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DE59006037D1 - Verfahren zur Herstellung von 1-(Aminomethyl)cyclohexanessigsäure. - Google Patents

Verfahren zur Herstellung von 1-(Aminomethyl)cyclohexanessigsäure.

Info

Publication number
DE59006037D1
DE59006037D1 DE59006037T DE59006037T DE59006037D1 DE 59006037 D1 DE59006037 D1 DE 59006037D1 DE 59006037 T DE59006037 T DE 59006037T DE 59006037 T DE59006037 T DE 59006037T DE 59006037 D1 DE59006037 D1 DE 59006037D1
Authority
DE
Germany
Prior art keywords
cyanocyclohexyl
aminomethyl
preparation
acetic acid
cyclohexane acetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE59006037T
Other languages
German (de)
English (en)
Inventor
Hans Peter Dr Mettler
Felix Dr Previdoli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG filed Critical Lonza AG
Application granted granted Critical
Publication of DE59006037D1 publication Critical patent/DE59006037D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/45Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04Formation of amino groups in compounds containing carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/28Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
DE59006037T 1989-11-16 1990-11-14 Verfahren zur Herstellung von 1-(Aminomethyl)cyclohexanessigsäure. Expired - Fee Related DE59006037D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH412889 1989-11-16

Publications (1)

Publication Number Publication Date
DE59006037D1 true DE59006037D1 (de) 1994-07-14

Family

ID=4270351

Family Applications (1)

Application Number Title Priority Date Filing Date
DE59006037T Expired - Fee Related DE59006037D1 (de) 1989-11-16 1990-11-14 Verfahren zur Herstellung von 1-(Aminomethyl)cyclohexanessigsäure.

Country Status (14)

Country Link
US (2) US5095148A (no)
EP (1) EP0432504B1 (no)
JP (1) JPH03176459A (no)
AT (1) ATE106861T1 (no)
CA (1) CA2030107A1 (no)
DE (1) DE59006037D1 (no)
DK (1) DK0432504T3 (no)
ES (1) ES2057334T3 (no)
FI (1) FI905584A (no)
IL (1) IL96360A0 (no)
NO (1) NO177531C (no)
PT (1) PT95894B (no)
RU (1) RU2029761C1 (no)
YU (1) YU215290A (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ293759B6 (cs) * 1996-03-14 2004-07-14 Warner-Lambert Company Substituovaná cyklická aminokyselina, její použití a farmaceutický prostředek na její bázi
US6372792B1 (en) 1996-04-26 2002-04-16 Guy Chouinard Method for treating anxiety, anxiety disorders and insomnia
US6255526B1 (en) 1996-12-24 2001-07-03 Teva Pharmaceutical Industries Ltd. Preparation of gabapentin
WO1999018063A2 (en) 1997-10-07 1999-04-15 Warner-Lambert Company Process for preparing a cyclic amino acid anticonvulsant compound
HU225502B1 (en) * 1998-12-29 2007-01-29 Richter Gedeon Vegyeszet Process for producing 1-(amino-metyl)-cyclohexene-acetic-acid and intermediates
CZ200339A3 (cs) * 2000-06-16 2003-06-18 Teva Pharmaceutical Industries Ltd. Stabilní gabapentin vykazující neutrální pH
AU2003262383A1 (en) * 2002-04-16 2003-11-03 Taro Pharmaceutical Industries Ltd. Process for preparing gabapentin
AU2002356424A1 (en) * 2002-11-18 2004-06-15 Nicholas Piramal India Limited Improved process for preparation of gabapentin
EP1628656B1 (en) * 2003-03-25 2008-10-15 Kiel Laboratories, Inc. Gabapentin tannate in liquid and/or semi-solid dosage forms
EP1622603A4 (en) 2003-03-25 2010-03-24 Kiel Lab Inc GABAPENTINIC PHENOLIC ACID SALTS IN SOLID DOSAGE FORMS AND METHODS OF USE
WO2004093866A1 (en) * 2003-03-25 2004-11-04 Kiel Laboratories, Inc. Process for preparing phenolic acid salts of gabapentin
US7439387B2 (en) * 2003-04-21 2008-10-21 Matrix Laboratories Ltd. Process for the preparation of Gabapentin form-II
US20050187295A1 (en) * 2004-02-19 2005-08-25 Surendra Kalyan Processes for the preparation of gabapentin
GB0416228D0 (en) 2004-07-20 2004-08-25 Sandoz Ind Products S A Process for the preparation of gabapentin
EP2038249B1 (en) * 2006-06-30 2013-09-11 ZaCh System S.p.A. Process for preparing gabapentin
CN101585778B (zh) * 2008-05-19 2014-08-13 上海臣邦医药科技有限公司 一种普瑞巴林制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2264354A (en) * 1937-12-22 1941-12-02 Ig Farbenindustrie Ag Addition products of dienes and unsaturated esters, ketones, or nitriles
US2467927A (en) * 1947-05-29 1949-04-19 Goodrich Co B F Preparation of monomeric alkyl alpha-cyano-acrylates
DE2460891C2 (de) * 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2611690A1 (de) * 1976-03-19 1977-09-22 Goedecke Ag Cyclische sulfonyloxyimide
YU162789A (en) * 1988-09-01 1990-12-31 Lonza Ag 2-aza-4-(alcoxycarbonyl) spiro/4,5/decan-3-ones
AU633612B2 (en) * 1989-08-25 1993-02-04 Warner-Lambert Company Improved process for cyclic amino acid anticonvulsant compounds

Also Published As

Publication number Publication date
NO177531B (no) 1995-06-26
NO177531C (no) 1995-10-04
US5095148A (en) 1992-03-10
NO904953D0 (no) 1990-11-15
PT95894A (pt) 1991-09-13
EP0432504B1 (de) 1994-06-08
ES2057334T3 (es) 1994-10-16
IL96360A0 (en) 1991-08-16
ATE106861T1 (de) 1994-06-15
CA2030107A1 (en) 1991-05-17
EP0432504A1 (de) 1991-06-19
YU215290A (sh) 1993-05-28
RU2029761C1 (ru) 1995-02-27
NO904953L (no) 1991-05-21
FI905584A0 (fi) 1990-11-12
DK0432504T3 (da) 1994-07-04
FI905584A (fi) 1991-05-17
PT95894B (pt) 1998-01-30
JPH03176459A (ja) 1991-07-31
US5130455A (en) 1992-07-14

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee