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DE602005001367T2 - Vorrichtung und Verfahren zur Vermessung biologischen Materials - Google Patents

Vorrichtung und Verfahren zur Vermessung biologischen Materials Download PDF

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Publication number
DE602005001367T2
DE602005001367T2 DE602005001367T DE602005001367T DE602005001367T2 DE 602005001367 T2 DE602005001367 T2 DE 602005001367T2 DE 602005001367 T DE602005001367 T DE 602005001367T DE 602005001367 T DE602005001367 T DE 602005001367T DE 602005001367 T2 DE602005001367 T2 DE 602005001367T2
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DE
Germany
Prior art keywords
electrode
conductive
field effect
effect transistor
probe
Prior art date
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DE602005001367T
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German (de)
English (en)
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DE602005001367D1 (de
Inventor
Masao Hitachi Kamahori
Yoshiaki Hitachi Yazawa
Maki Shimoda
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Hitachi Ltd
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Hitachi Ltd
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Publication of DE602005001367D1 publication Critical patent/DE602005001367D1/de
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Active legal-status Critical Current
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438Electrodes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403Cells and electrode assemblies
    • G01N27/414Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4145Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Electrochemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Thin Film Transistor (AREA)
  • Insulated Gate Type Field-Effect Transistor (AREA)
DE602005001367T 2004-07-21 2005-03-07 Vorrichtung und Verfahren zur Vermessung biologischen Materials Active DE602005001367T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004213130A JP3874772B2 (ja) 2004-07-21 2004-07-21 生体関連物質測定装置及び測定方法
JP2004213130 2004-07-21

Publications (2)

Publication Number Publication Date
DE602005001367D1 DE602005001367D1 (de) 2007-07-26
DE602005001367T2 true DE602005001367T2 (de) 2008-02-21

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Family Applications (1)

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DE602005001367T Active DE602005001367T2 (de) 2004-07-21 2005-03-07 Vorrichtung und Verfahren zur Vermessung biologischen Materials

Country Status (4)

Country Link
US (1) US8383396B2 (ja)
EP (1) EP1619496B1 (ja)
JP (1) JP3874772B2 (ja)
DE (1) DE602005001367T2 (ja)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8536661B1 (en) 2004-06-25 2013-09-17 University Of Hawaii Biosensor chip sensor protection methods
EP1619342B1 (en) 2004-07-22 2009-04-29 Bea S.A. Thermally sensitive array device for presence detection around automatic doors
JP4775262B2 (ja) * 2004-09-03 2011-09-21 三菱化学株式会社 センサユニット及び反応場セルユニット並びに分析装置
JP2008536103A (ja) * 2005-03-08 2008-09-04 ナショナル リサーチ カウンシル オブ カナダ 静電的に制御された原子的な規模の導電性デバイス
JP4081477B2 (ja) * 2005-03-29 2008-04-23 株式会社日立製作所 生体分子検出装置及びそれを用いた生体分子検出方法
JP4353958B2 (ja) * 2005-09-15 2009-10-28 株式会社日立製作所 Dna計測装置、及びdna計測方法
JP4331181B2 (ja) * 2006-03-30 2009-09-16 株式会社日立製作所 測定装置及び分析用素子
KR100773549B1 (ko) 2006-04-03 2007-11-07 삼성전자주식회사 동일 전계 효과 트랜지스터를 이용하여 생분자를 검출하는방법
JP5150893B2 (ja) * 2006-07-13 2013-02-27 国立大学法人富山大学 酸化還元物質の信号増幅検出方法及びその測定装置
JP4936536B2 (ja) * 2006-07-13 2012-05-23 国立大学法人富山大学 定量・定性分析方法
JP4825976B2 (ja) * 2006-08-03 2011-11-30 国立大学法人豊橋技術科学大学 pH検出装置
JP4759473B2 (ja) * 2006-08-23 2011-08-31 善孝 伊藤 小型pH計
JP4751302B2 (ja) * 2006-11-21 2011-08-17 株式会社日立製作所 電位差式センサ及び分析用素子
US11339430B2 (en) 2007-07-10 2022-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
CN101669026B (zh) 2006-12-14 2014-05-07 生命技术公司 利用大规模fet阵列测量分析物的方法和装置
EP2251435B1 (en) * 2007-03-02 2013-10-16 DNA Electronics Ltd Sensing apparatus for monitoring nucleic acid amplification, using an ion-sensitive field effect transistor (ISFET) for pH sensing
JP4922816B2 (ja) * 2007-04-27 2012-04-25 株式会社日立ハイテクノロジーズ イオン濃度測定装置
KR101375547B1 (ko) * 2007-06-19 2014-03-25 삼성전자주식회사 표준 전극이 포함된 전계 효과 트랜지스터 어레이를 이용한생체 분자의 검출 장치 및 방법
DE102007043132B4 (de) * 2007-09-11 2012-07-26 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Biosensor und Verfahren zum Messen einer Konzentration eines Analyten in einem Medium
JP2009092647A (ja) * 2007-09-19 2009-04-30 Hitachi High-Technologies Corp 陰イオン濃度測定装置及び陰イオン濃度測定素子
EP2040067A3 (en) * 2007-09-19 2013-01-02 Hitachi High-Technologies Corporation Anion concentration measuring device and element
KR100882554B1 (ko) 2007-11-08 2009-02-12 삼성전자주식회사 생분자 동정 방법
JP4731544B2 (ja) * 2007-12-17 2011-07-27 株式会社日立製作所 生体分子検出装置及びそれを用いた生体分子検出方法
JP5159453B2 (ja) * 2008-06-13 2013-03-06 ローム株式会社 イオンセンサ
KR100987105B1 (ko) 2008-06-19 2010-10-11 성균관대학교산학협력단 유기 전계효과 트랜지스터를 적용한 바이오센서 및 그제조방법
JP5467312B2 (ja) * 2008-06-24 2014-04-09 独立行政法人物質・材料研究機構 バイオセンサ、バイオセンサを用いた生体物質の検出方法、及びそのキット
EP2982437B1 (en) * 2008-06-25 2017-12-06 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale fet arrays
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
KR101239137B1 (ko) 2008-12-05 2013-03-07 한국전자통신연구원 바이오 센서 리더기 및 바이오 센서 리더기 시스템
US20100141280A1 (en) * 2008-12-05 2010-06-10 Electronics And Telecommunications Research Institute Biosensor reader and biosensor reader system
JP4958941B2 (ja) * 2009-05-08 2012-06-20 株式会社日立製作所 分析用素子
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
CN103189986A (zh) 2010-06-30 2013-07-03 生命科技公司 用于检测和测量化学反应和化合物的晶体管电路
JP2013533482A (ja) 2010-06-30 2013-08-22 ライフ テクノロジーズ コーポレーション イオン感応性電荷蓄積回路および方法
WO2012006222A1 (en) 2010-07-03 2012-01-12 Life Technologies Corporation Chemically sensitive sensor with lightly doped drains
US8373206B2 (en) * 2010-07-20 2013-02-12 Nth Tech Corporation Biosensor apparatuses and methods thereof
US9618475B2 (en) 2010-09-15 2017-04-11 Life Technologies Corporation Methods and apparatus for measuring analytes
TWI432722B (zh) * 2010-09-24 2014-04-01 Tatung Co 細胞測量系統
CN103299182A (zh) 2010-09-24 2013-09-11 生命科技公司 匹配的晶体管对电路
GB2489504A (en) * 2011-03-31 2012-10-03 Sapient Sensors A device for identifying the presence of a specific target molecule or biomarker by sensing an electrical property
US9617590B2 (en) * 2011-09-30 2017-04-11 Stc.Unm DNA sample preparation and sequencing
US9970984B2 (en) 2011-12-01 2018-05-15 Life Technologies Corporation Method and apparatus for identifying defects in a chemical sensor array
JP5507534B2 (ja) * 2011-12-05 2014-05-28 株式会社日立ハイテクノロジーズ イオン濃度測定装置及びイオン濃度測定素子
US8747748B2 (en) 2012-01-19 2014-06-10 Life Technologies Corporation Chemical sensor with conductive cup-shaped sensor surface
US8821798B2 (en) 2012-01-19 2014-09-02 Life Technologies Corporation Titanium nitride as sensing layer for microwell structure
US8786331B2 (en) 2012-05-29 2014-07-22 Life Technologies Corporation System for reducing noise in a chemical sensor array
US10526218B2 (en) * 2012-10-01 2020-01-07 The Board Of Trustees Of The Leland Stanford Junior University Flow control method and apparatuses
US9080968B2 (en) 2013-01-04 2015-07-14 Life Technologies Corporation Methods and systems for point of use removal of sacrificial material
US9841398B2 (en) 2013-01-08 2017-12-12 Life Technologies Corporation Methods for manufacturing well structures for low-noise chemical sensors
US8841217B1 (en) 2013-03-13 2014-09-23 Life Technologies Corporation Chemical sensor with protruded sensor surface
US8963216B2 (en) 2013-03-13 2015-02-24 Life Technologies Corporation Chemical sensor with sidewall spacer sensor surface
US9116117B2 (en) 2013-03-15 2015-08-25 Life Technologies Corporation Chemical sensor with sidewall sensor surface
CN105283758B (zh) 2013-03-15 2018-06-05 生命科技公司 具有一致传感器表面区域的化学传感器
WO2014149780A1 (en) 2013-03-15 2014-09-25 Life Technologies Corporation Chemical sensor with consistent sensor surface areas
CN103592353B (zh) * 2013-11-13 2016-05-18 胡文闯 基于蜿蜒线形沟道离子敏感场效应晶体管的生物传感器
CN103604854B (zh) * 2013-11-28 2016-08-17 胡文闯 基于离子敏感场效应晶体管的生物传感器阵列
US10006910B2 (en) 2014-12-18 2018-06-26 Agilome, Inc. Chemically-sensitive field effect transistors, systems, and methods for manufacturing and using the same
TWI794007B (zh) 2014-12-18 2023-02-21 美商生命技術公司 積體電路裝置、感測器裝置及積體電路
US10020300B2 (en) 2014-12-18 2018-07-10 Agilome, Inc. Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids
US10429342B2 (en) 2014-12-18 2019-10-01 Edico Genome Corporation Chemically-sensitive field effect transistor
US10379079B2 (en) * 2014-12-18 2019-08-13 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US11782057B2 (en) 2014-12-18 2023-10-10 Cardea Bio, Inc. Ic with graphene fet sensor array patterned in layers above circuitry formed in a silicon based cmos wafer
US11921112B2 (en) 2014-12-18 2024-03-05 Paragraf Usa Inc. Chemically-sensitive field effect transistors, systems, and methods for manufacturing and using the same
US10077472B2 (en) 2014-12-18 2018-09-18 Life Technologies Corporation High data rate integrated circuit with power management
US9618474B2 (en) 2014-12-18 2017-04-11 Edico Genome, Inc. Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids
WO2016130753A1 (en) * 2015-02-13 2016-08-18 Desa Johann Piezoelectric biochips having fluidic channels
EP3459115A4 (en) * 2016-05-16 2020-04-08 Agilome, Inc. GRAPHEN-FET DEVICES, SYSTEMS AND METHODS FOR USE THEREOF FOR SEQUENCING NUCLEIC ACIDS
TWI635274B (zh) * 2017-01-09 2018-09-11 麥博森股份有限公司 生物感測器裝置
EP3588075A4 (en) * 2017-02-21 2021-01-06 Provigate Inc. HIGH SENSITIVITY BIOSENSOR
EP3588076A4 (en) * 2017-02-21 2020-12-30 Provigate Inc. ION SENSITIVE BIOCAPTER
US11905552B2 (en) 2017-08-04 2024-02-20 Keck Graduate Institute Of Applied Life Sciences Immobilized RNPs for sequence-specific nucleic acid capture and digital detection
US11264653B2 (en) 2017-10-16 2022-03-01 Neapco Intellectual Property Holdings, Llc Battery cell monitoring system
JP6877394B2 (ja) * 2018-09-18 2021-05-26 株式会社東芝 ケミカルセンサ用液膜材料及びケミカルセンサ
CN112864252A (zh) * 2021-01-05 2021-05-28 上海应用技术大学 一种基于薄膜晶体管的dna传感器及其制备方法
CN117741117A (zh) * 2023-05-08 2024-03-22 上海新势聚芯医疗科技有限公司 生物感测芯片、生物感测芯片制造方法及微流道系统

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4020830A (en) * 1975-03-12 1977-05-03 The University Of Utah Selective chemical sensitive FET transducers
GB2096824A (en) * 1981-04-09 1982-10-20 Sibbald Alastair Chemically sensitive field effect transistor
US4490216A (en) * 1983-02-03 1984-12-25 Molecular Devices Corporation Lipid membrane electroanalytical elements and method of analysis therewith
GB8406955D0 (en) * 1984-03-16 1984-04-18 Serono Diagnostics Ltd Assay
EP0213825A3 (en) * 1985-08-22 1989-04-26 Molecular Devices Corporation Multiple chemically modulated capacitance
JPH07128279A (ja) * 1993-06-25 1995-05-19 Hitachi Ltd 固体イオンセンサ
EP0894148A4 (en) 1996-04-17 1999-06-16 Motorola Inc MOLECULAR DETECTION, APPARATUS AND METHOD WITH INTEGRATED TRANSISTOR
US6355436B1 (en) 1996-05-17 2002-03-12 L'ecole Centrale De Lyon Method for analyzing biological substances in a conductive liquid medium
JP3634086B2 (ja) * 1996-08-13 2005-03-30 株式会社半導体エネルギー研究所 絶縁ゲイト型半導体装置の作製方法
US6413792B1 (en) * 2000-04-24 2002-07-02 Eagle Research Development, Llc Ultra-fast nucleic acid sequencing device and a method for making and using the same
US20040126814A1 (en) * 2000-08-21 2004-07-01 Singh Waheguru Pal Sensor having molecularly imprinted polymers
US6749731B2 (en) * 2001-01-31 2004-06-15 Kyocera Corporation Gene detection chip and detection device
US20020179439A1 (en) * 2001-05-31 2002-12-05 Tsu-Tseng Weng Microelectronic system and method of use and fabrication
US20030073071A1 (en) * 2001-10-12 2003-04-17 Jurgen Fritz Solid state sensing system and method for measuring the binding or hybridization of biomolecules
AU2003210438A1 (en) * 2002-01-04 2003-07-24 Board Of Regents, The University Of Texas System Droplet-based microfluidic oligonucleotide synthesis engine
JP3917595B2 (ja) * 2003-02-26 2007-05-23 株式会社東芝 核酸濃度定量分析チップ、核酸濃度定量分析装置および核酸濃度定量分析方法
KR100580621B1 (ko) * 2003-03-07 2006-05-16 삼성전자주식회사 전도성 화합물, 이를 포함하는 전극 및 센서, 상기 센서를이용한 표적 물질 검출방법
JP2005077210A (ja) * 2003-08-29 2005-03-24 National Institute For Materials Science 生体分子検出素子及びそれを用いた核酸解析方法
JP4751302B2 (ja) * 2006-11-21 2011-08-17 株式会社日立製作所 電位差式センサ及び分析用素子

Also Published As

Publication number Publication date
EP1619496B1 (en) 2007-06-13
DE602005001367D1 (de) 2007-07-26
US20060016699A1 (en) 2006-01-26
JP3874772B2 (ja) 2007-01-31
EP1619496A1 (en) 2006-01-25
JP2006030132A (ja) 2006-02-02
US8383396B2 (en) 2013-02-26

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