DE602005001367T2 - Vorrichtung und Verfahren zur Vermessung biologischen Materials - Google Patents
Vorrichtung und Verfahren zur Vermessung biologischen Materials Download PDFInfo
- Publication number
- DE602005001367T2 DE602005001367T2 DE602005001367T DE602005001367T DE602005001367T2 DE 602005001367 T2 DE602005001367 T2 DE 602005001367T2 DE 602005001367 T DE602005001367 T DE 602005001367T DE 602005001367 T DE602005001367 T DE 602005001367T DE 602005001367 T2 DE602005001367 T2 DE 602005001367T2
- Authority
- DE
- Germany
- Prior art keywords
- electrode
- conductive
- field effect
- effect transistor
- probe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/403—Cells and electrode assemblies
- G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
- G01N27/4145—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Electrochemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Thin Film Transistor (AREA)
- Insulated Gate Type Field-Effect Transistor (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004213130A JP3874772B2 (ja) | 2004-07-21 | 2004-07-21 | 生体関連物質測定装置及び測定方法 |
JP2004213130 | 2004-07-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE602005001367D1 DE602005001367D1 (de) | 2007-07-26 |
DE602005001367T2 true DE602005001367T2 (de) | 2008-02-21 |
Family
ID=35427239
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602005001367T Active DE602005001367T2 (de) | 2004-07-21 | 2005-03-07 | Vorrichtung und Verfahren zur Vermessung biologischen Materials |
Country Status (4)
Country | Link |
---|---|
US (1) | US8383396B2 (ja) |
EP (1) | EP1619496B1 (ja) |
JP (1) | JP3874772B2 (ja) |
DE (1) | DE602005001367T2 (ja) |
Families Citing this family (77)
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JP2008536103A (ja) * | 2005-03-08 | 2008-09-04 | ナショナル リサーチ カウンシル オブ カナダ | 静電的に制御された原子的な規模の導電性デバイス |
JP4081477B2 (ja) * | 2005-03-29 | 2008-04-23 | 株式会社日立製作所 | 生体分子検出装置及びそれを用いた生体分子検出方法 |
JP4353958B2 (ja) * | 2005-09-15 | 2009-10-28 | 株式会社日立製作所 | Dna計測装置、及びdna計測方法 |
JP4331181B2 (ja) * | 2006-03-30 | 2009-09-16 | 株式会社日立製作所 | 測定装置及び分析用素子 |
KR100773549B1 (ko) | 2006-04-03 | 2007-11-07 | 삼성전자주식회사 | 동일 전계 효과 트랜지스터를 이용하여 생분자를 검출하는방법 |
JP5150893B2 (ja) * | 2006-07-13 | 2013-02-27 | 国立大学法人富山大学 | 酸化還元物質の信号増幅検出方法及びその測定装置 |
JP4936536B2 (ja) * | 2006-07-13 | 2012-05-23 | 国立大学法人富山大学 | 定量・定性分析方法 |
JP4825976B2 (ja) * | 2006-08-03 | 2011-11-30 | 国立大学法人豊橋技術科学大学 | pH検出装置 |
JP4759473B2 (ja) * | 2006-08-23 | 2011-08-31 | 善孝 伊藤 | 小型pH計 |
JP4751302B2 (ja) * | 2006-11-21 | 2011-08-17 | 株式会社日立製作所 | 電位差式センサ及び分析用素子 |
US11339430B2 (en) | 2007-07-10 | 2022-05-24 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
US8262900B2 (en) | 2006-12-14 | 2012-09-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
CN101669026B (zh) | 2006-12-14 | 2014-05-07 | 生命技术公司 | 利用大规模fet阵列测量分析物的方法和装置 |
EP2251435B1 (en) * | 2007-03-02 | 2013-10-16 | DNA Electronics Ltd | Sensing apparatus for monitoring nucleic acid amplification, using an ion-sensitive field effect transistor (ISFET) for pH sensing |
JP4922816B2 (ja) * | 2007-04-27 | 2012-04-25 | 株式会社日立ハイテクノロジーズ | イオン濃度測定装置 |
KR101375547B1 (ko) * | 2007-06-19 | 2014-03-25 | 삼성전자주식회사 | 표준 전극이 포함된 전계 효과 트랜지스터 어레이를 이용한생체 분자의 검출 장치 및 방법 |
DE102007043132B4 (de) * | 2007-09-11 | 2012-07-26 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Biosensor und Verfahren zum Messen einer Konzentration eines Analyten in einem Medium |
JP2009092647A (ja) * | 2007-09-19 | 2009-04-30 | Hitachi High-Technologies Corp | 陰イオン濃度測定装置及び陰イオン濃度測定素子 |
EP2040067A3 (en) * | 2007-09-19 | 2013-01-02 | Hitachi High-Technologies Corporation | Anion concentration measuring device and element |
KR100882554B1 (ko) | 2007-11-08 | 2009-02-12 | 삼성전자주식회사 | 생분자 동정 방법 |
JP4731544B2 (ja) * | 2007-12-17 | 2011-07-27 | 株式会社日立製作所 | 生体分子検出装置及びそれを用いた生体分子検出方法 |
JP5159453B2 (ja) * | 2008-06-13 | 2013-03-06 | ローム株式会社 | イオンセンサ |
KR100987105B1 (ko) | 2008-06-19 | 2010-10-11 | 성균관대학교산학협력단 | 유기 전계효과 트랜지스터를 적용한 바이오센서 및 그제조방법 |
JP5467312B2 (ja) * | 2008-06-24 | 2014-04-09 | 独立行政法人物質・材料研究機構 | バイオセンサ、バイオセンサを用いた生体物質の検出方法、及びそのキット |
EP2982437B1 (en) * | 2008-06-25 | 2017-12-06 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale fet arrays |
US20100301398A1 (en) | 2009-05-29 | 2010-12-02 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
US20100137143A1 (en) | 2008-10-22 | 2010-06-03 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
KR101239137B1 (ko) | 2008-12-05 | 2013-03-07 | 한국전자통신연구원 | 바이오 센서 리더기 및 바이오 센서 리더기 시스템 |
US20100141280A1 (en) * | 2008-12-05 | 2010-06-10 | Electronics And Telecommunications Research Institute | Biosensor reader and biosensor reader system |
JP4958941B2 (ja) * | 2009-05-08 | 2012-06-20 | 株式会社日立製作所 | 分析用素子 |
US8776573B2 (en) | 2009-05-29 | 2014-07-15 | Life Technologies Corporation | Methods and apparatus for measuring analytes |
CN103189986A (zh) | 2010-06-30 | 2013-07-03 | 生命科技公司 | 用于检测和测量化学反应和化合物的晶体管电路 |
JP2013533482A (ja) | 2010-06-30 | 2013-08-22 | ライフ テクノロジーズ コーポレーション | イオン感応性電荷蓄積回路および方法 |
WO2012006222A1 (en) | 2010-07-03 | 2012-01-12 | Life Technologies Corporation | Chemically sensitive sensor with lightly doped drains |
US8373206B2 (en) * | 2010-07-20 | 2013-02-12 | Nth Tech Corporation | Biosensor apparatuses and methods thereof |
US9618475B2 (en) | 2010-09-15 | 2017-04-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes |
TWI432722B (zh) * | 2010-09-24 | 2014-04-01 | Tatung Co | 細胞測量系統 |
CN103299182A (zh) | 2010-09-24 | 2013-09-11 | 生命科技公司 | 匹配的晶体管对电路 |
GB2489504A (en) * | 2011-03-31 | 2012-10-03 | Sapient Sensors | A device for identifying the presence of a specific target molecule or biomarker by sensing an electrical property |
US9617590B2 (en) * | 2011-09-30 | 2017-04-11 | Stc.Unm | DNA sample preparation and sequencing |
US9970984B2 (en) | 2011-12-01 | 2018-05-15 | Life Technologies Corporation | Method and apparatus for identifying defects in a chemical sensor array |
JP5507534B2 (ja) * | 2011-12-05 | 2014-05-28 | 株式会社日立ハイテクノロジーズ | イオン濃度測定装置及びイオン濃度測定素子 |
US8747748B2 (en) | 2012-01-19 | 2014-06-10 | Life Technologies Corporation | Chemical sensor with conductive cup-shaped sensor surface |
US8821798B2 (en) | 2012-01-19 | 2014-09-02 | Life Technologies Corporation | Titanium nitride as sensing layer for microwell structure |
US8786331B2 (en) | 2012-05-29 | 2014-07-22 | Life Technologies Corporation | System for reducing noise in a chemical sensor array |
US10526218B2 (en) * | 2012-10-01 | 2020-01-07 | The Board Of Trustees Of The Leland Stanford Junior University | Flow control method and apparatuses |
US9080968B2 (en) | 2013-01-04 | 2015-07-14 | Life Technologies Corporation | Methods and systems for point of use removal of sacrificial material |
US9841398B2 (en) | 2013-01-08 | 2017-12-12 | Life Technologies Corporation | Methods for manufacturing well structures for low-noise chemical sensors |
US8841217B1 (en) | 2013-03-13 | 2014-09-23 | Life Technologies Corporation | Chemical sensor with protruded sensor surface |
US8963216B2 (en) | 2013-03-13 | 2015-02-24 | Life Technologies Corporation | Chemical sensor with sidewall spacer sensor surface |
US9116117B2 (en) | 2013-03-15 | 2015-08-25 | Life Technologies Corporation | Chemical sensor with sidewall sensor surface |
CN105283758B (zh) | 2013-03-15 | 2018-06-05 | 生命科技公司 | 具有一致传感器表面区域的化学传感器 |
WO2014149780A1 (en) | 2013-03-15 | 2014-09-25 | Life Technologies Corporation | Chemical sensor with consistent sensor surface areas |
CN103592353B (zh) * | 2013-11-13 | 2016-05-18 | 胡文闯 | 基于蜿蜒线形沟道离子敏感场效应晶体管的生物传感器 |
CN103604854B (zh) * | 2013-11-28 | 2016-08-17 | 胡文闯 | 基于离子敏感场效应晶体管的生物传感器阵列 |
US10006910B2 (en) | 2014-12-18 | 2018-06-26 | Agilome, Inc. | Chemically-sensitive field effect transistors, systems, and methods for manufacturing and using the same |
TWI794007B (zh) | 2014-12-18 | 2023-02-21 | 美商生命技術公司 | 積體電路裝置、感測器裝置及積體電路 |
US10020300B2 (en) | 2014-12-18 | 2018-07-10 | Agilome, Inc. | Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids |
US10429342B2 (en) | 2014-12-18 | 2019-10-01 | Edico Genome Corporation | Chemically-sensitive field effect transistor |
US10379079B2 (en) * | 2014-12-18 | 2019-08-13 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
US11782057B2 (en) | 2014-12-18 | 2023-10-10 | Cardea Bio, Inc. | Ic with graphene fet sensor array patterned in layers above circuitry formed in a silicon based cmos wafer |
US11921112B2 (en) | 2014-12-18 | 2024-03-05 | Paragraf Usa Inc. | Chemically-sensitive field effect transistors, systems, and methods for manufacturing and using the same |
US10077472B2 (en) | 2014-12-18 | 2018-09-18 | Life Technologies Corporation | High data rate integrated circuit with power management |
US9618474B2 (en) | 2014-12-18 | 2017-04-11 | Edico Genome, Inc. | Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids |
WO2016130753A1 (en) * | 2015-02-13 | 2016-08-18 | Desa Johann | Piezoelectric biochips having fluidic channels |
EP3459115A4 (en) * | 2016-05-16 | 2020-04-08 | Agilome, Inc. | GRAPHEN-FET DEVICES, SYSTEMS AND METHODS FOR USE THEREOF FOR SEQUENCING NUCLEIC ACIDS |
TWI635274B (zh) * | 2017-01-09 | 2018-09-11 | 麥博森股份有限公司 | 生物感測器裝置 |
EP3588075A4 (en) * | 2017-02-21 | 2021-01-06 | Provigate Inc. | HIGH SENSITIVITY BIOSENSOR |
EP3588076A4 (en) * | 2017-02-21 | 2020-12-30 | Provigate Inc. | ION SENSITIVE BIOCAPTER |
US11905552B2 (en) | 2017-08-04 | 2024-02-20 | Keck Graduate Institute Of Applied Life Sciences | Immobilized RNPs for sequence-specific nucleic acid capture and digital detection |
US11264653B2 (en) | 2017-10-16 | 2022-03-01 | Neapco Intellectual Property Holdings, Llc | Battery cell monitoring system |
JP6877394B2 (ja) * | 2018-09-18 | 2021-05-26 | 株式会社東芝 | ケミカルセンサ用液膜材料及びケミカルセンサ |
CN112864252A (zh) * | 2021-01-05 | 2021-05-28 | 上海应用技术大学 | 一种基于薄膜晶体管的dna传感器及其制备方法 |
CN117741117A (zh) * | 2023-05-08 | 2024-03-22 | 上海新势聚芯医疗科技有限公司 | 生物感测芯片、生物感测芯片制造方法及微流道系统 |
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US4020830A (en) * | 1975-03-12 | 1977-05-03 | The University Of Utah | Selective chemical sensitive FET transducers |
GB2096824A (en) * | 1981-04-09 | 1982-10-20 | Sibbald Alastair | Chemically sensitive field effect transistor |
US4490216A (en) * | 1983-02-03 | 1984-12-25 | Molecular Devices Corporation | Lipid membrane electroanalytical elements and method of analysis therewith |
GB8406955D0 (en) * | 1984-03-16 | 1984-04-18 | Serono Diagnostics Ltd | Assay |
EP0213825A3 (en) * | 1985-08-22 | 1989-04-26 | Molecular Devices Corporation | Multiple chemically modulated capacitance |
JPH07128279A (ja) * | 1993-06-25 | 1995-05-19 | Hitachi Ltd | 固体イオンセンサ |
EP0894148A4 (en) | 1996-04-17 | 1999-06-16 | Motorola Inc | MOLECULAR DETECTION, APPARATUS AND METHOD WITH INTEGRATED TRANSISTOR |
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JP3634086B2 (ja) * | 1996-08-13 | 2005-03-30 | 株式会社半導体エネルギー研究所 | 絶縁ゲイト型半導体装置の作製方法 |
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US20020179439A1 (en) * | 2001-05-31 | 2002-12-05 | Tsu-Tseng Weng | Microelectronic system and method of use and fabrication |
US20030073071A1 (en) * | 2001-10-12 | 2003-04-17 | Jurgen Fritz | Solid state sensing system and method for measuring the binding or hybridization of biomolecules |
AU2003210438A1 (en) * | 2002-01-04 | 2003-07-24 | Board Of Regents, The University Of Texas System | Droplet-based microfluidic oligonucleotide synthesis engine |
JP3917595B2 (ja) * | 2003-02-26 | 2007-05-23 | 株式会社東芝 | 核酸濃度定量分析チップ、核酸濃度定量分析装置および核酸濃度定量分析方法 |
KR100580621B1 (ko) * | 2003-03-07 | 2006-05-16 | 삼성전자주식회사 | 전도성 화합물, 이를 포함하는 전극 및 센서, 상기 센서를이용한 표적 물질 검출방법 |
JP2005077210A (ja) * | 2003-08-29 | 2005-03-24 | National Institute For Materials Science | 生体分子検出素子及びそれを用いた核酸解析方法 |
JP4751302B2 (ja) * | 2006-11-21 | 2011-08-17 | 株式会社日立製作所 | 電位差式センサ及び分析用素子 |
-
2004
- 2004-07-21 JP JP2004213130A patent/JP3874772B2/ja not_active Expired - Fee Related
-
2005
- 2005-03-07 EP EP05004939A patent/EP1619496B1/en not_active Not-in-force
- 2005-03-07 US US11/072,507 patent/US8383396B2/en not_active Expired - Fee Related
- 2005-03-07 DE DE602005001367T patent/DE602005001367T2/de active Active
Also Published As
Publication number | Publication date |
---|---|
EP1619496B1 (en) | 2007-06-13 |
DE602005001367D1 (de) | 2007-07-26 |
US20060016699A1 (en) | 2006-01-26 |
JP3874772B2 (ja) | 2007-01-31 |
EP1619496A1 (en) | 2006-01-25 |
JP2006030132A (ja) | 2006-02-02 |
US8383396B2 (en) | 2013-02-26 |
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Legal Events
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