DE602006005240D1 - Herstellungsverfahren für aztreonam - Google Patents
Herstellungsverfahren für aztreonamInfo
- Publication number
- DE602006005240D1 DE602006005240D1 DE602006005240T DE602006005240T DE602006005240D1 DE 602006005240 D1 DE602006005240 D1 DE 602006005240D1 DE 602006005240 T DE602006005240 T DE 602006005240T DE 602006005240 T DE602006005240 T DE 602006005240T DE 602006005240 D1 DE602006005240 D1 DE 602006005240D1
- Authority
- DE
- Germany
- Prior art keywords
- aztreonam
- manufacturing process
- taem
- azetidine
- butyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Optical Integrated Circuits (AREA)
- Saccharide Compounds (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Materials For Medical Uses (AREA)
- Bridges Or Land Bridges (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67931305P | 2005-05-09 | 2005-05-09 | |
US68180805P | 2005-05-17 | 2005-05-17 | |
PCT/US2006/018261 WO2006122253A1 (en) | 2005-05-09 | 2006-05-09 | Process for making aztreonam |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602006005240D1 true DE602006005240D1 (de) | 2009-04-02 |
Family
ID=37012142
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602006005240T Active DE602006005240D1 (de) | 2005-05-09 | 2006-05-09 | Herstellungsverfahren für aztreonam |
Country Status (11)
Country | Link |
---|---|
US (1) | US7601832B2 (de) |
EP (1) | EP1888576B1 (de) |
JP (1) | JP2008505189A (de) |
AT (1) | ATE423115T1 (de) |
CA (1) | CA2606901A1 (de) |
DE (1) | DE602006005240D1 (de) |
ES (1) | ES2321336T3 (de) |
IL (1) | IL185030A0 (de) |
MX (1) | MX2007000526A (de) |
PT (1) | PT1888576E (de) |
WO (1) | WO2006122253A1 (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7452991B2 (en) * | 2003-05-15 | 2008-11-18 | Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Aztreonam β polymorph with very low residual solvent content |
US20090069286A1 (en) * | 2007-09-12 | 2009-03-12 | Protia, Llc | Deuterium-enriched aztreonam |
CN102086196B (zh) | 2011-01-28 | 2012-06-13 | 海南灵康制药有限公司 | 一种氨曲南的方法 |
CN102382026A (zh) * | 2011-10-17 | 2012-03-21 | 重庆南松医药科技股份有限公司 | 氨曲南主环(3s-反式)-3-氨基-4-甲基-2-氧代-1-氮杂环丁烷基磺酸的环保合成工艺 |
CN103570707B (zh) * | 2012-07-21 | 2016-03-09 | 重庆圣华曦药业股份有限公司 | 一种改进的氨曲南的合成方法 |
CN114437059A (zh) * | 2020-11-04 | 2022-05-06 | 重庆圣华曦药业股份有限公司 | 一种氨曲南二聚体杂质的制备方法 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4923998A (en) | 1977-03-14 | 1990-05-08 | Fujisawa Pharmaceutical Company, Ltd. | Cephem and cepham compounds and processes for preparation thereof |
NZ196202A (en) * | 1980-02-07 | 1984-07-31 | Squibb & Sons Inc | Beta-lactam antibiotics (of azetidine-sulphonic acid type) |
US4775670A (en) | 1980-09-29 | 1988-10-04 | E. R. Squibb & Sons, Inc. | 2-oxo-1-azetidinesulfonic acid salts |
US4529698A (en) | 1981-01-19 | 1985-07-16 | E. R. Squibb & Sons, Inc. | Process for preparing a 2-oxo-1-azetidinesulfonic acid salt |
CA1181075A (en) | 1981-07-13 | 1985-01-15 | David M. Floyd | CRYSTALLINE ANHYDROUS FORM OF [3-S-[3.alpha.(Z),4 .beta.]]-3-[[(2-AMINO-4-THIAZOLYL) [(1-CARBOXY-1-METHYLETHOXY)IMINO]ACETYL] AMINO]-4-METHYL-2-OXO-1-AZETIDINESULFONIC ACID |
US4946838A (en) | 1981-07-13 | 1990-08-07 | E. R. Squibb & Sons, Inc. | Crystalline anhydrous aztreonam |
US4443374A (en) * | 1982-02-01 | 1984-04-17 | E. R. Squibb & Sons, Inc. | Process for preparing (3S)-3-[[(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]-acetyl]amino]-2-oxo-1-azetidinesulfonic acid, and 4-substituted derivatives |
EP0096296B1 (de) * | 1982-06-03 | 1987-07-29 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | 1-Sulfo-2-oxoazetidinderivate |
US4652651A (en) | 1983-05-31 | 1987-03-24 | Hoffmann-La Roche Inc. | Process for the manufacture of 1-sulpho-2-oxoazetidine carboxylic acid intermediates via catalytic ester cleavage |
US4826973A (en) | 1984-07-20 | 1989-05-02 | E. R. Squibb & Sons, Inc. | Delta form of aztreonam and preparation thereof |
CA1339136C (en) | 1987-07-01 | 1997-07-29 | Sailesh Amilal Varia | Amorphous form of aztreonam |
US5254681A (en) * | 1989-08-02 | 1993-10-19 | Consiglio Nazionale Delle Ricerche | Process for preparing monobactames and their intermediate product |
IT1231770B (it) * | 1989-08-02 | 1991-12-21 | Consiglio Nazionale Ricerche | Processo per la preparazione di monobattami ed intermedio di preparazione. |
US5194604A (en) * | 1990-06-29 | 1993-03-16 | E. R. Squibb & Sons, Inc. | Process and intermediates for beta-lactams having aminothiazole(iminooxyacetic acid)acetic acid sidechains |
PL165700B1 (pl) | 1991-10-15 | 1995-01-31 | Pan | Sposób wytwarzania kwasu 32/2-amtnotiazoiilo-4/-2/1 -t-butoksykarbonylo- 1 -metyloetoksylmino/octowego |
US7214364B2 (en) | 2000-12-27 | 2007-05-08 | Corus Pharma, Inc. | Inhalable aztreonam lysinate formulation for treatment and prevention of pulmonary bacterial infections |
CA2433280C (en) | 2000-12-27 | 2010-09-21 | Salus Pharma, Inc. | Inhalable aztreonam for treatment and prevention of pulmonary bacterial infections |
WO2003018578A1 (en) | 2001-08-27 | 2003-03-06 | Aurobindo Pharma Ltd. | Method for producing beta form of crystalline anhydrous aztreonam |
KR100687001B1 (ko) * | 2002-08-05 | 2007-02-27 | 테바 기오기스제르갸르 자르트쾨렌 뮈쾨되 레스즈베니타르사사그 | 아즈트레오남의 제법 |
AU2002356646A1 (en) | 2002-12-11 | 2004-06-30 | Pari Gmbh | Pharmaceutical compositions for the pulmonary delivery of aztreonam |
DE112004001191B4 (de) | 2003-07-02 | 2017-11-09 | Corus Pharma Inc. | Verfahren zur Herstellung des L-Lysin-Salzes von Aztreonam und Verfahren zur Bestimmung des Verunreinigungsgrads in einem amorphen Aztreonam Lysin-Salz |
WO2007083187A2 (en) | 2006-01-16 | 2007-07-26 | Orchid Chemicals & Pharmaceuticals Limited | An improved process for the preparation of monobactam antibiotic |
-
2006
- 2006-05-09 ES ES06759579T patent/ES2321336T3/es active Active
- 2006-05-09 JP JP2007520595A patent/JP2008505189A/ja active Pending
- 2006-05-09 AT AT06759579T patent/ATE423115T1/de not_active IP Right Cessation
- 2006-05-09 WO PCT/US2006/018261 patent/WO2006122253A1/en active Application Filing
- 2006-05-09 DE DE602006005240T patent/DE602006005240D1/de active Active
- 2006-05-09 US US11/431,178 patent/US7601832B2/en not_active Expired - Fee Related
- 2006-05-09 MX MX2007000526A patent/MX2007000526A/es active IP Right Grant
- 2006-05-09 PT PT06759579T patent/PT1888576E/pt unknown
- 2006-05-09 CA CA002606901A patent/CA2606901A1/en not_active Abandoned
- 2006-05-09 EP EP06759579A patent/EP1888576B1/de not_active Not-in-force
-
2007
- 2007-08-02 IL IL185030A patent/IL185030A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
MX2007000526A (es) | 2007-03-28 |
IL185030A0 (en) | 2007-12-03 |
CA2606901A1 (en) | 2006-11-16 |
ATE423115T1 (de) | 2009-03-15 |
US7601832B2 (en) | 2009-10-13 |
JP2008505189A (ja) | 2008-02-21 |
US20060276640A1 (en) | 2006-12-07 |
PT1888576E (pt) | 2009-04-03 |
WO2006122253A1 (en) | 2006-11-16 |
ES2321336T3 (es) | 2009-06-04 |
EP1888576A1 (de) | 2008-02-20 |
EP1888576B1 (de) | 2009-02-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |