DK1193265T3 - Fremgangsmåde til fremstilling af 4-2-(aryl eller heterocyclo)-1H-imidazol-1-yl-benzensulfonamider - Google Patents
Fremgangsmåde til fremstilling af 4-2-(aryl eller heterocyclo)-1H-imidazol-1-yl-benzensulfonamiderInfo
- Publication number
- DK1193265T3 DK1193265T3 DK01123289T DK01123289T DK1193265T3 DK 1193265 T3 DK1193265 T3 DK 1193265T3 DK 01123289 T DK01123289 T DK 01123289T DK 01123289 T DK01123289 T DK 01123289T DK 1193265 T3 DK1193265 T3 DK 1193265T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- protected
- halo
- aryl
- forming
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59216796A | 1996-01-26 | 1996-01-26 | |
| PCT/US1997/000300 WO1997027181A1 (en) | 1996-01-26 | 1997-01-24 | Heterocyclo-substituted imidazoles for the treatment of inflammation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1193265T3 true DK1193265T3 (da) | 2007-02-19 |
Family
ID=24369588
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97901952T DK0880504T3 (da) | 1996-01-26 | 1997-01-24 | Heterocyclosubstituerede imidazoler til behandling af inflammation |
| DK01123289T DK1193265T3 (da) | 1996-01-26 | 1997-01-24 | Fremgangsmåde til fremstilling af 4-2-(aryl eller heterocyclo)-1H-imidazol-1-yl-benzensulfonamider |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97901952T DK0880504T3 (da) | 1996-01-26 | 1997-01-24 | Heterocyclosubstituerede imidazoler til behandling af inflammation |
Country Status (12)
| Country | Link |
|---|---|
| EP (2) | EP0880504B1 (da) |
| JP (1) | JP2000503987A (da) |
| AT (2) | ATE236130T1 (da) |
| AU (1) | AU730642B2 (da) |
| DE (3) | DE69737042T8 (da) |
| DK (2) | DK0880504T3 (da) |
| ES (2) | ES2274843T3 (da) |
| HK (1) | HK1045843B (da) |
| NZ (1) | NZ327022A (da) |
| PT (2) | PT1193265E (da) |
| WO (1) | WO1997027181A1 (da) |
| ZA (1) | ZA97670B (da) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6512121B2 (en) | 1998-09-14 | 2003-01-28 | G.D. Searle & Co. | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
| NZ333399A (en) | 1997-12-24 | 2000-05-26 | Sankyo Co | Cyclooxygenase-2 inhibitors (COX-2) for the prevention and treatment of tumors, cachexia and tumor-metastasis |
| KR20010034220A (ko) | 1998-01-28 | 2001-04-25 | 시오노 요시히코 | 신규 삼환식 화합물 |
| US6727238B2 (en) | 1998-06-11 | 2004-04-27 | Pfizer Inc. | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents |
| US6294558B1 (en) | 1999-05-31 | 2001-09-25 | Pfizer Inc. | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents |
| US6410562B1 (en) | 1998-12-18 | 2002-06-25 | Eli Lilly And Company | Hypoglycemic imidazoline compounds |
| ES2166710B1 (es) * | 2000-04-25 | 2004-10-16 | J. URIACH & CIA, S.A. | Nuevos compuestos heterociclicos con actividad antiinflamatoria. |
| JP4759207B2 (ja) * | 2000-05-15 | 2011-08-31 | あすか製薬株式会社 | １−（ベンゾチアゾール−２−イル）ピラゾール誘導体およびそれを含有するｃｏｘ−２阻害剤 |
| US6555563B1 (en) * | 2001-11-16 | 2003-04-29 | Medinox, Inc. | Heteroaryl substituted amidinyl and imidazolyl compounds and methods employing same for the treatment of inflammation |
| WO2003084937A2 (en) * | 2002-04-10 | 2003-10-16 | Orchid Chemicals & Pharmaceuticals Limited | Pyrimidinedione derivatives useful for the treatment of inflammation and immunological diseases |
| US6878735B2 (en) * | 2002-05-31 | 2005-04-12 | Board Of Trustees Of Michigan State University | Multi-substituted imidazolines and method of use thereof |
| WO2004002420A2 (en) | 2002-06-28 | 2004-01-08 | Nitromed, Inc. | Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxigenase-2 selective inhibitors, compositions and methods of use |
| WO2004060367A1 (en) * | 2002-12-30 | 2004-07-22 | Fujisawa Pharmaceutical Co., Ltd. | Imidazole and triazole derivatives useful as selective cox-1 inhibitors |
| JP4354984B2 (ja) | 2003-05-07 | 2009-10-28 | オステオロジックス エイ／エス | 水溶性ストロンチウム塩を用いる軟骨／骨症状の治療 |
| US20070197513A1 (en) * | 2004-03-08 | 2007-08-23 | Robert Zelle | Ion channel modulators |
| CN102584695B (zh) * | 2012-01-13 | 2014-02-19 | 江苏中邦制药有限公司 | 一种5-甲基烟酸的制备方法 |
| US20240165148A1 (en) | 2021-03-15 | 2024-05-23 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory diseases |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0624159B1 (en) * | 1992-01-13 | 1998-11-25 | Smithkline Beecham Corporation | Pyridyl substituted imidazoles |
| US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| US5475018A (en) * | 1993-11-30 | 1995-12-12 | G. D. Searle & Co. | 1,5-diphenyl pyrazole compounds for treatment of inflammation |
| US5616601A (en) * | 1994-07-28 | 1997-04-01 | Gd Searle & Co | 1,2-aryl and heteroaryl substituted imidazolyl compounds for the treatment of inflammation |
-
1997
- 1997-01-24 AT AT97901952T patent/ATE236130T1/de not_active IP Right Cessation
- 1997-01-24 DE DE69737042T patent/DE69737042T8/de active Active
- 1997-01-24 AT AT01123289T patent/ATE346849T1/de not_active IP Right Cessation
- 1997-01-24 ES ES01123289T patent/ES2274843T3/es not_active Expired - Lifetime
- 1997-01-24 PT PT01123289T patent/PT1193265E/pt unknown
- 1997-01-24 EP EP97901952A patent/EP0880504B1/en not_active Expired - Lifetime
- 1997-01-24 WO PCT/US1997/000300 patent/WO1997027181A1/en active IP Right Grant
- 1997-01-24 ES ES97901952T patent/ES2197983T3/es not_active Expired - Lifetime
- 1997-01-24 NZ NZ327022A patent/NZ327022A/xx unknown
- 1997-01-24 DE DE69737042A patent/DE69737042D1/de not_active Expired - Fee Related
- 1997-01-24 JP JP9526876A patent/JP2000503987A/ja not_active Abandoned
- 1997-01-24 DK DK97901952T patent/DK0880504T3/da active
- 1997-01-24 DE DE69720428T patent/DE69720428T2/de not_active Expired - Fee Related
- 1997-01-24 DK DK01123289T patent/DK1193265T3/da active
- 1997-01-24 EP EP01123289A patent/EP1193265B1/en not_active Expired - Lifetime
- 1997-01-24 AU AU15739/97A patent/AU730642B2/en not_active Ceased
- 1997-01-24 PT PT97901952T patent/PT880504E/pt unknown
- 1997-01-27 ZA ZA9700670A patent/ZA97670B/xx unknown
-
2002
- 2002-10-03 HK HK02107266.0A patent/HK1045843B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HK1045843B (zh) | 2007-03-02 |
| JP2000503987A (ja) | 2000-04-04 |
| WO1997027181A1 (en) | 1997-07-31 |
| DE69720428D1 (de) | 2003-05-08 |
| AU1573997A (en) | 1997-08-20 |
| EP1193265B1 (en) | 2006-11-29 |
| PT880504E (pt) | 2003-08-29 |
| DE69720428T2 (de) | 2004-02-12 |
| EP0880504B1 (en) | 2003-04-02 |
| EP1193265A2 (en) | 2002-04-03 |
| EP0880504A1 (en) | 1998-12-02 |
| ES2274843T3 (es) | 2007-06-01 |
| ES2197983T3 (es) | 2004-01-16 |
| NZ327022A (en) | 1999-06-29 |
| DE69737042D1 (de) | 2007-01-11 |
| DE69737042T8 (de) | 2007-11-22 |
| ZA97670B (en) | 1998-04-16 |
| DK0880504T3 (da) | 2003-07-21 |
| ATE236130T1 (de) | 2003-04-15 |
| EP1193265A3 (en) | 2002-04-10 |
| DE69737042T2 (de) | 2007-07-19 |
| HK1045843A1 (en) | 2002-12-13 |
| PT1193265E (pt) | 2007-03-30 |
| ATE346849T1 (de) | 2006-12-15 |
| AU730642B2 (en) | 2001-03-08 |
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