DE20004010U1 - Dietary composition containing glycosaminoglycans - Google Patents
Dietary composition containing glycosaminoglycansInfo
- Publication number
- DE20004010U1 DE20004010U1 DE20004010U DE20004010U DE20004010U1 DE 20004010 U1 DE20004010 U1 DE 20004010U1 DE 20004010 U DE20004010 U DE 20004010U DE 20004010 U DE20004010 U DE 20004010U DE 20004010 U1 DE20004010 U1 DE 20004010U1
- Authority
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- Prior art keywords
- dietary composition
- composition according
- vitamin
- content
- dietary
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 235000007882 dietary composition Nutrition 0.000 title claims description 24
- 229920002683 Glycosaminoglycan Polymers 0.000 title claims description 13
- 241000237536 Mytilus edulis Species 0.000 claims description 14
- 235000020638 mussel Nutrition 0.000 claims description 14
- 229940024606 amino acid Drugs 0.000 claims description 10
- 235000001014 amino acid Nutrition 0.000 claims description 10
- 150000001413 amino acids Chemical class 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- 210000002808 connective tissue Anatomy 0.000 claims description 9
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 8
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 8
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 8
- 210000002435 tendon Anatomy 0.000 claims description 8
- 239000011573 trace mineral Substances 0.000 claims description 8
- 235000013619 trace mineral Nutrition 0.000 claims description 8
- 210000001188 articular cartilage Anatomy 0.000 claims description 7
- 230000004060 metabolic process Effects 0.000 claims description 7
- 235000019154 vitamin C Nutrition 0.000 claims description 7
- 239000011718 vitamin C Substances 0.000 claims description 7
- 235000019165 vitamin E Nutrition 0.000 claims description 7
- 239000011709 vitamin E Substances 0.000 claims description 7
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 6
- 229930003231 vitamin Natural products 0.000 claims description 6
- 235000013343 vitamin Nutrition 0.000 claims description 6
- 239000011782 vitamin Substances 0.000 claims description 6
- 229940088594 vitamin Drugs 0.000 claims description 6
- FFEARJCKVFRZRR-UHFFFAOYSA-N L-Methionine Natural products CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 claims description 5
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims description 5
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 claims description 5
- 235000019393 L-cystine Nutrition 0.000 claims description 5
- 239000004158 L-cystine Substances 0.000 claims description 5
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 5
- 229930195722 L-methionine Natural products 0.000 claims description 5
- 229930182821 L-proline Natural products 0.000 claims description 5
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 5
- 229960003067 cystine Drugs 0.000 claims description 5
- 229960004452 methionine Drugs 0.000 claims description 5
- 229960002429 proline Drugs 0.000 claims description 5
- 239000011669 selenium Substances 0.000 claims description 5
- 229910052711 selenium Inorganic materials 0.000 claims description 5
- 235000011649 selenium Nutrition 0.000 claims description 5
- 235000019158 vitamin B6 Nutrition 0.000 claims description 5
- 239000011726 vitamin B6 Substances 0.000 claims description 5
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 4
- 229930003268 Vitamin C Natural products 0.000 claims description 4
- 229930003427 Vitamin E Natural products 0.000 claims description 4
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 4
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 4
- 229940046009 vitamin E Drugs 0.000 claims description 4
- 229940011671 vitamin b6 Drugs 0.000 claims description 4
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical compound [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 claims description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 3
- 229940108925 copper gluconate Drugs 0.000 claims description 3
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims description 3
- 229910000359 iron(II) sulfate Inorganic materials 0.000 claims description 3
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 claims description 3
- 229910000357 manganese(II) sulfate Inorganic materials 0.000 claims description 3
- 239000011787 zinc oxide Substances 0.000 claims description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 2
- 229910052802 copper Inorganic materials 0.000 claims description 2
- 239000010949 copper Substances 0.000 claims description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 2
- 229910052742 iron Inorganic materials 0.000 claims description 2
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims description 2
- 229940091258 selenium supplement Drugs 0.000 claims description 2
- 239000011701 zinc Substances 0.000 claims description 2
- 229910052725 zinc Inorganic materials 0.000 claims description 2
- 229930003270 Vitamin B Natural products 0.000 claims 1
- 235000019156 vitamin B Nutrition 0.000 claims 1
- 239000011720 vitamin B Substances 0.000 claims 1
- 210000000845 cartilage Anatomy 0.000 description 10
- 210000001179 synovial fluid Anatomy 0.000 description 9
- 210000000988 bone and bone Anatomy 0.000 description 5
- 239000002775 capsule Substances 0.000 description 4
- 235000015097 nutrients Nutrition 0.000 description 3
- 235000005911 diet Nutrition 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 230000001050 lubricating effect Effects 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 206010042209 Stress Diseases 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 210000000281 joint capsule Anatomy 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 210000002346 musculoskeletal system Anatomy 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
- A23L33/28—Substances of animal origin, e.g. gelatin or collagen
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Description
FEB-012-DE 0073/019 22. Februar 2000FEB-012-DE 0073/019 February 22, 2000
Febena Pharma GmbH
Oskar-Jäger-Straße 115Febena Pharma GmbH
Oskar-Jäger-Strasse 115
50825 Köln
Bundesrepublik Deutschland50825 Cologne
Federal Republic of Germany
Diätische Zusammensetzung mit einem Gehalt an GlycosaminoglycanenDietary composition containing glycosaminoglycans
Die Erfindung betrifft eine diätische Zusammensetzung, insbesondere zur Unterstützung des Stoffwechsels von Gelenkknorpel, Sehnen und Bindegewebe.The invention relates to a dietary composition, in particular for supporting the metabolism of articular cartilage, tendons and connective tissue.
Die Gelenke, das heißt Gelenkknorpel, Sehnen und Bindegewebe, werden durch ihre Betätigung ständig belastet. Die beweglichen Verbindungsstellen zwischen den Knochen besitzen einen komplexen Aufbau. Sie werden von einer festen, mit Bändern verstärkten Kapsel aus Bindegewebe, der sogenannten Gelenkkapsel, umschlossen. Damit die Knochen im Gelenk nicht direkt aufeinander reiben, sind sie mit einer schützenden Knorpelschicht überzogen. Im eigentlichen Gelenkspalt sorgt die Gelenkschmiere für den reibungslosen Ablauf der Bewegungen. Über die Gelenkschmiere werden außerdem die Knorpelschichten mit Nährstoffen versorgt.The joints, i.e. articular cartilage, tendons and connective tissue, are constantly stressed by their activity. The movable connection points between the bones have a complex structure. They are enclosed by a solid capsule made of connective tissue, the so-called joint capsule, which is reinforced with ligaments. To prevent the bones in the joint from rubbing directly against each other, they are covered with a protective layer of cartilage. In the actual joint space, the synovial fluid ensures that movements run smoothly. The synovial fluid also supplies the cartilage layers with nutrients.
Mit der Zeit können sich Veränderungen am Bewegungsapparat einstellen. Knochen und Knorpel verlieren an Elastizität. Die Gelenkschmiere wird weniger geschmeidig und es kommt zu Verschleißerscheinungen. Ein solcher Gelenkverschleiß kann durch verschiedene Faktoren begünstigt werden. Beispiele dafür sind eine ständige Überbelastung der Gelenke entweder durch einseitige Belastung beim Sport oder bei der Arbeit oder auch durch Übergewicht, ungesunde Ernährung, Bewegungsmangel aber auch gleichzeitig ein Übermaß an Sport.Over time, changes can occur in the musculoskeletal system. Bones and cartilage lose elasticity. The synovial fluid becomes less supple and signs of wear and tear occur. This type of joint wear and tear can be caused by various factors. Examples include constant over-stressing of the joints, either through one-sided strain during sport or at work, or through being overweight, an unhealthy diet, lack of exercise, or at the same time, excessive sport.
Um diese Stresserscheinungen an den Gelenken zu mildern, ist es erforderlich, dafür Sorge zu tragen, dass Gelenkknorpel, Sehnen und Bindegewebe in ausreichendem Maße mit Nährstoffen versorgt werden und die Zusammensetzung der Gelenkschmiere die für ihre Schmierwirkung erforderliche Konsistenz beibehält. Ansonsten wird der Schutzfilm zu dünnflüssig und die Knorpelflächen reiben direkt aufeinander.In order to alleviate these stress symptoms on the joints, it is necessary to ensure that the articular cartilage, tendons and connective tissue are supplied with sufficient nutrients and that the composition of the synovial fluid maintains the consistency required for its lubricating effect. Otherwise, the protective film becomes too thin and the cartilage surfaces rub directly against each other.
Erfindungsgemäß wird demzufolge eine diätische Zusammensetzung zur Verfügung gestellt, die insbesondere zur Unterstützung des Stoffwechsels von Gelenkknorpel, Sehnen und Bindegewebe einsetzbar ist, und einen wesentlichen Gehalt an GIycosaminoglycanen, sogenannten Mucopolysacchariden, enthält. Diese Glycosaminoglycane (GAGs) bewirken, dass die Gelenkschmiere die für ihre Schmierwirkung erforderliche Konsistenz beibehält oder diese Konsistenz wieder eingestellt wird, sofern die Gelenkschmiere aus irgend welchen Gründen zu dünnflüssig geworden ist.According to the invention, a dietary composition is therefore provided which can be used in particular to support the metabolism of articular cartilage, tendons and connective tissue and which contains a significant amount of glycosaminoglycans, so-called mucopolysaccharides. These glycosaminoglycans (GAGs) ensure that the synovial fluid maintains the consistency required for its lubricating effect or that this consistency is restored if the synovial fluid has become too thin for any reason.
Vorzugsweise werden diese Glycosaminoglycane aus Muschelextrakt, insbesondere dem Extrakt der neuseeländischen Grünlipp Muschel gewonnen. Sie enthalten Proteine und Mineralstoffe, welche für die Funktion von Sehnen, Bindegewebe und Knorpel wesentlich sind.These glycosaminoglycans are preferably obtained from mussel extract, especially the extract of the New Zealand green-lipped mussel. They contain proteins and minerals that are essential for the function of tendons, connective tissue and cartilage.
Erfindungsgemäß enthält die diätische Zusammensetzung als weiteren wesentlichen Bestandteil einen Gehalt an Aminosäuren sowie Vitaminen und/oder Spurenelementen, die in ihrem Zusammenwirken mit den Glycosaminoglycanen aus dem erfindungsgemäß eingesetzten Muschelextrakt den Stoffwechsel von Gelenkknorpel, Sehnen und Bindegewebe in positiver Weise unterstützen und helfen, die Gelenkschmiere in der erforderlichen Konsistenz zu halten.According to the invention, the dietary composition contains, as a further essential component, a content of amino acids as well as vitamins and/or trace elements which, in their interaction with the glycosaminoglycans from the mussel extract used according to the invention, positively support the metabolism of articular cartilage, tendons and connective tissue and help to keep the synovial fluid in the required consistency.
Bei einer vorteilhaften Ausführungsform der erfindungsgemäßen diätischen Zusammensetzung werden die zugesetzten Aminosäuren aus L-Prolin, L-Methionin und/oder L-Cystin ausgewählt. Diese können einzeln oder in Kombination miteinander dem erfindungsgemäßen diätischen Produkt zugesetzt sein.In an advantageous embodiment of the dietary composition according to the invention, the added amino acids are selected from L-proline, L-methionine and/or L-cystine. These can be added individually or in combination with one another to the dietary product according to the invention.
Die erfindungsgemäß eingesetzten Vitamine werden bevorzugt aus den Vitaminen C, E und B6 ausgewählt. Dabei dienen die Vitamine C und E insbesondere dem Erhalt der Knorpelstruktur.The vitamins used according to the invention are preferably selected from vitamins C, E and B6. Vitamins C and E serve in particular to maintain the cartilage structure.
Ferner kann in vorteilhafter Weise die diätische Zusammenset-Furthermore, the dietary composition can be advantageously
Setzung ausgewählte Spurenelemente, wie beispielsweise Selen, Eisen, Mangan, Kupfer und/oder Zink, enthalten, wobei diese Spurenelemente zur Unterstützung des Stoffwechsels von Knorpel und Knochen dienen.Contains selected trace elements such as selenium, iron, manganese, copper and/or zinc, which serve to support the metabolism of cartilage and bones.
Gemäß einer bevorzugten Ausführungsform der vorliegenden Erfindung umfasst die diätische Zusammensetzung getrocknetes Muschelextrakt, insbesondere getrocknetes Extrakt der neuseeländischen Grünlipp Muschel, L-Prolin, L-Methionin, L-Cystin, Vitamin C, Vitamin E, Vitamin B6, Selenhefe, Eisen-(II)-sulfat, Mangan-(II)-sulfat, Kupfergluconat und Zinkoxid. Wie bereits erwähnt sorgen die Vitamine C und E für den Erhalt der Knorpelstruktur. Die Glycosaminoglycane (GAGs) dienen als Aufbaustoffe für die Gelenkschmiere. Mineralstoffe und Spurenelemente dienen der "Unterstützung des Stoffwechsels von Knorpel und Knochen und Proteine und Aminosäuren dienen dem Knorpelgerüst. Demzufolge enthält die erfindungsgemäße diätische Zusammensetzung einmal Nährstoffe für das Gelenk und zum anderen Aufbaustoffe für die Gelenkschmiere.According to a preferred embodiment of the present invention, the dietary composition comprises dried mussel extract, in particular dried extract of the New Zealand green-lipped mussel, L-proline, L-methionine, L-cystine, vitamin C, vitamin E, vitamin B6, selenium yeast, iron (II) sulfate, manganese (II) sulfate, copper gluconate and zinc oxide. As already mentioned, vitamins C and E ensure the maintenance of the cartilage structure. The glycosaminoglycans (GAGs) serve as building blocks for the synovial fluid. Minerals and trace elements serve to "support the metabolism of cartilage and bones and proteins and amino acids serve the cartilage structure. Accordingly, the dietary composition according to the invention contains nutrients for the joint and building blocks for the synovial fluid.
Erfindungsgemäß machen die Vitamine, Spurenelemente und Aminosäuren 20 bis 30 % der Gesamt zusammensetzung aus. Davon stellen die Aminosäuren 9 bis 12 % der Gesamtzusammensetzung. Das Muschelextrakt kann ebenfalls in weiten Grenzen variieren, stellt aber in jedem Fall den Hauptanteil der wirksamen, d.h. diätischen Komponenten dar und bildet vorzugsweise 40 bis 80 % der Gesamt zusammensetzung, bevorzugter 50 bis 7 0 % und am bevorzugtesten 60 bis 65 %.According to the invention, the vitamins, trace elements and amino acids make up 20 to 30% of the total composition. Of these, the amino acids make up 9 to 12% of the total composition. The mussel extract can also vary within wide limits, but in any case represents the main part of the active, i.e. dietary components and preferably forms 40 to 80% of the total composition, more preferably 50 to 70% and most preferably 60 to 65%.
Die diätische Zusammensetzung, insbesondere zur Unterstützung des Stoffwechsels von Ge.lenkknorpel, Sehnen und Bindegewebe, wird vorzugsweise in Form von Dragees, bevorzugter in Form von Kapseln, formuliert, wobei als Trägerstoff vorzugsweise Hydroxypropylmethylcellulose verwendet wird, ist aber nicht darauf beschränkt. Die Zusammensetzung wird dabei so formuliert, dass sie an den wesentlichen Bestandteilen, nämlich dem Muschelextrakt, den Aminosäuren, den Vitaminen und Spurenelemen-The dietary composition, in particular to support the metabolism of articular cartilage, tendons and connective tissue, is preferably formulated in the form of dragees, more preferably in the form of capsules, with hydroxypropylmethylcellulose preferably being used as the carrier, but is not limited to this. The composition is formulated in such a way that it contains the essential components, namely the mussel extract, the amino acids, the vitamins and trace elements.
ten jeweils so viel an wirksamen Komponenten enthält, dass sie je nach Art und Schwere des eingetretenen Mangels für den erforderlichen Ausgleich sorgen können.each contains enough effective components to provide the necessary compensation depending on the type and severity of the deficiency that has occurred.
In einer ganz speziellen Ausführungsform der vorliegenden Erfindung enthält eine Kapsel zu 0,55 g Inhaltsstoffe 350 mg Muschelextrakt, 30 mg L-Prolin, 30 mg L-Methionin, 10 mg L-Cystin, 26 mg Vitamin C, 8,0 mg Vitamin E, 1,2 mg Vitamin B6, 12,5 mg Selenhefe, 8,0 mg Eisen-(II)-sulfat, 4,6 mg Mangan-(II)-sulfat, 2,9 mg Kupfergluconat und 2,5 mg Zinkoxid. Bei dieser Formulierung läßt sich der Tagesbedarf beispielsweise durch die Verabreichung von drei Kapseln regulieren.In a very special embodiment of the present invention, a capsule containing 0.55 g of ingredients contains 350 mg of mussel extract, 30 mg of L-proline, 30 mg of L-methionine, 10 mg of L-cystine, 26 mg of vitamin C, 8.0 mg of vitamin E, 1.2 mg of vitamin B6, 12.5 mg of selenium yeast, 8.0 mg of iron (II) sulfate, 4.6 mg of manganese (II) sulfate, 2.9 mg of copper gluconate and 2.5 mg of zinc oxide. With this formulation, the daily requirement can be regulated, for example, by administering three capsules.
Claims (14)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE20004010U DE20004010U1 (en) | 2000-03-02 | 2000-03-02 | Dietary composition containing glycosaminoglycans |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE20004010U DE20004010U1 (en) | 2000-03-02 | 2000-03-02 | Dietary composition containing glycosaminoglycans |
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| DE20004010U1 true DE20004010U1 (en) | 2000-06-21 |
Family
ID=7938267
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| DE20004010U Expired - Lifetime DE20004010U1 (en) | 2000-03-02 | 2000-03-02 | Dietary composition containing glycosaminoglycans |
Country Status (1)
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| DE (1) | DE20004010U1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001082938A2 (en) * | 2000-04-28 | 2001-11-08 | Ocean Nutrition Canada Limited | Compositions useful in the treatment of diseases of connective tissues comprising a ferrous ion and an ascorbate |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3814047C1 (en) | 1988-04-26 | 1989-11-16 | Fratzer, Antje-Mandy, 6719 Hettenleidelheim, De | Composition for the treatment of multiple sclerosis |
| WO1998048816A1 (en) | 1997-04-28 | 1998-11-05 | Nutramax Laboratories, Inc. | Aminosugar, glycosaminoglycan or glycosaminoglycan-like compounds, and s-adenosylmethionine |
| WO1999040926A1 (en) | 1998-02-13 | 1999-08-19 | Nutramax Laboratories, Inc. | Agents and methods for protection, treatment and repair of connective tissue |
| WO1999062459A2 (en) | 1998-06-05 | 1999-12-09 | Nutramax Laboratories, Inc. | Agents and methods for protection, treatment and repair of connective tissue |
-
2000
- 2000-03-02 DE DE20004010U patent/DE20004010U1/en not_active Expired - Lifetime
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3814047C1 (en) | 1988-04-26 | 1989-11-16 | Fratzer, Antje-Mandy, 6719 Hettenleidelheim, De | Composition for the treatment of multiple sclerosis |
| WO1998048816A1 (en) | 1997-04-28 | 1998-11-05 | Nutramax Laboratories, Inc. | Aminosugar, glycosaminoglycan or glycosaminoglycan-like compounds, and s-adenosylmethionine |
| WO1999040926A1 (en) | 1998-02-13 | 1999-08-19 | Nutramax Laboratories, Inc. | Agents and methods for protection, treatment and repair of connective tissue |
| WO1999062459A2 (en) | 1998-06-05 | 1999-12-09 | Nutramax Laboratories, Inc. | Agents and methods for protection, treatment and repair of connective tissue |
Non-Patent Citations (1)
| Title |
|---|
| Datenbank CABA bei STN, AN 92:149814 CABA zu: Treatment of deforming arthopathy in working dogs with "Canosan", a new glycosaminoglycan preparation, KORTHAUER,W., et.al., Kleintierpraxis 1992, Vol.37, No.7, S.467-478 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001082938A2 (en) * | 2000-04-28 | 2001-11-08 | Ocean Nutrition Canada Limited | Compositions useful in the treatment of diseases of connective tissues comprising a ferrous ion and an ascorbate |
| WO2001082938A3 (en) * | 2000-04-28 | 2002-08-08 | Ocean Nutrition Canada Ltd | Compositions useful in the treatment of diseases of connective tissues comprising a ferrous ion and an ascorbate |
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