DE3586224D1 - 3-carbonyl-1-aminoalkyl-1h-indole, verwendbar als analgetika und ihre herstellung. - Google Patents

3-carbonyl-1-aminoalkyl-1h-indole, verwendbar als analgetika und ihre herstellung.

Info

Publication number: DE3586224D1
Authority: DE; Germany
Prior art keywords: analgetic; aminoalkyl; indole; carbonyl; production
Prior art date: 1984-08-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE8585109689T

Other languages

English (en)

Other versions

DE3586224T2 (de

Inventor

Malcolm Rice Bell

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanofi Aventis France

Original Assignee

Sterling Winthrop Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-08-06

Filing date

1985-08-01

Publication date

1992-07-23

1985-08-01 Application filed by Sterling Winthrop Inc filed Critical Sterling Winthrop Inc

1992-07-23 Publication of DE3586224D1 publication Critical patent/DE3586224D1/de

1993-01-28 Application granted granted Critical

1993-01-28 Publication of DE3586224T2 publication Critical patent/DE3586224T2/de

2005-08-02 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Pain & Pain Management (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Rheumatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DE8585109689T 1984-08-06 1985-08-01 3-carbonyl-1-aminoalkyl-1h-indole, verwendbar als analgetika und ihre herstellung. Expired - Fee Related DE3586224T2 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US63793184A	1984-08-06	1984-08-06

Publications (2)

Publication Number	Publication Date
DE3586224D1 true DE3586224D1 (de)	1992-07-23
DE3586224T2 DE3586224T2 (de)	1993-01-28

Family

ID=24557949

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE8585109689T Expired - Fee Related DE3586224T2 (de)	1984-08-06	1985-08-01	3-carbonyl-1-aminoalkyl-1h-indole, verwendbar als analgetika und ihre herstellung.

Country Status (20)

Country	Link
EP (1)	EP0171037B1 (de)
JP (1)	JPH0670010B2 (de)
KR (1)	KR870000548B1 (de)
AR (1)	AR244665A1 (de)
AT (1)	ATE77371T1 (de)
AU (1)	AU574817B2 (de)
DE (1)	DE3586224T2 (de)
DK (1)	DK170279B1 (de)
ES (5)	ES8609246A1 (de)
FI (1)	FI852973L (de)
GR (1)	GR851937B (de)
IE (1)	IE57863B1 (de)
IL (1)	IL75966A (de)
MX (4)	MX160612A (de)
MY (1)	MY101186A (de)
NO (1)	NO169067C (de)
NZ (3)	NZ225467A (de)
PH (2)	PH23498A (de)
PT (1)	PT80919B (de)
ZA (1)	ZA855923B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8623819D0 (en) *	1986-10-03	1986-11-05	Glaxo Group Ltd	Heterocyclic compounds
US4840950A (en) *	1987-02-11	1989-06-20	Sterling Drug Inc.	4-arylcarbonyl-1-[(4-morpholinyl)-lower-alkyl]-1H-indoles
US5068234A (en) *	1990-02-26	1991-11-26	Sterling Drug Inc.	3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles
GB9011335D0 (en) *	1990-05-21	1990-07-11	Fujisawa Pharmaceutical Co	Indolebutyric acid derivatives and process for preparation thereof
US5312829A (en) *	1990-05-21	1994-05-17	Fujisawa Pharmaceutical Co., Ltd.	Indole derivatives
GB9204365D0 (en) *	1992-02-28	1992-04-08	Pfizer Ltd	Indoles
TW270114B (de) *	1993-10-22	1996-02-11	Hoffmann La Roche
US5486525A (en) *	1993-12-16	1996-01-23	Abbott Laboratories	Platelet activating factor antagonists: imidazopyridine indoles
KR20020035857A (ko) *	1999-08-26	2002-05-15	후지야마 아키라	인돌 유도체 또는 그의 염의 제조방법
JP6493786B2 (ja) *	2015-01-06	2019-04-03	パナソニックＩｐマネジメント株式会社	免疫原、それを用いた抗体の製造方法、及び、そのモノクローナル抗体
JP6435505B2 (ja) *	2015-01-13	2018-12-12	パナソニックＩｐマネジメント株式会社	化合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3238215A (en) *	1963-10-17	1966-03-01	Sterling Drug Inc	1-[(3-, 2-, and 1-indolyl)-lower-alkyl-, lower-alkenyl-, and lower-alkynyl]piperidines
US3217011A (en) *	1965-05-07	1965-11-09	Sterling Drug Inc	1-(indolyglyoxalyl)-piperidines
US3489770A (en) *	1967-12-18	1970-01-13	American Home Prod	1-cyclo(lower)alkanoyl or admantanylcarbonyl - 3 - (2-substituted ethyl)indoles
GB1374414A (en) *	1972-06-12	1974-11-20	Sterling Drug Inc	1-acyl-3-amino-alkyl-indoles and their preparation
GB1436771A (en) *	1973-02-16	1976-05-26	Labaz	Indole derivatives and process for preparing the same
FR2354766A1 (fr) *	1976-06-17	1978-01-13	Labaz	Derives n-aminoalkyles d'indole et procedes pour les preparer
PH20395A (en) *	1984-02-07	1986-12-12	Pfizer	1,3-disubstituted oxindoles as analgesic and anti-inflammatory agents

1985
- 1985-07-29 PH PH32579A patent/PH23498A/en unknown
- 1985-07-30 IL IL75966A patent/IL75966A/xx not_active IP Right Cessation
- 1985-08-01 DE DE8585109689T patent/DE3586224T2/de not_active Expired - Fee Related
- 1985-08-01 AT AT85109689T patent/ATE77371T1/de not_active IP Right Cessation
- 1985-08-01 FI FI852973A patent/FI852973L/fi not_active Application Discontinuation
- 1985-08-01 EP EP85109689A patent/EP0171037B1/de not_active Expired - Lifetime
- 1985-08-01 NZ NZ225467A patent/NZ225467A/xx unknown
- 1985-08-01 NZ NZ212953A patent/NZ212953A/xx unknown
- 1985-08-01 NZ NZ225466A patent/NZ225466A/xx unknown
- 1985-08-02 IE IE1930/85A patent/IE57863B1/en not_active IP Right Cessation
- 1985-08-02 NO NO853066A patent/NO169067C/no not_active IP Right Cessation
- 1985-08-05 KR KR1019850005643A patent/KR870000548B1/ko not_active IP Right Cessation
- 1985-08-05 DK DK354485A patent/DK170279B1/da not_active IP Right Cessation
- 1985-08-05 AU AU45764/85A patent/AU574817B2/en not_active Ceased
- 1985-08-05 ES ES545894A patent/ES8609246A1/es not_active Expired
- 1985-08-06 AR AR85301206A patent/AR244665A1/es active
- 1985-08-06 JP JP60173058A patent/JPH0670010B2/ja not_active Expired - Fee Related
- 1985-08-06 MX MX8194A patent/MX160612A/es unknown
- 1985-08-06 PT PT80919A patent/PT80919B/pt unknown
- 1985-08-06 ZA ZA855923A patent/ZA855923B/xx unknown
- 1985-08-06 GR GR851937A patent/GR851937B/el unknown
1986
- 1986-03-12 ES ES552912A patent/ES8800149A1/es not_active Expired
- 1986-03-12 ES ES552911A patent/ES8800902A1/es not_active Expired
- 1986-03-12 ES ES552910A patent/ES8801203A1/es not_active Expired
- 1986-03-12 ES ES552909A patent/ES8800901A1/es not_active Expired
1987
- 1987-01-26 PH PH34765A patent/PH25360A/en unknown
- 1987-09-28 MY MYPI87002036A patent/MY101186A/en unknown
1989
- 1989-01-04 MX MX1442989A patent/MX14429A/es unknown
- 1989-01-04 MX MX1443189A patent/MX14431A/es unknown
- 1989-01-04 MX MX1443289A patent/MX14432A/es unknown

Also Published As

Publication number	Publication date
ES8800149A1 (es)	1987-10-16
IE57863B1 (en)	1993-05-05
KR870000548B1 (ko)	1987-03-18
GR851937B (de)	1985-12-05
MY101186A (en)	1991-07-31
EP0171037B1 (de)	1992-06-17
AR244665A1 (es)	1993-11-30
PT80919A (en)	1985-09-01
ES545894A0 (es)	1986-07-16
EP0171037A3 (en)	1987-08-26
AU4576485A (en)	1986-02-13
PH23498A (en)	1989-08-16
NO169067B (no)	1992-01-27
JPS6147463A (ja)	1986-03-07
IL75966A (en)	1989-08-15
ATE77371T1 (de)	1992-07-15
MX160612A (es)	1990-03-28
NZ212953A (en)	1990-02-26
EP0171037A2 (de)	1986-02-12
PT80919B (pt)	1987-09-30
NZ225466A (en)	1990-02-26
ES8609246A1 (es)	1986-07-16
NO169067C (no)	1992-05-06
DK170279B1 (da)	1995-07-24
JPH0670010B2 (ja)	1994-09-07
NO853066L (no)	1986-02-07
KR860001805A (ko)	1986-03-22
DE3586224T2 (de)	1993-01-28
PH25360A (en)	1991-05-13
IL75966A0 (en)	1985-12-31
ES552912A0 (es)	1987-10-16
MX14429A (es)	1993-09-01
ES8801203A1 (es)	1987-12-16
ZA855923B (en)	1986-03-26
ES552910A0 (es)	1987-12-16
FI852973L (fi)	1986-02-07
ES552909A0 (es)	1987-12-01
MX14432A (es)	1993-08-01
MX14431A (es)	1993-08-01
ES8800901A1 (es)	1987-12-01
DK354485A (da)	1986-02-07
IE851930L (en)	1986-02-06
DK354485D0 (da)	1985-08-05
AU574817B2 (en)	1988-07-14
ES552911A0 (es)	1987-12-01
ES8800902A1 (es)	1987-12-01
NZ225467A (en)	1990-02-26
FI852973A0 (fi)	1985-08-01

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Legal Events

Date	Code	Title	Description
1993-07-15	8364	No opposition during term of opposition
1998-08-06	8327	Change in the person/name/address of the patent owner	Owner name: SANOFI, PARIS, FR
2001-07-19	8327	Change in the person/name/address of the patent owner	Owner name: SANOFI-SYNTHELABO, PARIS, FR
2001-07-19	8328	Change in the person/name/address of the agent	Free format text: MUELLER, SCHUPFNER & GAUGER, 80539 MUENCHEN
2005-06-09	8339	Ceased/non-payment of the annual fee