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DE60130865D1 - Benzimidazol-derivate als menschliche chymase - inhibitoren - Google Patents

Benzimidazol-derivate als menschliche chymase - inhibitoren

Info

Publication number
DE60130865D1
DE60130865D1 DE60130865T DE60130865T DE60130865D1 DE 60130865 D1 DE60130865 D1 DE 60130865D1 DE 60130865 T DE60130865 T DE 60130865T DE 60130865 T DE60130865 T DE 60130865T DE 60130865 D1 DE60130865 D1 DE 60130865D1
Authority
DE
Germany
Prior art keywords
halo
optionally substituted
oxo
trihalomethyl
alk
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60130865T
Other languages
English (en)
Other versions
DE60130865T2 (de
Inventor
Naoki Tsuchiya
Yoshiyuki Matsumoto
Hiroshi Saitou
Tsuyoshi Mizuno
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Pharma Ltd
Original Assignee
Teijin Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Pharma Ltd filed Critical Teijin Pharma Ltd
Application granted granted Critical
Publication of DE60130865D1 publication Critical patent/DE60130865D1/de
Publication of DE60130865T2 publication Critical patent/DE60130865T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
DE60130865T 2000-01-17 2001-01-17 Benzimidazol-derivate als menschliche chymase - inhibitoren Expired - Lifetime DE60130865T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2000007533 2000-01-17
JP2000007533 2000-01-17
JP2000392303 2000-12-25
JP2000392303 2000-12-25
PCT/JP2001/000271 WO2001053291A1 (fr) 2000-01-17 2001-01-17 Derives benzimidazoles

Publications (2)

Publication Number Publication Date
DE60130865D1 true DE60130865D1 (de) 2007-11-22
DE60130865T2 DE60130865T2 (de) 2008-07-17

Family

ID=26583615

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60130865T Expired - Lifetime DE60130865T2 (de) 2000-01-17 2001-01-17 Benzimidazol-derivate als menschliche chymase - inhibitoren

Country Status (19)

Country Link
EP (1) EP1249450B1 (de)
JP (1) JP4059671B2 (de)
KR (2) KR100763779B1 (de)
CN (2) CN100415723C (de)
AT (1) ATE375156T1 (de)
AU (2) AU777813B2 (de)
CA (1) CA2396908A1 (de)
CZ (1) CZ301504B6 (de)
DE (1) DE60130865T2 (de)
DK (1) DK1249450T3 (de)
ES (1) ES2295128T3 (de)
HK (1) HK1050009A1 (de)
IL (1) IL150565A0 (de)
NO (1) NO324049B1 (de)
NZ (1) NZ520028A (de)
PT (1) PT1249450E (de)
RU (1) RU2263674C2 (de)
SI (1) SI1249450T1 (de)
WO (1) WO2001053291A1 (de)

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JP3999128B2 (ja) 2001-02-22 2007-10-31 帝人株式会社 ベンゾ［ｂ］チオフェン誘導体、およびその製造方法
CN1205204C (zh) 2001-05-07 2005-06-08 帝人株式会社 3－羟甲基－苯并[b]噻吩衍生物及其制备方法
NZ528291A (en) * 2001-08-24 2007-03-30 Teijin Ltd Drugs containing chymase inhibitor and ace inhibitor as the active ingredients
CL2004001034A1 (es) * 2003-05-14 2005-03-28 Teijin Pharma Ltd Formas cristalinas de acido 4-(1-((,etilbenzotiofen-3-il)me til)benzimidazol-2-iltio)butanoico; procedimiento de preparacion de las formas cristalinas; composicion farmaceutica; y su uso para el tratamiento de enfermedades inflamatorias, alergicas, r
KR20060120601A (ko) * 2003-08-22 2006-11-27 데이진 화-마 가부시키가이샤 키마제 저해제를 유효 성분으로서 함유하는 약제
JPWO2006052026A1 (ja) * 2004-11-12 2008-05-29 帝人ファーマ株式会社 ベンズイミダゾール誘導体の酸性塩及びその結晶
EP1915988A4 (de) 2005-08-18 2012-07-25 Teijin Pharma Ltd Tablette mit mehreren arzneihaltigen segmenten
CN102008392B (zh) 2005-08-18 2013-07-31 帝人制药株式会社 具有准确的用量分割功能的制剂
TW200734320A (en) 2005-10-27 2007-09-16 Teijin Pharma Ltd 3-Hydroxymethylbenzo [b] thiophen derivatives and a process for producing 3-hydroxymethylbenzo [b] thiophen derivatives
KR20080058435A (ko) 2005-10-27 2008-06-25 데이진 화-마 가부시키가이샤 벤조[ｂ]티오펜 유도체 및 그 제조 방법
PE20070698A1 (es) 2005-11-14 2007-08-17 Teijin Pharma Ltd Comprimido de disgregacion rapida intraoral que contiene hidrocloruro de ambroxol
UA95788C2 (en) * 2005-12-15 2011-09-12 Ф. Хоффманн-Ля Рош Аг Fused pyrrole derivatives
EP2152674B1 (de) 2007-05-22 2011-08-03 Boehringer Ingelheim International GmbH Benzimidazolonchymasehemmer
BRPI0812163A2 (pt) 2007-05-25 2014-12-16 Abbott Gmbh & Co Kg Compostos heterocíclicos como moduladores positivos do receptor metabotrópico de glutamato 2 (receptor mglu2)
WO2008153129A1 (ja) * 2007-06-14 2008-12-18 Teijin Pharma Limited 尿酸値低下剤
WO2009133964A1 (ja) * 2008-04-28 2009-11-05 国立大学法人九州大学 酸化ストレス抑制剤
WO2010030500A1 (en) * 2008-09-09 2010-03-18 Boehringer Ingelheim International Gmbh Aza-benzimidazolone chymase inhibitors
JP5764064B2 (ja) 2008-09-26 2015-08-12 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 抗糖尿病薬として有用な新規な環状ベンゾイミダゾール誘導体
CN102264228A (zh) 2008-10-22 2011-11-30 默沙东公司 用于抗糖尿病药的新的环状苯并咪唑衍生物
WO2010051176A1 (en) 2008-10-29 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
WO2010051206A1 (en) 2008-10-31 2010-05-06 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
EP2501697B1 (de) * 2009-11-18 2013-10-23 Neomed Institute Benzoimidazolverbindungen und ihre verwendungen
JP2013520502A (ja) 2010-02-25 2013-06-06 メルク・シャープ・エンド・ドーム・コーポレイション 有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体
EP2677869B1 (de) 2011-02-25 2017-11-08 Merck Sharp & Dohme Corp. Neue cyclische azabenzimidazolderivate als antidiabetika
CN104603127B (zh) * 2012-05-04 2016-10-05 诺华股份有限公司 补体途径调节剂及其应用
RU2015106909A (ru) 2012-08-02 2016-09-27 Мерк Шарп И Доум Корп. Антидиабетические трициклические соединения
ES2755087T3 (es) 2012-08-22 2020-04-21 Merck Sharp & Dohme Derivados de benzimidazol hexahidrofuro[3,2-b]furano útiles como activadores de proteína cinasa activada por AMP
EP2888007B1 (de) 2012-08-22 2019-09-18 Merck Sharp & Dohme Corp. Benzimidazoltetrahydrofuranderivate als amp-aktivierte proteinkinase-aktivatoren
EP2906040B1 (de) 2012-08-22 2021-02-17 Merck Sharp & Dohme Corp. Neuartige benzimidazoltetrahydropyranderivate
EP2888006B1 (de) 2012-08-22 2019-04-24 Merck Sharp & Dohme Corp. Neuartige azabenzimidazol-tetrahydropyran-derivate als ampk aktivatoren
WO2014031515A1 (en) 2012-08-22 2014-02-27 Merck Sharp & Dohme Corp. Novel azabenzimidazole hexahydrofuro[3,2-b]furan derivatives
WO2014031517A1 (en) 2012-08-22 2014-02-27 Merck Sharp & Dohme Corp. Novel azabenzimidazole tetrahydrofuran derivatives
US9650375B2 (en) 2013-03-14 2017-05-16 Merck Sharp & Dohme Corp. Indole derivatives useful as anti-diabetic agents
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
WO2015073342A1 (en) 2013-11-15 2015-05-21 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
WO2015089809A1 (en) 2013-12-19 2015-06-25 Merck Sharp & Dohme Corp. Antidiabetic substituted heteroaryl compounds
CN111004125B (zh) * 2019-12-24 2022-11-22 东华理工大学 一种缩醛或缩酮化合物的制备方法
CN116903541B (zh) * 2023-08-14 2023-12-08 中国环境科学研究院 用于酚类污染物检测的酰基咪唑类化合物、制备方法及应用

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Also Published As

Publication number Publication date
NZ520028A (en) 2004-07-30
CA2396908A1 (en) 2001-07-26
CN100415723C (zh) 2008-09-03
HK1050009A1 (en) 2003-06-06
NO20023415D0 (no) 2002-07-16
EP1249450B1 (de) 2007-10-10
AU2005200172B2 (en) 2007-08-23
CN1418211A (zh) 2003-05-14
NO324049B1 (no) 2007-08-06
AU2704901A (en) 2001-07-31
CN1198819C (zh) 2005-04-27
DK1249450T3 (da) 2008-02-11
EP1249450A1 (de) 2002-10-16
KR20070057276A (ko) 2007-06-04
AU777813B2 (en) 2004-11-04
RU2263674C2 (ru) 2005-11-10
RU2002122105A (ru) 2004-01-10
DE60130865T2 (de) 2008-07-17
ATE375156T1 (de) 2007-10-15
AU2005200172A1 (en) 2005-02-10
KR20020065929A (ko) 2002-08-14
NO20023415L (no) 2002-07-16
JP4059671B2 (ja) 2008-03-12
WO2001053291A1 (fr) 2001-07-26
IL150565A0 (en) 2003-02-12
PT1249450E (pt) 2008-01-02
EP1249450A4 (de) 2003-04-09
CN1680339A (zh) 2005-10-12
ES2295128T3 (es) 2008-04-16
CZ301504B6 (cs) 2010-03-24
KR100763779B1 (ko) 2007-10-05
SI1249450T1 (sl) 2008-04-30

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