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DE3582961D1 - Platinkoordinationsverbindungen. - Google Patents

Platinkoordinationsverbindungen.

Info

Publication number
DE3582961D1
DE3582961D1 DE8585304131T DE3582961T DE3582961D1 DE 3582961 D1 DE3582961 D1 DE 3582961D1 DE 8585304131 T DE8585304131 T DE 8585304131T DE 3582961 T DE3582961 T DE 3582961T DE 3582961 D1 DE3582961 D1 DE 3582961D1
Authority
DE
Germany
Prior art keywords
platino
coordination connections
functional group
coordination
connections
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8585304131T
Other languages
English (en)
Inventor
James Gerard Heffernan
Paul Cedric Hydes
Donald Harold Picker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johnson Matthey PLC
Original Assignee
Johnson Matthey PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson Matthey PLC filed Critical Johnson Matthey PLC
Application granted granted Critical
Publication of DE3582961D1 publication Critical patent/DE3582961D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Catalysts (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Electrotherapy Devices (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
DE8585304131T 1984-06-27 1985-06-11 Platinkoordinationsverbindungen. Expired - Lifetime DE3582961D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62525184A 1984-06-27 1984-06-27

Publications (1)

Publication Number Publication Date
DE3582961D1 true DE3582961D1 (de) 1991-07-04

Family

ID=24505219

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585304131T Expired - Lifetime DE3582961D1 (de) 1984-06-27 1985-06-11 Platinkoordinationsverbindungen.

Country Status (7)

Country Link
US (1) US4760155A (de)
EP (1) EP0167310B1 (de)
JP (1) JPH0662654B2 (de)
AT (1) ATE63919T1 (de)
AU (1) AU583827B2 (de)
CA (1) CA1283750C (de)
DE (1) DE3582961D1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0665648B2 (ja) * 1985-09-25 1994-08-24 塩野義製薬株式会社 白金系抗癌物質の安定な凍結真空乾燥製剤
US5041581A (en) * 1985-10-18 1991-08-20 The University Of Texas System Board Of Regents Hydrophobic cis-platinum complexes efficiently incorporated into liposomes
US5384127A (en) * 1985-10-18 1995-01-24 Board Of Regents, The University Of Texas System Stable liposomal formulations of lipophilic platinum compounds
US5117022A (en) * 1985-10-18 1992-05-26 The Board Of Regents, The University Of Texas System Hydrophobic cis-platinum complexes efficiently incorporated into liposomes
GB8620917D0 (en) * 1986-08-29 1986-10-08 Davidson B C Platinum derivatives & cancer treatments
US4793986A (en) * 1987-02-25 1988-12-27 Johnson Matthey, Inc. Macromolecular platinum antitumor compounds
US4921963A (en) * 1987-04-13 1990-05-01 British Columbia Cancer Foundation Platinum complexes with one radiosensitizing ligand
CN1016693B (zh) * 1987-06-05 1992-05-20 北京工业大学 新顺铂铬合物的制备方法
IT1216687B (it) * 1988-04-01 1990-03-08 Boehringer Biochemia Srl Complessi di platino (ii), loro preparazione e impiego come antitumorali.
US5041578A (en) * 1988-11-22 1991-08-20 Board Of Regents, The University Of Texas System Water soluble 1,2-diaminocyclohexane platinum (IV) complexes as antitumor agents
US5434256A (en) * 1988-11-22 1995-07-18 Board Of Regents, The University Of Texas System Diamine platinum complexes as antitumor agents
US5393909A (en) * 1988-11-22 1995-02-28 Board Of Regents, The University Of Texas System Diamine platinum complexes as antitumor agents
ATE161852T1 (de) * 1989-03-14 1998-01-15 Univ Nebraska Monoklonale antikörper für metall kationen
US5972656A (en) * 1989-03-14 1999-10-26 Bionebraska, Inc. Mercury binding polypeptides and nucleotides coding therefore
US5639624A (en) * 1989-03-14 1997-06-17 Board Of Regents Of The University Of Nebraska Monoclonal antibodies specific for metallic cations and method therefor
JP3492763B2 (ja) 1994-06-03 2004-02-03 エスエス製薬株式会社 白金錯体及びこれを含有する悪性腫瘍治療剤
GB9502799D0 (en) * 1995-02-14 1995-04-05 Johnson Matthey Plc Improvements in platinum complexes
US6111079A (en) * 1995-06-05 2000-08-29 Bionebraska, Inc. Lead binding polypeptides and nucleotides coding therefore
US5843475A (en) * 1996-12-06 1998-12-01 Board Of Regents, The University Of Texas System Delivery and activation through liposome incorporation of diaminocyclohexane platinum (II) complexes
SK286374B6 (sk) * 1999-04-13 2008-08-05 Anormed Inc. Spôsob prípravy cis-komplexu platiny a cis-komplex platiny
AU5755200A (en) 1999-08-27 2001-03-26 Joel R.L. Ehrenkranz Method of using dihydrochalcone derivatives to block glucose transfer
EP2289549A3 (de) 1999-10-01 2011-06-15 Immunogen, Inc. Immunokonjugate für Krebsbehandlung
GB0011903D0 (en) * 2000-05-18 2000-07-05 Astrazeneca Ab Combination chemotherapy
US6894049B1 (en) 2000-10-04 2005-05-17 Anormed, Inc. Platinum complexes as antitumor agents
EP1465876B1 (de) * 2001-12-31 2008-11-05 Hans Rudolf Pfaendler Langkettige fettalkoholsubstituenten in mitteln gegen krebs
US7138520B2 (en) * 2003-01-13 2006-11-21 Massachusetts Institute Of Technology Coordination complexes having tethered therapeutic agents and/or targeting moieties, and methods of making and using the same
US8168661B2 (en) * 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8173686B2 (en) 2006-11-06 2012-05-08 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8178564B2 (en) * 2006-11-06 2012-05-15 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8168662B1 (en) 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US20110033528A1 (en) * 2009-08-05 2011-02-10 Poniard Pharmaceuticals, Inc. Stabilized picoplatin oral dosage form
TW200916094A (en) * 2007-06-27 2009-04-16 Poniard Pharmaceuticals Inc Stabilized picoplatin dosage form
US20100260832A1 (en) * 2007-06-27 2010-10-14 Poniard Pharmaceuticals, Inc. Combination therapy for ovarian cancer
WO2009011861A1 (en) * 2007-07-16 2009-01-22 Poniard Pharmaceuticals, Inc. Oral formulations for picoplatin
WO2009099651A1 (en) * 2008-02-08 2009-08-13 Poniard Pharmaceuticals, Inc. Use of picoplatin and cetuximab to treat colorectal cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2019405A (en) * 1978-04-20 1979-10-31 Johnson Matthey & Co Ltd Pt Pt (II) and (IV) Amino-Acid Complexes
JPS5851959B2 (ja) * 1980-06-11 1983-11-19 呉羽化学工業株式会社 プラチナ化合物とその医薬組成物
DE3128144A1 (de) * 1981-07-16 1983-02-03 Basf Ag, 6700 Ludwigshafen "cis-dichloro-aminosaeure-platin(ii)-komplexe"
US4500465A (en) * 1982-06-28 1985-02-19 Engelhard Corporation Solubilized platinum (II) complexes
IL66338A (en) * 1982-07-15 1986-03-31 Yeda Res & Dev Anti-cancer drugs comprising platinum complexed antitumor immunoglobulins
JPS59112995A (ja) * 1982-12-21 1984-06-29 Shionogi & Co Ltd 新規グリコ−ル酸白金錯体
JPS59222498A (ja) * 1983-06-01 1984-12-14 Shionogi & Co Ltd 新規グリコ−ル酸系白金錯体および抗悪性腫瘍剤
JPS6087295A (ja) * 1983-10-19 1985-05-16 Nippon Kayaku Co Ltd 新規白金錯体

Also Published As

Publication number Publication date
EP0167310A3 (en) 1986-04-23
CA1283750C (en) 1991-04-30
ATE63919T1 (de) 1991-06-15
JPH0662654B2 (ja) 1994-08-17
EP0167310A2 (de) 1986-01-08
US4760155A (en) 1988-07-26
AU583827B2 (en) 1989-05-11
JPS6183194A (ja) 1986-04-26
EP0167310B1 (de) 1991-05-29
AU4393085A (en) 1987-01-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee