/US1995/000861 patent/WO1995019771A1/en active IP Right Grant
- 1995-01-20 CA CA002181371A patent/CA2181371A1/en not_active Abandoned
- 1995-01-20 PT PT95908099T patent/PT804186E/pt unknown
- 1995-01-20 AU AU16058/95A patent/AU689207B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
US5541208A (en) | 1996-07-30 |
DE69526452T2 (de) | 2002-11-14 |
EP0804186A4 (de) | 1998-04-22 |
JP3689108B2 (ja) | 2005-08-31 |
ES2173177T3 (es) | 2002-10-16 |
WO1995019771A1 (en) | 1995-07-27 |
EP0804186B1 (de) | 2002-04-17 |
EP0804186A1 (de) | 1997-11-05 |
ATE216233T1 (de) | 2002-05-15 |
CA2181371A1 (en) | 1995-07-27 |
JPH09508271A (ja) | 1997-08-26 |
DK0804186T3 (da) | 2002-06-17 |
AU1605895A (en) | 1995-08-08 |
AU689207B2 (en) | 1998-03-26 |
PT804186E (pt) | 2002-08-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |