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DE60327600D1 - Verfahren und nukleinsäuren zur analyse von kolonkrebszellen - Google Patents

Verfahren und nukleinsäuren zur analyse von kolonkrebszellen

Info

Publication number
DE60327600D1
DE60327600D1 DE60327600T DE60327600T DE60327600D1 DE 60327600 D1 DE60327600 D1 DE 60327600D1 DE 60327600 T DE60327600 T DE 60327600T DE 60327600 T DE60327600 T DE 60327600T DE 60327600 D1 DE60327600 D1 DE 60327600D1
Authority
DE
Germany
Prior art keywords
analysis
nucleic acids
cancer cells
colon cancer
cell proliferative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60327600T
Other languages
English (en)
Inventor
Peter Adorjan
Matthias Burger
Sabine Maier
Inko Nimmrich
Evelyne Becker
Ralf Lesche
Tamas Rujan
Armin Schmitt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epigenomics AG
Original Assignee
Epigenomics AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epigenomics AG filed Critical Epigenomics AG
Application granted granted Critical
Publication of DE60327600D1 publication Critical patent/DE60327600D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
DE60327600T 2002-02-27 2003-02-27 Verfahren und nukleinsäuren zur analyse von kolonkrebszellen Expired - Lifetime DE60327600D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02004551A EP1340818A1 (de) 2002-02-27 2002-02-27 Verfahren und Nukleinsäuren zur Analyse von Kolonkrebszellen
PCT/EP2003/002035 WO2003072821A2 (en) 2002-02-27 2003-02-27 Method and nucleic acids for the analysis of a colon cell proliferactive disorder

Publications (1)

Publication Number Publication Date
DE60327600D1 true DE60327600D1 (de) 2009-06-25

Family

ID=27675653

Family Applications (3)

Application Number Title Priority Date Filing Date
DE60317045T Expired - Lifetime DE60317045T2 (de) 2002-02-27 2003-02-13 Verfahren und nukleinsäuren zur analyse von störungen der proliferation kolorektaler zellen
DE60327600T Expired - Lifetime DE60327600D1 (de) 2002-02-27 2003-02-27 Verfahren und nukleinsäuren zur analyse von kolonkrebszellen
DE60335245T Expired - Lifetime DE60335245D1 (de) 2002-02-27 2003-02-27 Verfahren und nukleinsäuren zur analyse von kolonkrebs

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60317045T Expired - Lifetime DE60317045T2 (de) 2002-02-27 2003-02-13 Verfahren und nukleinsäuren zur analyse von störungen der proliferation kolorektaler zellen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60335245T Expired - Lifetime DE60335245D1 (de) 2002-02-27 2003-02-27 Verfahren und nukleinsäuren zur analyse von kolonkrebs

Country Status (9)

Country Link
US (6) US8691503B2 (de)
EP (4) EP1340818A1 (de)
JP (3) JP2005518218A (de)
AT (3) ATE376596T1 (de)
AU (3) AU2003210265A1 (de)
CA (1) CA2451982A1 (de)
DE (3) DE60317045T2 (de)
ES (2) ES2295607T3 (de)
WO (3) WO2003072812A2 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9201067B2 (en) * 2003-03-05 2015-12-01 Posco Size-controlled macromolecule
EP1340818A1 (de) 2002-02-27 2003-09-03 Epigenomics AG Verfahren und Nukleinsäuren zur Analyse von Kolonkrebszellen
US20040029128A1 (en) * 2002-08-08 2004-02-12 Epigenomics, Inc. Methods and nucleic acids for the analysis of CpG dinucleotide methylation status associated with the calcitonin gene
WO2005071111A1 (en) * 2004-01-23 2005-08-04 Lingvitae As Improving polynucleotide ligation reactions
US20090023134A1 (en) * 2004-03-17 2009-01-22 The Johns Hopkins University Neoplasia diagnostic compositions and methods of use
WO2006002344A1 (en) * 2004-06-23 2006-01-05 Epigenomics Ag Methods and nucleic acids for the detection of metastasis of colon cell proliferative disorders
KR100617649B1 (ko) 2004-09-24 2006-09-04 (주)지노믹트리 대장암 특이적 발현감소 유전자의 메틸화된 프로모터를 함유하는 암 진단용 조성물 및 그 용도
EP1794319B1 (de) * 2004-09-30 2014-08-13 Epigenomics AG Verfahren zur bereitstellung von dna-fragmenten aus einer archivierten probe
US7932027B2 (en) 2005-02-16 2011-04-26 Epigenomics Ag Method for determining the methylation pattern of a polynucleic acid
WO2006088978A1 (en) 2005-02-16 2006-08-24 Epigenomics, Inc. Method for determining the methylation pattern of a polynucleic acid
WO2006113770A1 (en) 2005-04-15 2006-10-26 Epigenomics Ag A method for providing dna fragments derived from a remote sample
US20100143899A1 (en) * 2005-05-17 2010-06-10 University Of Vermont And State Agricultural College Methods and products for diagnosing cancer
EP2081950B1 (de) * 2006-09-21 2013-03-20 Nuclea Biomarkers LLC Mit irinotecan-behandlung assoziierte expressionsprofile
US8445442B2 (en) * 2007-04-26 2013-05-21 University Of Vermont And State Agricultural College CCL18 and CCL3 methods and compositions for detecting and treating cancer
JP2010540534A (ja) * 2007-09-28 2010-12-24 イントレキソン コーポレーション 生体治療分子の発現のための治療遺伝子スイッチ構築物およびバイオリアクター、ならびにその使用
AU2008312457B2 (en) * 2007-10-19 2014-04-17 Genentech, Inc. Cysteine engineered anti-TENB2 antibodies and antibody drug conjugates
RU2565540C2 (ru) * 2007-10-23 2015-10-20 Клиникал Джиномикс Пти. Лтд. Способ диагностики неоплазм-ii
KR100969692B1 (ko) * 2008-01-18 2010-07-14 한국생명공학연구원 대장암 과발현 유전자를 이용한 대장암 진단 마커
US20100112713A1 (en) * 2008-11-05 2010-05-06 The Texas A&M University System Methods For Detecting Colorectal Diseases And Disorders
EP2379744B1 (de) * 2008-12-18 2016-10-12 Koninklijke Philips N.V. Verfahren zum nachweis von dna-methylierungsmustern
ES2829198T3 (es) * 2011-02-02 2021-05-31 Exact Sciences Dev Co Llc Análisis digital de secuencia de la metilación de ADN
US9994900B2 (en) 2011-10-17 2018-06-12 King Abdullah University Of Science And Technology Composite biomarkers for non-invasive screening, diagnosis and prognosis of colorectal cancer
US9598735B2 (en) * 2012-11-14 2017-03-21 JBS Science Inc. Detection of a panel of urine DNA markers for HCC screening and disease management
EP2886659A1 (de) * 2013-12-20 2015-06-24 AIT Austrian Institute of Technology GmbH Genmethylierung basierend auf der Diagnose von Kolorektalkrebs

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585481A (en) * 1987-09-21 1996-12-17 Gen-Probe Incorporated Linking reagents for nucleotide probes
US5023090A (en) * 1989-08-16 1991-06-11 Levin Robert H Topical compositions containing LYCD and other topically active medicinal ingredients for the treatment of ACNE
US5457183A (en) * 1989-03-06 1995-10-10 Board Of Regents, The University Of Texas System Hydroxylated texaphyrins
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5580722A (en) * 1989-07-18 1996-12-03 Oncogene Science, Inc. Methods of determining chemicals that modulate transcriptionally expression of genes associated with cardiovascular disease
US5180808A (en) * 1989-11-27 1993-01-19 La Jolla Cancer Research Foundation Versican core protein, nucleic acid sequences encoding the same, nucleic acid probes, anti-versican antibodies, and methods of detecting the same
US5245022A (en) * 1990-08-03 1993-09-14 Sterling Drug, Inc. Exonuclease resistant terminally substituted oligonucleotides
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5565552A (en) * 1992-01-21 1996-10-15 Pharmacyclics, Inc. Method of expanded porphyrin-oligonucleotide conjugate synthesis
US5574142A (en) * 1992-12-15 1996-11-12 Microprobe Corporation Peptide linkers for improved oligonucleotide delivery
SE501439C2 (sv) 1993-06-22 1995-02-13 Pharmacia Lkb Biotech Sätt och anordning för analys av polynukleotidsekvenser
US5837832A (en) * 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
EP1352956A1 (de) 1993-11-30 2003-10-15 McGILL UNIVERSITY Inhibition der DNA Methyltransferase
US5597696A (en) * 1994-07-18 1997-01-28 Becton Dickinson And Company Covalent cyanine dye oligonucleotide conjugates
US5786146A (en) * 1996-06-03 1998-07-28 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US6017704A (en) * 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
AU6293798A (en) 1997-01-29 1998-08-18 Institut Pasteur Polynucleotide associated with the bo or bor syndrome, its corresponding polypeptide and diagnostic and therapeutic applications
DE19754482A1 (de) 1997-11-27 1999-07-01 Epigenomics Gmbh Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
JP2003528564A (ja) 1998-06-06 2003-09-30 ジェノスティック ファーマ リミテッド 遺伝的プロファイリングに使用するプローブ
US7700324B1 (en) * 1998-11-03 2010-04-20 The Johns Hopkins University School Of Medicine Methylated CpG island amplification (MCA)
US5958773A (en) * 1998-12-17 1999-09-28 Isis Pharmaceuticals Inc. Antisense modulation of AKT-1 expression
AU3316600A (en) 1999-02-22 2000-09-21 Torben F. Orntoft Gene expression in bladder tumors
US6331393B1 (en) * 1999-05-14 2001-12-18 University Of Southern California Process for high-throughput DNA methylation analysis
DE19935772C2 (de) * 1999-07-26 2002-11-07 Epigenomics Ag Verfahren zur relativen Quantifizierung der Methylierung von Cytosin Basen in DNA-Proben
AU1131901A (en) * 1999-07-30 2001-02-19 Epidauros Biotechnologie Ag Polymorphisms in the human mdr-1 gene and their use in diagnostic and therapeutic applications
DE10019058A1 (de) * 2000-04-06 2001-12-20 Epigenomics Ag Detektion von Variationen des DNA-Methylierungsprofils
JP2004507214A (ja) * 2000-03-15 2004-03-11 エピゲノミクス　アーゲー 腫瘍抑制遺伝子と腫瘍遺伝子に関連する疾患の診断
JP2003528630A (ja) * 2000-03-28 2003-09-30 カイロン コーポレイション ヒト遺伝子および発現産物
DE10029915B4 (de) * 2000-06-19 2005-06-16 Epigenomics Ag Verfahren zum Nachweis von Cytosin-Methylierungen
AU2001289617A1 (en) * 2000-06-30 2002-01-08 Epigenomics Ag Diagnosis of diseases associated with signal transduction
IL154663A0 (en) * 2000-09-01 2003-09-17 Epigenomics Ag Method for determining the degree of methylation of defined cytosines in genomic dna in the sequence context 5'-cpg-3'
US7029851B2 (en) * 2001-03-15 2006-04-18 Clemson University Polynucleotide encoding a gene conferring resistance to Bacillus thuringiensis toxins
DE10120798B4 (de) * 2001-04-27 2005-12-29 Genovoxx Gmbh Verfahren zur Bestimmung der Genexpression
EP1468110A4 (de) * 2001-06-10 2008-01-30 Irm Llc Molekulare signaturen normalerweise zum tod führender karzinome
US20030215842A1 (en) * 2002-01-30 2003-11-20 Epigenomics Ag Method for the analysis of cytosine methylation patterns
EP1340818A1 (de) 2002-02-27 2003-09-03 Epigenomics AG Verfahren und Nukleinsäuren zur Analyse von Kolonkrebszellen
US7501430B2 (en) * 2006-04-17 2009-03-10 Arqule, Inc. RAF inhibitors and their uses

Also Published As

Publication number Publication date
WO2003072820A2 (en) 2003-09-04
ATE431429T1 (de) 2009-05-15
ATE491038T1 (de) 2010-12-15
DE60317045T2 (de) 2008-08-07
AU2003219002A1 (en) 2003-09-09
JP2005518218A (ja) 2005-06-23
AU2003210265A1 (en) 2003-09-09
AU2003248349A1 (en) 2003-09-09
DE60335245D1 (de) 2011-01-20
EP1478784A2 (de) 2004-11-24
US9988683B2 (en) 2018-06-05
EP1340818A1 (de) 2003-09-03
US20050003463A1 (en) 2005-01-06
WO2003072812A3 (en) 2003-10-23
EP1478784B1 (de) 2007-10-24
US8691503B2 (en) 2014-04-08
CA2451982A1 (en) 2003-09-04
EP1481095B1 (de) 2010-12-08
DE60317045D1 (de) 2007-12-06
US20110046005A1 (en) 2011-02-24
US20140179563A1 (en) 2014-06-26
US20060246433A1 (en) 2006-11-02
WO2003072820A3 (en) 2004-04-08
AU2003219002B2 (en) 2008-04-24
ATE376596T1 (de) 2007-11-15
ES2325363T3 (es) 2009-09-02
AU2003248349B2 (en) 2008-05-01
US20150275312A1 (en) 2015-10-01
EP1478778B1 (de) 2009-05-13
EP1478778A2 (de) 2004-11-24
JP2005518220A (ja) 2005-06-23
US20060234224A1 (en) 2006-10-19
EP1481095A2 (de) 2004-12-01
ES2295607T3 (es) 2008-04-16
WO2003072821A3 (en) 2004-04-01
WO2003072812A2 (en) 2003-09-04
WO2003072821A2 (en) 2003-09-04
JP2005518219A (ja) 2005-06-23

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Legal Events

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