DE60013338D1 - Stickstoffmonoxidmetabolit-Polyoxyalkylen-Hämoglobin Komplex - Google Patents
Stickstoffmonoxidmetabolit-Polyoxyalkylen-Hämoglobin KomplexInfo
- Publication number
- DE60013338D1 DE60013338D1 DE60013338T DE60013338T DE60013338D1 DE 60013338 D1 DE60013338 D1 DE 60013338D1 DE 60013338 T DE60013338 T DE 60013338T DE 60013338 T DE60013338 T DE 60013338T DE 60013338 D1 DE60013338 D1 DE 60013338D1
- Authority
- DE
- Germany
- Prior art keywords
- polyoxyalkylene
- hemoglobin complex
- nitric monoxide
- monoxide metabolite
- metabolite
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical class [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 title 1
- 102000001554 Hemoglobins Human genes 0.000 title 1
- 108010054147 Hemoglobins Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11067239A JP2000230000A (ja) | 1999-02-08 | 1999-02-08 | 一酸化窒素代謝物−ポリオキシアルキレン−ヘモグロビン結合体 |
| JP6723999 | 1999-02-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60013338D1 true DE60013338D1 (de) | 2004-10-07 |
| DE60013338T2 DE60013338T2 (de) | 2005-09-08 |
Family
ID=13339178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60013338T Expired - Fee Related DE60013338T2 (de) | 1999-02-08 | 2000-02-08 | Stickstoffmonoxidmetabolit-Polyoxyalkylen-Hämoglobin Komplex |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US6667292B1 (de) |
| EP (1) | EP1029551B1 (de) |
| JP (1) | JP2000230000A (de) |
| DE (1) | DE60013338T2 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4841066B2 (ja) * | 2000-09-01 | 2011-12-21 | ライスユニバーシティ | 酸化窒素生成ヒドロゲル物質 |
| JP4412461B2 (ja) * | 2002-11-20 | 2010-02-10 | 日油株式会社 | 修飾された生体関連物質、その製造方法および中間体 |
| US8828373B2 (en) * | 2002-11-20 | 2014-09-09 | Nof Corporation | Polyalkylene glycol derivative and modified bio-related substance |
| US8003117B2 (en) * | 2002-11-20 | 2011-08-23 | Nof Corporation | Polyalkylene glycol derivative and modified bio-related substance |
| SG10201806917PA (en) | 2013-10-15 | 2018-09-27 | Seattle Genetics Inc | Pegylated drug-linkers for improved ligand-drug conjugate pharmacokinetics |
| GB201506236D0 (en) * | 2015-04-13 | 2015-05-27 | Jellagen Pty Ltd | Modified collagen, methods of manufacture thereof |
| WO2017165851A1 (en) | 2016-03-25 | 2017-09-28 | Seattle Genetics, Inc. | Process for the preparation of pegylated drug-linkers and intermediates thereof |
| EP3600443A1 (de) | 2017-03-24 | 2020-02-05 | Seattle Genetics, Inc. | Verfahren zur herstellung von glucuronidwirkstoff-linkern und zwischenprodukten davon |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6023084B2 (ja) * | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| JPS57206622A (en) * | 1981-06-10 | 1982-12-18 | Ajinomoto Co Inc | Blood substitute |
| JPS6153223A (ja) | 1984-08-22 | 1986-03-17 | Ajinomoto Co Inc | ヘモグロビン−ポリアルキレングリコ−ル結合体の製造方法 |
| DE3675588D1 (de) | 1985-06-19 | 1990-12-20 | Ajinomoto Kk | Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist. |
| US5840701A (en) | 1993-08-16 | 1998-11-24 | Hsia; Jen-Chang | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules |
| US5804561A (en) * | 1993-08-16 | 1998-09-08 | Hsia; Jen-Chang | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules |
| TW381022B (en) | 1993-08-16 | 2000-02-01 | Hsia Jen Chang | Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute |
| WO1996030006A1 (en) * | 1995-03-24 | 1996-10-03 | Brigham And Women's Hospital | Nitrosylated blood substitutes |
| WO1997018000A1 (en) * | 1995-11-13 | 1997-05-22 | Brigham And Women's Hospital | S-nitroso-hemoglobin and therapeutic uses thereof |
| AU6150298A (en) | 1997-02-06 | 1998-08-26 | Duke University Medical Center | No-modified hemoglobins and uses therefor |
-
1999
- 1999-02-08 JP JP11067239A patent/JP2000230000A/ja active Pending
-
2000
- 2000-02-08 DE DE60013338T patent/DE60013338T2/de not_active Expired - Fee Related
- 2000-02-08 EP EP00102156A patent/EP1029551B1/de not_active Expired - Lifetime
- 2000-02-08 US US09/499,758 patent/US6667292B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1029551A3 (de) | 2001-03-07 |
| EP1029551B1 (de) | 2004-09-01 |
| DE60013338T2 (de) | 2005-09-08 |
| JP2000230000A (ja) | 2000-08-22 |
| EP1029551A2 (de) | 2000-08-23 |
| US6667292B1 (en) | 2003-12-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |