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DE60039111D1 - Agonisten des rezeptors 3 (r3) von pituitary adenylate cyclase aktivierendem peptid (pacap) und ihre pharmakologische verwendung - Google Patents

Agonisten des rezeptors 3 (r3) von pituitary adenylate cyclase aktivierendem peptid (pacap) und ihre pharmakologische verwendung

Info

Publication number
DE60039111D1
DE60039111D1 DE60039111T DE60039111T DE60039111D1 DE 60039111 D1 DE60039111 D1 DE 60039111D1 DE 60039111 T DE60039111 T DE 60039111T DE 60039111 T DE60039111 T DE 60039111T DE 60039111 D1 DE60039111 D1 DE 60039111D1
Authority
DE
Germany
Prior art keywords
peptides
pacap
agonists
receptor
insulin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60039111T
Other languages
English (en)
Inventor
Clark Pan
Manami Tsutsumi
Armen B Shanafelt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Corp filed Critical Bayer Corp
Application granted granted Critical
Publication of DE60039111D1 publication Critical patent/DE60039111D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE60039111T 1999-09-28 2000-09-27 Agonisten des rezeptors 3 (r3) von pituitary adenylate cyclase aktivierendem peptid (pacap) und ihre pharmakologische verwendung Expired - Lifetime DE60039111D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40783299A 1999-09-28 1999-09-28
US59528000A 2000-06-15 2000-06-15
PCT/US2000/026638 WO2001023420A2 (en) 1999-09-28 2000-09-27 Pituitary adenylate cyclase activating peptide (pacap) receptor 3 (r3) agonists and their pharmacological methods of use

Publications (1)

Publication Number Publication Date
DE60039111D1 true DE60039111D1 (de) 2008-07-17

Family

ID=27020026

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60039111T Expired - Lifetime DE60039111D1 (de) 1999-09-28 2000-09-27 Agonisten des rezeptors 3 (r3) von pituitary adenylate cyclase aktivierendem peptid (pacap) und ihre pharmakologische verwendung

Country Status (19)

Country Link
EP (1) EP1192182B1 (de)
AT (1) ATE397625T1 (de)
AU (1) AU7726600A (de)
CA (1) CA2379604A1 (de)
CO (1) CO5280048A1 (de)
CZ (1) CZ296858B6 (de)
DE (1) DE60039111D1 (de)
DO (1) DOP2000000071A (de)
ES (1) ES2307534T3 (de)
GT (1) GT200000162A (de)
HU (1) HUP0202175A3 (de)
MY (1) MY131983A (de)
PE (1) PE20010612A1 (de)
RU (1) RU2269354C2 (de)
SK (1) SK5552002A3 (de)
SV (1) SV2002000184A (de)
TW (1) TWI264438B (de)
UY (1) UY26360A1 (de)
WO (1) WO2001023420A2 (de)

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Publication number Priority date Publication date Assignee Title
UA74912C2 (en) 2001-07-06 2006-02-15 Merck & Co Inc Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
EP1476178A4 (de) * 2002-02-14 2009-08-26 Bayer Pharmaceuticals Corp Formulierungsstrategien zur stabilisierung von peptiden in organischen lösungsmitteln und in getrockneten zuständen
WO2004062684A2 (en) * 2003-01-16 2004-07-29 D. Collen Research Foundation Vzw Onderwijs En Navorsing Campus Gasthuisberg K.U. Leuven Treatment of thrombocytopenia with inhibitors of pacap
CA2510040C (en) 2003-05-23 2012-01-03 Nektar Therapeutics Al, Corporation Polymeric reagents and polymer-biomolecule conjugates comprising carbamate linkages
US7947261B2 (en) 2003-05-23 2011-05-24 Nektar Therapeutics Conjugates formed from polymer derivatives having particular atom arrangements
AU2005208911A1 (en) * 2004-01-27 2005-08-11 Bayer Healthcare Llc Pituitary adenylate cyclase activating peptide (PACAP) receptor (VPAC2) agonists and their pharmacological methods of use
EP1756156B1 (de) * 2004-05-21 2008-10-22 Eli Lilly And Company Selektive peptidische agonisten des vpac2-rezeptors
US20080096811A1 (en) * 2004-05-21 2008-04-24 Eli Lilly And Company Selective vpac2 receptor peptide agonists
CA2575101A1 (en) * 2004-06-12 2005-12-29 Bayer Pharmaceuticals Corporation Pegylation of vasoactive intestinal peptide (vip)/pituitary adenylate cyclase activating peptide (pacap) receptor 2 (vpac2) agonists and methods of use
WO2006023359A2 (en) * 2004-08-18 2006-03-02 Eli Lilly And Company Selective vpac2 receptor peptide agonists
US7595294B2 (en) * 2004-10-08 2009-09-29 Transition Therapeutics, Inc. Vasoactive intestinal polypeptide pharmaceuticals
KR20070067136A (ko) * 2004-10-08 2007-06-27 포베스 메디-테크 (리서치) 인코포레이티드 혈관작용성 장내 폴리펩티드 제약
SI1853266T1 (sl) 2005-01-10 2012-02-29 Cortendo Ab Publ 2S,4R ketokonazol za zdravljenje diabetesa, metabolnega sindroma in drugih stanj
EP1896048A4 (de) * 2005-05-06 2010-11-03 Bayer Pharmaceuticals Corp Pacap (pituitary adenylate cyclase activating peptide)-rezeptor (vpac2)-agonisten und ihre pharmakologischen anwendungsverfahren
EP1915393A1 (de) * 2005-08-11 2008-04-30 Eli Lilly And Company Selektive vpac2-rezeptor-peptidagonisten
US7582608B2 (en) 2005-10-26 2009-09-01 Eli Lilly And Company Selective VPAC2 receptor peptide agonists
EP1801098A1 (de) 2005-12-16 2007-06-27 Merck Sante 2-Adamantylharnstoff Derivative als selektive 11B-HSD1 Inhibitoren
TW200745163A (en) * 2006-02-17 2007-12-16 Syntonix Pharmaceuticals Inc Peptides that block the binding of IgG to FcRn
US9198906B2 (en) 2006-10-02 2015-12-01 Cortendo Ab (Publ) Ketoconazole enantiomer in humans
EP1935420A1 (de) 2006-12-21 2008-06-25 Merck Sante 2-Adamantyl-Butyramid Derivate als selektive 11Beta-HSD1 Inhibitoren
EP2110374A1 (de) 2008-04-18 2009-10-21 Merck Sante Benzofuran, Benzothiophen, Benzothiazolderivate als FXR-Modulatoren
CA2729327C (en) 2008-06-27 2016-10-11 Xenon Pharmaceuticals Inc. Heterocyclic derivatives that modulate the activity of stearoyl-coa desaturase
AU2009314200B2 (en) 2008-11-17 2011-11-17 Merck Sharp & Dohme Corp. Substituted bicyclic amines for the treatment of diabetes
US20120010135A1 (en) 2009-04-01 2012-01-12 Xenon Pharmaceuticals Inc. Spiro derivatives for the modulation of stearoyl-coa desaturase
US20120220567A1 (en) 2009-07-23 2012-08-30 Shipps Jr Gerald W Benzo-fused oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors
WO2011011506A1 (en) 2009-07-23 2011-01-27 Schering Corporation Spirocyclic oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors
PE20121439A1 (es) 2009-10-01 2012-11-06 Novartis Ag Derivados de pirazol que modulan la estearoil-coa-desaturasa
AU2010317842A1 (en) 2009-11-16 2012-07-12 Mellitech [1,5]-diazocin derivatives
CN102791701B (zh) 2009-12-30 2014-02-12 深圳信立泰药业股份有限公司 作为二肽基肽酶iv(dpp-iv)抑制剂的3-(3-氨基哌啶-1-基)-5-氧代-1,2,4-三嗪衍生物
CU24075B1 (es) * 2011-08-26 2015-01-29 Ct De Ingeniería Genética Y Biotecnología Composición vacunal que comprende el péptido activador de la adenilato ciclasa de pituitaria como adyuvante molecular.
KR20140145624A (ko) 2012-04-16 2014-12-23 카네크 파마 인코포레이티드 Ptp-1b 억제제에 대한 전구체로서의 융합된 방향족 포스포네이트 유도체
WO2015023890A1 (en) * 2013-08-14 2015-02-19 The Arizona Board Of Regents On Behalf Of The University Of Arizona Glycosylated pacap/vip analogues with enhanced cns penetration for treatment of neurodegenerative diseases
US9833463B2 (en) 2014-04-17 2017-12-05 Merck Sharp & Dohme Corp. Sitagliptin tannate complex
JP6917899B2 (ja) 2015-04-16 2021-08-11 ハー・ルンドベック・アクチエゼルスカベット 抗ｐａｃａｐ抗体及びそれらの使用
SG10202109691UA (en) 2016-04-15 2021-10-28 Alder Biopharmaceuticals Inc Anti-pacap antibodies and uses thereof
EP3863634A1 (de) 2018-10-12 2021-08-18 Strongbridge Dublin Limited Levoketoconazol zur behandlung von kongenitaler adrenalhyperplasie und primärem aldosteronismus

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0522159B1 (de) * 1990-03-17 2001-12-12 Takeda Chemical Industries, Ltd. Antikörper gegen hypophysäre adenylatzyklase aktivierende peptid-pacap, hybridome und bestimmung von pacap
AU656230B2 (en) * 1991-10-11 1995-01-27 F. Hoffmann-La Roche Ag Cyclic vasoactive peptides
WO1996041814A1 (fr) * 1995-06-09 1996-12-27 Itoham Foods Inc. Peptide, bronchodilatateur et agent facilitant l'ecoulement sanguin
WO1998002453A2 (en) * 1996-07-15 1998-01-22 Universite Libre De Bruxelles Peptidic ligands having a higher selectivity for the vip1 receptor than for the vip2 receptor
FR2775902B1 (fr) * 1998-03-13 2001-05-11 Assist Publ Hopitaux De Paris Utilisation d'analogues du vip dans la prevention et le traitement des lesions cerebrales du nouveau-ne humain
EP2161282A1 (de) * 1998-07-20 2010-03-10 Ipsen Pharma PACAP-Peptidanaloge

Also Published As

Publication number Publication date
TWI264438B (en) 2006-10-21
SV2002000184A (es) 2002-06-07
UY26360A1 (es) 2001-04-30
HUP0202175A2 (en) 2002-10-28
EP1192182B1 (de) 2008-06-04
ATE397625T1 (de) 2008-06-15
CZ20021085A3 (cs) 2003-01-15
MY131983A (en) 2007-09-28
ES2307534T3 (es) 2008-12-01
HUP0202175A3 (en) 2005-01-28
WO2001023420A2 (en) 2001-04-05
EP1192182A2 (de) 2002-04-03
SK5552002A3 (en) 2003-05-02
CA2379604A1 (en) 2001-04-05
GT200000162A (es) 2002-03-22
AU7726600A (en) 2001-04-30
WO2001023420A3 (en) 2001-08-30
RU2269354C2 (ru) 2006-02-10
PE20010612A1 (es) 2001-07-12
CZ296858B6 (cs) 2006-07-12
CO5280048A1 (es) 2003-05-30
DOP2000000071A (es) 2002-02-28

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