DE10350929A1 - Use of dispirotripiperazine derivatives to treat fungal infections or to prevent adhesion of fungi to surfaces - Google Patents

Abstract

Dispirotripiperazine (3,12-diaza-6,9-diazonia-dispiro[5.2.5.2]hexadecane) derivatives are used to treat fungal infections or to prevent adhesion of fungi to surfaces. Independent claims are also included for: (1) pharmaceutical or cosmetic composition comprising dispirotripiperazine derivatives; (2) washing products, cleaning products, textile treatment products, fabric conditioners, hand washing products, manual dishwashing products, dishwasher detergents and products for treating surfaces, building materials, sealants, filter media, building auxiliaries, ceramics, plastics, metals, textiles, furs, paper, hides, leather or packaging, all containing dispirotripiperazine derivatives; (3) filter media, adhesives, sealants, packaging, building materials, building auxiliaries, textiles, furs, paper, hides and leather, all containing or treated with dispirotripiperazine derivatives. ACTIVITY : Fungicide. MECHANISM OF ACTION : Fungal adhesion inhibitor. 2-Methylmercapto-4-chloro-5-nitrodispirotripiperazine gave 99% inhibition of adhesion of Candida albicans to SK-LMS-1 human leiomyosarcoma cells in vitro at a concentration of 100 Microg/ml.

Description

The This invention relates to the use of derivatives of the compound 3,12-diaza-6,9-diazonia (5,2,5,2) dispirohexadecane (Dispirotripiperazine) to reduce the adhesion of fungi on cells and surfaces and compositions containing these substances, preparations and Materials.

The Human pathogenic species of the genus Candida colonize in many healthy people skin and mucous membranes, without causing symptoms. With large proliferation of fungal cells, e.g. after damage bacterial mucosal flora caused by antibiotics, they cause but often local inflammations that also known as Thrush. In particular, these occur in the oral and genital area (so-called oral or vaginal thrush). Known are also skin and Windelsoor. The mucous membrane is red, it show lesions, a white one Surface and itching occur.

candidiasis (Candidiasis) usually arise with reduced immune defense in body folds (Intertriginous) in the genitoanal area, in the area of the vagina or on the oral mucosa (Thrush). Candida also complicates diaper dermatitis, causing cheilitis angularis (Perleche) and often a balanitis.

At of oral candidosis (thrush) fall especially carriers, since on the surface the prosthesis adhering fungal cells on contact colonize the mucous membranes, which are often damaged by pressure points. First of all formed an oral candidosis, so it is therefore for treatment The candidosis required both the mouth area itself as well To free the bit from fungal infestation, otherwise a quick reinfection the mouth area would be the result.

A similar There is a problem with thrush in the genital area. As more and more sensitive Textiles, such. B. silk or microfiber, which only at 30 or 40 ° C washed can be processed into garments fungi, such as the human pathogenic Candida albicans who are sensitive to high temperatures are at low temperatures to apply not killed. Especially after a fungal infection, it can be so adhering to the garments, not killed mushrooms come to a reinfection.

Around Break the vicious cycle and reinfect through on the clothes or on plastic surfaces to prevent sticky fungi Therefore, both the affected body area as well as with the body area in contact with objects how to remove clothing or teeth from the mushrooms.

Next The above-mentioned local candidoses can also be systemic candidoses occur. These are usually encountered in patients with a systemic immune deficiency, especially in AIDS patients. This can be caused by Candida too come to an infestation of internal organs such as the lungs or kidney.

to Prevention of infection by fungi and / or prevention The adhesion of fungi to surfaces are so far antimicrobial Substances are used that either inhibit the growth of fungi (Fungistatika), kill them (Fungicides) and / or adhesion reduce the fungi. Often For this purpose non-selective antimicrobial substances are used, which act against both bacteria and fungi. In addition, will often Used compounds because of the concentration in which they are have to be used possess toxic properties, can lead to skin irritation or other unwanted Own properties.

to Treatment of candidosis is especially the use of polyene antimycotics like Amphotericin B, nystatin and natamycin and the use of azole antimycotics such as clotrimazole and ketoconazole. Furthermore, will be Corticoids, also used in combination with antimycotics.

in this connection becomes amphotericin B particularly in local Candida infections, Preferably applied as a monosubstance. These are but a pretty toxic substance. For local application of Amphotericin B can Itching, skin irritations and redness occur.

Nystatin is used in superficial candidal infections of the skin and mucous membranes, especially by Candida albicans, or for local remediation of the gastrointestinal tract after oral administration. It also finds local application as a cream as well as vaginal infections as globules. It is also used for intestinal superficial candidiasis. However, one problem with using nystatin is that Hypersensitivity reactions or sensitizations may occur. In addition, nystatin is a yellow substance which turns yellow according to skin and washing.

Further is disadvantageous in the use of unselective antimicrobial substances with a view to the use as pharmaceuticals or prosthesis treatment agents, that by the unspecific destruction of the microflora also naturally occurring non-pathogenic microorganisms are destroyed, as natural Protective barrier opposite act pathogenic microorganisms. This is the danger a reinfection of the site of application, possibly also by other microorganisms, very high.

adversely is re the use of non-selective antimicrobial substances further in terms of their use in detergents and cleaners, that the biocides or biostats used pollute the wastewater and thus also the microbial treatment stages in the sewage treatment plants impair their function.

to solution the aforementioned problems with the toxic and nonspecific antimicrobial effects of conventionally used antimycotics, Fungistatika, fungicides and biocidal substances are connected, have already been described compounds that the attachment of fungi on surfaces decrease without being antimicrobially effective. So will by adding farnesol in Candida the transition into the filamentous form prevented without having a fungicidal or fungistatic effect occurs (Ki-Bong Oh et al. (2001) PNAS 98, 4664-4668; J. M. Hornby et al. (2001), Applied and Environmental Microbiology 67, 2982-2992).

In WO03 / 051124 describes that substances containing the dimorphism of fungi successfully influence the reduction of adhesion of mushrooms on surfaces can be used without exhibiting non-selective antimicrobial activity, wherein in particular, propolis extracts, plant extracts, monoterpenes, sesquiterpenes and diterpenes are described as useful substances.

task The present invention was to provide further substances for the treatment fungal diseases, in particular for the treatment of candidoses, to disposal especially those that are less toxic than today substances used for this purpose.

task The present invention further sought to find substances make the adhesion of Mushrooms on surfaces, especially on biotic and abiotic surfaces or at least significantly reduce it.

With In particular, the treatment of pathogenic fungal infection was Object of the present invention to find substances, the infestation of the human skin, mucous membrane and / or the appendages reduce by fungi.

With With regard to the treatment of fungal infections in the oral field it was a particular object of the present invention To locate substances that inhibit the adhesion of fungi to dentures significantly reduce.

Regarding of a possible Use in detergents, it was also an object of the present Invention to find substances with which specifically mushrooms of textile surfaces can be removed if possible, without these surfaces or at the laundry resulting wastewater with overly toxic To burden active ingredients.

Surprisingly it has now been found that derivatives of dispirotripiperazine (3,12-diaza-6,9-diazonia (5,2,5,2) -dispirohexadecane, hereinafter also referred to as Dispiro compounds) the adhesion of fungi on surfaces diminish, wherein the surfaces are both natural surfaces and around artificial surfaces and this may be both biotic and abiotic surfaces.

An object of the present invention is therefore the use of derivatives of dispirotripiperazine (3,12-diaza-6,9-diazonia (5,2,5,2) dispirohexadecane) for reducing the adhesion of fungi to surfaces, wherein the Surfaces around both natural and artificial surfaces and This may be both biotic and abiotic surfaces.

Under Reduction of attachment is a significant reduction in the number to understand the adherent fungal cells. Significant reduction In particular, it is a reduction relative to an untreated reference by more than 40%, preferably more than 60%, especially more than 80 % to understand. The adhesion is particularly preferably complete or almost completely prevented.

Under Fungi are according to the invention in particular Yeasts, molds, dermatophytes and keratinophilic fungi. Yeasts in the context of the invention are unicellular fungi, which are predominantly multiply by budding. Yeast fungi do not represent an independent taxonomic Category in system of mushrooms. Systematically most of them become Assigned yeasts to the endomycetes. In addition, but also occur in different other fungi in the development cycle or under certain environmental conditions Shoot cell stages, referred to as yeast stages. Such unicellular, yeast-like budding growth forms occur in the Ascomycetes, but also with the Zygomycetes, Basidomycetes and Deuteromycetes on. Also according to the invention to understand all of these growth forms among yeasts.

at The fungi according to the invention are preferably human pathogens Fungi, in particular the human pathogenic species of the genus Ascomycota, Basidiomycota, Deuteromycota and Zygomycota, especially it can be to treat human pathogenic forms of Candida.

To Another particularly preferred embodiment is the adhesion of fungi of the species Candida (hereinafter abbreviated to C.) as z. C. aaseri, C. actiscondensi, C. acutus, C. agrestis, C. albicans, C. amapae, C. anatomiae, C. ancudensis, C. antarctica, C. antillancae, C. apicola, C. apis, C. aquaetextoris, C. aquatica, C. atlantica, C. atmaerica, C. auringiensis, C. azyma, C. beechii, C. benhamii, C. bertae, C. berthetii, C. blankii, C. boidinii, C. boleticola, C. bombi, C. bondarzewiae, C. brumptii, C. buffonii, C. buinensis, C. cacaoi, C. cantarellii, C. capsuligena, C. cariosilignicola, C. caseinolytica, C. castellii, C. catenulata, C. chalmersi, C. chilensis, C. chiropterorum, C. ciferii, C. claussenii, C. coipomensis, C. colliculosa, C. conglobata, C. curiosa, C. cylindracea, C. dendrica, C. dendronema, C. deserticola, C. diddensiae, C. diffluens, C. diversa, C. drymisii, C. dubliniensis, C. edax, C. entomophila, C. eremophila, C. ergatensis, C. ernobii, C. etchellsii, C. etchellsii, C. ethanolica, C. ethanothermophilum, C. evantina, C. fabianii, C. famata, C. fennica, C. flareri, C. fluviotilis, C. fragariorum, C. fragi, C. fragicola, C. freyschussii, C. friedrichii, C. fructus, C. fusiformata, C. geochares, C. glabrata, C. glaebosa, C. graminis, C. gropengiesseri, C. guilliermondii, C. haemulonii, C. hellenica, C. heveanensis, C. holmii, C. homilentoma, C. humicola, C. humilis, C. iberica, C. incommunis, C. inconspicua, C. ingens, C. insectalens, C. insectamans, C. insectorum, C. intermedia, C ishiwadae, C. japonica, C. javanica, C. karawaiewii, C. kefyr, C. kruisii, C. krusei, C. krusoides, C. lactiscondensi, C. lambica, C. laureliae, C. lipolytica, C. llanquihuensis, C. iodderae, C. lusitaniae, C. magnoliae, C. malicola, C. maltosa, C. maris, C. maritima, C. melibiosica, C. melinii, C. membranaefaciens, C. mesenterica, C. methanosorbosa, C. milleri, C. mogii, C. molischiana, C. monosa, C. montana, C. mucilaginosa, C. multis-gemmis, C. musae, C. muscorum, C. mycoderma, C. naeodendra, C. nakasei, C. nemodendra, C. nitratophila, C. norvegensis, C novakii, C. oleophila, C. oregonensis, C. palmyrana, C. paludigena, C. parapsilosis, C. pararugosa, C. pelliculosa, C. peltata, C. periphelosum, C. pefrohuensis, C. pignaliae, C. pintolopesii, C. pinus, C. placentae, C. polymorpha, C. populi, C. pseudotropicalis, C. psychrophila, C. pulcherrima, C. punica, C. quercitrusa, C. quercuum, C. railenensis, C. ralunensis, C. reukaufii, C. rhagii, C. rugopelliculosa, C. rugosa, C. saitoana, C. sake, C. salmanticensis, C. santamariae, C. santjacobensis, C. savonica, C. schatavii, C. sequanensis, C. shehatae, C. silvae, C. silvanorum, C. silvicultrix, C. solani, C. sonorensis, C. sophiae reginae, C. sorboxylosa, C. spandovensis, C. sphaerica, C. stellata, C. stellatoidea, C. succiphila, C. sydowiorum, C. tanzawaensis, C. tenuis, C. tepae, C. terebra, C. torresii, C. tropicalis, C. tsuchiyae, C. tsukubaensis, C. utilis, C. valdiviana, C. valida, C. vanderwaltii, C. vartiovaarai, C. versatilis, C. vini, C. viswanathii, C. wickerhamii, C. xestobii, C. zeylanoides.

Especially in this case, the adhesion of the medically relevant is preferred Forms of Candida, for example C. albicans, C. boidinii, C. catenulata, C. ciferii, C. dubliniensis, C. glabrata, C. guilliermondii, C. haemulonii, C. kefyr, C. krusei, C. lipolytica, C. lusitaniae, C. norvegensis, C. parapsilosis, C. pulcherrima, C. rugosa, C. tropicalis, C. utilis, C. viswanathii. Especially C. albicans, C. stellatoidea, C. tropicalis, C. glabrata are preferred and C. parapsilosis.

To a further preferred embodiment becomes the attachment of mushrooms of the species Rhodotorula spp., Cryptococcus spp., Exophilia spp., Hormoconis spp. reduced.

In the case of molds according to the present invention, fungi are to be understood as meaning their Le in the soil, on food and / or animal feed or in concentrated nutrient solutions, form a typical mycelium and extract its nutrients from organic substances which decompose them (saprobiontic or saprophytic way of life). Furthermore, they multiply predominantly asexually by spores (especially sporangiospores or conidia) and form, if at all, only very small sexual reproductive organs.

Also in terms of of the molds are as examples species from the classes Ascomycota, Basidiomycota, Deuteromycota and Zygomycota, in particular all species of the genera Aspergillus, Penicillium, Cladosporium and Mucor and Stachybotrys, Phoma, Alternaria, Aureobasidium, Ulocladium, Epicoccum, Stemphyllium, Paecilomyces, Trichoderma, Scopulariopsis, Wallemia, Botrytis, Verticillium and Chaetonium.

To belong to the Ascomycota here in particular all species of the genera Aspergillus, Penicillium and Cladosporium. These fungi produce spores that when in contact with the skin or the respiratory tract a strong allergenic potential exhibit. To the Basidomycota is for example Cryptococcus neoformans too counting. Deuteromycota are all genera known as molds to count, especially those caused by the absence of a sexual stage not assigned to the classes Ascomycota, Basidiomycota or Zygomycota become.

Prefers in this case according to the invention, the adhesion all species of the genus Aspergillus on surfaces reduced, especially preferably of those species selected from Aspergillus aculeatus, Aspergillus albus, Aspergillus alliaceus, Aspergillus asperescens, Aspergillus awamori, Aspergillus candidus, Aspergillus carbonarius, Aspergillus carneus, Aspergillus chevalieri, Aspergillus chevalieri var. intermedius, Aspergillus clavatus, Aspergillus ficuum, Aspergillus flavipes, Aspergillus flavus, Aspergillus foetidus, Aspergillus fumigatus, Aspergillus giganteus, Aspergillus humicola, Aspergillus intermedius, Aspergillus japonicus, Aspergillus nidulans, Aspergillus niger, Aspergillus niveus, Aspergillus ochraceus, Aspergillus oryzae, Aspergillus ostianus, Aspergillus parasiticus, Aspergillus parasiticus var. Globosus, Aspergillus penicillioides, Aspergillus phoenicis, Aspergillus rugulosus, Aspergillus sclerotiorum, Aspergillus sojae var. Gymnosardae, Aspergillus sydowi, Aspergillus tamarii, Aspergillus ferreus, Aspergillus terricola, Aspergillus toxicarius, Aspergillus unguis, Aspergillus ustus, Aspergillus versicolor, Aspergillus vitricolae and Aspergillus wentii. Especially In this case, the attachment of Aspergillus flavus and Apsergillus nidulans diminished or substantially completely prevented.

Under keratinophilic fungi are to be understood as those skin and / or hair fungi in horny skin and its appendages (especially hair and / or nails) to grow. In particular, there are dermatophytes and all species to understand the genus Malassezia. Under dermatophytes are according to the invention in particular all species of the genera Trichophyton, Microsporum and Epidermophyton to understand.

Of the keratinophilic fungus Malassezia, a yeast fungus, is considered to be the causative agent of Increased dandruff of the skin, for example on the head (Dandruff). Furthermore This organism is triggered considered the skin disease Pityriasis versicolor. Especially It is therefore advantageous to the adhesion of Malassezia, in particular species of M. furfur (also known as Pityrosporum ovale), M. pachydermatis, M. sympodialis and / or M. globosa reduce or substantially prevent.

According to one preferred embodiment are the keratinophilic fungi selected from Trichophyton mentagrophytes, T. rubrum, T. asteroid, T. concentrium, T. equinum, T. meginii, T. gallinae, T. tonsurans, T. schoenleinii, T. terrestre, T. verrucosum, T. violaceum, Microsporum canis, Microsporum audounii, M. gypseum, Epidermophyton flossocum, Malassezia furfur, M. sympodialis, M. globosa and M. pachydermatis.

Under Dermatophytes are according to the invention in particular Trichophyton mentagrophytes, T. rubrum, T. asteroides, T. concentrium, T. equinum, T. meginii, T. gallinae, T. tonsurans, T. schoenleinii, T. terrestre, T. verrucosum, T. violaceum, Microsporum canis, Microsporum audounii, M. gypseum and Epidermophyton flossocum.

A particular advantage of the substances according to the invention is that they have only a very low toxicity (Schmidtke et al. (2002) Antiviral Research 55, 117-127), in particular in comparison to the conventionally used antimycotics, fungicides and fungistats. In addition, the substances according to the invention are effective in lower final concentrations than those conventionally used. For this reason, fewer side effects or allergies are to be feared. With regard to the use in a detergent, the pollution is also correspondingly low and also the ge rings of active substance also advantageous from a commercial point of view.

wobei n 1 oder 2 ist,
X für eine direkte Bindung, NH oder eine Methylengruppe steht,
Het für einen substituierten (C₅-C₆)-Heteroaryl-Rest mit ein bis drei, insbesondere zwei, Heteroatomen steht, wobei die Heteroatome insbesondere ausgewählt sein können aus N, O und S, wobei der Heteroaryl-Rest auch ein- oder mehrfach, insbesondere ein-, zwei- oder dreifach, substituiert sein kann, insbesondere durch Reste ausgewählt aus der Gruppe bestehend aus (C₁-C₆)-Alkyl, (C₁-C₆)-Alkylthio, Amino, Mono- oder Di-(C₁-C₆)-Alkylamino, Hydroxy, Trifluormethyl, Phenyl, Styryl, Nitro, CHO, COOH, CN, Pyrrolidino, Piperazino, Cyano, Isocyano, Thiocyano, Isothiocyano und Halogen.The derivatives of dispirotripiperazine which can be used according to the invention are preferably compounds of the general formula (I)

where n is 1 or 2,
X is a direct bond, NH or a methylene group,
Het is a substituted (C ₅ -C ₆ ) heteroaryl radical having one to three, in particular two, heteroatoms, wherein the heteroatoms may be selected in particular from N, O and S, wherein the heteroaryl radical also one or more times , in particular mono-, di- or trisubstituted, in particular by radicals selected from the group consisting of (C ₁ -C ₆ ) -alkyl, (C ₁ -C ₆ ) -alkylthio, amino, mono- or di- (C ₁ -C ₆ ) -Alkylamino, hydroxy, trifluoromethyl, phenyl, styryl, nitro, CHO, COOH, CN, pyrrolidino, piperazino, cyano, isocyano, thiocyano, isothiocyano and halogen.

wobei R₁ vorzugsweise für (C₁-C₆)-Alkylthio, insbesondere für Methylthio, R₂ vorzugsweise für Halogen, insbesondere für Chlor, und R₃ vorzugsweise für Nitro steht.Het here preferably stands for a pyrimidinyl radical, especially for a pyrimidin-6-yl radical of the formula (II)

where R _{1 is} preferably (C ₁ -C ₆ ) -alkylthio, in particular methylthio, R _{2 is} preferably halogen, in particular chlorine, and R _{3 is} preferably nitro.

Especially Preferably, the dispirotripiperazine derivatives are an N, N'-bis (4-halo-2-alkylthio-5-nitro-pyrimidinyl) derivative, especially N, N'-bis (4-chloro-2-methylthio-5-nitro-pyrimidinyl) -dispirotripiperazine.

The substances which can be used according to the invention can in this case be used in all salt forms known to the person skilled in the art (Y stands for any anion, in particular for an inorganic anion). In the case of pharmaceutical application, the use is preferably carried out in the form of its physiologically tolerated salts. Particularly preferred is the use in the form of a halide salt, in particular in the form of the chloride or fluoride (Y = Cl ^- or F ^- ).

According to one preferred embodiment become the substances according to the invention used in such final concentrations that they are not toxic Act. A particular advantage of the invention is that the Dispiro compounds according to the invention only must be present in low concentrations, so that the adhesion of the Fungi on surfaces diminished or substantially completely prevented.

The Concentrations that lead to the desired result in the final product are In addition, if necessary, significantly lower than the specified, since for many Products dilutions considered Need to become. For detergents must, for example, with a dilution factor (ratio detergent concentrate Water) from 1:20 to 1: 200. Often lies the dilution ratio for detergent between 1:60 and 1: 100, for example 1:80.

at the biotic surfaces, according to the invention with the Dispiro connections can be treated In particular, it may be the skin, especially the human Act skin. The term skin hereby includes the skin itself also the mucous membrane and the skin appendages.

In the abiotic surfaces, which can be treated according to the invention with the Dispiro compounds, it may be in particular textiles, ceramics, metals, filter media, building materials, Bauhilfs fabrics, furs, paper, skins, leather and / or plastics and / or surfaces that often come into contact with the human body. In this case, the surfaces may in particular be laundry, prostheses or dentures. The textiles may be, above all, sensitive textiles, for example silk, microfiber or synthetic fabrics. The articles may also be catheters or other medical devices made of plastic or metals. For use according to the invention, the active compounds can be added to or incorporated into washing and / or cleaning agents or to oral or dental care preparations.

object The present invention further relates to the use of derivatives compound 3,12-diaza-6,9-diazonia (5,2,5,2) dispirohexadecane (dispirotripiperazine) for the manufacture of medicaments for the treatment of fungal infections.

One Another object of the present invention are compositions, Preparations and materials, derivatives of the invention 3,12-Diaza-6,9-diazonia (5,2,5,2) dispirohexadecane (dispirotripiperazine) contained and / or coated with these or equipped.

at the compositions according to the invention, Preparations and / or materials may be, for example cosmetic and / or pharmaceutical preparations, detergents, Cleaning agents, textile treatment agents, rinse-off detergents, Hand washing, hand dishwashing, Automatic dishwasher detergents, Filter media, adhesives, sealants, packaging, building materials, Building aids, textiles, furs, paper, skins and leather as well Means to equipment or treatment of surfaces, Building materials, sealants, filter media, building aids, ceramics, Plastics, metals, textiles, furs, paper, skins, leather or packaging.

Pharmaceutical or cosmetic preparations

The active ingredients according to the invention can in particular in pharmaceutical or cosmetic preparations for the oral, peroral (e.g., sublingual), topical, enteral, parenteral (e.g., subcutaneous, intramuscular, intradermal or intravenous) or rectal administration. For use of the compounds of the invention as pharmaceuticals, these are preferably in the form of a pharmaceutical preparation brought, in addition to the active ingredient suitable carriers, excipients and / or additives for the respective application form and optionally other active ingredients contains.

The Dispiro compounds according to the invention are in this case preferably in amounts of up to 3 wt .-%, particularly preferred in amounts of from 0.05 to 2% by weight, in particular from 0.1 to 1 wt .-% in the preparations. The dosage of the active ingredients can, depending on the mode of administration, age and weight of the patient, type and severity of the disease to be treated and similar Factors vary.

The Application may be especially oral or sublingual as a solid in the form of capsules or tablets or as a liquid in the form of solutions, Tinctures, suspensions, elixirs, aerosols or emulsions or vaginal or rectal in the form of globules or suppositories or in the form of possibly also subcutaneously intramuscular or intravenously applicable injection solutions respectively. Likewise come the topical or intrathecal application in question.

For administration by enteral route the pharmaceutical preparations, for example in the form of tablets, Capsules, dragees, syrups, suspensions, solutions, powders, granules or emulsions are present.

For administration parenterally the preparations, for example in the form of solutions or suspensions for Perfusion or injection, in particular, the active ingredients according to the invention as watery solutions present in polyhydroxyethoxylated castor oil. For administration by the rectal route the preparations are for example in the form of suppositories.

For the preparation of pharmaceutical preparations, the active ingredients, optionally in combination with other active substances, together with one or more inert conventional carriers and / or diluents, for. As with gelatin, gum arabic, corn starch, lactose, cane sugar, sorbitol, microcrystalline cellulose, magnesium stearate, polyvinylpyrrolidone, citric acid, tartaric acid, water, benzyl alcohol, polyalkylene glycol, water / ethanol, water / glycerol, water / sorbitol, water / polyethylene glycol, propylene glycol , Titanium dioxide, a cellulose derivative such as carboxymethyl cellulose or fatty sub such as hard fat, talc or vegetable oils or their suitable mixtures in conventional pharmaceutical preparations such as tablets, dragees, capsules, powders, suspensions, drops, ampoules, juices or suppositories. Optionally, preservatives, stabilizers, wetting agents, emulsifiers or salts for altering the osmotic pressure or buffers may also be present. Surfactants such as salts of bile acids or animal or plant phospholipids, but also mixtures thereof and liposomes or components thereof can also be used as carriers.

The pharmaceutical according to the invention and cosmetic preparations in addition to the active compounds according to the invention for example, also other adhesion-inhibiting Active ingredients, for example those as in WO 03/051124 described. Furthermore, the use of the active compounds according to the invention in combination with antimicrobial, especially antibacterial, antifungal and / or antiseptic agents and / or in Combined with astringent substances.

at the antimycotic agents are preferably to those that are used to treat fungal infestations, especially in the case of candidoses, already common be applied. These may be, in particular, antimycotics of the polyene type, especially nystatin, amphotericin B or natamycin, and / or azole-type antimycotics, especially miconazole, clotrimazole or ketoconazole, act. By combination with other antimycotic Active ingredients may accelerate the removal of the fungi, if necessary be, with preferably a synergistic effect occurs. When using anti-microbial agents, these can be advantageously used in lower concentrations than usual in the previous treatment.

at the astringent substances may in particular be aluminum salts, Phenol condensation products (artificial Tanning agents), natural products and tanning agents.

So may, for example, be an "external" herd rehabilitation Candidoses by dispiro compounds according to the invention also in combination with nystatin or amphotericin B, in particular in the range of sigma (dragees), the oral mucosa (suspension, Adhesive ointment) and the vulva (globules). At the systemic Treatment may be additional short term ketoconazole can be used. In addition or alternatively can a desiccation treatment (powders, pastes, shake mixtures, linen strips between skin folds), as well as an initial short-term production an intact horny layer using corticoids or an "artificial" horny layer below Use of astringents carried out, wherein the Dispiro compounds of the invention can also be added here.

to local therapy in the mucous membrane area, especially in mucosal necrosis, can be brushing with an aqueous solution the Dispiro compounds according to the invention done in addition Pyoktanine (0.5-1 %). Alternatively, here is about a combination treatment of dispiro compounds according to the invention conceivable with Boraxglycerin.

in the vaginal area, for example, the application in the form of a Cream or in the form of globules, wherein in addition to the dispiro compounds according to the invention also Azole antimycotics, especially clotrimazole, may be included.

to prophylactic treatment or post-treatment may be a drug-free Powders and disinfectant creams are used as well the Dispiro compounds according to the invention can contain.

A Combination treatment (with antifungals and / or corticoids) can may be performed at the acute initial stage, especially secondary or simultaneous Candida colonization of eczema or psoriasis, especially in the intertriginous Area.

Skin treatment agents

In one according to the invention especially preferred embodiment these are the pharmaceutical or cosmetic preparations to those for topical application to the skin and its appendages and / or for application to the mucous membrane, in particular in the oral or genital area, or for intertriginous application. Hereinafter these preparations are referred to as skin treatment agents.

The skin treatment agent may in particular be a lotion, a cream, a Ointment, a paste, an oil, a gel, a powder, a spray or aerosol, a solution, in particular alcoholic solution, or tincture, to a moist dressing, an occlusion dressing, a plaster, a stick preparation, a hair treatment or hair care product , in particular a hair shampoo, a hair lotion, a hair conditioner or a hair tonic, a bubble bath, a shower bath or a foot bath act.

Of the physiological carriers the skin treatment agent preferably comprises one or more Auxiliaries, as they usually do used in such preparations, e.g. Fats, oils, superfatting agents, Waxes, silicones, emulsifiers, dispersants, pearlescent waxes, Alcohols, polyols, bodying agents, stabilizers, thickeners, Swelling agent, hydrotrope or moistening and / or moisturizing substances, Polymers, surfactants, plasticizers, foam brakes, alkalinization or acidifiers, softeners, Adsorbents, light stabilizers, electrolytes, sequestering agents, organic solvents, Preservatives, germ-inhibiting agents, especially fungicides or bactericides, antioxidants, biogenic agents, vitamins, Protein hydrolysates, mono-, oligo- and polysaccharides, enzyme inhibitors, in particular MMP1-inhibiting substances, deodorants or odor absorbers, Antiperspirants, antidandruff agents, α-hydroxy and α-ketocarboxylic acids, fragrances, Dyes and / or pigments.

In the skin treatment agent according to the invention Thus, for example, at least one substance selected from Vitamins, provitamins or vitamin precursors of the vitamin B group or derivatives thereof and derivatives of 2-furanone be.

• • Vitamin B₁, Trivialname Thiamin, chemische Bezeichung 3-[(4'-Amino-2'-methyl-5'-pyrimidinyl)-methyl]-5-(2-hydroxyethyl)-4-methylthiazoliumchlorid. Bevorzugt wird Thiaminhydrochlorid in Mengen von 0,05 bis 1 Gew.-%, bezogen auf das gesamte Mittel, eingesetzt.
• • Vitamin B₂, Trivialname Riboflavin, chemische Bezeichung 7,8-Dimethyl-10-(1-D-ribityl)-benzo[g]pteridin-2,4(3H,10H)-dion. In freier Form kommt Riboflavin z. B. in Molke vor, andere Riboflavin-Derivate lassen sich aus Bakterien und Hefen isolieren. Ein erfindungsgemäß ebenfalls geeignetes Stereoisomeres des Riboflavin ist das aus Fischmehl oder Leber isolierbare Lyxoflavin, das statt des D-Ribityl einen D-Arabityl-Rest trägt. Bevorzugt werden Riboflavin oder seine Derivate in Mengen von 0,05 bis 1 Gew.-%, bezogen auf das gesamte Mittel, eingesetzt.
• • Vitamin B₃. Unter dieser Bezeichnung werden häufig die Verbindungen Nicotinsäure und Nicotinsäureamid (Niacinamid) geführt. Erfindungsgemäß bevorzugt ist das Nicotinsäureamid, das in den erfindungsgemäßen Mitteln bevorzugt in Mengen von 0,05 bis 1 Gew.-%, bezogen auf das gesamte Mittel, enthalten ist.
• • Vitamin B₅ (Pantothensäure und Panthenol). Bevorzugt wird Panthenol eingesetzt. Erfindungsgemäß einsetzbare Derivate des Panthenols sind insbesondere die Ester und Ether des Panthenols sowie kationisch derivatisierte Panthenole. In einer weiteren bevorzugten Ausführungsform der Erfindung können an Stelle von sowie zusätzlich zu Pantothensäure oder Panthenol auch Derivate des 2-Furanon mit der allgemeinen Strukturformel (III) eingesetzt werden.
  
  Bevorzugt sind die 2-Furanon-Derivate, in denen die Substituenten R¹ bis R⁶ unabhängig voneinander ein Wasserstoffatom, einen Hydroxylrest, einen Methyl-, Methoxy-, Aminomethyl- oder Hydroxymethylrest, einen gesättigten oder ein- oder zweifach ungesättigten, linearen oder verzweigten C₂-C₄-Kohlenwasserstoffrest, einen gesättigten oder ein- oder zweifach ungesättigten, verzweigten oder linearen Mono-, Di- oder Trihydroxy-C₂-C₄-Kohlenwasserstoffrest oder einen gesättigten oder ein- oder zweifach ungesättigten, verzweigten oder linearen Mono-, Di- oder Triamino-C₂-C₄-Kohlenwasserstoffrest darstellen. Besonders bevorzugte Derivate sind die auch im Handel erhältlichen Substanzen Dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanon mit dem Trivialnamen Pantolacton (Merck), 4-Hydroxymethyl-γ-butyrolacton (Merck), 3,3-Dimethyl-2-hydroxy-γ-butyrolacton (Aldrich) und 2,5-Dihydro-5-methoxy-2-furanon (Merck), wobei ausdrücklich alle Stereoisomeren eingeschlossen sind. Das erfindungsgemäß außerordentlich bevorzugte 2-Furanon-Derivat ist Pantolacton (Dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanon), wobei in Formel (III) R¹ für eine Hydroxylgruppe, R² für ein Wasserstoffatom, R³ und R⁴ für eine Methylgruppe und R⁵ und R⁶ für ein Wasserstoffatom stehen. Das Stereoisomer (R)-Pantolacton entsteht beim Abbau von Pantothensäure. Die genannten Verbindungen des Vitamin B₅-Typs sowie die 2-Furanonderivate sind in den erfindungsgemäßen Mitteln bevorzugt in einer Gesamtmenge von 0,05 bis 10 Gew.-%, bezogen auf das gesamte Mittel, enthalten. Gesamtmengen von 0,1 bis 5 Gew.-% sind besonders bevorzugt.
• • Vitamin B₆, wobei man hierunter keine einheitliche Substanz, sondern die unter den Trivialnamen Pyridoxin, Pyridoxamin und Pyridoxal bekannten Derivate des 5-Hydroxymethyl-2-methylpyridin-3-ols versteht. Vitamin B₆ ist in den erfindungsgemäßen Mitteln bevorzugt in Mengen von 0,0001 bis 1,0 Gew.-%, insbesondere in Mengen von 0,001 bis 0,01 Gew.-%, enthalten.
• • Vitamin B₇ (Biotin), auch als Vitamin H oder "Hautvitamin" bezeichnet. Bei Biotin handelt es sich um (3aS,4S, 6aR)-2-Oxohexahydrothienol[3,4-d]- imidazol-4-valeriansäure. Biotin ist in den erfindungsgemäßen Mitteln bevorzugt in Mengen von 0,0001 bis 1,0 Gew.-%, insbesondere in Mengen von 0,001 bis 0,01 Gew.-% enthalten.

The vitamin B group or the vitamin B complex include, among others

• • Vitamin B ₁ , common name thiamin, chemical name 3 - [(4'-amino-2'-methyl-5'-pyrimidinyl) -methyl] -5- (2-hydroxyethyl) -4-methylthiazolium chloride. Thiamine hydrochloride is preferably used in amounts of from 0.05 to 1% by weight, based on the total agent.
• • Vitamin B ₂ , common name riboflavin, chemical name 7,8-dimethyl-10- (1-D-ribityl) -benzo [g] pteridine-2,4 (3H, 10H) -dione. In free form riboflavin z. As in whey, other riboflavin derivatives can be isolated from bacteria and yeasts. A stereoisomer of riboflavin which is likewise suitable according to the invention is the lyxoflavin which can be isolated from fishmeal or liver and carries a D-arabityl residue instead of the D-ribityl. Riboflavin or its derivatives are preferably used in amounts of from 0.05 to 1% by weight, based on the total agent.
• • Vitamin B ₃ . Under this name, the compounds nicotinic acid and nicotinamide (niacinamide) are often performed. Preferred according to the invention is the nicotinic acid amide, which is preferably present in the agents according to the invention in amounts of from 0.05 to 1% by weight, based on the total agent.
• • Vitamin B ₅ (pantothenic acid and panthenol). Panthenol is preferably used. Derivatives of panthenol which can be used according to the invention are, in particular, the esters and ethers of panthenol and also cationically derivatized panthenols. In a further preferred embodiment of the invention, instead of and in addition to pantothenic acid or panthenol, it is also possible to use derivatives of 2-furanone having the general structural formula (III).
  
  Preference is given to the 2-furanone derivatives in which the substituents R ¹ to R ⁶ independently of one another are a hydrogen atom, a hydroxyl radical, a methyl, methoxy, aminomethyl or hydroxymethyl radical, a saturated or mono- or diunsaturated, linear or branched one C ₂ -C ₄ -hydrocarbon radical, a saturated or mono- or diunsaturated, branched or linear mono-, di- or trihydroxy-C ₂ -C ₄ -hydrocarbon radical or a saturated or mono- or diunsaturated, branched or linear mono , Di- or triamino-C ₂ -C ₄ -hydrocarbon radical. Particularly preferred derivatives are the commercially available substances dihydro-3-hydroxy-4,4-dimethyl-2 (3H) -furanone with the trivial name pantolactone (Merck), 4-hydroxymethyl-γ-butyrolactone (Merck), 3,3 Dimethyl 2-hydroxy-γ-butyrolactone (Aldrich) and 2,5-dihydro-5-methoxy-2-furanone (Merck), expressly including all stereoisomers. The extremely preferred 2-furanone derivative according to the invention is pantolactone (dihydro-3-hydroxy-4,4-dimethyl-2 (3H) -furanone), where in formula (III) R ^{1 is} a hydroxyl group, R ^{2 is} a hydrogen atom, R ³ and R ^{4 are} a methyl group and R ⁵ and R ^{6 are} a Hydrogen atom stand. The stereoisomer (R) -pantolactone is formed during the degradation of pantothenic acid. The said compounds of the vitamin B ₅ type and the 2-furanone derivatives are preferably contained in the agents according to the invention in a total amount of from 0.05 to 10% by weight, based on the total agent. Total amounts of 0.1 to 5 wt .-% are particularly preferred.
• • Vitamin B ₆ , which is not understood to be a uniform substance but the derivatives of 5-hydroxymethyl-2-methylpyridin-3-ol known under the common names pyridoxine, pyridoxamine and pyridoxal. Vitamin B ₆ is preferably present in the agents according to the invention in amounts of from 0.0001 to 1.0% by weight, in particular in amounts of from 0.001 to 0.01% by weight.
• • Vitamin B ₇ (biotin), also referred to as vitamin H or "skin vitamin". Biotin is (3aS, 4S, 6aR) -2-oxohexahydrothienol [3,4-d] imidazole-4-valeric acid. Biotin is preferably present in the compositions according to the invention in amounts of from 0.0001 to 1.0% by weight, in particular in amounts of from 0.001 to 0.01% by weight.

panthenol, Pantolactone, nicotinic acid amide and biotin are very particular to the invention prefers.

In the skin treatment agent according to the invention may further contain at least one plant extract. Of the Plant extract, for example, by extraction of the entire Plant, but also exclusively by extraction from flowers and / or scrolling and / or seeds and / or other parts of plants. According to the invention are available especially the extracts from the meristem, that is, the divisible formation tissue of plants, and extracts of special plants such as green tea, Hamamelis, Chamomile, Marigold, Pansy, Paeonie, Aloe Vera, Horse chestnut, sage, willow bark, cinnamon tree, chrysanthemums, Oak bark, stinging nettle, hops, burdock root, horsetail, hawthorn, lime blossom, almonds, Spruce needles, sandalwood, juniper, coconut, kiwi, guava, lime, mango, Apricot, wheat, melon, orange, grapefruit, avocado, rosemary, Birch, Beech shoots, Mallow, Meadowfoam, Yarrow, Quendel, Thyme, lemon balm, toadstool, marshmallow (Althaea), mallow (Malva sylvestris), Violets, leaves blackcurrant, coltsfoot, five-fingered cabbage, ginseng, ginger root and sweet potato preferred as plant extract. Can also be used advantageously Algae extracts. The inventively used Algae extracts come from green algae, Brown algae, red algae or blue-green algae (cyanobacteria). The extraction used algae can both natural Origin as well as obtained by biotechnological processes and as desired across from the natural one Shape changed be. The change The organisms can be genetically engineered, by breeding or by cultivation in with selected nutrients enriched media. Preferred algae extracts are derived from seaweed, blue-green algae, from the green alga Codium tomentosum as well from the brown alga Fucus vesiculosus. A particularly preferred algae extract comes from blue algae of the species Spirulina, which is in a magnesium-enriched medium were cultivated.

Especially the extracts of spirulina, green tea, aloe vera, meristem are preferred Hamamelis, apricot, marigold, guava, sweet potato, lime, mango, Kiwi, cucumber, mallow, marshmallow and violets. The agents according to the invention can also mixtures of several, especially two, different plant extracts contain.

When Extraction agent for the preparation of said plant extracts can For example, water, alcohols and mixtures thereof used become. Among the alcohols are lower alcohols such as ethanol and isopropanol, but especially polyhydric alcohols such as ethylene glycol, Propylene glycol and butylene glycol, both as sole Extracting agent as well as in admixture with water, preferred. plant extracts based on water / propylene glycol in the ratio 1:10 to 10: 1 have become proved to be particularly suitable. The steam distillation falls under the invention the preferred extraction methods. The extraction may but if necessary also in the form of dry extraction.

The plant extracts can be used according to the invention both in pure and in diluted form. If they are used in diluted form, they usually contain about 2 to 80 wt .-% of active substance and as a solvent used in their extraction agent or extractant mixture. Depending on the choice of extractants, it may be preferable to stabilize the plant extract by adding a solubilizer. Suitable solubilizers are, for. B. Ethoxylation products of optionally hydrogenated vegetable and animal oils. Preferred solubilizers are ethoxylated mono-, di- and triglycerides of C _8-22 fatty acids having from 4 to 50 ethylene oxide units, e.g. Hydrogenated ethoxylated castor oil, olive oil ethoxylate, almond oil ethoxylate, mink oil ethoxylate, polyoxyethylene glycol caprylic / capric acid glycerides, polyoxyethylene glycerol monolaurate and polyoxyethylene glycol coconut fatty acid glycerides.

Farther it may be preferred in the inventive compositions of several, especially from two, different plant extracts use.

Regarding the invention usable Plant extracts continue to be referred to the extracts that in page 44 of the 3rd edition of the Guidance on the Declaration of Ingredients Cosmetic agent, published by the Industrieverband Körperpflege- and Detergents e.V. (IKW), Frankfurt, beginning table are listed.

As enzyme inhibitors, the skin treatment compositions according to the invention may contain, for example, esterase inhibitors. These are preferably trialkyl such as trimethyl citrate, tripropyl, triisopropyl, tributyl citrate and especially triethyl citrate (Hydagen® ^® CAT, Henkel KGaA, Dusseldorf / FRG). The substances inhibit the enzyme activity and thereby reduce odors. Further substances which are suitable as esterase inhibitors are sterol sulfates or phosphates, such as, for example, lanosterol, cholesterol, campesterol, stigmasterol and sitosterol sulfate or phosphate, dicarboxylic acids and their esters, for example glutaric acid, glutaric acid monoethyl ester, glutaric acid diethyl ester, adipic acid, Adipic acid monoethyl ester, diethyl adipate, malonic acid and diethyl malonate, hydroxycarboxylic acids and their esters such as citric acid, malic acid, tartaric acid or diethyl tartrate, and zinc glycinate.

Particularly suitable enzyme inhibitors are MMP-1-inhibiting substances, in particular those selected from photolyase and / or T4 endonuclease V, propyl gallate, precocenes, 6-hydroxy-7-methoxy-2,2-dimethyl-1 (2H) -benzopyran, 3,4-dihydro-6-hydroxy-7-methoxy-2,2-dimethyl-1 (2H) -benzopyran (available as a commercial product Lipochroman 6 ^™ from Lipotec SA) and mixtures thereof. Precocenes are plant-occurring chromene derivatives known as hormones (The Merck Index, 12th Edition, Merck & Co. 1996). The MMP-1-inhibiting effect of these substances is in the German Offenlegungsschrift DE 10016016 A1 described. They are used in amounts of 0.1 to 5, preferably 0.5 to 2 wt .-%, each based on the total agent.

The skin-treating agent of the invention may further contain at least one ester of retinol (vitamin A ₁ ) with a C _2-18 carboxylic acid. Preferred retinol esters are retinyl acetate and retinyl palmitate, particularly preferred is retinyl palmitate. The retinol esters are used in amounts of 0.1 to 5, preferably 0.5 to 2 wt .-%, each based on the total agent.

In a preferred embodiment, in particular when used as an emulsion, as a surfactant solution or as a cleaning agent, the skin treatment compositions according to the invention contain at least one surface-active substance as emulsifier or dispersant. Emulsifiers cause at the phase interface the formation of water- or oil-stable adsorption layers, which protect the dispersed droplets against coalescence and thus stabilize the emulsion. Emulsifiers are therefore constructed like surfactants from a hydrophobic and a hydrophilic part of the molecule. Hydrophilic emulsifiers preferably form O / W emulsions and hydrophobic emulsifiers preferably form W / O emulsions. W / O emulsions stabilized without hydrophilic emulsifiers are disclosed in the publications DE 19816665 A1 and DE 19801593 A1 disclosed.

• – Anlagerungsprodukte von 4 bis 30 Mol Ethylenoxid und/oder 0 bis 5 Mol Propylenoxid an lineare C₈-C₂₂-Fettalkohole, an C₁₂-C₂₂-Fettsäuren und an C₈-C₁₅-Alkylphenole,
• – C₁₂-C₂₂-Fettsäuremono- und -diester von Anlagerungsprodukten von 1 bis 30 Mol Ethylenoxid an C₃-C₆-Polyole, insbesondere an Glycerin,
• – Ethylenoxid- und Polyglycerin-Anlagerungsprodukte an Methylglucosid-Fettsäureester, Fettsäurealkanolamide und Fettsäureglucamide,
• – C₈-C₂₂-Alkylmono- und -oligoglycoside und deren ethoxylierte Analoga, wobei Oligomerisierungsgrade von 1,1 bis 5, insbesondere 1,2 bis 2,0, und Glucose als Zuckerkomponente bevorzugt sind,
• – Gemische aus Alkyl-(oligo)-glucosiden und Fettalkoholen, z. B. das im Handel erhältliche Produkt Montanov^®68,
• – Anlagerungsprodukte von 5 bis 60 Mol Ethylenoxid an Rizinusöl und gehärtetes Rizinusöl,
• – Partialester von Polyolen mit 3-6 Kohlenstoffatomen mit gesättigten C₈-C₂₂-Fettsäuren,
• – Sterole (Sterine). Als Sterole wird eine Gruppe von Steroiden verstanden, die am C-Atom 3 des Steroid-Gerüstes eine Hydroxylgruppe tragen und sowohl aus tierischem Gewebe (Zoosterole) wie auch aus pflanzlichen Fetten (Phytosterole) isoliert werden. Beispiele für Zoosterole sind das Cholesterol und das Lanosterol. Beispiele geeigneter Phytosterole sind Beta-Sitosterol, Stigmasterol, Campesterol und Ergosterol. Auch aus Pilzen und Hefen werden Sterole, die sogenannten Mykosterole, isoliert.
• – Phospholipide, vor allem die Glucose-Phospolipide, die z. B. als Lecithine bzw. Phosphatidylcholine aus z. B. Eidotter oder Pflanzensamen (z. B. Sojabohnen) gewonnen werden,
• – Fettsäureester von Zuckern und Zuckeralkoholen wie Sorbit,
• – Polyglycerine und Polyglycerinderivate, bevorzugt Polyglyceryl-2-dipolyhydroxystearat (Handelsprodukt Dehymuls^® PGPH) und Polyglyceryl-3-diisostearat (Handelsprodukt Lameform^® TGI),
• – Lineare und verzweigte C₈-C₃₀-Fettsäuren und deren Na-, K-, Ammonium-, Ca-, Mg- und Zn-Salze.

Emulsifiers which can be used according to the invention are, for example

• Addition products of 4 to 30 mol of ethylene oxide and / or 0 to 5 mol of propylene oxide onto linear C ₈ -C ₂₂ -fatty alcohols, on C ₁₂ -C ₂₂ -fatty acids and on C ₈ -C ₁₅ -alkylphenols,
• C ₁₂ -C ₂₂ -fatty acid mono- and diesters of addition products of from 1 to 30 mol of ethylene oxide onto C ₃ -C ₆ -polyols, in particular to glycerol,
• Ethylene oxide and polyglycerol addition products to methyl glucoside fatty acid esters, fatty acid alkanolamides and fatty acid glucamides,
• C ₈ -C ₂₂ -alkylmono- and -oligoglycosides and their ethoxylated analogues, preference being given to degrees of oligomerization of from 1.1 to 5, in particular from 1.2 to 2.0, and glucose as the sugar component,
• - Mixtures of alkyl (oligo) glucosides and fatty alcohols, eg. As the commercially available product Montanov ^® 68,
• Adducts of 5 to 60 moles of ethylene oxide with castor oil and hydrogenated castor oil,
• Partial esters of polyols having 3-6 carbon atoms with saturated C ₈ -C ₂₂ fatty acids,
• - Sterols (sterols). Sterols are understood to mean a group of steroids which have a hydroxyl group on C-atom 3 of the steroid skeleton and are isolated both from animal tissue (zoosterols) and from vegetable fats (phytosterols). Examples of zoosterols are cholesterol and lanosterol. Examples of suitable phytosterols are beta-sitosterol, stigmasterol, campesterol and ergosterol. From mushrooms and yeasts sterols, the so-called mycosterols, isolated.
• - Phospholipids, especially the glucose phospholipids, the z. B. as lecithins or phosphatidylcholines from z. Egg yolks or plant seeds (eg soybeans),
• Fatty acid esters of sugars and sugar alcohols such as sorbitol,
• - polyglycerols and polyglycerol, preferably Polyglyceryl-2 dipolyhydroxystearate (Dehymuls ^® PGPH commercial product) and polyglyceryl-3 diisostearate (Lameform ^® TGI commercial product)
• - Linear and branched C ₈ -C ₃₀ fatty acids and their Na, K, ammonium, Ca, Mg and Zn salts.

The agents according to the invention contain the emulsifiers preferably in amounts of 0.1 to 25 wt .-%, in particular 0,5 - 15 Wt .-%, based on the total agent.

In a preferred embodiment, at least one nonionic emulsifier having an HLB value of 8 and below, according to the Römpp Lexicon Chemistry (Eds .: J. Falbe, M. Regitz), 10th edition, Georg Thieme Verlag Stuttgart, New York , (1997), page 1764, listed definitions of the HLB value. Such emulsifiers are, for example, compounds of the general formula R ¹ -O-R ² , in which R ^{1 is} a primary linear alkyl, alkenyl or acyl group having 20-30 C atoms and R ^{2 is} hydrogen, a group having the formula C _n H _2n O) _x -H with x = 1 or 2 and n = 2-4 or a polyhydroxyalkyl group having 4-6 C atoms and 2-5 hydroxyl groups. Particularly preferred emulsifier of the formula R ¹ -O-R ² is a behene or erucyl derivative in which R ^{1 is} a linear, terminally substituted alkyl, alkenyl or acyl group having 22 C atoms.

Further preferred emulsifiers with an HLB value of 8 and below are the adducts of 1 or 2 moles of ethylene oxide or propylene oxide with behenyl alcohol, erucyl alcohol, arachidyl alcohol or behenic acid or erucic acid. Preferably, the monoesters of C ₁₆ -C ₃₀ fatty acids with polyols such as. As pentaerythritol, trimethylolpropane, diglycerol, sorbitol, glucose or methyl glucose. Examples of such products are z. B. sorbitan monobehenate or pentaerythritol monoerucate.

In another preferred embodiment, at least one ionic emulsifier selected from anionic, zwitterionic, ampholytic and cationic emulsifiers is included. Preferred anionic emulsifiers are alkyl sulfates, alkyl polyglycol ether sulfates and ether carboxylic acids having 10 to 18 carbon atoms in the alkyl group and up to 12 glycol ether groups in the molecule, sulfosuccinic acid mono- and dialkyl esters having 8 to 18 carbon atoms in the alkyl group and sulfosuccinic monoalkylpolyoxyethyl esters having 8 to 18 C atoms in the alkyl group and 1 to 6 oxyethyl groups, monoglyceride sulfates, alkyl and alkenyl ether phosphates and protein fatty acid condensates. Zwitterionic emulsifiers carry in the molecule at least one quaternary ammonium group and at least one -COO ^- - or -SO ₃ ^- group. Particularly suitable zwitterionic emulsifiers are the so-called betaines such as the N-alkyl-N, N-dimethylammonium glycinates, N-acyl-aminopropyl-N, N-dimethylammoniumglycinate and 2-alkyl-3-carboxymethyl-3-hydroxyethyl-imidazoline with 8 each to 18 carbon atoms in the alkyl or acyl group and Kokosacylaminoethylhydroxyethylcarboxymethylglycinat.

Ampholytic emulsifiers contain, in addition to a C ₈ -C ₂₄ -alkyl or -acyl group, at least one free amino group and at least one -COOH or -SO ₃ H group in the molecule and can form internal salts. Examples of suitable ampholytic emulsifiers are N-alkylglycines, N-alkylaminopropionic acids, N-alkylaminobutyric acids, N-alkyliminodipropionic acids, N-hydroxyethyl-N-alkylamidopropylglycines, N-alkyltaurines, N-alkylsarcosines, 2-alkylaminopropionic acids and alkylaminoacetic acids each having about 8 to 24 C Atoms in the alkyl group.

The ionic emulsifiers are in an amount of 0.01 to 5 wt .-%, preferably from 0.05 to 3 wt .-% and particularly preferably from 0.1 to 1 wt .-%, based on the total agent included.

• – alkoxylierte Fettsäurealkylester der Formel R¹CO-(OCH₂CHR²)_xOR³, in der R¹CO für einen linearen oder verzweigten, gesättigten und/oder ungesättigten Acylrest mit 6 bis 22 Kohlenstoffatomen, R² für Wasserstoff oder Methyl, R³ für lineare oder verzweigte Alkylreste mit 1 bis 4 Kohlenstoffatomen und x für Zahlen von 1 bis 20 steht,
• – Anlagerungsprodukte von Ethylenoxid an Fettsäurealkanolamide und Fettamine,
• – Fettsäure-N-alkylglucamide,
• – C₈-C₂₂-Alkylamin-N-oxide,
• – Alkylpolygykoside entsprechend der allgemeinen Formel RO-(Z)_x wobei R für eine C₈-C₁₆-Alkylgruppe, Z für Zucker sowie x für die Anzahl der Zuckereinheiten steht. Die erfindungsgemäß verwendbaren Alkylpolyglykoside können lediglich einen bestimmten Alkylrest R enthalten. Üblicherweise werden diese Verbindungen aber ausgehend von natürlichen Fetten und Ölen oder Mineralölen hergestellt. In diesem Fall liegen als Alkylreste R Mischungen entsprechend den Ausgangsverbindungen bzw. entsprechend der jeweiligen Aufarbeitung dieser Verbindungen vor. Besonders bevorzugt sind solche Alkylpolyglykoside, bei denen R im wesentlichen aus C₈- und C₁₀-Alkylgruppen, im wesentlichen aus C₁₂- und C₁₄-Alkylgruppen, im wesentlichen aus C₈- bis C₁₆-Alkylgruppen oder im wesentlichen aus C₁₂- bis C₁₆-Alkylgruppen besteht. Als Zuckerbaustein Z können beliebige Mono- oder Oligosaccharide eingesetzt werden. Üblicherweise werden Zucker mit 5 bzw. 6 Kohlenstoffatomen sowie die entsprechenden Oligosaccharide eingesetzt, beispielsweise Glucose, Fructose, Galactose, Arabinose, Ribose, Xylose, Lyxose, Allose, Altrose, Mannose, Gulose, Idose, Talose und Sucrose. Bevorzugte Zuckerbausteine sind Glucose, Fructose, Galactose, Arabinose und Sucrose; Glucose ist besonders bevorzugt. Die erfindungsgemäß verwendbaren Alkylpolyglykoside enthalten im Schnitt 1,1 bis 5, bevorzugt 1,1 bis 2,0 besonders bevorzugt 1,1 bis 1,8 Zuckereinheiten. Auch die alkoxylierten Homologen der genannten Alkylpolyglykoside können erfindungsgemäß eingesetzt werden. Diese Homologen können durchschnittlich bis zu 10 Ethylenoxid- und/oder Propylenoxideinheiten pro Alkylglykosideinheit enthalten.

Furthermore, the skin treatment compositions according to the invention may contain foaming nonionic, zwitterionic, anionic and cationic surfactants. Examples of nonionic surfactants are

• - alkoxylated fatty acid alkyl esters of the formula R ¹ CO- (OCH ₂ CHR ² ) _x OR ³ , in which R ¹ CO for a linear or branched, saturated and / or unsaturated acyl radical having 6 to 22 carbon atoms, R ^{2 is} hydrogen or methyl, R ^{3 represents} linear or branched alkyl radicals having 1 to 4 carbon atoms and x represents numbers from 1 to 20,
• Adducts of ethylene oxide with fatty acid alkanolamides and fatty amines,
• Fatty acid N-alkylglucamides,
• C ₈ -C ₂₂ -alkylamine N-oxides,
• - Alkylpolygykoside according to the general formula RO- (Z) _x wherein R is a C ₈ -C ₁₆ alkyl group, Z stands for sugar and x for the number of sugar units. The alkyl polyglycosides which can be used according to the invention can only contain one particular alkyl radical R. Usually, however, these compounds are prepared starting from natural fats and oils or mineral oils. In this case, the alkyl radicals R are mixtures corresponding to the starting compounds or corresponding to the particular work-up of these compounds. Particular preference is given to those alkyl polyglycosides in which R consists essentially of C ₈ and C ₁₀ -alkyl groups, essentially of C ₁₂ and C ₁₄ -alkyl groups, essentially of C ₈ to C ₁₆ -alkyl groups or essentially of C ₁₂ - To C ₁₆ alkyl groups. As sugar building block Z it is possible to use any desired mono- or oligosaccharides. Usually, sugars having 5 or 6 carbon atoms and the corresponding oligosaccharides are used, for example glucose, fructose, galactose, arabinose, ribose, xylose, lyxose, allose, altrose, mannose, gulose, idose, talose and sucrose. Preferred sugar building blocks are glucose, fructose, galactose, arabinose and sucrose; Glucose is particularly preferred. The alkyl polyglycosides which can be used according to the invention contain on average 1.1 to 5, preferably 1.1 to 2.0, more preferably 1.1 to 1.8 sugar units. The alkoxylated homologs of said alkyl polyglycosides can also be used according to the invention. These homologs may contain on average up to 10 ethylene oxide and / or propylene oxide units per alkyl glycoside unit.

Zwitterionic surfactants are those surface-active compounds which carry in the molecule at least one quaternary ammonium group and at least one -COO ^(-) or -SO ₃ ^(-) group. Particularly suitable zwitterionic surfactants are the so-called betaines such as N-alkyl-N, N-dimethylammonium glycinates, for example cocoalkyldimethylammonium glycinate, N-acylaminopropyl-N, N-dimethylammonium glycinates, for example cocoacylaminopropyldimethylammonium glycinate, and 2-alkyl-3-carboxymethyl-3 -hydroxyethylimidazolines having in each case 8 to 18 carbon atoms in the alkyl or acyl group, and the cocoacylaminoethylhydroxyethylcarboxymethylglycinate. A preferred zwitterionic surfactant is the fatty acid amide derivative known by the INCI name Cocamidopropyl Betaine.

• – Acylglutamate der Formel (IV),
  
  in der R¹CO für einen linearen oder verzweigten Acylrest mit 6 bis 22 Kohlenstoffatomen und 0, 1, 2 oder 3 Doppelbindungen und X für Wasserstoff, ein Alkali- und/oder Erdalkalimetall, Ammonium, Alkylammonium, Alkanolammonium oder Glucammonium steht, beispielsweise Acylglutamate, die sich von Fettsäuren mit 6 bis 22, vorzugsweise 12 bis 18 Kohlenstoffatomen ableiten, wie beispielsweise C_12/14- bzw. C_12/18-Kokosfettsäure, Laurinsäure, Myristinsäure, Palmitinsäure und/oder Stearinsäure, insbesondere Natrium-N-cocoyl- und Natrium-N-stearoyl-L-glutamat,
• – Ester einer hydroxysubstituierten Di- oder Tricarbonsäure der allgemeinen Formel (VII),
  
  in der X=H oder eine -CH₂COOR-Gruppe ist, Y=H oder -OH ist unter der Bedingung, dass Y=H ist, wenn X=-CH₂COOR ist, R, R¹ und R² unabhängig voneinander ein Wasserstoffatom, ein Alkali- oder Erdalkalimetallkation, eine Ammoniumgruppe, das Kation einer ammonium-organischen Base oder einen Rest Z bedeuten, der von einer polyhydroxylierten organischen Verbindung stammt, die aus der Gruppe der veretherten(C₆-C₁₈)-Alkylpolysaccharide mit 1 bis 6 monomeren Saccharideinheiten und/oder der veretherten aliphatischen (C₆-C₁₆)-Hydroxyalkylpolyole mit 2 bis 16 Hydroxylresten ausgewählt sind, unter der Maßgabe, daß wenigstens eine der Gruppen R, R¹ oder R² ein Rest Z ist,
• – Ester des Sulfobernsteinsäure-Salzes der allgemeinen Formel (VIII),
  
  in der R¹ und R² unabhängig voneinander ein Wasserstoffatom, ein Alkali- oder Erdalkalimetallkation, eine Ammoniumgruppe, das Kation einer ammoniumorganischen Base oder einen Rest Z bedeuten, der von einer polyhydroxylierten organischen Verbindung stammt, die aus der Gruppe der veretherten (C₆-C₁₈)-Alkylpolysaccharide mit 1 bis 6 monomeren Saccharideinheiten und/oder der veretherten aliphatischen(C₆-C₁₆)-Hydroxyalkylpolyole mit 2 bis 16 Hydroxylresten ausgewählt ist, unter der Maßgabe, daß wenigstens eine der Gruppen R¹ oder R² ein Rest Z ist,
• – Sulfobernsteinsäuremono- und -dialkylester mit 8 bis 24 C-Atomen in der Alkylgruppe und Sulfobernsteinsäuremonoalkylpolyoxyethylester mit 8 bis 24 C-Atomen in der Alkylgruppe und 1 bis 6 Ethoxygruppen,
• – Ester der Weinsäure und Zitronensäure mit Alkoholen, die Anlagerungsprodukte von etwa 2-15 Molekülen Ethylenoxid und/oder Propylenoxid an Fettalkohole mit 8 bis 22 C-Atomen darstellen,
• – lineare und verzweigte Fettsäuren mit 8 bis 30 C-Atomen (Seifen),
• – Ethercarbonsäuren der Formel R-O-(CH₂-CH₂O)_x-CH₂-COOH, in der R eine lineare Alkylgruppe mit 8 bis 30 C-Atomen und x = 0 oder 1 bis 16 ist,
• – Acylsarcosinate mit einem linearen oder verzweigten Acylrest mit 6 bis 22 Kohlenstoffatomen und 0, 1, 2 oder 3 Doppelbindungen,
• – Acyltaurate mit einem linearen oder verzweigten Acylrest mit 6 bis 22 Kohlenstoffatomen und 0, 1, 2 oder 3 Doppelbindungen,
• – Acylisethionate mit einem linearen oder verzweigten Acylrest mit 6 bis 22 Kohlenstoffatomen und 0, 1, 2 oder 3 Doppelbindungen,
• – lineare Alkansulfonate mit 8 bis 24 C-Atomen,
• – lineare Alpha-Olefinsulfonate mit 8 bis 24 C-Atomen,
• – Alpha-Sulfofettsäuremethylester von Fettsäuren mit 8 bis 30 C-Atomen,
• – Alkylsulfate und Alkylpolyglykolethersulfate der Formel R-O(CH₂-CH₂O)_z-SO₃X, in der R eine bevorzugt lineare Alkylgruppe mit 8 bis 30 C-Atomen, besonders bevorzugt mit 8 – 18 C-Atomen, z = 0 oder 1 bis 12, besonders bevorzugt 3, und X ein Natrium-, Kalium-, Magnesium-, Zink-, Ammoniumion oder ein Monoalkanol-, Dialkanol- oder Trialkanolammoniumion mit 2 bis 4 Kohlenstoffatomen in der Alkanolgruppe ist, wobei ein besonders bevorzugtes Beispiel Zinkcocoylethersulfat mit einem Ethoxylierungsgrad von z = 3 ist,
• – Gemische oberflächenaktiver Hydroxysulfonate gemäß DE-A-37 25 030,
• – sulfatierte Hydroxyalkylpolyethylen- und/oder Hydroxyalkylenpropylenglykolether gemäß DE-A-37 23 354,
• – Sulfonate ungesättigter Fettsäuren mit 8 bis 24 C-Atomen und 1 bis 6 Doppelbindungen gemäß DE-A-39 26 344,
• – Alkyl- und/oder Alkenyletherphosphate der Formel (V),
  
• – in der R¹ bevorzugt für einen aliphatischen Kohlenwasserstoffrest mit 8 bis 30 Kohlenstoffatomen, R² für Wasserstoff, einen Rest (CH₂CH₂O)_nR¹ oder X, n für Zahlen von 1 bis 10 und X für Wasserstoff, ein Alkali- oder Erdalkalimetall oder NR³R⁴R⁵R⁶, mit R³ bis R⁶ unabhängig voneinander stehend für einen C₁ bis C₄- Kohlenwasserstoffrest, steht,
• – sulfatierte Fettsäurealkylenglykolester der Formel R¹CO(AlkO)_nSO₃M , in der R¹CO- für einen linearen oder verzweigten, aliphatischen, gesättigten und/oder ungesättigten Acylrest mit 6 bis 22 C-Atomen, Alk für CH₂CH₂, CHCH₃CH₂ und/oder CH₂CHCH₃, n für Zahlen von 0,5 bis 5 und M für ein Kation steht, wie sie in der DE-OS 197 36 906 .5 beschrieben sind,
• – Monoglyceridsulfate und Monoglyceridethersulfate der Formel (VI),
  
  in der R⁸CO für einen linearen oder verzweigten Acylrest mit 6 bis 22 Kohlenstoffatomen, x, y und z in Summe für 0 oder für Zahlen von 1 bis 30, vorzugsweise 2 bis 10, und X für ein Alkali- oder Erdalkalimetall steht. Typische Beispiele für im Sinne der Erfindung geeignete Monoglycerid(ether)sulfate sind die Umsetzungsprodukte von Laurinsäuremonoglycerid, Kokosfettsäuremonoglycerid, Palmitinsäuremonoglycerid, Stearinsäuremonoglycerid, Ölsäuremonoglycerid und Talgfettsäuremonoglycerid sowie deren Ethylenoxidaddukte mit Schwefeltrioxid oder Chlorsulfonsäure in Form ihrer Natriumsalze. Vorzugsweise werden Monoglyceridsulfate der Formel (VI) eingesetzt, in der R⁸CO für einen linearen Acylrest mit 8 bis 18 Kohlenstoffatomen steht.

Suitable anionic surfactants in preparations according to the invention are all anionic surfactants suitable for use on the human body. These are characterized by a water-solubilizing, anionic group such as. As a carboxylate, sulfate, sulfonate or phosphate group and a lipophilic alkyl group having about 8 to 30 carbon atoms. In addition, glycol or polyglycol ether groups, ester, ether and amide groups and hydroxyl groups may be present in the molecule. Examples of suitable foaming anionic surfactants are, in each case in the form of the sodium, potassium and ammonium as well as the mono-, di- and trialkanolammonium salts having 2 to 4 carbon atoms in the alkanol group,

• Acylglutamates of the formula (IV),
  
  in which R ¹ CO is a linear or branched acyl radical having 6 to 22 carbon atoms and 0, 1, 2 or 3 double bonds and X is hydrogen, an alkali and / or alkaline earth metal, ammonium, alkylammonium, alkanolammonium or glucammonium, for example acylglutamates, which are derived from fatty acids having 6 to 22, preferably 12 to 18 carbon atoms, such as, for example, C _12/14 or C _12/18 coconut fatty acid, lauric acid, myristic acid, palmitic acid and / or stearic acid, in particular sodium N-cocoyl and sodium N-stearoyl-L-glutamate,
• Esters of a hydroxy-substituted di- or tricarboxylic acid of the general formula (VII),
  
  wherein X is H or a -CH ₂ COOR group, Y is H or -OH is under the condition that Y is H when X is -CH ₂ COOR, R, R ¹ and R ^{2 are} independently a hydrogen atom, an alkali or alkaline earth metal cation, an ammonium group, the cation of an ammonium organic base or a radical Z derived from a polyhydroxylated organic compound selected from the group of ether (C ₆ -C ₁₈ ) -alkyl polysaccharides having 1 to 6 monomeric saccharide units and / or the etherified aliphatic (C ₆ -C ₁₆ ) -hydroxyalkylpolyols having 2 to 16 hydroxyl radicals, with the proviso that at least one of the groups R, R ¹ or R ^{2 is} a radical Z,
• Esters of the sulfosuccinic acid salt of the general formula (VIII),
  
  in which R ¹ and R ² independently of one another denote a hydrogen atom, an alkali metal or alkaline earth metal cation, an ammonium group, the cation of an ammonium organic base or a radical Z derived from a polyhydroxylated organic compound selected from the group of etherified (C ₆ -) C ₁₈ ) -alkyl polysaccharides having 1 to 6 monomeric saccharide units and / or the etherified aliphatic (C ₆ -C ₁₆ ) -hydroxyalkylpolyols having 2 to 16 hydroxyl radicals, provided that at least one of R ¹ or R ^{2 is} a radical Z is,
• Sulfosuccinic acid mono- and dialkyl esters having 8 to 24 C atoms in the alkyl group and sulfosuccinic monoalkylpolyoxyethyl esters having 8 to 24 C atoms in the alkyl group and 1 to 6 ethoxy groups,
• Esters of tartaric acid and citric acid with alcohols which are adducts of about 2-15 molecules of ethylene oxide and / or propylene oxide with fatty alcohols containing 8 to 22 carbon atoms,
• - linear and branched fatty acids with 8 to 30 carbon atoms (soaps),
• Ether carboxylic acids of the formula RO- (CH ₂ -CH ₂ O) _x -CH ₂ -COOH, in which R is a linear alkyl group having 8 to 30 C atoms and x = 0 or 1 to 16,
• Acylsarcosinates having a linear or branched acyl radical having 6 to 22 carbon atoms and 0, 1, 2 or 3 double bonds,
• Acyl taurates having a linear or branched acyl radical having 6 to 22 carbon atoms and 0, 1, 2 or 3 double bonds,
• Acyl isethionates having a linear or branched acyl radical having 6 to 22 carbon atoms and 0, 1, 2 or 3 double bonds,
• - linear alkanesulfonates having 8 to 24 carbon atoms,
• - linear alpha-olefin sulfonates having 8 to 24 carbon atoms,
• Alpha-sulfofatty acid methyl esters of fatty acids having 8 to 30 C atoms,
• - Alkyl sulfates and alkyl polyglycol ether sulfates of the formula RO (CH ₂ -CH ₂ O) _z -SO ₃ X, in the R is a preferably linear alkyl group having 8 to 30 carbon atoms, more preferably having 8 - 18 carbon atoms, z = 0 or 1 to 12, more preferably 3, and X is a sodium, potassium, magnesium, zinc, ammonium or a monoalkanol, dialkanol or Trialkanolammoniumion having 2 to 4 carbon atoms in the alkanol group, with a particularly preferred example of zinc cocoyl ether sulfate with a degree of ethoxylation of z = 3,
• Mixtures of surface-active hydroxysulfonates according to DE-A-37 25 030,
• Sulfated hydroxyalkylpolyethylene and / or hydroxyalkylene-propylene glycol ethers according to DE-A-37 23 354,
• Sulfonates of unsaturated fatty acids having 8 to 24 C atoms and 1 to 6 double bonds according to DE-A-39 26 344,
• Alkyl and / or alkenyl ether phosphates of the formula (V),
  
• In which R ^{1 is} preferably an aliphatic hydrocarbon radical having 8 to 30 carbon atoms, R ^{2 is} hydrogen, a radical (CH ₂ CH ₂ O) _n R ¹ or X, n is from 1 to 10 and X is hydrogen, an alkali or alkaline earth metal or NR ³ R ⁴ R ⁵ R ⁶ , where R ³ to R ⁶ independently of one another represent a C ₁ to C ₄ hydrocarbon radical,
• Sulfated fatty acid alkylene glycol esters of the formula R ¹ CO (AlkO) _n SO ₃ M in which R ^{1 is} CO- for a linear or branched, aliphatic, saturated and / or unsaturated acyl radical having 6 to 22 C atoms, Alk for CH ₂ CH ₂ , CHCH ₃ CH ₂ and / or CH ₂ CHCH ₃ , n is from 0.5 to 5 and M is a cation as described in the DE-OS 197 36 906 .5 are described,
• Monoglyceride sulphates and monoglyceride ether sulphates of the formula (VI),
  
  in which R ⁸ CO is a linear or branched acyl radical having 6 to 22 carbon atoms, x, y and z are in total 0 or numbers of 1 to 30, preferably 2 to 10, and X is an alkali or alkaline earth metal. Typical examples of monoglyceride (ether) sulfates suitable for the purposes of the invention are the reaction products of lauric acid monoglyceride, coconut fatty acid monoglyceride, palmitic acid monoglyceride, stearic acid monoglyceride, oleic acid monoglyceride and tallow fatty acid monoglyceride and their ethylene oxide adducts with sulfur trioxide or chlorosulfonic acid in the form of their sodium salts. Monoglyceride sulfates of the formula (VI) in which R ⁸ CO is a linear acyl radical having 8 to 18 carbon atoms are preferably used.

According to the invention it can for certain Applications be beneficial, mild, i. particularly skin-friendly, Surfactants such as fatty alcohol polyglycol ether sulfates, monoglyceride sulfates, Mono- and / or dialkylsulfosuccinates, fatty acid isethionates, fatty acid sarcosinates, taurides, Fatty acid glutamates, α-olefinsulfonates, ether carboxylic acids, alkyl oligoglucosides, fatty acid glucamides, Alkylamidobetaines and / or protein fatty acid condensates, the latter preferably based on wheat proteins.

The Skin treatment agent according to the invention can furthermore at least one organic or mineral or modified mineral sunscreen filter included. In the sunscreen filters it is liquid or crystalline at room temperature Substances that are able to absorb ultraviolet rays and the energy absorbed in the form of non-longitudinal radiation, z. B. heat again leave. One differentiates between UVA filters and UVB filters. The UVA and UVB filters can used both individually and in mixtures. The use of filter mixtures is preferred according to the invention.

The organic UV filters used according to the invention are preferably selected from the derivatives of dibenzoylmethane, cinnamic esters, diphenylacrylic acid esters, benzophenone, camphor, p-aminobenzoic acid esters, o-aminobenzoic acid esters, salicylic acid esters, benzimidazoles, symmetrically or asymmetrically substituted 1,3,5-triazines, monomeric and oligomeric 4,4-Diarylbutadiencarbonsäureestern and -carbonsäureamiden, Ketotricyclo (5.2.1.0) decane, Benzalmalonsäureestern and any mixtures of the above components. The organic UV filters can be oil-soluble or water-soluble. According to the invention particularly oil-soluble UV filters preferred are 1- (4-tert-butylphenyl) -3- (4'-methoxyphenyl) propane-1,3-dione (Parsol ^® 1789), 1-phenyl-3- (4'- isopropylphenyl) -propane-1,3-dione, 3- (4'-methylbenzylidene) -D, L-camphor, 4- (dimethylamino) benzoic acid 2-ethylhexyl ester, 4- (dimethylamino) benzoic acid 2-octyl ester, 4 - (dimethylamino) benzoate, 4-methoxycinnamic acid 2-ethylhexyl ester, propyl 4-methoxycinnamate, isopentyl 4-methoxycinnamate, 2-cyano-3,3-phenylcinnamic acid 2-ethylhexyl ester (octocrylene), 2-ethylhexyl salicylate, salicylic acid-4 isopropylbenzyl ester, salicylic acid homomenthyl ester (3,3,5-trimethylcyclohexylsalicylate), 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 4-methoxybenzmalonic acid 2-ethylhexyl ester, 2,4,6-trianilino (p-carbo-2'-ethyl-1'-hexyloxy) -1,3,5-triazine (octyl triazone) and dioctyl butamido triazone ( ^Uvasorb® HEB) as well any mixtures of said Components.

preferred water-soluble UV filters are 2-phenylbenzimidazole-5-sulfonic acid and its alkali, alkaline earth, Ammonium, alkylammonium, alkanolammonium and glucammonium salts, sulfonic acid derivatives of benzophenones, preferably 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and their salts, sulfonic acid derivatives of the 3-benzylidene camphor, such as. B. 4- (2-oxo-3-bomylidenemethyl) benzenesulfonic acid and 2-methyl-5- (2-oxo-3-bomylidene) sulfonic acid and their salts.

Some of the oil-soluble UV filters can themselves serve as solvents or solubilizers for other UV filters. Thus, for example, solutions of the UV-A filter 1- (4-tert-butylphenyl) -3- (4'methoxyphenyl) propane-1,3-dione (z. B. Parsol ^® 1789) in various UV-B Make filters. Therefore, in a further preferred embodiment, the compositions according to the invention contain 1- (4-tert-butylphenyl) -3- (4'-methoxyphenyl) propane-1,3-dione in combination with at least one UV-B filter selected from 4 2-ethylhexyl 2-ethoxycinnamate, 2-ethylhexyl 2-cyano-3,3-phenylcinnamate, 2-ethylhexyl salicylate, and 3,3,5-trimethylcyclohexyl salicylate. In these combinations, the weight ratio of UV-B filter to 1- (4-tert-butylphenyl) -3- (4'-methoxyphenyl) propane-1,3-dione is between 1: 1 and 10: 1, preferably between 2: 1 and 8: 1, the molar ratio being between 0.3 and 3.8, preferably between 0.7 and 3.0.

The inventively preferred inorganic photoprotective pigments are finely dispersed or colloidally disperse metal oxides and metal salts, for example titanium dioxide, zinc oxide, iron oxide, aluminum oxide, cerium oxide, zirconium oxide, silicates (talc) and barium sulfate. The particles should have an average diameter of less than 100 nm, preferably between 5 and 50 nm and in particular between 15 and 30 nm, so-called nanopigments. They may have a spherical shape, but it is also possible to use those particles which have an ellipsoidal or otherwise deviating shape from the spherical shape. The pigments can also be surface-treated, ie hydrophilized or hydrophobized. Typical examples are coated titanium dioxides, such as. Example, titanium dioxide T 805 (Degussa) or Eusolex ^® T2000 (Merck). Suitable hydrophobic coating agents are in particular silicones and in particular trialkoxyoctylsilanes or simethicones. Particularly preferred are titanium dioxide and zinc oxide.

Furthermore, at least one protein hydrolyzate or its derivative can be present in the skin treatment compositions according to the invention. Both vegetable and animal protein hydrolysates can be used according to the invention. Animal protein hydrolysates are z. B. elastin, collagen, keratin, silk and milk protein protein hydrolysates, which may also be in the form of salts. Vegetable protein hydrolysates, eg. Soy, wheat, almonds, peas, potato and rice protein hydrolysates. Corresponding commercial products are z. B. DiaMin® ^® (Diamalt) Gluadin ^® (Cognis), Lexein ^® (Inolex) and Crotein ^® (Croda).

At Place of protein hydrolysates can on the one hand, otherwise obtained amino acid mixtures, on the other hand individual amino acids as well as their physiologically compatible Salts are used. The preferred amino acids of the invention include glycine, Serine, threonine, cysteine, asparagine, glutamine, pyroglutamic acid, alanine, Valine, leucine, isoleucine, proline, tryptophan, phenylalanine, methionine, aspartic acid, glutamic acid, Lysine, arginine and histidine as well as the zinc salts and the acid addition salts the said amino acids.

Also possible is the use of derivatives of protein hydrolysates, z. In the form of their fatty acid condensation products. Corresponding commercial products are z. B. Lamepon ^® (Cognis), Gluadin ^® (Cognis), Lexein ^® (Inolex), Crolastin ^{® ®} or Crotein (Croda).

Cationized protein hydrolysates can also be used according to the invention, it being possible for the underlying protein hydrolyzate to originate from the animal, from the plant, from marine life forms or from biotechnologically obtained protein hydrolysates. Preference is given to cationic protein hydrolysates whose protein content on which they are based has a molecular weight of from 100 to 25,000 daltons, preferably from 250 to 5,000 daltons. Furthermore, cationic protein hydrolyzates are to be understood as meaning quaternized amino acids and mixtures thereof. Furthermore, the cationic protein hydrolysates may also be further derivatized. As typical examples of inventively used cationic protein hydrolysates and derivatives, some are of the INCI - ^th names in the "International Cosmetic Ingredient Dictionary and Handbook" (seventh edition 1997, The Cosmetic, Toiletry, and Fragrance Association 1101 17 Street, NW, Suite 300, Washington, DC 20036-4702) and listed on the market: Cocodimonium Hydroxypropyl Hydrolyzed Collagen, Cocodimonium Hydroxypropyl Hydrolyzed Casein, Steardimonium Hydroxypropyl Hydrolyzed Collagen, Steardimonium Hydroxypropyl Hydrolyzed Hair Keratin, Lauryldimonium Hydroxypropyl Hydrolyzed Keratin, Cocodimonium Hydroxypropyl Hydrolyzed Rice Protein, Cocodimonium Hydroxypropyl Hydrolyzed Silk, Cocodimonium Hydroxypropyl Hydrolyzed Soy Protein, Cocodimonium Hydroxypropyl Hydrolyzed Wheat Protein, Cocodimonium Hydroxypropyl Silk Amino Acids, Hydroxypropyl Arginine Lauryl / Myristyl Ether HCl, Hydroxypropyltrimonium Gelatin. Very particular preference is given to the cationic protein hydrolysates and derivatives based on plants.

In the agents according to the invention are the protein hydrolysates and their derivatives or the amino acids and their derivatives in amounts of 0.01 - 10 wt .-%, based on the total funds included. Amounts of 0.1 to 5 wt.%, In particular 0.1 to 3 wt .-%, are particularly preferred.

Farther can the skin treatment compositions of the invention at least one mono-, oligo- or polysaccharide or their derivatives contain.

According to the invention suitable monosaccharides are z. Glucose, fructose, galactose, arabinose, Ri bose, xylose, lyxose, allose, altrose, mannose, gulose, idose and talose, the deoxy sugars fucose and rhamnose as well as amino sugars such as e.g. As glucosamine or galactosamine. Preferred are glucose, fructose, galactose, arabinose and fucose; Glucose is particularly preferred.

According to the invention suitable Oligosaccharides are composed of two to ten monosaccharide units, z. As sucrose, lactose or trehalose. A particularly preferred Oligosaccharide is sucrose. Also particularly preferred the use of honey, the predominant Contains glucose and sucrose.

Polysaccharides which are suitable according to the invention are composed of more than ten monosaccharide units. Preferred polysaccharides are the starches made from α-D-glucose units and starch degradation products such as amylose, amylopectin and dextrins. Particularly advantageous according to the invention are chemically and / or thermally modified starches, for. Hydroxypropyl starch phosphate, dihydroxypropyldistarch phosphate or the commercial products Dry ^Flo® . Further preferred are dextrans and their derivatives, eg. B. dextran sulfate. Also preferred are nonionic cellulose derivatives such as methylcellulose, hydroxypropylcellulose or hydroxyethylcellulose, as well as cationic cellulose derivatives, e.g. , The commercial products Celquat ^® and Polymer JR ^®, and preferably Celquat ^® H 100, Celquat L 200 and Polymer JR ^{® ®} 400 (Polyquaternium-10) as well as Polyquaternium-24th Further preferred examples are polysaccharides from fucose units, e.g. B. the commercial product Fucogel ^® . Particularly preferred are the polysaccharides composed of amino sugar units, in particular chitins and their deacetylated derivatives, the chitosans, and mucopolysaccharides. The inventively preferred mucopolysaccharides include hyaluronic acid and its derivatives, e.g. As sodium hyaluronate or Dimethylsilanolhyaluronat, and chondroitin and its derivatives, for. B. chondroitin sulfate.

Farther can the skin treatment compositions of the invention at least one film-forming, emulsion-stabilizing, thickening or adhesive Polymer included, selected from natural and synthetic polymers that are cationic, anionic, amphoteric charged or non-ionic.

According to the invention preferred are cationic, anionic and nonionic polymers.

Preferred among the cationic polymers are polysiloxanes having quaternary groups, e.g. , The commercial products Q2-7224 (Dow Corning), Dow Corning ^® 929 Emulsion (with amodimethicone), SM-2059 (General Electric), SLM-55067 (Wacker) and Abil ^® -Quat 3270 and 3272 (Th. Goldschmidt).

Preferred anionic polymers which can support the action of the active ingredient used according to the invention comprise carboxylate and / or sulfonate groups and as monomers, for example, acrylic acid, methacrylic acid, crotonic acid, maleic anhydride and 2-acrylamido-2-methylpropanesulfonic acid. The acidic groups may be wholly or partly present as sodium, potassium, ammonium, mono- or triethanolammonium salt. Preferred monomers are 2-acrylamido-2-methylpropanesulfonic acid and acrylic acid. Very particularly preferred anionic polymers contain 2-acrylamido-2-methylpropanesulfonic acid as the sole monomer or as a comonomer, it being possible for the sulfonic acid group to be wholly or partly in salt form. Within this embodiment, it is preferred to use copolymers of at least one anionic monomer and at least one nonionic monomer. With regard to the anionic monomers, reference is made to the substances listed above. Preferred nonionic monomers are acrylamide, methacrylamide, acrylic esters, methacrylic esters, vinylpyrrolidone, vinyl ethers and vinyl esters. Preferred anionic copolymers are acrylic acid-acrylamide copolymers and in particular polyacrylamide copolymers with sulfonic acid-containing monomers. A particularly preferred anionic copolymer consists of 70 to 55 mol% of acrylamide and 30 to 45 mol% of 2-acrylamido-2-methylpropanesulfonic acid, wherein the sulfonic acid groups are wholly or partly in the form of sodium, potassium, ammonium, mono- or triethanolammonium Salt present. This copolymer may also be crosslinked, with crosslinking agents preferably polyolefinically unsaturated compounds such as tetraallyloxyethane, allylsucrose, allylpentaerythritol and methylene-bisacrylamide are used. Such a polymer is contained in the commercial product Sepigel ^® 305 from SEPPIC. The use of this compound has proven to be particularly advantageous in the context of the teaching of the invention. Also sold under the name Simulgel ^® 600 as a compound with isohexadecane and polysorbate-80 Natriumacryloyldimethyltaurat copolymers have proved to be particularly effective according to the invention.

Further particularly preferred anionic homopolymers and copolymers are uncrosslinked and crosslinked polyacrylic acids. Allyl ethers of pentaerythritol, sucrose and propylene may be preferred crosslinking agents. Such compounds are for example the commercial products Carbopol ^®. A special preferred anionic copolymer contains as monomer 80-98% of an unsaturated, optionally substituted C _3-6 carboxylic acid or its anhydride and 2-20% of optionally substituted acrylic acid esters of saturated C _10-30 carboxylic acids, the copolymer with the aforementioned crosslinking agents can be networked. Corresponding commercial products are Pemulen ^® and Carbopol ^® grades 954, 980, 1342 and ETD 2020 (ex BF Goodrich).

Suitable nonionic polymers include polyvinyl alcohols, which may be partially saponified, for. B. the commercial products Mowiol ^® and vinylpyrrolidone / vinyl ester copolymers and polyvinylpyrrolidones z. B. under the trademark Luviskol ^® (BASF) are sold.

• – pflanzliche Öle, wie Sonnenblumenöl, Olivenöl, Sojaöl, Rapsöl, Mandelöl, Jojobaöl, Orangenöl, Weizenkeimöl, Pfirsichkernöl und die flüssigen Anteile des Kokosöls,
• – flüssige Paraffinöle, Isoparaffinöle und synthetische Kohlenwasserstoffe, z. B. 1,3-Di-(2-ethyl-hexyl)-cyclohexan (Cetiol^® S) oder Polydecen,
• – Di-n-alkylether mit insgesamt 12 bis 36, insbesondere 12 bis 24 C-Atomen, z. B. Di-n-octylether (Cetiol^® OE), Di-n- n-Hexyl-n-octylether und n-Octyl-n-decylether.
• – Fettsäuren, besonders lineare und/oder verzweigte, gesättigte und/oder ungesättigte C_8-30-Fettsäuren. Bevorzugt sind C_10-22-Fettsäuren. Beispiele sind die Isostearinsäuren und Isopalmitinsäuren wie die unter der Handelsbezeichnung Edenor^® vertriebenen Fettsäuren. Weitere typische Beispiele für solche Fettsäuren sind Capronsäure, Caprylsäure, 2-Ethylhexansäure, Caprinsäure, Laurinsäure, Isotridecansäure, Myristinsäure, Palmitinsäure, Palmitoleinsäure, Stearinsäure, Isostearinsäure, Ölsäure, Elaidinsäure, Petroselinsäure, Linolsäure, Linolensäure, Elaeostearinsäure, Arachidonsäure, Gadoleinsäure, Behensäure und Erucasäure sowie deren technische Mischungen. Besonders bevorzugt sind üblicherweise die Fettsäureschnitte, die aus Cocosöl oder Palmöl erhältlich sind; insbesondere bevorzugt ist der Einsatz von Stearinsäure.
• – Fettalkohole, besonders gesättigte, ein- oder mehrfach ungesättigte, verzweigte oder unverzweigte Fettalkohole mit 6 – 30, bevorzugt 10 – 22 und ganz besonders bevorzugt 12 – 22 Kohlenstoffatomen. Einsetzbar im Sinne der Erfindung sind z. B. Decanol, Octanol, Octenol, Dodecenol, Decenol, Octadienol, Dodecadienol, Decadienol, Oleylalkohol, Erucaalkohol, Ricinolalkohol, Stearylalkohol, Isostearylalkohol, Cetylalkohol, Laurylalkohol, Myristylalkohol, Arachidylalkohol, Caprylalkohol, Caprinalkohol, Linoleylalkohol, Linolenylalkohol und Behenylalkohol, sowie deren Guerbetalkohole, z. B. 2-Ethylhexanol, wobei diese Aufzählung beispielhaften und nicht limitierenden Charakter haben soll.
• – Esteröle, das heißt, Ester von C_6-30-Fettsäuren mit C_2-30-Fettalkoholen. Bevorzugt sind die Monoester der Fettsäuren mit Alkoholen mit 2 bis 24 C- Atomen. Als Alkohol- und Säurekomponenten der Esteröle können die vorstehend genannten Substanzen verwendet werden. Erfindungsgemäß besonders bevorzugt sind Isopropylmyristat, Isononansäure-C_16-18-alkylester, 2-Ethylhexylpalmitat, Stearinsäure-2-ethylhexylester, Cetyloleat, Glycerintricaprylat, Kokosfettalkoholcaprinat/-caprylat, n-Butylstearat, Oleylerucat, Isopropylpalmitat, Oleyloleat, Laurinsäurehexylester, Di-n-butyladipat, Myristylmyristat, Cetearyl Isononanoate und Ölsäuredecylester.
• – Hydroxycarbonsäurealkylester, wobei die Vollester der Glycolsäure, Milchsäure, Äpfelsäure, Weinsäure oder Citronensäure bevorzugt sind, aber auch Ester der β-Hydroxypropionsäure, der Tartronsäure, der D-Gluconsäure, Zuckersäure, Schleimsäure oder Glucuronsäure geeignet sind und besonders bevorzugt die Ester von C₁₂-C₁₅-Fettalkoholen, z. B. die Handelsprodukte Cosmacol^® der EniChem, Augusta Industriale, sind,
• – Dicarbonsäureester wie Di-n-butyladipat, Di-(2-ethylhexyl)-adipat, Di-(2-ethylhexyl)-succinat und Di-isotridecylacelaat sowie Diolester wie Ethylenglykoldioleat, Ethylenglykol-di-isotridecanoat, Propylenglykoldi(2-ethylhexanoat), Propylenglykol-di-isostearat, Propylenglykol-di-pelargonat, Butandiol-di-isostearat, Neopentylglykoldicaprylat,
• – symmetrische, unsymmetrische oder cyclische Ester der Kohlensäure mit Fettalkoholen, z. B. Glycerincarbonat oder Dicaprylylcarbonat (Cetiol^® CC),
• – Mono,- Di- und Trifettsäureester von gesättigten und/oder ungesättigten linearen und/oder verzweigten Fettsäuren mit Glycerin, z. B. Monomuls^® 90-O18, Monomuls^® 90-L12 oder Cutina^® MD,
• – Wachse, insbesondere Insektenwachse wie Bienenwachs und Hummelwachs, Pflanzenwachse wie Candelillawachs und Carnaubawachs, Fruchtwachse, Ozokerit, Mikrowachs, Ceresin, Paraffin, Triglyceride gesättigter und gegebenenfalls hydroxylierter C_16-30-Fettsäuren, wie z. B. gehärtete Triglyceridfette (hydriertes Palmöl, hydriertes Kokosöl, hydriertes Rizinusöl), Glyceryltribehenat oder Glyceryltri-12-hydroxystearat, synthetische Vollester aus Fettsäuren und Glykolen (z. B. Syncrowachs^®) oder Polyolen mit 2 – 6 C-Atomen, Ester von gegebenenfalls hydroxylierten C_2-4- Carbonsäuren mit Lanolinalkoholen und C_12-18-Fettalkoholen, Cholesterol- oder Lanosterolester von C_10-30-Fettsäuren, ethoxylierte C_12-20-Fettsäureglykolester, Fettsäuremonoalkanolamide mit einem C_12-22-Acylrest und einem C_2-4-Alkanolrest, synthetische Fettsäure-Fettalkoholestern, z. B. Stearylstearat oder Cetylpalmitat sowie Esterwachse aus natürlichen Fettsäuren und synthetischen C_20-40-Fettalkoholen (INCI-Bezeichnung C20-40 Alkyl Stearate),
• – Siliconverbindungen, ausgewählt aus Decamethylcyclopentasiloxan, Dodecamethylcyclohexasiloxan und Siliconpolymeren, die gewünschtenfalls quervernetzt sein können, z. B. Polydialkylsiloxane, Polyalkylarylsiloxane, ethoxylierte Polydialkylsiloxane, bevorzugt die Substanzen mit der INCI-Bezeichnung Dimethicone Copolyol, sowie Polydialkylsiloxane, die Amin- und/oder Hydroxy-Gruppen enthalten.

In a further preferred embodiment of the invention, the effect of the topical compositions according to the invention by fatty substances can be further optimized. Suitable fatty substances are, for example:

• Vegetable oils, such as sunflower oil, olive oil, soybean oil, rapeseed oil, almond oil, jojoba oil, orange oil, wheat germ oil, peach kernel oil and the liquid portions of coconut oil,
• Liquid paraffin oils, isoparaffin oils and synthetic hydrocarbons, e.g. B. 1,3-di- (2-ethyl-hexyl) -cyclohexane (Cetiol ^® S) or polydecene,
• - Di-n-alkyl ethers having a total of 12 to 36, in particular 12 to 24 carbon atoms, for. As di-n-octyl ether (Cetiol ^® OE), di-n-n-hexyl-n-octyl ether and n-octyl-n-decyl ether.
• Fatty acids, especially linear and / or branched, saturated and / or unsaturated C _8-30 fatty acids. C _10-22 fatty acids are preferred. Examples are the isostearic and isopalmitic such as those sold under the trade name Edenor ^® fatty acids. Other typical examples of such fatty acids are caproic, caprylic, 2-ethylhexanoic, capric, lauric, isotridecanoic, myristic, palmitic, palmitoleic, stearic, isostearic, oleic, elaidic, petroselic, linoleic, linolenic as well as their technical mixtures. Particularly preferred are usually the fatty acid cuts obtainable from coconut oil or palm oil; especially preferred is the use of stearic acid.
• - Fatty alcohols, particularly saturated, mono- or polyunsaturated, branched or unbranched fatty alcohols having 6 - 30, preferably 10 - 22 and most preferably 12 - 22 carbon atoms. Applicable for the purposes of the invention are z. B. decanol, octanol, octenol, dodecenol, decenol, octadienol, dodecadienol, decadienol, oleyl alcohol, eruca alcohol, ricinoleic alcohol, stearyl alcohol, isostearyl alcohol, cetyl alcohol, lauryl alcohol, myristyl alcohol, arachidyl alcohol, caprylic alcohol, capric alcohol, linoleyl alcohol, linolenyl alcohol and behenyl alcohol, and their Guerbet alcohols, z. B. 2-ethylhexanol, this list should have exemplary and non-limiting character.
• Ester oils, that is, esters of C _6-30 fatty acids with C _2-30 fatty alcohols. The monoesters of the fatty acids with alcohols having 2 to 24 carbon atoms are preferred. As the alcohol and acid components of the ester oils, the above-mentioned substances can be used. Particularly preferred according to the invention are isopropyl myristate, isononanoic acid C _16-18 alkyl esters, 2-ethylhexyl palmitate, 2-ethylhexyl stearate, cetyl oleate, glycerol tricaprylate, coconut fatty alcohol caprylate / caprylate, n-butyl stearate, oleyl erucate, isopropyl palmitate, oleyl oleate, hexyl laurate, di-n-butyl butyladipate, myristyl myristate, cetearyl isononanoate and oleic acid decyl ester.
• - Hydroxycarboxylic acid alkyl esters, wherein the full esters of glycolic acid, lactic acid, malic acid, tartaric acid or citric acid are preferred, but also esters of β-hydroxypropionic acid, tartronic acid, D-gluconic acid, sugar acid, mucic acid or glucuronic acid are suitable and particularly preferably the esters of C _12th -C ₁₅ fatty alcohols, e.g. B. the commercial products Cosmacol ^® EniChem, Augusta Industriale, are,
• Dicarboxylic esters such as di-n-butyl adipate, di (2-ethylhexyl) adipate, di- (2-ethylhexyl) succinate and di-isotridecyl acelate, and diol esters such as ethylene glycol dioleate, ethylene glycol diisotridecanoate, propylene glycol di (2-ethylhexanoate), Propylene glycol di-isostearate, propylene glycol di-pelargonate, butanediol di-isostearate, neopentyl glycol dicaprylate,
• - Symmetrical, asymmetric or cyclic esters of carbonic acid with fatty alcohols, eg. As glycerol carbonate or dicaprylyl carbonate (Cetiol ^® CC),
• - mono, - di- and tri-fatty acid esters of saturated and / or unsaturated linear and / or branched fatty acids with glycerol, z. B. ^® Monomuls 90-O18, Monomuls 90-L12 ^® or Cutina ^® MD,
• Waxes, in particular insect waxes such as beeswax and bumblebee wax, plant waxes such as candelilla wax and carnauba wax, fruit waxes, ozokerite, microwax, ceresin, paraffin, triglycerides of saturated and optionally hydroxylated C _16-30 fatty acids, such as. B. hydrogenated triglyceride fats (eg Syncrowachs ^®.) (Hydrogenated palm oil, hydrogenated coconut oil, hydrogenated castor oil), glyceryl tribehenate or glyceryl tri-12-hydroxystearate, synthetic Vollester of fatty acids and glycols or polyols containing 2 - 6 carbon atoms, esters of optionally hydroxylated C _2-4 carboxylic acids with lanolin alcohols and C _12-18 fatty alcohol , cholesterol or lanosterol esters of C _10-30 fatty acids, C _12-20 ethoxylated fatty acid glycol esters, fatty acid monoalkanolamides having a C _12-22 acyl radical and a C _2-4 alkanol radical, fatty acid fatty acid synthetic fatty acid esters, eg. Stearyl stearate or cetyl palmitate and ester waxes of natural fatty acids and synthetic C _20-40 fatty alcohols (INCI name C20-40 alkyl stearates),
• Silicone compounds selected from decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane and silicone polymers, which may be crosslinked, if desired, e.g. As polydialkylsiloxanes, polyalkylarylsiloxanes, ethoxylated polydialkylsiloxanes, preferably the substances with the INCI name dimethicone copolyol, as well as polydialkylsiloxanes containing amine and / or hydroxyl groups.

The Use amount of fatty substances is 0.1 - 50 % By weight, preferably 0.1-20 % By weight and particularly preferably 0.1-15% by weight, in each case based on the entire remedy.

As superfatting agent can Substances such as lanolin and lecithin and polyethoxylated or acylated lanolin and lecithin derivatives, polyol fatty acid esters, Monoglycerides and fatty acid alkanolamides be used, the latter also as foam stabilizers serve.

When Pearlescent waxes are, for example, suitable: alkylene glycol esters, especially ethylene glycol distearate; Fatty acid alkanolamides, especially coconut fatty acid diethanolamide; Partial glycerides, especially stearic acid monoglyceride; Esters of polyfunctional, optionally hydroxysubstituted carboxylic acids with Fatty alcohols with 6 to 22 carbon atoms, especially long-chain Esters of tartaric acid; Fatty substances, such as, for example, fatty alcohols, fatty ketones, fatty aldehydes, Fatty ethers and fatty carbonates having a total of at least 24 carbon atoms, especially Lauron and distearyl ether; Fatty acids such as stearic acid, hydroxystearic acid or behenic, Ring opening products of olefin epoxides having 12 to 22 carbon atoms with fatty alcohols having 12 to 22 carbon atoms and / or polyols having 2 to 15 carbon atoms and 2 to 10 hydroxyl groups and mixtures thereof.

When Bodying agents are primarily fatty alcohols or hydroxy fatty alcohols with 12 to 22 and preferably 16 to 18 carbon atoms and next to it Partial glycerides, fatty acids or hydroxy fatty acids in Consideration. Preference is given to a combination of these substances with alkyl oligoglucosides and / or fatty acid N-methylglucamides same chain length and / or polyglycerol poly-12-hydroxy stearates.

When Anti-dandruff agents can Climbazole, octopirox and zinc pyrethion. Preference may be given to fight of dandruff the preparations according to the invention with at least one of these anti-dandruff agents can be used in combination.

The Skin treatment agents according to the invention may further comprise at least one α-hydroxycarboxylic acid or α-ketocarboxylic acid or their ester, lactone or salt form included. Suitable α-hydroxycarboxylic acids or α-ketocarboxylic acids are especially selected from lactic acid, Tartaric acid, citric acid, 2-hydroxybutanoic acid, 2,3-dihydroxypropanoic acid, 2-hydroxypentanoic acid, 2-hydroxyhexanoic acid, 2-hydroxyheptanoic acid, 2-hydroxyoctanoic acid, 2-hydroxydecanoic acid, 2-hydroxydodecanoic acid, 2-hydroxytetradecanoic acid, 2-hydroxyhexadecanoic acid, 2-hydroxyoctadecanoic acid, mandelic acid, 4- Hydroxymandelic acid, malic acid, erythraric acid, threaric acid, glucaric acid, galactaric acid, mannaric acid, gular acid, 2-hydroxy-2-methylsuccinic acid, gluconic acid, pyruvic acid, glucuronic acid and Galacturonic. The esters of the acids mentioned are selected from the methyl, ethyl, propyl, isopropyl, butyl, amyl, pentyl, Hexyl, 2-ethylhexyl, octyl, decyl, dodecyl and hexadecyl esters. The α-hydroxycarboxylic acids or α-ketocarboxylic acids or their derivatives are in amounts of 0.1-10% by weight, preferably 0.5-5% by weight, in each case based on the total composition.

• – Vitamine, Provitamine und Vitaminvorstufen aus den Gruppen A, C, E und F, insbesondere 3,4-Didehydroretinol (Vitamin A₂), β-Carotin (Provitamin des Vitamin A₁), Ascorbinsäure (Vitamin C), sowie die Palmitinsäureester, Glucoside oder Phosphate der Ascorbinsäure, Tocopherole, insbesondere α-Tocopherol sowie seine Ester, z. B. das Acetat, das Nicotinat, das Phosphat und das Succinat; weiterhin Vitamin F, worunter essentielle Fettsäuren, besonders Linolsäure, Linolensäure und Arachidonsäure, verstanden werden;
• – Allantoin,
• – Bisabolol,
• – Antioxidantien, zum Beispiel Imidazole (z. B. Urocaninsäure) und deren Derivate, Peptide wie D,L-Carnosin, D-Carnosin, L-Carnosin und deren Derivate (z. B. Anserin), Chlorogensäure und deren Derivate, Liponsäure und deren Derivate (z. B. Dihydroliponsäure), Aurothioglucose, Propylthiouracil und andere Thiole (z. B. Thioredoxin, Glutathion, Cystein, Cystin, Cystamin und deren Glycosyl-, N-Acetyl-, Methyl-, Ethyl-, Propyl-, Amyl-, Butyl- und Lauryl-, Palmitoyl-, Oleyl-, γ-Linoleyl-, Cholesteryl- und Glycerylester) sowie deren Salze, Dilaurylthiodipropionat, Distearylthiodipropionat, Thiodipropionsäure und deren Derivate (Ester, Ether, Peptide, Lipide, Nukleotide, Nukleoside und Salze) sowie Sulfoximinverbindungen (z. B. Buthioninsulfoximine, Homocysteinsulfoximin, Butioninsulfone, Penta-, Hexa-, Heptathioninsulfoximin) in sehr geringen verträglichen Dosierungen (z. B. pmol bis μmol/kg), ferner (Metall)-Chelatoren (z. B. α-Hydroxyfettsäuren, Palmitinsäure, Phytinsäure, Lactoferrin), Huminsäure, Gallensäure, Gallenextrakte, Bilirubin, Biliverdin, EDTA, EGTA und deren Derivate, ungesättigte Fettsäuren und deren Derivate (z. B. γ-Linolensäure, Linolsäure, Ölsäure), Folsäure und deren Derivate, Ubichinon und Ubichinol und deren Derivate, das Koniferylbenzoat des Benzoeharzes, Rutinsäure und deren Derivate, α-Glycosylrutin, Ferulasäure, Furfurylidenglucitol, Carnosin, Butylhydroxytoluol, Butylhydroxyanisol, Nordihydroguajakharzsäure, Nordihydroguajaretsäure, Trihydroxybutyrophenon, Harnsäure und deren Derivate, Katalase, Superoxid-Dismutase, Zink und dessen Derivate (z. B. ZnO, ZnSO₄), Selen und dessen Derivate (z. B. Selen-Methionin), Stilbene und deren Derivate (z. B. Stilbenoxid, trans-Stilbenoxid) und die als Antioxidans geeigneten Derivate (Salze, Ester, Ether, Zucker, Nukleotide, Nukleoside, Peptide und Lipide) dieser Wirkstoffe,
• – Ceramide und Pseudoceramide,
• – Triterpene, insbesondere Triterpensäuren wie Ursolsäure, Rosmarinsäure, Betulinsäure, Boswelliasäure und Bryonolsäure,
• – Monomere Catechine, besonders Catechin und Epicatechin, Leukoanthocyanidine, Catechinpolymere (Catechin-Gerbstoffe) sowie Gallotannine,
• – Verdickungsmittel, z. B. Gelatine, Pflanzengumme und/oder Polysaccharide wie Agar-Agar, Guar-Gum, Guar-Guar, Alginate, Xanthan-Gum, Gummi arabicum, Karaya-Gummi, Tylosen oder Johannisbrotkernmehl, hydrophile Kieselsäuren und/oder natürliche und synthetische Tone und Schichtsilikate, z. B. Bentonit, Hectorit, Montmorillonit oder Laponite^®, Ca-, Mg- oder Zn-Seifen von Fettsäuren, Carboxymethylcellulose und Hydroxyethylcellulose, höhermolekulare Polyethylenglycolmono- und -diester von Fettsäuren, Polyacrylate, (z.B. Carbopole^® von Goodrich oder Synthalene^® von Sigma), Polyacrylamide, vollsynthetische Hydrokolloide wie Polyvinylalkohol und Polyvinylpyrrolidon, Tenside wie beispielsweise ethoxylierte Fettsäureglyceride, Ester von Fettsäuren mit Polyolen wie beispielsweise Pentaerythrit oder Trimethylolpropan, Fettalkoholethoxylate mit eingeengter Homologenverteilung oder Alkyloligoglucoside sowie Elektrolyte wie Kochsalz und Ammoniumchlorid,
• – Pflanzenglycoside,
• – Strukturanten wie Maleinsäure und Milchsäure,
• – Dimethylisosorbid,
• – Alpha-, beta- sowie gamma-Cyclodextrine, insbesondere zur Stabilisierung von Retinol,
• – Lösungsmittel, Quell- und Penetrationsstoffe wie Ethanol, Isopropanol, Ethylenglykol, Propylenglykol, Propylenglykolmonoethylether, Glycerin und Diethylenglykol, Carbonate, Hydrogencarbonate, Guanidine, Harnstoffe sowie primäre, sekundäre und tertiäre Phosphate
• – Parfümöle, Pigmente sowie Farbstoffe zum Anfärben des Mittels,
• – Substanzen zur Einstellung des pH-Wertes, z. B. α- und β-Hydroxycarbonsäuren,
• – Komplexbildner wie EDTA, NTA, β-Alanindiessigsäure und Phosphonsäuren,
• – Trübungsmittel wie Latex, Styrol/PVP- und Styrol/Acrylamid-Copolymere,
• – Perlglanzmittel wie Ethylenglykolmono- und -distearat sowie PEG-3-distearat,
• – Treibmittel wie Propan-Butan-Gemische, N₂O, Dimethylether, CO₂ und Luft.

The compositions of the invention may contain other active ingredients, auxiliaries and additives, for example:

• Vitamins, provitamins and vitamin precursors from groups A, C, E and F, in particular 3,4-didehydroretinol (vitamin A ₂ ), β-carotene (provitamin of vitamin A ₁ ), ascorbic acid (vitamin C) and the palmitic acid esters, Glucosides or phosphates of ascorbic acid, tocopherols, especially α-tocopherol and its esters, eg. The acetate, the nicotinate, the phosphate and the succinate; vitamin F, which is understood as meaning essential fatty acids, especially linoleic acid, linolenic acid and arachidonic acid;
• - allantoin,
• - bisabolol,
• Antioxidants, for example imidazoles (for example urocanic acid) and derivatives thereof, peptides such as D, L-carnosine, D-carnosine, L-carnosine and their derivatives (for example anserine), chlorogenic acid and its derivatives, lipoic acid and their derivatives (eg dihydrolipoic acid), aurothioglucose, propylthiouracil and other thiols (eg thioredoxin, glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, Pro pyl, amyl, butyl and lauryl, palmitoyl, oleyl, γ-linoleyl, cholesteryl and glyceryl esters) and their salts, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and derivatives thereof (esters, ethers, peptides, lipids, nucleotides , Nucleosides and salts) and sulfoximine compounds (eg buthionine sulfoximines, homocysteine sulfoximine, bithine sulfones, penta, hexa, heptathionine sulfoximine) in very low tolerated dosages (eg pmol to μmol / kg), furthermore (metal) chelators ( eg α-hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin), humic acid, bile acid, bile extracts, bilirubin, biliverdin, EDTA, EGTA and their derivatives, unsaturated fatty acids and their derivatives (eg γ-linolenic acid, linoleic acid, oleic acid) , Folic acid and its derivatives, ubiquinone and ubiquinol and their derivatives, the benzylic resin coniferyl benzoate, rutinic acid and its derivatives, α-glycosylrutin, ferulic acid, furfurylidene glucitol, carnosine, butylhydroxytoluene ol, butylhydroxyanisole, nordihydroguaiacetic acid, nordihydroguiaretic acid, trihydroxybutyrophenone, uric acid and its derivatives, catalase, superoxide dismutase, zinc and its derivatives (e.g. ZnO, ZnSO ₄ ), selenium and its derivatives (eg selenium methionine), stilbenes and their derivatives (eg stilbene oxide, trans-stilbene oxide) and derivatives suitable as antioxidant (salts, esters, ethers, Sugars, nucleotides, nucleosides, peptides and lipids) of these drugs,
• Ceramides and pseudoceramides,
• Triterpenes, in particular triterpenic acids such as ursolic acid, rosmarinic acid, betulinic acid, boswellic acid and bryonolic acid,
• - Monomeric catechins, especially catechin and epicatechin, leucoanthocyanidins, catechin polymers (catechin tannins) and gallotannins,
• - Thickener, z. As gelatin, plant gums and / or polysaccharides such as agar-agar, guar-gum, guar-guar, alginates, xanthan gum, gum arabic, karaya gum, tyloses or locust bean gum, hydrophilic silicic acids and / or natural and synthetic clays and phyllosilicates , z. As bentonite, hectorite, montmorillonite or Laponite ^®, Ca, Mg or Zn soaps of fatty acids, carboxymethyl cellulose and hydroxyethyl cellulose, high molecular weight polyethylene and diesters of fatty acids, polyacrylates (for example Carbopol ^® of Goodrich or Synthalens ^® of Sigma) , Polyacrylamides, fully synthetic hydrocolloids such as polyvinyl alcohol and polyvinylpyrrolidone, surfactants such as ethoxylated fatty acid glycerides, esters of fatty acids with polyols such as pentaerythritol or trimethylolpropane, fatty alcohol ethoxylates with restricted homolog distribution or alkyl oligoglucosides and electrolytes such as sodium chloride and ammonium chloride,
• - vegetable glycosides,
• - structurants such as maleic acid and lactic acid,
• - dimethyl isosorbide,
• Alpha, beta and gamma cyclodextrins, in particular for the stabilization of retinol,
• - Solvents, swelling and penetrating agents such as ethanol, isopropanol, ethylene glycol, propylene glycol, propylene glycol monoethyl ether, glycerol and diethylene glycol, carbonates, bicarbonates, guanidines, ureas and primary, secondary and tertiary phosphates
• Perfume oils, pigments and dyes for staining the agent,
• - substances for adjusting the pH, z. B. α- and β-hydroxycarboxylic acids,
• Complexing agents such as EDTA, NTA, β-alaninediacetic acid and phosphonic acids,
• Opacifiers such as latex, styrene / PVP and styrene / acrylamide copolymers,
• Pearlescing agents such as ethylene glycol mono- and distearate and PEG-3-distearate,
• - Propellants such as propane-butane mixtures, N ₂ O, dimethyl ether, CO ₂ and air.

The Skin treatment agent according to the invention are advantageously in the form of a topical administration liquid or solid oil-in-water emulsion, Water-in-oil emulsion, Multiple emulsion, microemulsion, PIT emulsion or Pickering emulsion, in the form of a hydrogel, an alkhoholic gel, a lipogel, in the form of a single- or multi-phase solution, a foam, a Ointment, a plaster, a suspension, a powder or a Mixture with at least one suitable as a medical adhesive Polymer before. The skin treatment agents according to the invention can also in anhydrous form, such as an oil or a Balm, to be presented. Here, the carrier may be a vegetable or animal oil, a mineral oil, a synthetic oil or a Mixture of such oils be.

In a particular embodiment, the skin treatment agents are present as a microemulsion. In the context of the invention, microemulsions are understood as meaning not only the thermodynamically stable microemulsions but also the so-called "PIT" emulsions. These emulsions are systems with the 3 components water, oil and emulsifier, which are present at room temperature as an oil-in-water emulsion. When these systems are heated, microemulsions form in a certain temperature range (referred to as the phase inversion temperature or "PIT"), which on further heating converts to water-in-oil (W / O) emulsions. Upon subsequent cooling O / W emulsions are again formed, but also at room temperature as microemulsions or as very finely divided emulsions with a average particle diameter below 400 nm and especially from about 100-300 nm. According to the invention, those micro- or "PIT" emulsions may be preferred which have an average particle diameter of about 200 nm. Details regarding these "PIT emulsions" z. B. the publication Angew. Chem. 97, 655 - 669 (1985).

It is also conceivable that the skin treatment compositions according to the invention are present in the form of antiperspirants and / or deodorants. Suitable antiperspirant active substances according to the invention are, for example, water-soluble astringent or protein-coagulating metallic salts, in particular inorganic and organic salts of aluminum, zirconium, zinc and titanium, and any desired mixtures of these salts. Water solubility according to the invention is understood as meaning a solubility of at least 4 g of active substance per 100 g of solution at 20 ° C. For example, alum (KAl (SO ₄ ) ₂ 12 H ₂ O), aluminum sulfate, aluminum lactate, sodium aluminum chlorhydroxactate, aluminum chlorohydrate, aluminum chlorohydrate, aluminum sulfocarbolate, aluminum zirconium chlorohydrate, zinc chloride, zinc sulfocarbolate, zinc sulfate, zirconium chlorohydrate, aluminum Zirconium chlorohydrate-glycine complexes and complexes of basic aluminum chlorides with propylene glycol or polyethylene glycol. The liquid active substance preparations preferably comprise an astringent aluminum salt, in particular aluminum chlorohydrate, and / or an aluminum-zirconium compound. Aluminum chlorohydrates, for example, in powder form sold as Micro Dry ^® Ultrafine or in activated form as Reach ^® 501 or Reach ^® 103 from Reheis and in the form of aqueous solutions as Locron ^® L of Clariant ^® or as Chlorhydrol from Reheis. Under the name ^Reach® 301 an aluminum sesquichlorohydrate from Reheis is offered. The use of aluminum-zirconium tri- or tetrachlorohydrex glycine complexes, which are, for example, from Reheis under the name Rezal 36G ^® commercially, according to the invention is particularly advantageous.

Of the antiperspirant Active ingredient is in the compositions of the invention in one Quantity of 0.01 - 40 Wt .-%, preferably 2 - 30 Wt .-% and in particular 5 - 25 Wt .-%, based on the amount of the active substance in the whole Composition, included.

When Deodorant agents are, for example, fragrances, antimicrobial, antibacterial or germ-inhibiting substances, enzyme-inhibiting substances, Antioxidants and Genuchsadsorbentien used.

Suitable antimicrobial, antibacterial or antimicrobial substances are in particular C ₁ -C ₄ -alkanols, C ₂ -C ₄ -alkanediols, onganohalogen compounds and halides, quaternary ammonium compounds, a range of plant extracts and zinc compounds.

The compositions of the invention may further contain at least one water-soluble polyol, in particular selected from water-soluble diols, triols and higher-grade alcohols and polyethylene glycols. Among the diols are C ₂ -C ₁₂ diols, in particular 1,2-propylene glycol, butylene glycols such. For example, 1,2-butylene glycol, 1,3-butylene glycol and 1,4-butylene glycol, pentanediols, e.g. As 1,2-pentanediol, and hexanediols, z. For example, 1,6-hexanediol. Also preferred are glycerol and technical Oligoglyceringemische with an intrinsic degree of condensation of 1.5 to 10 such as technical Diglyceringemische having a Diglycerine content of 40 to 50 wt .-% or triglycerol, further 1,2,6-hexanediol and polyethylene glycols (PEG) with a average molecular weight of 100 to 1000 daltons, for example PEG-400, PEG-600 or PEG-1000. Other suitable higher alcohols are the C ₄ , C ₅ and C ₆ monosaccharides and the corresponding sugar alcohols, eg. Mannitol or sorbitol.

The Compositions of the invention contain the water-soluble Polyol in amounts of 1-50 Wt .-%, preferably 1 - 15 Wt .-% and particularly preferably 1-5 wt .-%, each based on the entire composition.

Oral and prosthetic treatment

In another particularly according to the invention preferred embodiment these are the cosmetic and / or pharmaceutical preparations those for oral administration, where the destination of the application the mouth itself is. In a preferred embodiment, this is one the skin treatment agent described above, wherein the Composition chosen It will be that the drug a mouth cream, an ointment, a tincture or a suspension is. The term "pharmaceutical Preparations for oral administration "also includes denture cleansing compositions, especially denture cleansing tablets.

Furthermore, in the oral area, mouthwashes, toothpastes, tablets, especially lozenges letten and sprays or aerosols further preferred embodiments.

The Composition for oral, dental and / or denture care contains here the Dispiro compounds according to the invention preferably in amounts of up to 3 wt .-%, particularly preferably in amounts from 0.01 to 1 wt .-%, in particular in amounts of 0.05 to 0.5 wt .-%. If the composition is a concentrate, the preferred concentration is correspondingly higher.

at Partial dentures or dentition is suitable both the presentation as Teeth cleaning tablets, as well as mouthwash or mouthwash or as Toothpaste.

The oral, Tooth and / or dental prosthesis care agents can be used, for example, as mouthwash, Gel, liquid Toothbrush lotion, stiff toothpaste, denture cleaner or denture adhesive cream available. For this it is necessary to use the invention Substances in a suitable carrier contribute.

When carrier can e.g. also powdery Preparations or aqueous-alcoholic solutions serve as mouthwashes 0 to 15% by weight of ethanol, 1 to 1.5% by weight of aroma oils and 0.01 to 0.5% by weight sweeteners or as mouthwash concentrates 15 to 60 wt .-% ethanol, 0.05 to 5% by weight of aroma oils, 0.1 to 3% by weight sweeteners and possibly other excipients may contain and before use with water dilute become. The concentration of the components must be chosen so high, that after dilution the mentioned lower concentration limits in the application not be fallen below.

When carrier can but gels as well as more or less flowable pastes serve that out flexible plastic containers or tubes and with the help of a toothbrush on the teeth be applied. Such products contain higher amounts of humectants and binders or consistency regulators and polishing components. Furthermore Aromatic oils, sweeteners and water are also contained in these preparations.

The toothpastes according to the invention and tooth gels can as ingredients in addition to the active compounds according to the invention in particular Surfactants, cleaning agents, Flavors, sweeteners as well as other agents known to those skilled in the art. To serve as a carrier preferably water and binder. Furthermore, humectants, Preservatives, consistency and / or color pigments included be.

at the mouthwashes according to the invention can it is watery, especially alcoholic, flavored concentrates or also for ready-to-use solutions act. The mouthwashes can in addition to the active compounds according to the invention especially surfactants, flavors, dyes, fluorides, astringents, contain antibacterial substances and / or other active ingredients.

at the aforementioned other active ingredients in the oral treatment agents can be included For example, it may be a fluorine compound to an active ingredient against plaque bacteria, an anticalculus drug, for reminalization, against sensitive teeth or to protect the gums act. Furthermore, the further active ingredient may be another active ingredient for fungal treatment, in particular candidiasis treatment, act.

A preferred fluorine compound is a caries-inhibiting fluorine compound, preferably from the group of fluorides or monofluorophosphates in an amount of 0.1 to 0.5 wt .-% fluorine. Suitable fluorine compounds are, for example, sodium monofluorophosphate (Na ₂ PO ₃ F), potassium monofluorophosphate, sodium or potassium fluoride, tin fluoride or an organic amine fluoride.

at the active substance against plaque bacteria may be, for example, cetylpyridinium chloride, Chlorhexidine, hexetidines, domiphenchloride, triclosan and / or sodium benzoate in concentrations between 0.05 and 0.3 wt .-% act.

As anticalculus agents and as demineralization inhibitors, condensed phosphates may be present in the form of their alkali metal salts, preferably in the form of their sodium or potassium salts, but also zinc-containing compounds. The aqueous solutions of these phosphates react alkaline due to hydrolytic effects. By addition of acid, the pH of the oral, dental and / or dental prosthesis care agents according to the invention is adjusted to the preferred values of 7.5-9. It is also possible to use mixtures of different condensed phosphates or else hydrated salts of the condensed phosphates. The specified amounts of 2-12% by weight, however, refer to the anhydrous salts. Preferred are as condensed phosphates pyrophosphates, aza-cycloheptane-2,2-diphosphonate (AHP) and, preferably in an amount of 5-10 wt .-%, a sodium or potassium tripolyphosphate.

When Active ingredients for reminalization can in addition to the aforementioned fluorine compounds For example, calcium glycerol phosphate, or phosphate cleaning body, in particular Calcium hydrogen phosphate, be included. As active ingredients against sensitive Teeth can be for example Potassium nitrate and potassium chloride in concentrations of 5-10% by weight or strontium chloride or hydroxyapatite.

When Active ingredients for the protection of the gums are particularly suitable Substances with anti-inflammatory Influence as the active ingredients of chamomile, especially the α-bisalbolol and the Chamazulen. Furthermore, suitable for this example Eugenol, vitamin A and plant extracts of aloe, arnica, calendula, Witch hazel, myrrh, rosemary and sage or tannins found in these Extracts are included. Furthermore, astringent substances, such as. Aluminum lactate, as an active ingredient for the protection of the gums used.

Water-insoluble inorganic substances with particle sizes of preferably less than 15 μm, in particular in concentrations of 10-50% by weight, can be used as the cleaning body or polishing components. Examples include precipitation and gel silicas, aluminum hydroxide, aluminum silicate, alumina, alumina trihydrate, insoluble sodium metaphosphate, calcium pyrophosphate, calcium hydrogen phosphate, calcium hydrogen phosphate dihydrate, calcium carbonate, dicalcium phosphate, chalk, hydroxyapatite, hydrotalcites, talc, magnesium aluminum silicate (Veegum ^®), calcium sulfate, magnesium carbonate , Magnesium oxide, sodium bicarbonate and sodium aluminum silicates, for example zeolite A. Alternatively, for example, organic polymers, for example polymethyl acrylate, can also be used.

Next The aforementioned active ingredients may be the oral and prosthetic treatment agents of the invention other ingredients such as those listed below contain.

When Surfactants are in the oral hygiene compositions according to the invention in particular Alkyl and / or alkenyl (oligo) glycosides can be used. Your production and use as a surface-active Fabrics are, for example, US-A-3,839,318, US-A-3,707,535, US-A-3 547 828 DE-A-19 43 689, DE-A-20 36 472 and DE-A-30 01 064 and EP-A-77 167 known. In terms of of the glycoside residue, both Monoglycosides (x = 1) in which a pentose or hexose residue is glycosidic to a primary Alcohol is bound with 4 to 16 carbon atoms, as well as oligomeric glycosides with a degree of oligomerization x to 10 are suitable. The degree of oligomerization is a statistical mean, the one for such technical products usual Homolog distribution is based.

As alkyl and / or alkenyl (oligo) glycoside, an alkyl and / or alkenyl (oligo) glucoside of the formula RO (C ₆ H ₁₀ O) _x -H in which R is an alkyl radical and is preferably suitable / or alkenyl group having 8 to 14 carbon atoms and x has an average of 1 to 4. Particular preference is given to alkyl oligoglucosides based on hydrogenated C _12/14 coconut oil having a DP of from 1 to 3. The alkyl and / or alkenyl glycoside surfactant can be used very sparingly, amounts of from 0.005 to 1% by weight being sufficient ,

In addition to the alkyl glucoside surfactants mentioned, other nonionic, ampholytic and cationic surfactants may also be present, for example: fatty alcohol polyglycol ether sulfates, monoglyceride sulfates, monoglyceride ether sulfates, mono- and / or dialkyl sulfosuccinates, fatty acid isethionates, fatty acid sarcosinates, fatty acid taurides, fatty acid glutamates, ether carboxylic acids, fatty acid glucamides, alkylamido betaine and / or protein fatty acid condensates, the latter preferably based on wheat proteins. In particular, to solubilize the usually water-insoluble aroma oils, a non-ionic solubilizer from the group of surface-active compounds may be required. Particularly suitable for this purpose are, for example, ethoxylated fatty acid glycerides, ethoxylated fatty acid sorbitan partial esters or fatty acid partial esters of glycerol or sorbitan ethoxylates. Solubilizers from the group of ethoxylated Fettsäureglyceride include especially addition products of 20 to 60 moles of ethylene oxide with mono- and diglycerides of linear fatty acids having 12 to 18 carbon atoms or triglycerides of hydroxy fatty acids such as oxystearic acid or ricinoleic acid. Further suitable solubilizers are ethoxylated fatty acid sorbitan partial esters; these are preferably addition products of 20 to 60 moles of ethylene oxide with sorbitan monoesters and sorbitan diesters of fatty acids with 12 to 18 carbon atoms. Also suitable solubilizers are fatty acid partial esters of glycerol or sorbitan ethoxylates; these are preferably mono- and diesters of C ₁₂ -C ₁₈ -fatty acids and adducts of 20 to 60 moles of ethylene oxide with 1 mole of glycerol or 1 mole of sorbitol.

Suitable binders and consistency regulators are, for example, natural and synthetic water-soluble polymers such as alginates obtained from brown algae, carrageenans available from red algae, guar or guar gum from guar gum, tragacanth, carobine from locust bean gum, starch and their non-ionic derivatives such as hydroxypropyl guar, hydroxyethyl starch, cellulose ethers such as hydroxyethyl cellulose or methyl hydroxypropyl cellulose. Also, agar-agar, xanthan and xanthan gum, pectins, water-soluble carboxyvinyl polymers (for example Carbopol ^® types), polyvinyl alcohol, polyvinyl pyrrolidone, high molecular weight polyethylene glycols (molecular weight 10 ³ to 10 ⁶ D). Further substances which are suitable for viscosity control are phyllosilicates such as montmorillonite clays, colloidal thickening silicas, eg airgel silica or fumed silicas.

When Humectants can e.g. Glycerin, sorbitol, xylitol, propylene glycols, polyethenylene glycols or mixtures of these polyols, especially those Polyethenylenglycole with molecular weights of 200 to 800 (from 400 to 2000) are used be. Preferred as humectant sorbitol in an amount of 25 - 40 Wt .-% included.

The according to the invention and / or oral care products by adding aromatic oils and sweeteners be improved in their organoleptic properties. As aroma oils come all for Oral, dental and / or Denture care products in use natural and synthetic flavors in question. Natural flavors can be both in the form of the essential oils isolated from the drugs as well as in Form of used from these isolated individual components. Preferably at least one aromatic oil from the group of peppermint oil, spearmint oil, aniseed oil, clove oil, lemon oil, wintergreen oil, caraway oil, eucalyptus oil, fennel oil, thyme oil, marjoram oil, basil oil, citrus oil, Gaultheria oil or a or a plurality of synthetically produced components isolated therefrom these oils be included. The main components of these oils are e.g. Menthol, carvone, anethole, cineole, eugenol, citronellol, linalool, Salves, thymol, terpinene, terpinol, methylchavicol and methyl salicylate. Rounding of the aroma may be achieved by seasoning and flower oils, e.g. Rose oil, geranium oil, cinnamon oil or sage oil or by their ingredients such as cinnamon aldehyde or geraniol or by fruity notes respectively. Other suitable flavors are e.g. Menthyl acetate, vanillin, Jonone, linalyl acetate, rhodinol and piperitone. Aromatic oils are preferably in an amount of up to 1% by weight in toothpastes, in an amount of up to 0.5% by weight in mouthwashes and in an amount of up to 5% by weight in mouthwash concentrates.

The oral, Tooth and / or denture care agents preferably contain as a solubilizer for possibly contained aroma oils Addition products of 20 to 60 moles of ethylene oxide to hardened or uncured castor oil (i.e., oxystearic acid or ricinoleic acid triglyceride), glycerol mono- and / or distearate or sorbitan mono- and / or distearate.

Farther can as a sweetener natural Sugars such as sucrose, maltose, lactose and fructose or synthetic sweeteners such as. the sodium salt of saccharin, sodium cyclamate, acesulfame, Aspartame or glycyrrhizin may be included.

When dye are for mouthwashes water-soluble Dyes such as patent blue V, quinoline yellow or cooking oil A suitable, for toothpastes are also color pigments such. Titanium oxide suitable.

• – pH-Stellmittel und Puffersubstanzen wie z.B. Natriumbicarbonat, Natriumcitrat, Natriumbenzoat, Zitronensäure, Phosphorsäure oder saure Salze, z.B. NaH₂PO₄
• – wundheilende und entzündungshemmende Stoffe wie z.B. Allantoin, Harnstoff, Panthenol, Azulen bzw. Kamillenextrakt
• – weitere gegen Zahnstein wirksame Stoffe wie z.B. Organophosphonate, z.B. Hydroxyethandiphosphonate oder Azacycloheptandiphosphonat
• – Konservierungsstoffe wie z.B. Sorbinsäure-Salze, Natriumbenzoat, Chlorhexidindigluconat, p-Hydroxybenzoesäure oder deren Ester.
• – Plaque-Inhibitoren wie z.B. Hexachlorophen, Chlorhexidin, Hexetidin, Triclosan, Bromchlorophen, Phenylsalicylsäureester.

Other common additives for oral, dental and / or denture care medium are, for example

• PH adjusting agents and buffer substances, for example sodium bicarbonate, sodium citrate, sodium benzoate, citric acid, phosphoric acid or acid salts, for example NaH ₂ PO ₄
• - Wound-healing and anti-inflammatory substances such as allantoin, urea, panthenol, azulene or chamomile extract
• - Other anti-calculus substances such as organophosphonates, eg Hydroxyethandiphosphonate or Azacycloheptandiphosphonat
• Preservatives such as sorbic acid salts, sodium benzoate, chlorhexidine digluconate, p-hydroxybenzoic acid or their esters.
• - Plaque inhibitors such as hexachlorophene, chlorhexidine, hexetidine, triclosan, bromochlorophene, Phenylsalicylsäureester.

In a particular embodiment the composition is a mouthwash, a mouthwash, a denture cleanser or a denture adhesive.

For denture cleaners, in particular prosthesis cleansing tablets and powders, per-compounds such as, for example, peroxoborate, peroxomonosulfate or percarbonate are suitable as additional active ingredients in addition to the already mentioned ingredients for oral, dental and / or dental prosthesis care. they have the Advantage that they also act deodorant and / or disinfecting at the same time in addition to the bleaching effect. The use of such per-compounds in prosthesis cleaners is between 0.01 and 10 wt .-%, in particular between 0.5 and 5 wt .-%.

When other ingredients are also enzymes, e.g. Proteases and carbohydrase, suitable for breaking down proteins and carbohydrates. The pH can be between pH 4 and pH 12, in particular between pH 5 and pH 11.

For the prosthesis cleansing tablets, additional auxiliaries are additionally necessary, such as, for example, agents which give off a bubbling effect, for example CO ₂ releasing substances such as sodium bicarbonate, fillers, for example sodium sulfate or dextrose, lubricants, for example magnesium stearate, flow regulators, for example colloidal silica and granulating agents, such as the already mentioned high molecular weight polyethylene glycols or polyvinylpyrrolidone.

Denture adhesives can be offered as powders, creams, foils or liquids and support the adhesion of the prostheses.

When Active ingredients are natural and synthetic swelling substances. As natural swelling substances are in addition Alginates also include plant gums, such as Gum arabic, tragacanth and karaya gum as well as more natural To name rubber as an example. In particular, alginates have and synthetic swelling agents, e.g. sodium carboxymethylcellulose, high molecular weight ethylene oxide copolymers, salts of poly (vinyl ether-co-maleic acid) and Polyacrylamides proven.

When Excipients for pasty and liquid Products are particularly suitable hydrophobic basics, in particular Hydrocarbons, such as white Vaseline (DAB) or paraffin oil.

Detergents and cleaners

To another particular embodiment become the substances according to the invention to detergents and / or cleaning agents or for oral care or denture cleaning products added.

One further subject of the invention are therefore detergents and / or cleaning agents, the Dispiro compounds of the invention contain. Such detergents and cleaners can be relatively without burdening the wastewater small amounts of substances according to the invention contain. Since they are used in concentrated form and on the appropriately diluted concentrations in the wash liquor, have to the active ingredients in correspondingly higher Concentration can be used. Common are dilutions of detergents and cleaners with water between 1:40 and 1: 200. The dispiro compounds according to the invention are therefore preferably in amounts of up to 10% by weight in the detergents and / or cleaners contain. Particularly preferred are concentrations of 0.1 to 5.0 wt .-% and in particular 0.5 to 2 wt .-%. Very particularly preferred if a concentration is chosen so that when diluting to Washing liquor or optionally, if another detergent concentrate is used when diluting to the finished detergent a final concentration in the wash liquor or in the cleaner solution of between 0.02 and 0.5% by weight, in particular between 0.05 and 0.2% by weight.

The Inventive substances can also to detergents that are used to clean hard surfaces, such as for example, floors, Tiles, tiles, plastics and other hard surfaces in the Household or in the doctor's office, used to be added.

Under Detergents and cleaning agents are in the context of the invention in the broadest sense surfactant-containing preparations in solid form (particles, Powder, etc.), semi-solid form (pastes, etc.), liquid form (solutions, Emulsions, suspensions, gels, etc.) and gas-like form (aerosols, etc.) understood that with regard to a beneficial effect in the Application, a surfactant or more surfactants, usually in addition to other components that are customary for the particular application. examples for Such surfactant-containing preparations are surfactant-containing detergent preparations, surfactant-containing cleaning agents for hard surfaces, or surfactant-containing Aviviermittelzubereitungen, each solid or be liquid can, however, may also be in a form which includes solid and liquid components or subsets of the components side by side.

The detergents and cleaners may contain commonly contained ingredients, such as anionic, nonionic, cationic and amphoteric surfactants, inorganic and organic builders, special polymers (for example those with co-builder properties), foam inhibitors, dyes and possibly additional fragrances (perfumes), bleaches (such as peroxy bleach and chlorine bleach), bleach activators, bleach stabilizers, bleach catalysts, enzymes and grayness inhibitors, without the ingredients on these Substance groups are limited. Often, important ingredients of these preparations are also washing aids, for example, and not limiting optical brighteners, UV-protective substances, so-called. Soil repellents, ie polymers that counteract a re-soiling of fibers understood. The individual substance groups will be explained in more detail below.

In the case, that the preparations are at least partly present as shaped bodies, can also contain binding and disintegration aids.

When Surfactants can for example anionic, nonionic, zwitterionic or cationic Surfactants or mixtures thereof can be used.

As anionic surfactants, for example, those of the sulfonate type and sulfates are used. Suitable surfactants of the sulfonate type are preferably C _9-13 -alkylbenzenesulfonates, olefinsulfonates, ie mixtures of alkene and hydroxyalkanesulfonates and disulfonates, such as, for example, from C _12-18 -monoolefins with terminal or internal double bond by sulfonating with gaseous sulfur trioxide and subsequent alkaline or acidic hydrolysis of the sulfonation obtained. Also suitable are alkanesulfonates which are obtained from C _12-18 alkanes, for example by sulfochlorination or sulfoxidation with subsequent hydrolysis or neutralization. Likewise suitable are the esters of 2-sulfofatty acids (ester sulfonates), for example the 2-sulfonated methyl esters of hydrogenated coconut, palm kernel or tallow fatty acids.

Further Suitable anionic surfactants are sulfated fatty acid glycerol esters. Among fatty acid glycerol esters are the mono-, di- and triesters and their mixtures to understand as in the preparation by esterification of a monoglycerol with 1 to 3 moles of fatty acid or in the transesterification of triglycerides with 0.3 to 2 moles of glycerol to be obtained. Preferred sulfated fatty acid glycerol esters are included the sulphonated products of saturated fatty acids with 6 to 22 carbon atoms, for example the caproic acid, caprylic acid, capric acid, myristic acid, lauric acid, palmitic acid, stearic acid or Behenic acid.

Alk (en) ylsulfates are the alkali metal salts and in particular the sodium salts of the sulfuric monoesters of C ₁₂ -C ₁₈ fatty alcohols, for example coconut fatty alcohol, tallow fatty alcohol, lauryl, myristyl, cetyl or stearyl alcohol or the C ₁₀ -C ₂₀ oxo alcohols and those half-esters of secondary alcohols of these chain lengths are preferred. Also preferred are alk (en) ylsulfates of said chain length, which contain a synthetic, produced on a petrochemical basis straight-chain alkyl radical, which have an analogous degradation behavior as the adequate compounds based on oleochemical raw materials. In washing and cleaning agents, the C ₁₂ -C ₁₆ alkyl sulfates and C ₁₂ -C ₁₅ alkyl sulfates and C ₁₄ -C ₁₅ alkyl sulfates are preferred. In addition, 2,3-alkyl sulfates, which are produced for example in accordance with US Patent No. 3,234,258 or 5,075,041 and can be obtained as commercial products from Shell Oil Company under the name DAN ^®, are suitable anionic surfactants.

The sulfuric acid monoesters of straight-chain or branched C _7-21 -alcohols ethoxylated with from 1 to 6 mol of ethylene oxide, such as 2-methyl-branched C _9-11- alcohols having on average 3.5 mol of ethylene oxide (EO) or C _12-18 . Fatty alcohols with 1 to 4 EO are suitable. Due to their high foaming behavior, they are only used in detergents and cleaners in relatively small amounts, for example in amounts of from 1 to 5% by weight.

Further suitable anionic surfactants are also the salts of alkylsulfosuccinic acid, which are also referred to as sulfosuccinates or as sulfosuccinic acid esters, and the monoesters and / or diesters of sulfosuccinic acid with alcohols, preferably fatty alcohols and in particular ethoxylated fatty alcohols. Preferred sulfosuccinates contain C _8-18 fatty alcohol residues or mixtures of these. Particularly preferred sulfosuccinates contain a fatty alcohol residue derived from ethoxylated fatty alcohols, which in themselves constitute nonionic surfactants (see description below). Sulfosuccinates, whose fatty alcohol residues are derived from ethoxylated fatty alcohols with a narrow homolog distribution, are again particularly preferred. Likewise, it is also possible to use alk (en) ylsuccinic acid having preferably 8 to 18 carbon atoms in the alk (en) yl chain or salts thereof.

As further anionic surfactants are particularly soaps into consideration. Suitable are saturated fatty acid soaps, such as the salts of lauric acid, myristic acid, palmitic acid, stearic acid, hydrogenated eruca acid and behenic acid and, in particular, from natural fatty acids, for example coconut, palm kernel or tallow fatty acids, derived soap mixtures.

The including anionic surfactants the soaps can in the form of their sodium, potassium or ammonium salts and as soluble salts organic bases, such as mono-, di- or triethanolamine. Preference is given to the sodium or potassium salts, in particular the sodium salts. The surfactants can also be used in the form of their magnesium salts.

in the Within the scope of the present invention, such agents are preferred. the 5 to 50 wt .-%, preferably 7.5 to 40 wt .-% and in particular 15 to 25 wt .-% of one or more anionic surfactant (s) included.

The nonionic surfactants used are preferably alkoxylated, advantageously ethoxylated, in particular primary, alcohols having preferably 8 to 18 carbon atoms and on average 1 to 12 moles of ethylene oxide (EO) per mole of alcohol, in which the alcohol radical can be linear or preferably methyl-branched in the 2-position or linear and methyl-branched radicals in the mixture can contain, as they are usually present in Oxoalkoholresten. In particular, however, alcohol ethoxylates with linear radicals of alcohols of natural origin having 12 to 18 carbon atoms, for example of coconut, palm, tallow or oleyl alcohol, and on average 2 to 8 EO per mole of alcohol are preferred. The preferred ethoxylated alcohols include, for example, C _12-14 alcohols with 3 EO or 4 EO, C _9-11 alcohols with 7 EO, C _13-15 alcohols with 3 EO, 5 EO, 7 EO or 8 EO, C _12-18 alcohols with 3 EO, 5 EO or 7 EO and mixtures of these, and mixtures of C _12-14 -alcohol with 3 EO and C _12-18 -alcohol with 5 EO. The degrees of ethoxylation given represent statistical means which, for a particular product, may be an integer or a fractional number. Preferred alcohol ethoxylates have a narrow homolog distribution (narrow range ethoxylates, NRE). In addition to these nonionic surfactants, fatty alcohols with more than 12 EO can also be used. Examples include tallow fatty alcohol with 14 EO, 25 EO, 30 EO or 40 EO.

A another class of preferred nonionic surfactants, the either as the sole nonionic surfactant or in combination with other nonionic surfactants are alkoxylated, preferably ethoxylated or ethoxylated and propoxylated fatty acid alkyl esters, preferably having 1 to 4 carbon atoms in the alkyl chain, in particular Fatty acid methyl ester.

Another class of nonionic surfactants that can be used to advantage are alkyl polyglycosides (APG). Usable Alkypolyglycoside meet the general formula RO (G) _z , in which R is a linear or branched, especially methyl-branched in the 2-position, saturated or unsaturated, aliphatic radical having 8 to 22, preferably 12 to 18 carbon atoms and G is the Is a symbol which represents a glycose unit having 5 or 6 C atoms, preferably glucose. The degree of glycosidation z is between 1.0 and 4.0, preferably between 1.0 and 2.0 and in particular between 1.1 and 1.4.

Prefers used are linear alkyl polyglucosides, ie alkyl polyglycosides, in which the polyglycosyl residue is a glucose residue and the alkyl residue is an n-alkyl radical.

The surfactant-containing according to the invention Preparations can preferably contain alkylpolyglycosides, wherein contents of washing, Rinsing or Preparations intended for cleaning purposes to APG of more than 0.2 Wt .-%, based on the total preparation, are preferred. Especially preferred surfactant-containing preparations contain APG in amounts of 0.2 to 10 wt .-%, preferably in amounts of 0.2 to 5 wt .-% and in particular in amounts of 0.5 to 3 wt .-%.

Also nonionic surfactants of the amine oxide type, for example N-cocoalkyl-N, N-dimethylamine oxide and N-tallow alkyl-N, N-dihydroxyethylamine oxide, and the fatty acid alkanolamide can be suitable. The amount of these nonionic surfactants is preferably not more than that of the ethoxylated fatty alcohols, in particular not more than half from that.

in der R⁴CO für einen aliphatischen Acylrest mit 6 bis 22 Kohlenstoffatomen, R⁵ für Wasserstoff, einen Alkyl- oder Hydroxyalkylrest mit 1 bis 4 Kohlenstoffatomen und [Z¹] für einen linearen oder verzweigten Polyhydroxyalkylrest mit 3 bis 10 Kohlenstoffatomen und 3 bis 10 Hydroxylgruppen steht. Bei den Polyhydroxyfettsäureamiden handelt es sich um bekannte Stoffe, die üblicherweise durch reduktive Aminierung eines reduzierenden Zuckers mit Ammoniak, einem Alkylamin oder einem Alkanolamin und nachfolgende Acylierung mit einer Fettsäure, einem Fettsäurealkylester oder einem Fettsäurechlorid erhalten werden können.Further suitable surfactants are polyhydroxy fatty acid amides of the formula (IX)

in the R ⁴ CO for an aliphatic acyl radical having 6 to 22 carbon atoms, R ^{5 is} hydrogen, an alkyl or hydroxyalkyl radical having 1 to 4 carbon atoms and [Z ¹ ] represents a linear or branched polyhydroxyalkyl radical having 3 to 10 carbon atoms and 3 to 10 hydroxyl groups. The polyhydroxy fatty acid amides are known substances which can usually be obtained by reductive amination of a reducing sugar with ammonia, an alkylamine or an alkanolamine and subsequent acylation with a fatty acid, a fatty acid alkyl ester or a fatty acid chloride.

in der R⁶ für einen linearen oder verzweigten Alkyl- oder Alkenylrest mit 7 bis 12 Kohlenstoffatomen, R⁷ für einen linearen, verzweigten oder cyclischen Alkylrest oder einen Arylrest mit 2 bis 8 Kohlenstoffatomen und R⁸ für einen linearen, verzweigten oder cyclischen Alkylrest oder einen Arylrest oder einen Oxy-Alkylrest mit 1 bis 8 Kohlenstoffatomen steht, wobei C_1-4-Alkyl- oder Phenylreste bevorzugt sind und [Z²] für einen linearen Polyhydroxyalkylrest steht, dessen Alkylkette mit mindestens zwei Hydroxylgruppen substituiert ist, oder alkoxylierte, vorzugsweise ethoxylierte oder propxylierte Derivate dieses Restes.The group of polyhydroxy fatty acid amides also includes compounds of the formula (X)

in the R ^{6 is} a linear or branched alkyl or alkenyl radical having 7 to 12 carbon atoms, R ^{7 is} a linear, branched or cyclic alkyl radical or an aryl radical having 2 to 8 carbon atoms and R ^{8 is} a linear, branched or cyclic alkyl radical or a Aryl radical or an oxy-alkyl radical having 1 to 8 carbon atoms, wherein C _1-4 alkyl or phenyl radicals are preferred and [Z ² ] is a linear polyhydroxyalkyl radical whose alkyl chain is substituted with at least two hydroxyl groups, or alkoxylated, preferably ethoxylated or propylated derivatives of this residue.

[Z ² ] is preferably obtained by reductive amination of a reduced sugar, for example glucose, fructose, maltose, lactose, galactose, mannose or xylose. The N-alkoxy- or N-aryloxy-substituted compounds can then be converted, for example, as described in WO-A-95/07331, into the desired polyhydroxy fatty acid amides by reaction with fatty acid methyl esters in the presence of an alkoxide as catalyst.

Farther It may be preferred, in addition to anionic and nonionic surfactants also to use cationic surfactants.

When Fabric softening substances are in particular cationic surfactants to call. Examples of cationic surfactants are, in particular, quaternary ammonium compounds, cationic polymers and emulsifiers.

wobei in (XII) R^a und R^b für einen acyclischen Alkylrest mit 12 bis 24 Kohlenstoffatomen, R^c für einen gesättigten C₁-C₄ Alkyl- oder Hydroxyalkylrest steht, R^d entweder gleich R^a, R^b oder R^c ist oder für einen aromatischen Rest steht. X^- steht entweder für ein Halogenid-, Metho-sulfat-, Methophosphat- oder Phosphation sowie Mischungen aus diesen. Beispiele für kationische Verbindungen der Formel (XI) sind Didecyldimethylammoniumchlorid, Ditalgdimethylammoniumchlorid oder Dihexadecylammoniumchlorid.Suitable examples are quaternary ammonium compounds of the formulas (XI) and (XII)

wherein in (XII) R ^a and R ^{b is} an acyclic alkyl radical having 12 to 24 carbon atoms, R ^{c is} a saturated C ₁ -C ₄ alkyl or hydroxyalkyl radical, R ^{d is} either R ^a , R ^b or R ^c is or represents an aromatic radical. X ^- is either a halide, methosulfate, methophosphate or phosphate ion and mixtures thereof. Examples of cationic compounds of the formula (XI) are didecyldimethylammonium chloride, ditallowdimethylammonium chloride or dihexadecylammonium chloride.

Compounds of the formula (XII) are so-called ester quats. Esterquats are characterized by excellent biodegradability. Here R ^{e is} an aliphatic acyl radical having 12 to 22 carbon atoms with 0, 1, 2 or 3 double bonds; R ^f is H, OH or O (CO) R ^h , R ^g is independently of R ^{f is} H, OH or O (CO) R ⁱ , wherein R ^h and R ⁱ are each independently an aliphatic acyl radical having 12 to 22 carbon atoms with 0, 1, 2 or 3 double bonds. m, n and p can each independently be 1, 2 or 3. X ^- may be either a halide, methosulfate, methophosphate or phosphate ion, as well as mixtures of these. Preference is given to compounds which contain the group O (CO) R ^h for R ^f and for R ^c and R ^h contain alkyl radicals having 16 to 18 carbon atoms. Particularly preferred are compounds in which R ^{9 is} also OH. Examples of compounds of the formula (XII) are methyl N- (2-hydroxyethyl) -N, N-di (tallowacyl oxyethyl) ammonium methosulfate, bis (palmitoyl) ethyl hydroxyethyl methyl ammonium methosulfate or methyl N , N-bis (acyloxyethyl) -N- (2-hydroxyethyl) ammonium methosulfate. If quaternized compounds of the formula (XII) which have unsaturated alkyl chains are used, the acyl groups whose corresponding fatty acids have an iodine value between 5 and 80 are preferred preferably between 10 and 60 and in particular between 15 and 45 and which have a cis / trans isomer ratio (in wt .-%) of greater than 30: 70, preferably greater than 50: 50 and in particular greater than 70: 30 have. Commercial examples are sold by Stepan under the name Stepantex® ^® methylhydroxyalkyldialkoyloxyalkylammonium or known by Dehyquart® ^® products from Cognis or known by Rewoquat ^® products from Goldschmidt-Witco. Further preferred compounds are the diesterquats corresponding to formula (XIII), under the name Rewoquat ^® W 222 LM or CR 3099 are available and provide in addition to the softness also for stability and color protection.

R ^k and R ^l are each independently an aliphatic acyl radical having 12 to 22 carbon atoms with 0, 1, 2 or 3 double bonds.

wobei R^m für H oder einen gesättigten Alkylrest mit 1 bis 4 Kohlenstoffatomen, Rⁿ und R^o unabhängig voneinander jeweils für einen aliphatischen, gesättigten oder ungesättigten Alkylrest mit 12 bis 18 Kohlenstoffatomen, Rⁿ alternativ auch für O(CO)R^p stehen kann, wobei R^p einen aliphatischen, gesättigten oder ungesättigten Alkylrest mit 12 bis 18 Kohlenstoffatomen bedeutet, und Z eine NH-Gruppe oder Sauerstoff bedeutet und X^- ein Anion ist. q kann ganzzahlige Werte zwischen 1 und 4 annehmen.In addition to the quaternary compounds described above, it is also possible to use other known compounds, for example quaternary imidazolinium compounds of the formula (XIV)

where R ^{m is} H or a saturated alkyl radical having 1 to 4 carbon atoms, R ⁿ and R ^o are each independently an aliphatic, saturated or unsaturated alkyl radical having 12 to 18 carbon atoms, R ⁿ alternatively also O (CO) R ^p wherein R ^{p is} an aliphatic, saturated or unsaturated alkyl radical having 12 to 18 carbon atoms, and Z is an NH group or oxygen and X ^{- is} an anion. q can take integer values between 1 and 4.

wobei R^q, R^r und R^s unabhängig voneinander für eine C_1-4-Alkyl-, Alkenyl- oder Hydroxyalkylgruppe steht, R^t und R^u jeweils unabhängig ausgewählt eine C_8-28-Alkylgruppe darstellt und r eine Zahl zwischen 0 und 5 ist.Further suitable quaternary compounds are described by formula (XV),

wherein R ^q , R ^r and R ^s independently represent a C _1-4 alkyl, alkenyl or hydroxyalkyl group, each of R ^t and R ^u independently represents a C _8-28 alkyl group and r represents a number between 0 and 5 is.

Next The compounds of the formulas XI to XV can also be short-chain, water-soluble, Quaternary ammonium compounds can be used, such as trihydroxyethylmethylammonium methosulfate or the alkyltrimethylammonium chlorides, dialkyldimethylammonium chlorides and trialkylmethylammonium chlorides, e.g. Cetyltrimethylammonium chloride, Stearyltrimethylammonium chloride, distearyldimethylammonium chloride, Lauryldimethylammonium chloride, Lauryldimethylbenzylammoniumchlorid and tricetylmethylammonium chloride.

Also protonated alkylamine compounds which have a softening effect, and the non-quaternized, protonated precursors of cationic Emulsifiers are suitable.

Further usable according to the invention cationic compounds constitute the quaternized protein hydrolysates represents.

Suitable cationic polymers include the polyquaternium polymers as described in the CTFA Cosmetic Ingredient Dictionary (The Cosmetic, Toiletry and Fragrance, Inc., 1997), in particular the Polyquaternium-6, Polyquaternium-7, Polyquaternium, also known as Merquats. 10-polymers (Ucare Polymer IR 400, Amerchol), polyquaternium-4 copolymers, such as graft copolymers having a cellulose backbone and quaternary ammonium groups bonded via allyldimethylammonium chloride, cationic cellulose derivatives such as cationic guar such as guar hydroxypropyl triammonium chloride and similar quaternized guar derivatives (eg Cosmedia Guar, manufacturer: Cognis GmbH), cationic quaternary sugar derivatives (cationic alkyl polyglucosides), e.g. For example, the commercial product Glucquat ^® 100, according to CTFA nomenclature a "Lauryl Methyl Gluceth-10 hydroxypropyl Dimonium Chloride", copolymers of PVP and dimethylaminomethacrylate, copolymers of vinylimidazole and vinylpyrrolidone, aminosilicone polymers and copolymers, Also usable are polyquaternized polymers (eg. B. Luviquat Care from BASF) and also cationic biopolymers based on chitin and derivatives thereof, for example, under the trade designation chitosan ^® (manufacturer: Cognis available) polymer.

Also suitable in the present invention are cationic silicone oils such as the commercially available products Q2-7224 (manufactured by Dow Corning, a stabilized trimethylsilylamodimethicone), Dow Corning 929 emulsion (containing a hydroxylamino-modified silicone, also referred to as amodimethicones), SM -2059 (manufacturer: General Electric), SLM-55067 (manufacturer: Wacker) Abil ^® -Quat 3270 and 3272 (manufacturer: Goldschmidt-Rewo; diquaternary polydimethylsiloxanes, quaternium-80), and Silicone quat Rewoquat ^® SQ 1 (Tegopren ^® 6922, Manufacturer: Goldschmidt-Rewo).

die Alkylamidoamine in ihrer nicht quaternierten oder, wie dargestellt, ihrer quaternierten Form, sein können. R^v kann ein aliphatischer Acylrest mit 12 bis 22 Kohlenstoffatomen mit 0, 1, 2 oder 3 Doppelbindungen sein. s kann Werte zwischen 0 und 5 annehmen. R^w und R^x stehen unabhängig voneinander jeweils für H, C_1-4-Alkyl oder Hydroxyalkyl. Bevorzugte Verbindungen sind Fettsäureamidoamine wie das unter der Bezeichnung Tego Amid^®S 18 erhältliche Stearylamidopropyldimethylamin oder das unter der Bezeichnung Stepantex^® X 9124 erhältliche 3-Talgamidopropyl-trimethylammonium-methosulfat, die sich neben einer guten konditionierenden Wirkung auch durch farbübertragungsinhibierende Wirkung sowie speziell durch ihre gute biologische Abbaubarkeit auszeichnen.Also usable are compounds of the formula (XVI),

the alkylamidoamines may be in their quaternized or, as shown, their quaternized form. R ^v can be an aliphatic acyl radical having 12 to 22 carbon atoms with 0, 1, 2 or 3 double bonds. s can take values between 0 and 5. R ^w and R ^x are each independently H, C _1-4 alkyl or hydroxyalkyl. Preferred compounds are fatty acid amidoamines such as Stearylamidopropyldimethylamin available under the name Tego Amid ^® S 18 or 3-Talgamidopropyl-trimethylammonium methosulfate available under the name Stepantex ^® X 9124, which in addition to a good conditioning effect by color transfer inhibiting effect and especially by their good distinguish biodegradability.

Become cationic surfactants used, they are in the preparations preferably in amounts of 0.01 to 10 wt .-%, in particular of 0.1 contain up to 3.0 wt .-%.

Of the Total surfactant content in the inventive compositions between 5 and 50 wt .-%, preferably between 10 and 35 wt .-% are.

Next The surfactants are builders the most important ingredients of detergents and cleaners. In the surfactant-containing according to the invention Preparations can usually Be contained in detergents and cleaning agents builders, in particular So zeolites, silicates, carbonates, organic cobuilders and - where no ecological Prejudices against their use exist - even the phosphates.

Suitable crystalline layered sodium silicates have the general formula NaMSi _x O _{2x + 1} .H ₂ O, where M is sodium or hydrogen, x is a number from 1.9 to 4 and y is a number from 0 to 20 and preferred values for x 2, 3 or 4 are. Such crystalline layered silicates are described, for example, in European Patent Application EP-A-0 164 514. Preferred crystalline layered silicates of the formula given are those in which M is sodium and x assumes the values 2 or 3. In particular, both β- and δ-sodium disilicates Na ₂ Si ₂ O ₅ .yH ₂ O are preferred, and β-sodium disilicate can be obtained, for example, by the method described in International Patent Application WO-A-91/08171.

It is also possible to use amorphous sodium silicates with a Na ₂ O: SiO ₂ modulus of from 1: 2 to 1: 3.3, preferably from 1: 2 to 1: 2.8 and in particular from 1: 2 to 1 2.6, which delay dissolution are and have secondary washing properties. The dissolution delay compared to conventional amorphous sodium silicates may have been caused in various ways, for example by surface treatment, compounding, compaction / densification or by overdrying. So-called X-ray amorphous silicates, which also have a dissolution delay compared to conventional water glasses, are described for example in the German patent application DE-A-44 00 024. The products have microcrystalline areas of size 10 to several hundred nm, with values up to max. 50 nm and in particular up to max. 20 nm are preferred. Especially preferred are densified / compacted amorphous silicates, compounded amorphous silicates and overdried X-ray amorphous silicates.

A fine crystalline, synthetic and bound water-containing zeolite optionally used is preferably zeolite A and / or P. Zeolite MAP (eg, commercial product: Doucil A24 from Crosfield) is particularly preferred as the P-type zeolite. Also suitable, however, are zeolite X and mixtures of A, X and / or P. Commercially available and preferably usable in the context of the present invention is, for example, a cocrystal of zeolite X and zeolite A (about 80% by weight of zeolite X) ), which is sold by the company CONDEA Augusta SpA under the brand name VEGOBOND AX ^® and by the formula nNa ₂ O • (1-n) K ₂ O • Al ₂ O ₃ • (2 - 2.5) SiO ₂ • (3.5-5.5) H ₂ O can be described. Suitable zeolites have an average particle size of less than 10 μm (volume distribution, measuring method: Coulter Counter) and preferably contain 18 to 22% by weight, in particular 20 to 22% by weight, of bound water.

Of course it is in detergents also a use of the well-known phosphates as builder substances possible, unless such use is avoided for environmental reasons should be. Particularly suitable are the sodium salts of orthophosphates, the pyrophosphates and in particular the tripolyphosphates.

useful organic builders For example, they can be used in the form of their sodium salts polycarboxylic where among polycarboxylic acids such carboxylic acids be understood that carry more than one acid function. For example these are citric acid, adipic acid, Succinic acid, Glutaric acid, malic acid, tartaric acid, maleic acid, fumaric acid, sugar acids, aminocarboxylic acids, nitrilotriacetic acid (NTA), provided their use of ecological establish not to complain about, as well as mixtures of these. preferred Salts are the salts of polycarboxylic acids such as citric acid, adipic acid, succinic acid, glutaric acid, tartaric acid, sugar acids and Mixtures of these. The acids themselves can also be used become. The acids In addition to their builder effect, they also typically have the property an acidifying component and thus serve to set a lower and milder one pH of surfactant-containing preparations according to the invention. Especially are in this context, citric acid, succinic acid, glutaric acid, adipic acid, gluconic acid and to name any mixtures of these.

When Builders are further suitable polymeric polycarboxylates. these are for example, the alkali metal salts of polyacrylic acid or polymethacrylic acid, for example, those having a molecular weight of 500 to 70,000 g / mol.

In the context of the present invention, the molecular weights stated for polymeric polycarboxylates are weight-average molar masses M _{w of} the particular acid form, which were determined in principle by means of gel permeation chromatography (GPC), a UV detector being used. The measurement was carried out against an external polyacrylic acid standard, which provides realistic molecular weight values due to its structural relationship with the polymers investigated. These data differ significantly from the molecular weight data, in which polystyrene sulfonic acids are used as standard. The molar masses measured against polystyrene acids are generally significantly higher than the molecular weights specified in the context of the present invention.

suitable Polymers are in particular polyacrylates, which preferably have a molecular weight from 2,000 to 20,000 g / mol. Because of their superior solubility can from this group, in turn, the short-chain polyacrylates are preferred be, the molecular weights of 2,000 to 10,000 g / mol, more preferably from 3,000 to 5,000 g / mol.

Suitable are furthermore copolymeric polycarboxylates, especially those of acrylic acid with methacrylic acid or the acrylic acid or methacrylic acid with maleic acid. Particularly suitable are copolymers of acrylic acid with maleic which contain 50 to 90% by weight of acrylic acid and 50 to 10% by weight of maleic acid. Their relative molecular weight, based on free acids, is generally 2,000 to 70,000 g / mol, preferably 20,000 to 50,000 g / mol and especially 30,000 up to 40,000 g / mol.

The (co) polymeric polycarboxylates can be used either as a powder or as an aqueous solution. The content of (co) polymeric polycarboxylates in the washing and cleaning agents preferably 0.5 to 20 wt .-%, in particular 3 to 10 wt .-%.

to Improvement of water solubility can the polymers also include allylsulfonic acids, allyloxybenzenesulfonic and methallylsulfonic acid as a monomer.

Especially Biodegradable polymers of more than two are also preferred various monomer units, for example, those as monomers Salts of acrylic acid and maleic acid and vinyl alcohol or vinyl alcohol derivatives or salts of acrylic acid and of 2-alkylallyl sulfonic acid as well as sugar derivatives contain.

Further preferred copolymers are those which are preferably used as monomers Acrolein and acrylic acid / acrylic acid salts or acrolein and vinyl acetate.

As well are as further preferred builders polymeric aminodicarboxylic acids whose Salts or their precursors to call. Particular preference is given to polyaspartic acids or their salts and derivatives, some in addition to co-builder properties also have a bleach-stabilizing effect.

Further Suitable builders are polyacetals, which by reaction of dialdehydes can be obtained with Polyolcarbonsäuren, the 5 to 7 carbon atoms and at least 3 hydroxy groups. Preferred polyacetals are selected from dialdehydes such as glyoxal, glutaraldehyde, Terephthalaldehyde and mixtures thereof and from Polyolcarbonsäuren such gluconic and / or glucoheptonic acid receive.

Further suitable organic builders are dextrins, for example Oligomers or polymers of carbohydrates by partial Hydrolysis of starches can be obtained. The hydrolysis can be carried out according to usual, for example acidic or enzyme-catalyzed processes. Preferably These are hydrolysis products with average molecular weights in the range from 400 to 500,000 g / mol. It is a polysaccharide with a Dextrose equivalent (DE) in the range from 0.5 to 40, in particular from 2 to 30, preferred where DE is a common one Measure of the reducing Effect of a polysaccharide compared to dextrose is which a DE of 100 owns. Useful are both maltodextrins with a DE between 3 and 20 and dry glucose syrup with a DE between 20 and 37 as well as so-called yellow dextrins and white dextrins with higher Molar masses in the range of 2,000 to 30,000 g / mol. A preferred dextrin is described in British Patent Application 94 19 091.

The oxidized derivatives of such dextrins are their reaction products with oxidizing agents which are capable of oxidizing at least one alcohol function of the saccharide ring to the carboxylic acid function. Also suitable is an oxidized oligosaccharide, wherein a product oxidized to C _{6 of} the saccharide ring may be particularly advantageous.

Also Oxydisuccinates and other derivatives of disuccinates, preferably Ethylenediamine disuccinate is another suitable co-builder. there becomes ethylenediamine-N, N'-disuccinate (EDDS) preferably used in the form of sodium or magnesium salts. Also preferred in this context are glycerol disuccinates and glycerol trisuccinates. Suitable amounts are zeolithhaltigen and / or silicate-containing formulations at 3 to 15 wt .-%.

Further useful organic co-builders are, for example, acetylated hydroxy or their salts, which may also be present in lactone form can and which at least 4 carbon atoms and at least one hydroxy group and a maximum of two acid groups contain.

Another class of substances with co-builder properties are the phosphonates. These are, in particular, hydroxyalkane or aminoalkanephosphonates. Among the hydroalkane phosphonates, the 1-hydroxyethane-1,1-diphosphonate (HEDP) is of particular importance as a co-builder. It is preferably used as the sodium salt, the disodium salt neutral and the tetrasodium salt alkaline (pH = 9). Preferred aminoalkanephosphonates are ethylenediamine tetramethylenephosphonate (EDTMP), diethylenetriaminepentamethylenephosphonate (DTPMP) and their higher homologs. They are preferably used in the form of the neutral-reacting sodium salts, for example as the hexasodium salt of EDTMP or as hepta- and octasodium salt of DTPMP. The builder used here is preferably HEDP from the class of phosphonates. The Aminoalkanphosphonate also have a pronounced heavy metal-binding capacity. Accordingly, in particular when the surfactant-containing preparations according to the invention also contain bleach, it may be preferable to use aminoalkanephosphonates, in particular DTPMP, or to use mixtures of the phosphonates mentioned.

Furthermore can all compounds that are capable of complexes with alkaline earth metal ions to be used as a co-builder.

Among the compounds serving as bleaches in water H ₂ O ₂ , sodium perborate tetrahydrate and sodium perborate monohydrate are of particular importance. Other useful bleaching agents are, for example, sodium percarbonate, peroxypyrophosphates, citrate perhydrates and H ₂ O ₂ -producing peracidic salts or peracids, such as perbenzoates, peroxophthalates, diperazelaic acid, phthaloiminoperacid or diperdodecanedioic acid. When cleaning or bleaching preparations for automatic dishwashing are prepared, it is also possible to use bleaching agents from the group of organic bleaching agents. Typical organic bleaches are the diacyl peroxides such as dibenzoyl peroxide. Other typical organic bleaches are the peroxyacids, examples of which include the alkyl peroxyacids and the aryl peroxyacids. Preferred representatives are (a) the peroxybenzoic acid and its ring-substituted derivatives, such as alkylperoxybenzoic acids, but also peroxy-α-naphthoic acid and magnesium monoperphthalate; (b) the aliphatic or substituted aliphatic peroxyacids such as peroxylauric acid, peroxystearic acid, ε-phthalimidoperoxycaproic acid [phthaloiminoperoxyhexanoic acid (PAP)], o-carboxybenzamido-peroxycaproic acid, N-nonenylamidoperadipic acid and N-nonenylamidopersuccinates; and (c) aliphatic and araliphatic peroxydicarboxylic acids such as 1,12-diperoxycarboxylic acid, 1,9-diperoxyazelaic acid, diperocysebacic acid, diperoxybrassylic acid, the diperoxyphthalic acids, 2-decyldiperoxybutane-1,4-diacid, N, N-terephthaloyl-di (6-aminopercapronic acid ) can be used.

Around when washing or cleaning at temperatures of 60 ° C and below To achieve an improved bleaching effect, bleach activators can be incorporated into the surfactant-containing preparations are incorporated. As bleach activators can Compounds which, under perhydrolysis conditions, are aliphatic peroxycarboxylic acids preferably 1 to 10 C atoms, in particular 2 to 4 C atoms, and / or optionally substituted perbenzoic acid, are used. Suitable substances are the O- and / or N-acyl groups of the mentioned C atom number and / or optionally substituted benzoyl groups wear. Preference is given to polyacylated alkylenediamines, in particular Tetraacetylethylenediamine (TAED), acylated triazine derivatives, in particular 1,5-diacetyl-2,4-dioxohexahydro-1,3,5-triazine (DADHT), acylated glycolurils, especially tetraacetylglycoluril (TAGU), N-acylimides, especially N-nonanoylsuccinimide (NOSI), acylated Phenolsulfonates, especially n-nonanoyl or isononanoyloxybenzenesulfonate (n- or iso-NOBS), carboxylic acid anhydrides, in particular phthalic anhydride, acylated polyhydric alcohols, especially triacetin, ethylene glycol diacetate and 2,5-diacetoxy-2,5-dihydrofuran.

In addition to The conventional bleach activators or in their place may also so-called bleach catalysts in the surfactant-containing preparations be incorporated. These substances are bleach-enhancing transition metal salts or transition metal complexes such as Mn, Fe, Co, Ru or Mo saline complexes or carbonyl complexes. Also Mn, Fe, Co, Ru, Mo, Ti, V and Cu complexes with N-containing tripod ligands and Co, Fe, Cu and Ru ammine complexes are useful as bleach catalysts.

When Enzymes come from the class of proteases, lipases, amylases, Cellulases or mixtures thereof in question. Especially suitable are from bacterial strains or fungi such as Bacillus subtilis, Bacillus licheniformis and Streptomyces griseus derived enzymatic agents. Preferably, proteases of the subtilisin type and in particular proteases derived from Bacillus lentus are used. These are enzyme mixtures, for example from protease and amylase or protease and lipase or protease and cellulase or from cellulase and lipase or from Protease, amylase and lipase or protease, lipase and cellulase, but especially cellulase-containing mixtures of particular Interest. Peroxidases or oxidases have also been found in some make proved to be suitable. The enzymes can be adsorbed to carriers and / or in encasing substances be embedded to protect them against premature decomposition. Of the Proportion of the enzymes, enzyme mixtures or enzyme granules in the surfactant-containing according to the invention Preparations may, for example, about 0.1 to 5 wt .-%, preferably 0.1 to about 2 wt .-%, amount.

A preferred group of suitable additives are optical brighteners. Can be used here, the usual in detergents optical brightener. Examples of optical brighteners are derivatives of diaminostilbene disulfonic acid or its alkali metal salts. Suitable z. B. salts of 4, 4'-bis (2-anili no-4-morpholino1,3,5-tniazinyl-6-amino-) stilbene-2,2'-disulphonic acid or similarly constructed compounds which, instead of the morpholino group, have a diethanolamino group, a methylamino group, an anilino group or carry a 2-methoxyethylamino group. Furthermore, brighteners of the type of substituted diphenylstyrene may be present in the partial portions (wash-active preparations) of the surfactant-containing preparations according to the invention, eg. For example, the alkali salts of 4,4'-bis (2-sulfostyryl) diphenyl, 4,4'-bis (4-chloro-3-sulfostyryl) diphenyl or 4- (4-chlorostyryl) 4 '- (2 -sulfostyryl-) biphenyl. Mixtures of the aforementioned brightener can be used.

Another group of additives which is preferred according to the invention are UV protection substances. UV absorbers can be applied to the treated textiles and improve the lightfastness of the fibers and / or the lightfastness of the other constituents of the formulation. Under UV absorber are organic substances (sunscreen) to understand, which are able to absorb ultraviolet rays and the absorbed energy in the form of longer-wave radiation, eg heat to give back. Compounds having these desired properties include, for example, the non-radiative deactivating compounds and derivatives of benzophenone having substituents in the 2- and / or 4-position. In addition, substituted benzotriazoles, such as the water-soluble benzenesulfonic acid-3- (2H-benzotriazol-2-yl) -4-hydroxy-5- (methylpnopyl) monosodium salt (Ciba ^® Fast H), 3-phenyl-substituted acrylates (cinnamic acid derivatives) , optionally with cyano groups in the 2-position, salicylates, organic Ni complexes and natural substances such as umbelliferone and the body's urocanic acid suitable. Of particular importance are biphenyl and especially Stilbenderivate as described for example in the EP 0728749 A are described and are available as Tinosorb FD ^{® ®} or Tinosorb FR ex Ciba commercially. As UV-B absorber are 3-benzylidene camphor or 3-Benzylidennorcampher and its derivatives, for example 3- (4-methylbenzylidene) camphor, as in EP 0693471 B1 described; 4-aminobenzoic acid derivatives, preferably 2-ethylhexyl 4- (dimethylamino) benzoate, 2-octyl 4- (dimethylamino) benzoate and 4- (dimethylamino) benzoic acid ester; Esters of cinnamic acid, preferably 4-methoxycinnamic acid 2-ethylhexyl ester, 4-methoxycinnamic acid propyl ester, 4-methoxycinnamic acid isoamyl ester, 2-cyano-3,3-phenylcinnamic acid 2-ethylhexyl ester (octocrylene); Esters of salicylic acid, preferably 2-ethylhexyl salicylate, 4-isopropylbenzyl salicylate, homomenthyl salicylate; Derivatives of benzophenone, preferably 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone; Esters of benzalmalonic acid, preferably di-2-ethylhexyl 4-methoxybenzmalonate; Triazine derivatives such as 2,4,6-trianilino (p-carbo-2'-ethyl-1'-hexyloxy) -1,3,5-triazine and octyl triazone, as described in U.S. Pat EP 0818450 A1 Dioctyl Butamido Triazone or described (Uvasorb HEB ^®); Propane-1,3-diones such as 1- (4-tert-butylphenyl) -3- (4'-methoxyphenyl) propane-1,3-dione; Ketotricyclo (5.2.1.0) decane derivatives as described in U.S.P. EP 0694521 B1 described. Also suitable are 2-phenylbenzimidazole-5-sulfonic acid and its alkali metal, alkaline earth metal, ammonium, alkylammonium, alkanolammonium and glucammonium salts; Sulfonic acid derivatives of benzophenones, preferably 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and its salts; Sulfonic acid derivatives of 3-Benzylidencamphers, such as 4- (2-oxo-3-bomylidenemethyl) benzenesulfonic acid and 2-methyl-5- (2-oxo-3-bomylidene) sulfonic acid and salts thereof.

As a typical UV-A filter in particular derivatives of benzoylmethane are suitable, such as 1- (4'-tert-butylphenyl) -3- (4'-methoxyphenyl) propane-1,3-dione, 4-tert-butyl 4'-methoxydibenzoylmethane (Parsol 1789), 1-phenyl-3- (4'-isopropylphenyl) -propane-1,3-dione, and enamine compounds as described in U.S.P. DE 19712033 A1 (BASF). Of course, the UV-A and UV-B filters can also be used in mixtures. In addition to the soluble substances mentioned, insoluble photoprotective pigments, namely finely dispersed, preferably nano-metal oxides or salts, are also suitable for this purpose. Examples of suitable metal oxides are in particular zinc oxide and titanium dioxide and, in addition, oxides of iron, zirconium, silicon, manganese, aluminum and cerium and mixtures thereof. As salts silicates (talc), barium sulfate or zinc stearate can be used. The oxides and salts are already used in the form of the pigments for skin-care and skin-protecting emulsions and decorative cosmetics. The particles should have an average diameter of less than 100 nm, preferably between 5 and 50 nm and in particular between 15 and 30 nm. They may have a spherical shape, but it is also possible to use those particles which have an ellipsoidal or otherwise deviating shape from the spherical shape. The pigments can also be surface-treated, ie hydrophilized or hydrophobized. Typical examples are coated titanium dioxides, for example Titandioxid T 805 (Degussa) or Eusolex ^® T2000 (Merck). Suitable hydrophobic coating agents are in particular silicones and in particular trialkoxyoctylsilanes or simethicones. Preferably, micronized zinc oxide is used. Further suitable UV photoprotective filters can be found in the review by P.Finkel in SÖFW-Journal 122, 543 (1996).

The UV absorbers are usually used in amounts of from 0.01% by weight to 5% by weight, preferably from 0.03 wt .-% to 1 wt .-%, used.

A further preferred according to the invention Group of additives are dyes, in particular water-soluble or water-dispersible dyes. Dyes are preferred here, as they are used to improve the optical product appearance in the washing, rinsing, Cleaning and textile treatment agents are commonly used. The selection of such dyes is not difficult for a person skilled in the art especially since such usual Dyes have a high storage stability and insensitivity to the other ingredients the detergent-active preparations and against light and no pronounced substantivity to textile fibers have to not stain them. The dyes are according to the invention in the washing and / or cleaning agents according to the invention in amounts of less than 0.01 wt .-% present.

A Another class of additives according to the invention the detergents and / or cleaning agents can be added are polymers. Come under these polymers on the one hand polymers in question when washing or cleaning or do the washing up Cobuilder properties show, for example, polyacrylic acids, too modified polyacrylic acids or corresponding copolymers. Another group of polymers are polyvinylpyrrolidone and other grayness inhibitors, such as Copolymers of polyvinyl pyrrolidone, cellulose ethers and the like. Other preferred polymers are so-called soil repellents in question, as described in detail below.

When further additives according to the invention can be Detergents and cleaners also contain so-called soil repellents, So polymers that are absorbed by fibers, the oil and Fettauswaschbarkeit from textiles positively and thus a Wiederanschmutzung counteract specifically. This effect becomes particularly clear when a textile is dirty, which has been repeatedly with a inventive washing or Cleaning agent containing these oil and fat-dissolving Component contains was washed. Among the preferred oil and fat dissolving components counting for example, nonionic cellulose ethers such as methyl cellulose and methylhydroxypropylcellulose with a proportion of methoxy groups from 15 to 30% by weight and of hydroxypropoxy groups from 1 to 15 Wt .-%, each based on the nonionic cellulose ether, and the known from the prior art polymers of phthalic acid and / or of terephthalic acid or of their derivatives, in particular polymers of ethylene terephthalates and / or polyethylene glycol terephthalates or anionic and / or nonionically modified derivatives of these. Especially preferred of these are the sulfonated derivatives of phthalic acid and the terephthalic acid polymers.

Especially if it is liquid or gelatinous Preparations is, can these also solvents contain. examples for suitable solvents mono- or polyhydric alcohols having 1 to 4 carbon atoms. preferred Alcohols are ethanol, 1,2-propanediol, glycerol and any of them Mixtures. The solvents can in liquid Preparations in an amount of 2 to 12 wt .-%, based on the finished Preparation, be included.

The additives mentioned are the detergents and / or cleaning agents in quantities up to at most 30 wt .-%, preferably 2 to 20 wt .-%, added.

These enumeration of washing and cleaning agent ingredients used in the washing, cleaning and cleaning compositions according to the invention, Rinsing or Detergents may occur is by no means exhaustive, but only gives the essential ingredients typical such means again. In particular, as far as liquid or gel Preparations is, in the funds and organic solvents be included. Preferably, it is mono- or polyvalent Alcohols with 1 to 4 carbon atoms. Preferred alcohols in such agents are ethanol, 1,2-propanediol, glycerol and mixtures of these Alcohols. In preferred embodiments Such agents contain 2 to 12 wt .-% of such alcohols.

To a particular embodiment are especially liquid or solid detergents are preferred. Also particularly preferred are detergents and cleaners that are suitable for delicate washing or gentle treatment of delicate textiles are suitable.

Especially are also textile care agents, in particular textile aftertreatment agents, preferably textile conditioners, fabric softeners or dryer sheets suitable, contain the substances that influence the dimorphism of fungi.

Depending on the intended use further ingredients can be used. Softener compositions for rinse-aid are broadly described in the art. Üblicherwei These compositions contain as active substance a cationic quaternary ammonium compound which is dispersed in water. Depending on the content of active substance in the finished plasticizer composition, this is referred to as dilute, ready-to-use products (active substance contents below 7% by weight) or so-called concentrates (active substance content above 7% by weight). Because of the lower volume and the concomitantly reduced packaging and transport costs, the textile softener concentrates have advantages from an ecological point of view and have become more and more prevalent in the market. Due to the incorporation of cationic compounds, which have only a low water solubility, conventional softener compositions are in the form of dispersions, have a milky-cloudy appearance and are not translucent. For reasons of product aesthetics, it may also be desirable to provide the consumer with translucent, clear fabric softeners which visually stand out from the known products.

As fabric-softening active substance, fabric softeners according to the invention preferably contain cationic surfactants which have already been described in detail above. These agents according to the invention particularly preferably contain so-called esterquats. While there are a large number of possible compounds from this class of substances, esterquats according to the invention are used with particular preference, which can be prepared in a conventional manner by reacting trialkanolamines with a mixture of fatty acids and dicarboxylic acids, optionally subsequent alkoxylation of the reaction product and quaternization, as is in the DE 195 39 846 is described.

The Esterquats prepared in this way are suitable in excellent Way for the preparation of portions according to the invention, used as a fabric softener can be. As depending on the choice of trialkanolamine, fatty acids and dicarboxylic acids as well the quaternizing a variety of suitable products and in the agents according to the invention can be used, is a description of the invention preferably about to be used esterquats their production route more precisely as the indication of a general formula.

The mentioned components which together preferably to be used Esterquats can react in varying proportions be used to each other. In the context of the present invention are softener in which a reaction product of trialkanolamines with a mixture of fatty acids and dicarboxylic acids in a molar ratio 1:10 to 10: 1, preferably 1: 5 to 5: 1, optionally alkoxylated and subsequently was quaternized in a conventional manner, in amounts of 2 to 60, preferably 3 to 35 and in particular 5 to 30 wt .-% is. Particularly preferred is the use of triethanolamine, so that more preferred fabric softener the present invention, a reaction product of triethanolamine with a mixture of fatty acids and dicarboxylic acids in a molar ratio 1:10 to 10: 1, preferably 1: 5 to 5: 1, optionally alkoxylated and subsequently was quaternized in a conventional manner, in amounts of 2 to 60, preferably 3 to 35 and in particular 5 to 30 wt .-%.

When fatty acids can in the reaction mixture for the production of the esterquats all used from vegetable or animal oils and fats acids become. It can in the Rekationsgemisch as fatty acid quite well at Room temperature non-solid, i. pasty to liquid, fatty acid used become.

The fatty acids can independently saturated by their state of aggregation or one or more times unsaturated be. Of course can not just "pure" fatty acids used but also those obtained from fats and oils technical fatty acid mixtures, these mixtures being of economic View again are clearly preferred.

So can be in the reaction mixtures for the preparation of the esterquats for the clear according to the invention aqueous softener, for example single species or mixtures of the following acids: caprylic, pelargonic, capric, lauric, myristic, palmitic, stearic, octadecan-12-ol, arachidic, behenic, lignoceric, cerotic, melissic, 10-undecenoic, petroselic, petroselaidic, oleic, Elaidic acid, ricinoleic acid, linolaidic acid, α- and β-estarainic acid, gadoleic acid, erucic acid, brassidic acid. Of course they are also with the fatty acids odd number of carbon atoms, for example, undecanoic, tridecanoic, pentadecanoic, heptadecanoic, nonadecanoic, heneicosanic, tricanoic, pentacosanic, heptacosanic.

In the context of the present invention, the use of fatty acids of the formula XIII in Reakti onsgemisch preferred for the preparation of the esterquats, so that preferred fabric softeners a reaction product of trialkanolamines with a mixture of fatty acids of the formula XVII, R ¹ -CO-OH (XVII) in which R 1-CO- is an aliphatic, linear or branched acyl radical having 6 to 22 carbon atoms and 0 and / or 1, 2 or 3 double bonds and dicarboxylic acids in a molar ratio of 1:10 to 10: 1, preferably 1: 5 to 5 : 1, which is optionally alkoxylated and then quaternized in a conventional manner, in amounts of 2 to 60, preferably 3 to 35 and especially 5 to 30 wt .-% in the compositions.

Suitable dicarboxylic acids which are suitable for the preparation of the esterquats to be used in the compositions according to the invention are, in particular, saturated or mono- or polyunsaturated α, □ dicarboxylic acids. Examples include the saturated species of oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, sebacic acid, undecane and dodecanoic acid, brassylic acid, tetra- and pentadecanoic acid, thapic acid and hepta-, octa- and nonadecanoic, eicosane and heneicosanoic acid as well as phellogenic acid. Dicarboxylic acids which follow the general formula XIII are preferably used in the reaction mixture, so that agents according to the invention are preferred which comprise a reaction product of trialkanolamines with a mixture of fatty acids and dicarboxylic acids of the formula XVIII, HO-OC- [X] -CO-OH (XVIII) in which X is an optionally hydroxy-substituted alkylene group having 1 to 10 carbon atoms, in a molar ratio of 1:10 to 10: 1, preferably 1: 5 to 5: 1, which is optionally alkoxylated and then quaternized in a conventional manner, in quantities from 2 to 60, preferably 3 to 35 and in particular 5 to 30 wt .-% in the compositions.

Under have the plurality of producible and usable according to the invention Esterquats in turn, those are particularly useful in which the alkanolamine Treithanolamine and the dicarboxylic acid adipic acid is. Thus, in the context of the present invention means are particular which is a reaction product of triethanolamine with a Mixture of fatty acids and adipic acid in a molar ratio 1: 5 to 5: 1, preferably 1: 3 to 3: 1, which subsequently in quaternized in a manner known per se, in amounts of 2 to 60, preferably 3 to 35 and in particular 5 to 30 wt .-% in the means contain

The compositions of the invention can - and depending on whether they are formulated as a laundry detergent, washing aid or softener - are also equipped with other additional benefits. Here, for example, color transfer inhibiting compositions, anti-gray formula agents, ironing facilitators, fragrance release agents, soil repellency improvers, antibacterial agents, UV protectants, color refreshing agents, etc. can be formulated. Some examples are explained below:
Since textile fabrics, in particular of rayon, rayon, cotton and their mixtures, can crumple because the individual fibers against bending, kinking. Pressing and squeezing transverse to the fiber direction are sensitive, the compositions of the invention may contain synthetic crease inhibitors. These include, for example, synthetic products based on fatty acids, fatty acid esters. Fatty acid amides, alkylol esters, alkylolamides or fatty alcohols, which are usually reacted with ethylene oxide, or products based on lecithin or modified phosphoric acid ester.

One increased Comfort can come from the extra Use of antistatic agents resulting in the agents of the invention additionally enclosed become. Antistatic agents increase the Surface conductivity and enable thus an improved drainage formed charges. External antistatic agents are usually substances with at least one hydrophilic molecule ligand and give on the surfaces a more or less hygroscopic film. These mostly surface-active Antistatic agents can be converted into nitrogen-containing (amines, amides, quaternary ammonium compounds), phosphorus-containing (phosphoric acid ester) and sulfur-containing (alkyl sulfonates, alkyl sulfates) antistatic agents. Lauryl (or stearyl) dimethylbenzylammonium chlorides are suitable as antistatics for Textiles or as an additive to detergents, with an additional Avivageeffekt is achieved.

In order to improve the water absorbency, the rewettability of the treated textiles and to facilitate the ironing of the treated textiles may be in the compositions of the invention For example, silicone derivatives are used. These additionally improve the rinsing out of the compositions according to the invention by their foam-inhibiting properties. Preferred silicone derivatives are, for example, polydialkyl or alkylaryl siloxanes in which the alkyl groups have one to five carbon atoms and are completely or partially fluorinated. Preferred silicones are polydimethylsiloxanes, which may optionally be derivatized and are then amino-functional or quaternized or have Si-OH, Si-H and / or Si-Cl bonds. The viscosities of the preferred silicones are in the range between 100 and 100,000 centistokes at 25 ° C, wherein the silicones in amounts between 0.2 and 5 wt .-%, based on the total agent can be used.

Finally, the agents according to the invention also contain UV absorbers which are absorbed by the treated textiles and the light resistance improve the fibers. Connections that those desired Properties are, for example, those by radiationless Deactivation of effective compounds and derivatives of benzophenone with substituents in the 2- and / or 4-position. Continue to be substituted benzotriazoles, in the 3-position phenyl-substituted acrylates (Cinnamic acid derivatives), optionally with cyano groups in the 2-position, salicylates, organic Ni complexes as well as natural products such as umbelliferone and the body's own urocanic suitable.

Other items

With Especially with regard to reducing the adhesion of molds more items The present invention also packaging, in particular such for Food, as well as filter media, building materials, building aids, textiles, Furs, paper, hides or leather, dispiro compounds of the invention to reduce the adhesion of fungi to surfaces and / or with Dispiro compounds according to the invention equipped were.

The equipment of packaging, surfaces, Textiles, furs, skins or leather are known in the art Way, for example by dipping or spraying the Paper or textiles, furs, skins or leather in a suitable concentrated solution of dispiro compounds according to the invention. So can for example, works of art on paper, parchment, wood and / or Canvas before infestation by fungi, especially mold, protected or freed from this. The equipment of filter media, building materials or building aids, for example, by mechanical incorporation or applying a suitably concentrated solution of an agent according to the invention in or on the filter media, building materials or building aids.

Preferably are the building materials equipped according to the invention or building aids under adhesives, sealants, fillers and paints, plastics, Paints, paints, plaster, mortar, Screed, concrete, insulating materials and primers. Especially preferred building materials or building aids are jointing compounds (For example, silicone-containing jointing compounds), wallpaper paste, plaster, Carpet fixer, silicone adhesive, tile adhesive.

sealants and in particular jointing compounds typically contain organic polymers as well as in many cases mineral or organic fillers and other additives.

suitable Polymers are, for example, thermoplastic elastomers, as in DE-A-3602526 by the applicant, preferably polyurethanes and acrylates. Suitable polymers are also in the published patent applications DE-A-3726547, DE-A-4029504 and DE-A-4009095 of the applicant as well as in DE-A-19704553 and DE-A-4233077, on which is hereby incorporated by reference.

The sealing compounds according to the invention (Sealants or sealant mixtures) preferably contain 0.01-2.0% by weight Dispiro compounds according to the invention. Particularly preferred are ranges between 0.1 and 1.0 wt .-%.

According to the invention, the equipment of the sealants according to the invention can be carried out both in the uncured or cured at 60 ° C state. In the context of the invention, sealants are materials according to DIN EN 26927, in particular those which cure plastically or elastically as sealants. The sealants of the invention may contain all additives typical of the corresponding sealants, such as typical thickeners, reinforcing fillers, crosslinkers, crosslinking catalysts, pigments, adhesives or other bulk extenders. Sealants containing dispiro compounds can be prepared by dispersing in a manner known to those skilled in the art, for example by the use of dispersing equipment, kneaders, planetary mixers, etc., with the exclusion of moisture and oxygen both in the fer term as well as in parts of these sealants or incorporated together with one or more components of the sealants.

Even the treatment of already cured, crosslinked sealant surfaces can by Applying solutions or suspensions of the substance used according to the invention are carried out, by swelling or diffusion into the sealant is transported.

Sealants which can be used according to the invention can be produced both on silicone, urethane and acrylic bases. Urethane-based sealants are described, for example, in Ullmann's Encyclopedia of Industrial Chemistry (8th Edition 2003, Chapter 4) and in US 4,417,042 disclosed.

Silicone sealants are known in the art, for example. From the EP 0 118 030 A . EP 0 316 591 A . EP 0 327 847 A . EP 0 553 143 A . DE 195 49 425 A and US 4,417,042 ,

Examples of acrylic sealants are inter alia in WO 01/09249 or the US 5,077,360 disclosed.

In particular, at room temperature crosslinking systems, such as. In the EP 0 327 847 or US 5,077,360 described, preferred. These may be single-component or multi-component systems, it being possible for catalyst and crosslinker to be present separately in the multicomponent systems (for example disclosed in the patents US 4,891,400 and US 5,502,144 ), or other so-called silicone RVT 2K systems, in particular platinum-free systems.

Particularly preferred are so-called one-component systems which contain all ingredients for the construction of a sealant, are stored under exclusion of atmospheric moisture and / or atmospheric oxygen and cure on site under reaction with the atmospheric oxygen. Particularly preferred are the so-called silicone neutral systems, in which the reaction of crosslinking agents with the water of the ambient air does not lead to corrosive, acidic, basic or odor-intensive cleavage products. Examples of such systems are in the DE 195 49 425 , of the US 4,417,042 or the EP 0 327 847 disclosed.

The Sealants and in particular jointing compounds may be aqueous or organic solvents contain. As organic solvents come hydrocarbons such as cyclohexane, toluene or xylene or petroleum ether in question. Other suitable solvents are ketones such as Methyl butyl ketone or chlorinated hydrocarbons.

Farther can the sealants still contain other rubbery polymers. Here come relatively low molecular weight, commercially available types of polyisobutylene, Polyisoprene or polybutadiene styrene in question. Also the co-use of degraded natural rubber or neoprene rubber is possible. Here can even at room temperature still flowable types are used, which often be referred to as "liquid rubber".

The sealing compounds according to the invention can be used to different materials with each other to connect or seal. Here is primarily to use on concrete, on glass, on plaster and / or enamel as well as ceramic and porcelain thought. But also the joining or sealing of moldings or Profiles made of aluminum, steel, zinc or even plastics such as PVC or polyurethanes or acrylic resins is possible. Finally, be the sealing of wood or wood materials with the most diverse mentions other materials.

The Stability of jointing compounds is usually through Adding finely divided solids - also called fillers - achieved. These can be in such organic and inorganic type differ. As inorganic fillers, for example, silica / silica (coated or uncoated), chalk - coated or uncoated - and / or Zeolites are preferred. The latter can also be used as a desiccant act. As organic filler comes z. As PVC powder into consideration. The fillers generally wear essential to the sealing compound after use possesses a necessary internal support, so that leakage or Discharging the sealant from vertical joints is prevented. The aforementioned additives or fillers can be reduced to pigments and thixotropic fillers, also abbreviated as Thixotropic agent referred to, divide.

Suitable thixotropic agents are the known thixotropic agents such as bentones, kaolins or organic compounds such as hydrogenated castor oil or derivatives thereof with polyfunctional amines or the reaction products of stearic acid or ricinoleic acid with ethylenediamine. As special It has proven favorable to the concomitant use of silica, in particular of silica from pyrolysis. In addition, suitable thixotropic agents are essentially swellable polymer powders. Examples of these are polyacrylonitrile, polyurethane, polyvinyl chloride, polyacrylic acid esters, polyvinyl alcohols, polyvinyl acetates and the corresponding copolymers. Particularly good results can be obtained with finely divided polyvinyl chloride powder. In addition to the thixotropic agents, it is also possible to use additional adhesion promoters, such as, for example, mercaptoalkylsilane. Here it has proven to be expedient to use a Monomercaptoalkyltrialkoxysilan. Commercially available is, for example, mercaptopropyltrimethoxysilane.

The Properties of a jointing compound can be further developed improve when the plastic powder used as thixotropic agent additional components are added. These are substances under the category of for Plastics used plasticizers or swelling agents and swelling aids fall.

It come z. As plasticizers, especially for the sealants on urethane or acrylic base from the class of phthalic acid esters into consideration. Examples for applicable Compounds of this class of substances are dioctyl phthalate, dibutyl phthalate and benzyl butyl phthalate. Further suitable substance classes are Chloroparaffins, alkylsulfonic acid esters such as the phenols or cresols and fatty acid esters.

For the silicone sealants are silicone oils as plasticizers, particularly preferred polydimethylsiloxanes, and hydrocarbons and / or mixtures thereof, especially hydrocarbons or their mixtures with a boiling point of greater than 200 ° C, especially greater 230 ° C, well suited.

When Swelling aids are such low molecular weight organic substances can be used, which is miscible with the polymer powder and the plasticizer are. Such source aids can be submitted to the relevant plastic and polymer manuals for the professional remove. Serve as preferred swelling aids for polyvinyl chloride powder Esters, ketones, aliphatic hydrocarbons, aromatic hydrocarbons as well aromatic hydrocarbons with alkyl substituents.

When Pigments and dyes become known for these uses Substances such as titanium dioxide, iron oxides and soot used

to Improvement of storage stability become known the sealants stabilizers such as benzoyl chloride, acetyl chloride, toluenesulfonate, Carbodiimides and / or polycarbodiimides added. As special good stabilizers have olefins with 8 to 20 carbon atoms proved. In addition to the stabilizing effect, these can also be tasks of Meet plasticizers or swelling agents. Preference is given to olefins with 8 to 18 carbon atoms, especially when the double bond is arranged in 1,2-position. Best results are obtained, if the molecular structure of these stabilizers is linear.

at the application of the invention of dispiro compounds in mold-prone construction and building materials, in particular in sealing compounds and particularly preferably in jointing compounds are caused by the reduction of the adhesion of molds surfaces several desired ones Effects achieved: it will be discoloration It prevents the spread through pigmented molds delayed the mold infestation and the allergen load is reduced.

A further preferred embodiment The present invention is a wallpaper adhesive containing preferably 0.01 to 3 wt .-% Dispiro compounds. The wallpaper adhesives may be wallpaper paste aqueous solutions of hydrocolloids such as methylcellulose, methylhydroxypropylcellulose or water-soluble starch derivatives or about watery Dispersions of film-forming high molecular weight such as polyvinyl acetate, in particular in connection with the already mentioned cellulose and starch derivatives, act.

When Filter media can All known species are used as long as they are for use in water or air filter systems, in particular for air conditioners or room humidifiers are suitable. In particular, filter materials are made of cellulose, Glass fibers, PVC fibers, polyester fibers, polyamide fibers, in particular Nylon fibers, nonwovens, sintered materials and membrane filters too call.

The Concentration of to reduce the adhesion of micro-organisms on surfaces Dispiro compounds to be used in the compositions according to the invention can be varied by the skilled person in a wide range, dependent from the conditions of use of the funds.

The agents according to the invention be after usual and recipes known to those skilled in the art. The dispiro connections are preferably added to the ready-made agents, you can but also while be added to the manufacturing process, if desired.

The in the following Examples are intended to illustrate the invention in more detail explain, without restricting it to it.

Mikrotiterglattentest for the determination of the adhesion of Candida albicans SC5314 on SK-LMS-1 human cells under the influence of active ingredients

Cells of the human cell line SK-LMS-1 (Leiomyosarcosoma, vulva) were grown in microtiter plates for 3-4 days in RPMI medium. About 20 hours before the test, 5 × 10 ⁵ Candida albicans SC5314 cells are counted in 20 ml YPD [2% (w / v) dextrose, 2% (w / v) peptone, 1% (w / v) yeast extract , pH 6.0]. This culture is cultured at 30 ° C for 16 h. Then, the cell number is set to 2 × 10 ⁷ / ml in 1.5 ml of YPD medium by cell counting. After addition of the active ingredient dissolved in a suitable solvent (final concentration: 100 μg / ml), the sample is shaken for 2 hours at 30 ° C. in a 15 ml glass test tube. Finally, the active ingredient is removed by washing 2 times with YPD medium and the pH is changed from 6.0 to 4.5. Each 200 .mu.l Candida albicans cells are now added to the human cells (6 parallel samples) and incubated for 2 h at 37 ° C in an incubator. Thereafter, the Candida cells are stained with Calcofluor (12.5 μg / ml) at 37 ° C for 30 min. The unbound calcofluor and non-adherent cells are removed by washing 2 × with PBS buffer (140 mM NaCl, 2 mM KCl, 10 mM Na ₂ HPO ₄ , 1.8 mM KH ₂ PO ₄ , pH 7.2). The measurement of relative fluorescence takes place in the fluoroscan microtiter plate reader. When calculating the relative adhesion inhibition, the mean value (6 samples each) of Control 1 is first determined. Then the mean value of control 3 is determined and the value of control 1 subtracted therefrom. Control 1 is also subtracted from the mean values of the active substance tests. The inhibition is calculated by assuming control 3 at 100% and comparing the determined active substance values with it. For example, if the value of the control is twice as high as the drug value, there is a 50% inhibition of adhesion. All values above 65% were retested. For the substance 2-methylmercapto-4-chloro-5-nitro-dispirotripiperazine, an inhibition of 99% was found in the first test and of 72% in the second test.

controls:

• 1. Human cells without Candida
• 2. Adhesion without active ingredient
• 3. Adhesion with solvent without active ingredient
• 4. Adhesion with 5 μg / ml Amphotericin, dissolved in DMSO (90-100% inhibition)

Determination of the adherence of Candida albicans SC5314 to "human buccal ephithelium cells "(HBEC) under the influence of active ingredients

With a suitable adjuvant, HBE cells are removed from the oral mucosa and taken up in 4-8 ml of 1 × PBS for cell cultures (GIBCO, pH 7.2). The cell count is determined in the cell counter (about 3-4 × 10 ⁵ cells per ml). The cells are washed once more with 1 × PBS and adjusted to a concentration of 2 × 10 ⁵ / ml in 1 × PBS. The cells are now prepared for use in the adhesion test. About 20 hours before the test, 5 × 10 ⁵ Candida albicans SC5314 cells are counted in 20 ml YPD [2% (w / v) dextrose, 2% (w / v) peptone, 1% (w / v) yeast extract , pH 6.0]. This culture is cultured at 30 ° C for 16 h. Then, the cell number is set to 2 × 10 ⁷ / ml in 1 ml of YPD medium by cell counting. In 15 ml glass centrifuge tubes, these 1 ml of C. albicans cells are shaken with the active ingredient (100 μg / ml) and, as a control, with the appropriate amount of solvent without active ingredient for 2 h at 30 ° C. After removal of the drug by 2 × washing with 1 × PBS, the number of living cells compared to the controls is checked by plating 100 μl of a 10 ^-4 dilution onto YPD plates. Now, 1 ml of HBEC in 1 × PBS (2 × 10 ⁵ cells) and 1 ml of Candida cells in 1 × PBS (2 × 10 ⁷ ) are incubated together at 37 ° C. for 2 hours. Finally, the HBEC are viewed under a microscope with a 40x objective. 100 individual HBEC for adhesion of C. albicans are examined. If the number of HBEC without adherent C. albicans cell in the control without active ingredient is half as high as under the influence of active ingredient, this corresponds to an inhibition of 100%. For the substance 2-methylmercapto-4-chloro-5-nitro-dispirotripiperazine an inhibition of 180% was observed at an inhibitory concentration of 100 μg / ml. Furthermore, no influence on the growth of C. albicans.

Adhesion assay on denture plastic with C. albicans K 6710

When germ carrier became methacrylate platelets used as the active ingredient 2-methylmercapto-4-chloro-5-nitro-dispirotripiperazine in a concentration of 100μg / ml (Double determination).

To carry out the adhesion assay, the Candida cells were grown in 50 ml SD broth (30 ° C., 150 rpm), then the cells were incubated in bidist. Water resuspended and set an optical density (OD ₆₀₀ ) of 1. Subsequently, the cells were starved for 2h at 30 ° C (150rpm). Thereafter, a yeast (Y) and a hyphal (H) sample were prepared.

To the Preparing the yeast sample, the cells were diluted 1:10 in YPD by Add 1 ml of starvation culture cells to 9 ml of YPD medium. To the Making the hyphal sample, the cells were diluted 1:10 by Add 1 ml Hunger-Kulter to 8 ml YP medium and 1 ml horse serum. It was also each the germ carrier and the drug to be tested added.

To Determination of starting germ content were the samples thus obtained 1.5 h at 150 rpm at 30 ° C (Y) or 37 ° C (H) cultivated. Now an inhibition control was plated out and subsequently were the approaches 5 × with each 25ml redist. Washed water at 200 rpm, the germ carrier in 50 Transferred ml Falcon tube and 3 ml redist. Water and 5 ml glass beads added. It was then shaken for 10 min at 400 rpm at room temperature and then the germ count in the shaking fluid as well as on the germ carrier and the glass balls. For this purpose, the germ carrier and the glass balls embedded in agar. Incubation of the agar was carried out for ≥ 2 days at 30 ° C.

When Result was found to be in the presence of 2-methylmercapto-4-chloro-5-nitro-dispirotripiperazine 100% adhesion reduction compared to untreated controls can be seen.

Combination treatment with amphotericin paste for Candida therapy in intertriginous spaces

Cream for acute local Candida infections

Combination treatment with Nystatin Paste for the treatment of candidal infections of the corners of the mouth and intertriginous spaces

Washable emulsifier-free ointment

Greasy ointment

Hydrous hydrophilic ointments (combination treatment with clotrimazole)

Perform adhesion tests textiles

to Assessment of the inhibitory effect of various substances on the adherence of Mushrooms are applied to a process with which the adhesion begins Textiles semiquantitativ can be detected.

A 50 ml C. albicans culture (Strain SC5314) is about this Night at 30 ° C with shaking in an Erlenmeyer flask up to an optical density (OD) of approx. 1 (measured at 600 nm using a spectrophotometer) attracted. After a single wash in water, the cells are re-added for one hour 30 ° C below shake incubated. Subsequently 2.5 ml of the culture in 22.5 ml of YPD medium (1% yeast extract, 2% peptone, 2% glucose) or YPS medium (1% yeast extract, 2% peptone, 10% horse serum). The YPD cultures are for 2 hours at 30 ° C, the YPS cultures are used to induce hyphae for 2 hours at 37 ° C with shaking incubated.

Optional is added to the media test substance. The media will also be one 2.5 × 2.5 cm big Piece of test fabric (Polyester microfiber) given. After incubation, the textile pieces are thrice with washing liquor (Perwoll powder, 12 ml / l water) and twice with Washed with water (5 min each with shaking), then in a 6well plate and transferred with YPD tetrazolium blue agar (1% yeast extract, 2% peptone, 2% glucose, 1.5% agar, 0.5 mg / ml tetrazolium blue chloride).

Of the Degree of blue coloration due to enzymatic conversion of the dye tetrazolium blue chloride (3,3 '- [3,3'-dimethoxy (1,1'-biphenyl) -4,4'-diyl] bis [2,5-diphenyl-2H-tetrazolium] dichloride (Sigma, T4375) by cellular Dehydrogenases of adherent C. albicans serves as a measure of the number the adherent Candida cells and will over the measurement of relative light reflection (measurement geometry d / 8 °) with a Color difference meter (Dr. Lange Micro Color). The calibration of the device takes place according to manufacturer's instructions. For this the textile dumbbells are released from the agar and the Measured with the color difference meter. The color difference meter determines according to DIN 5033 the diffuse reflection of the samples at an angle of 8 °.

Under the chosen one Conditions are exclusive Hyphae (in the YPS cultures) able to adhere to textile fabric. Yeast cells (YPD culture) are completely washed off, it shows no blue color of the Tissue. The adherents Hyphae (YPS) cause a reduction of the relative light reflection in the Comparison to yeast cells (YPD, reference).

Washing tests to determine the influence of the test substance on the adhesion

The washing tests were carried out in commercially available household washing machines (Miele W 918 Novotronic), which were previously disinfected, in the easy-care program at 30 ° C. The fungal cells were applied to textile carriers (polyamide, 2.5 × 2.5 cm) (2 × 10 ⁵ cells / germ carrier) and washed with the detergent formulations together with 3.5 kg of disinfected filling laundry. For comparison, it is washed with the same detergent without test substance. After washing and drying in air, both residual germ load and germination are determined on other sterile textiles.

Liquid detergent with Dispiro connection

Preportioned liquid detergent in polyvinyl alcohol film with dispiro compounds

Powdered detergent with Dispiro compounds

The Dispiro compound may also be a component of the perfume. It is then preferably in concentrations of 0.1-80% in the Perfume oil included and will be over the registered in the detergent formulation perfume oil in the wash liquor.

mouthwash

toothpaste

Denture cleaner, powdered

denture adhesives:

Claims (23)

Pharmaceutical or cosmetic composition containing derivatives of compound 3,12-diaza-6,9-diazonia (5,2,5,2) dispirohexadecane (Dispirotripiperazine). Composition according to Claim 1, characterized that it is a preparation for oral, dental or denture care is. Composition according to Claim 2, characterized that it is a mouthwash, a mouthwash, a denture cleaner or a denture adhesive is. A composition according to any one of claims 1 to 3, characterized in that it is in the Derivative of dispirotripiperazine to a compound of the general formula

where n is 1 or 2, X is a direct bond, NH or a methylene group, Het is a substituted (C ₅ -C ₆ ) heteroaryl radical having one to three heteroatoms, wherein the heteroatoms may be selected in particular from N, O and S, where the heteroaryl radical may also be mono- or polysubstituted, in particular by radicals selected from the group consisting of (C ₁ -C ₆ ) -alkyl, (C ₁ -C ₆ ) -alkylthio, Amino, mono- or di- (C ₁ -C ₆ ) -alkylamino, hydroxy, trifluoromethyl, phenyl, styryl, nitro, CHO, COOH, CN, pyrrolidino, piperazino, cyano, isocyano, thiocyano, isothiocyano and halogen and wherein Y is an anion stands. A composition according to claim 4, characterized in that Het is a pyrimidinyl radical of the formula

wherein R _{1 is} (C ₁ -C ₆ ) alkylthio, R _{2 is} halogen and R _{3 is} nitro. Use of derivatives of compound 3,12-diaza-6,9-diazonia (5,2,5,2) dispirohexadecane (Dispirotripiperazine) for the manufacture of medicaments for treatment from fungal infections. Use of derivatives of compound 3,12-diaza-6,9-diazonia (5,2,5,2) dispirohexadecane (Dispirotripiperazine) for reducing the adhesion of fungi to surfaces. Use according to claim 7, characterized that it is at the surfaces around biotic surfaces is. Use according to claim 8, characterized that the biotic surface is the human skin is. Use according to claim 7, characterized that it is at the surfaces around abiotic surfaces is. Use according to claim 10, characterized that it is surfaces which come in contact with the human body. Use according to claim 10 or 11, characterized that the abiotic surfaces are textiles, ceramics, Metals, filter media, building materials, building aids, furs, paper, Skins, leather and / or plastics. Use according to one of claims 10 to 12, characterized that the abiotic surfaces are laundry, prostheses or dentures is. Use according to one of claims 7 to 13, characterized that the active ingredients to detergents and / or detergents or to Oral and / or dental care products be added or incorporated therein. Use according to one of claims 6 to 14, characterized in that it is in the De rivat of dispirotripiperazine to give a compound of general formula (I)

where n is 1 or 2, X is a direct bond, NH or a methylene group, Het is a substituted (C ₅ -C ₆ ) heteroaryl radical having one to three heteroatoms, wherein the heteroatoms may be selected in particular from N, O and S, where the heteroaryl radical may also be mono- or polysubstituted, in particular by radicals selected from the group consisting of (C ₁ -C ₆ ) -alkyl, (C ₁ -C ₆ ) -alkylthio, Amino, mono- or di- (C ₁ -C ₆ ) -alkylamino, hydroxy, trifluoromethyl, phenyl, styryl, nitro, CHO, COOH, CN, pyrrolidino, piperazino, cyano, isocyano, thiocyano, isothiocyano and halogen and wherein Y is an anion stands. Use according to claim 15, characterized in that Het is a pyrimidinyl radical of the formula (II)

wherein R _{1 is} (C ₁ -C ₆ ) alkylthio, R _{2 is} halogen and R _{3 is} nitro. Use according to one of Claims 6 to 16, characterized that the attachment of human pathogenic fungi is reduced. Use according to one of Claims 6 to 17, characterized that the adhesion of yeasts, molds, dermatophytes and / or keratinophilic fungi is reduced. Use according to one of Claims 6 to 18, characterized that reduces the attachment of fungi to the species of Candida becomes. Use according to one of Claims 6 to 18, characterized that the substances in the final concentrations used are non-toxic Act. Use according to one of the preceding claims, characterized in that the substances contain from 0.000001 to 3% by weight are. Compositions selected from the group consisting from detergents, cleaning agents, textile treatment agents, rinsing agents, Hand washing, hand dishwashing, Machine dishwashing detergents and Means to equipment or treatment of surfaces, Building materials, sealants, filter media, building aids, ceramics, Plastics, metals, textiles, furs, paper, skins, leather or packaging, characterized in that they are derivatives of Compound 3,12-Diaza-6,9-diazonia (5,2,5,2) dispirohexadecane (Dispirotripiperazine). Materials selected from the group from filter media, adhesives, sealants, packaging, building materials, Building aids, textiles, furs, paper, skins and leather, by in that they are derivatives of the compound 3,12-diaza-6,9-diazonia (5,2,5,2) dispirohexadecane (Dispirotripiperazine) and / or are equipped with them.