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ATE375156T1 - Benzimidazol-derivate als menschliche chymase - inhibitoren - Google Patents

Benzimidazol-derivate als menschliche chymase - inhibitoren

Info

Publication number
ATE375156T1
ATE375156T1 AT01901397T AT01901397T ATE375156T1 AT E375156 T1 ATE375156 T1 AT E375156T1 AT 01901397 T AT01901397 T AT 01901397T AT 01901397 T AT01901397 T AT 01901397T AT E375156 T1 ATE375156 T1 AT E375156T1
Authority
AT
Austria
Prior art keywords
halo
optionally substituted
oxo
trihalomethyl
alk
Prior art date
Application number
AT01901397T
Other languages
English (en)
Inventor
Naoki Tsuchiya
Yoshiyuki Matsumoto
Hiroshi Saitou
Tsuyoshi Mizuno
Original Assignee
Teijin Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Pharma Ltd filed Critical Teijin Pharma Ltd
Application granted granted Critical
Publication of ATE375156T1 publication Critical patent/ATE375156T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
AT01901397T 2000-01-17 2001-01-17 Benzimidazol-derivate als menschliche chymase - inhibitoren ATE375156T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000007533 2000-01-17
JP2000392303 2000-12-25

Publications (1)

Publication Number Publication Date
ATE375156T1 true ATE375156T1 (de) 2007-10-15

Family

ID=26583615

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01901397T ATE375156T1 (de) 2000-01-17 2001-01-17 Benzimidazol-derivate als menschliche chymase - inhibitoren

Country Status (19)

Country Link
EP (1) EP1249450B1 (de)
JP (1) JP4059671B2 (de)
KR (2) KR100763779B1 (de)
CN (2) CN1198819C (de)
AT (1) ATE375156T1 (de)
AU (2) AU777813B2 (de)
CA (1) CA2396908A1 (de)
CZ (1) CZ301504B6 (de)
DE (1) DE60130865T2 (de)
DK (1) DK1249450T3 (de)
ES (1) ES2295128T3 (de)
HK (1) HK1050009A1 (de)
IL (1) IL150565A0 (de)
NO (1) NO324049B1 (de)
NZ (1) NZ520028A (de)
PT (1) PT1249450E (de)
RU (1) RU2263674C2 (de)
SI (1) SI1249450T1 (de)
WO (1) WO2001053291A1 (de)

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EP1362854B1 (de) * 2001-02-22 2007-10-31 Teijin Pharma Limited Benzo[b[thiophenderivate und Verfahren zu deren Herstellung
NZ523407A (en) * 2001-05-07 2005-04-29 Teijin Ltd 3-Hydroxymethyl-benzo[b]thiophene derivatives and process for making the same
US20040122042A1 (en) * 2001-08-24 2004-06-24 Hidenori Urata Drugs containing chymase inhibitor and ace inhibitors as the active ingredients
CL2004001034A1 (es) * 2003-05-14 2005-03-28 Teijin Pharma Ltd Formas cristalinas de acido 4-(1-((,etilbenzotiofen-3-il)me til)benzimidazol-2-iltio)butanoico; procedimiento de preparacion de las formas cristalinas; composicion farmaceutica; y su uso para el tratamiento de enfermedades inflamatorias, alergicas, r
EP1666067A4 (de) * 2003-08-22 2009-07-22 Teijin Pharma Ltd Arzneimittel mit chymase-hemmer als wirkstoff
JPWO2006052026A1 (ja) * 2004-11-12 2008-05-29 帝人ファーマ株式会社 ベンズイミダゾール誘導体の酸性塩及びその結晶
US20090155361A1 (en) 2005-08-18 2009-06-18 Masahiko Narasaki Tablet with multiple drug-containing sections
CN101291656B (zh) 2005-08-18 2012-11-07 帝人制药株式会社 具有准确的用量分割功能的制剂
US20090299074A1 (en) 2005-10-27 2009-12-03 Teijin Pharma Limited BENZO[b]THIOPHEN DERIVATIVES AND PROCESS FOR THEIR PRODUCTION
EP1947096A1 (de) 2005-10-27 2008-07-23 Teijin Pharma Limited 3-HYDROXYMETHYLBENZO[b]THIOPHENDERIVAT UND VERFAHREN ZU DESSEN HERSTELLUNG
PE20070698A1 (es) 2005-11-14 2007-08-17 Teijin Pharma Ltd Comprimido de disgregacion rapida intraoral que contiene hidrocloruro de ambroxol
UA95788C2 (en) * 2005-12-15 2011-09-12 Ф. Хоффманн-Ля Рош Аг Fused pyrrole derivatives
EP2152674B1 (de) 2007-05-22 2011-08-03 Boehringer Ingelheim International GmbH Benzimidazolonchymasehemmer
CA2686651C (en) * 2007-05-25 2015-11-24 Abbott Gmbh & Co. Kg Heterocyclic compounds as positive modulators of metabotropic glutamate receptor 2 (mglu2 receptor)
WO2008153129A1 (ja) * 2007-06-14 2008-12-18 Teijin Pharma Limited 尿酸値低下剤
WO2009133964A1 (ja) * 2008-04-28 2009-11-05 国立大学法人九州大学 酸化ストレス抑制剤
US9062056B2 (en) 2008-09-09 2015-06-23 Boehringer Ingelheim International Gmbh Aza-benzimidazolone Chymase inhibitors
WO2010036613A1 (en) 2008-09-26 2010-04-01 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
US8410284B2 (en) 2008-10-22 2013-04-02 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
MX2011004505A (es) 2008-10-29 2011-05-31 Merck Sharp & Dohme Derivados novedosos de bencimidazol ciclico, utiles como agentes antidiabeticos.
CN102271509A (zh) 2008-10-31 2011-12-07 默沙东公司 用于抗糖尿病药的新型环苯并咪唑衍生物
BR112012011518B8 (pt) * 2009-11-18 2023-01-10 Astrazeneca Ab Compostos, composição farmacêutica, kit e usos de um composto
CA2786314A1 (en) 2010-02-25 2011-09-01 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
CN103476258B (zh) 2011-02-25 2017-04-26 默沙东公司 用作抗糖尿病药剂的新的环状氮杂苯并咪唑衍生物
AP2014008040A0 (en) * 2012-05-04 2014-10-31 Novartis Ag Complement pathway modulators and uses thereof
CA2880901A1 (en) 2012-08-02 2014-02-06 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
CA2881836A1 (en) 2012-08-22 2014-02-27 James M. Apgar Novel azabenzimidazole hexahydrofuro[3,2-b]furan derivatives
US9868733B2 (en) 2012-08-22 2018-01-16 Merck Sharp & Dohme Corp. Azabenzimidazole tetrahydrofuran derivatives
WO2014031465A1 (en) 2012-08-22 2014-02-27 Merck Sharp & Dohme Corp. Novel azabenzimidazole tetrahydropyran derivatives
EP2887807B1 (de) 2012-08-22 2019-09-18 Merck Sharp & Dohme Corp. Benzimidazol-hexahydrofuro[3,2-b]furanderivate als amp-aktivierte proteinkinase-aktivatoren
US9540364B2 (en) 2012-08-22 2017-01-10 Merck Sharp & Dohme Corp. Benzimidazole tetrahydrofuran derivatives
EP2906040B1 (de) 2012-08-22 2021-02-17 Merck Sharp & Dohme Corp. Neuartige benzimidazoltetrahydropyranderivate
EP2970119B1 (de) 2013-03-14 2021-11-03 Merck Sharp & Dohme Corp. Neuartige indolderivate als antidiabetika
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
ES2747973T3 (es) 2013-11-15 2020-03-12 Merck Sharp & Dohme Compuestos tricíclicos antidiabéticos
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Also Published As

Publication number Publication date
CA2396908A1 (en) 2001-07-26
JP4059671B2 (ja) 2008-03-12
NO20023415D0 (no) 2002-07-16
AU777813B2 (en) 2004-11-04
EP1249450A1 (de) 2002-10-16
NZ520028A (en) 2004-07-30
RU2002122105A (ru) 2004-01-10
CN100415723C (zh) 2008-09-03
CN1418211A (zh) 2003-05-14
NO324049B1 (no) 2007-08-06
EP1249450B1 (de) 2007-10-10
DE60130865T2 (de) 2008-07-17
CN1198819C (zh) 2005-04-27
CN1680339A (zh) 2005-10-12
KR20020065929A (ko) 2002-08-14
KR20070057276A (ko) 2007-06-04
EP1249450A4 (de) 2003-04-09
IL150565A0 (en) 2003-02-12
PT1249450E (pt) 2008-01-02
CZ301504B6 (cs) 2010-03-24
SI1249450T1 (sl) 2008-04-30
DE60130865D1 (de) 2007-11-22
AU2005200172A1 (en) 2005-02-10
DK1249450T3 (da) 2008-02-11
ES2295128T3 (es) 2008-04-16
AU2704901A (en) 2001-07-31
RU2263674C2 (ru) 2005-11-10
AU2005200172B2 (en) 2007-08-23
HK1050009A1 (en) 2003-06-06
NO20023415L (no) 2002-07-16
KR100763779B1 (ko) 2007-10-05
WO2001053291A1 (fr) 2001-07-26

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