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DE60324684D1 - Multisubstituierte imidazoline und verfahren zu deren anwendung - Google Patents

Multisubstituierte imidazoline und verfahren zu deren anwendung

Info

Publication number
DE60324684D1
DE60324684D1 DE60324684T DE60324684T DE60324684D1 DE 60324684 D1 DE60324684 D1 DE 60324684D1 DE 60324684 T DE60324684 T DE 60324684T DE 60324684 T DE60324684 T DE 60324684T DE 60324684 D1 DE60324684 D1 DE 60324684D1
Authority
DE
Germany
Prior art keywords
imidazolines
agents
treatment
inflammatory
well
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60324684T
Other languages
English (en)
Inventor
Jetze J Tepe
Satyamaheshwar Peddibhotla
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Michigan State University MSU
Original Assignee
Michigan State University MSU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Michigan State University MSU filed Critical Michigan State University MSU
Application granted granted Critical
Publication of DE60324684D1 publication Critical patent/DE60324684D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/40—Two or more oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60324684T 2002-05-31 2003-05-06 Multisubstituierte imidazoline und verfahren zu deren anwendung Expired - Lifetime DE60324684D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38516202P 2002-05-31 2002-05-31
US10/347,323 US6878735B2 (en) 2002-05-31 2003-01-17 Multi-substituted imidazolines and method of use thereof
PCT/US2003/014169 WO2003101969A1 (en) 2002-05-31 2003-05-06 Multi-substituded imidazolines and method of use thereof

Publications (1)

Publication Number Publication Date
DE60324684D1 true DE60324684D1 (de) 2008-12-24

Family

ID=29715034

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60324684T Expired - Lifetime DE60324684D1 (de) 2002-05-31 2003-05-06 Multisubstituierte imidazoline und verfahren zu deren anwendung
DE60327700T Expired - Lifetime DE60327700D1 (de) 2002-05-31 2003-05-30 Nf-kb-inhibitoren und deren anwendungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60327700T Expired - Lifetime DE60327700D1 (de) 2002-05-31 2003-05-30 Nf-kb-inhibitoren und deren anwendungen

Country Status (9)

Country Link
US (3) US6878735B2 (de)
EP (2) EP1532117B1 (de)
KR (1) KR100723072B1 (de)
AT (2) ATE414062T1 (de)
AU (2) AU2003234507A1 (de)
CA (2) CA2486836C (de)
DE (2) DE60324684D1 (de)
ES (1) ES2315497T3 (de)
WO (2) WO2003101969A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080114015A1 (en) * 2002-05-31 2008-05-15 Board Of Trustees Of Michigan State University NF-kB inhibitors and uses thereof
US6878735B2 (en) * 2002-05-31 2005-04-12 Board Of Trustees Of Michigan State University Multi-substituted imidazolines and method of use thereof
US7528161B2 (en) * 2002-05-31 2009-05-05 Michigan State University NF-kappaB inhibitors and uses thereof
US7345078B2 (en) * 2002-05-31 2008-03-18 The Board Of Trustees Of Michigan State University NF-κB inhibitors and uses thereof
US7173044B2 (en) 2004-02-19 2007-02-06 Solvay Pharmaceuticals B.V. Imidazoline derivatives having CB1-antagonistic activity
KR20060131908A (ko) * 2004-02-19 2006-12-20 솔베이 파마슈티칼스 비. 브이 Ｃｂ1-길항 활성을 갖는 이미다졸린 유도체
TWI335321B (en) * 2004-02-19 2011-01-01 Solvay Pharm Bv Imidazoline derivatives having cb1-antagonistic activity
JP4870778B2 (ja) * 2005-12-01 2012-02-08 エフ．ホフマン−ラ ロシュ アーゲー 抗ガン剤として使用されるｐ５３およびｍｄｍ２タンパク質間の相互作用の阻害剤としての２，４，５−トリフェニルイミダゾリン誘導体
DE102005061430A1 (de) 2005-12-22 2007-07-05 Grünenthal GmbH Substituierte Imidazolin-Derivate
US8252942B2 (en) * 2007-10-09 2012-08-28 Board Of Trustees Of Michigan State University Substituted imidazoline compounds
JP5781928B2 (ja) * 2008-07-16 2015-09-24 ビトップ アーゲーｂｉｔｏｐ ＡＧ 環状アミジンの合成
MA38849B1 (fr) 2013-07-31 2018-09-28 Council Scient Ind Res Nouveaux composés d'indazole pour le traitement du diabete et leur procede de preparation
US20220380317A1 (en) 2019-06-27 2022-12-01 Nanyang Technological University Compounds having antimalarial activity

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3354173A (en) * 1964-04-16 1967-11-21 Janssen Pharmaceutica Nv Imidazole carboxylates
US5804374A (en) 1980-12-05 1998-09-08 Massachusetts Insti. Technology Nuclear factors associates with transcriptional regulation
US6410516B1 (en) 1986-01-09 2002-06-25 President & Fellows Of Harvard College Nuclear factors associated with transcriptional regulation
US6001563A (en) 1992-10-27 1999-12-14 Queen's University At Kingston Methods for identifying chemosensitizers
DK1193265T3 (da) * 1996-01-26 2007-02-19 Searle Llc Fremgangsmåde til fremstilling af 4-2-(aryl eller heterocyclo)-1H-imidazol-1-yl-benzensulfonamider
US5821072A (en) 1996-02-20 1998-10-13 Sloan-Kettering Institute For Cancer Research Combinations of PKC inhibitors and therapaeutic agents for treating cancers
US6123525A (en) 1999-02-12 2000-09-26 Coorstek, Inc. Fluid pulsation stabilizer system and method
JP2004532797A (ja) * 2000-10-12 2004-10-28 スミスクライン・ビーチャム・コーポレイション ＮＦ−κＢ阻害剤
US6878735B2 (en) * 2002-05-31 2005-04-12 Board Of Trustees Of Michigan State University Multi-substituted imidazolines and method of use thereof
US7528161B2 (en) * 2002-05-31 2009-05-05 Michigan State University NF-kappaB inhibitors and uses thereof

Also Published As

Publication number Publication date
US20100204260A1 (en) 2010-08-12
US20030232870A1 (en) 2003-12-18
AU2003234507A1 (en) 2003-12-19
EP1532117B1 (de) 2008-11-12
CA2486836A1 (en) 2003-12-11
WO2003101954A2 (en) 2003-12-11
US7858808B2 (en) 2010-12-28
AU2003240533A1 (en) 2003-12-19
AU2003240533A8 (en) 2003-12-19
EP1534686B1 (de) 2009-05-20
CA2486836C (en) 2012-02-07
ATE414062T1 (de) 2008-11-15
US6878735B2 (en) 2005-04-12
EP1534686A2 (de) 2005-06-01
ES2315497T3 (es) 2009-04-01
DE60327700D1 (de) 2009-07-02
EP1532117A1 (de) 2005-05-25
WO2003101969A1 (en) 2003-12-11
US7652056B2 (en) 2010-01-26
CA2486872A1 (en) 2003-12-11
US20050192330A1 (en) 2005-09-01
EP1534686A4 (de) 2006-06-07
KR100723072B1 (ko) 2007-05-29
WO2003101954A3 (en) 2004-09-02
EP1532117A4 (de) 2006-05-10
KR20050004227A (ko) 2005-01-12
ATE431819T1 (de) 2009-06-15
CA2486872C (en) 2011-09-06

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Legal Events

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8364 No opposition during term of opposition