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CY2396B1 - Pharmaceutical composition of fenofibrate with high biological availability and method for preparingsame. - Google Patents

Pharmaceutical composition of fenofibrate with high biological availability and method for preparingsame.

Info

Publication number
CY2396B1
CY2396B1 CY0300091A CY0300091A CY2396B1 CY 2396 B1 CY2396 B1 CY 2396B1 CY 0300091 A CY0300091 A CY 0300091A CY 0300091 A CY0300091 A CY 0300091A CY 2396 B1 CY2396 B1 CY 2396B1
Authority
CY
Cyprus
Prior art keywords
preparingsame
fenofibrate
pharmaceutical composition
high biological
biological availability
Prior art date
Application number
CY0300091A
Other languages
English (en)
Inventor
Andre Stamm
Pawan Seth
Original Assignee
Fournier Lab Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9502710&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2396(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Fournier Lab Sa filed Critical Fournier Lab Sa
Publication of CY2396B1 publication Critical patent/CY2396B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CY0300091A 1997-01-17 2003-12-05 Pharmaceutical composition of fenofibrate with high biological availability and method for preparingsame. CY2396B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9700479A FR2758459B1 (fr) 1997-01-17 1997-01-17 Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation

Publications (1)

Publication Number Publication Date
CY2396B1 true CY2396B1 (en) 2004-09-10

Family

ID=9502710

Family Applications (4)

Application Number Title Priority Date Filing Date
CY0300091A CY2396B1 (en) 1997-01-17 2003-12-05 Pharmaceutical composition of fenofibrate with high biological availability and method for preparingsame.
CY0500028A CY2513B1 (en) 1997-01-17 2005-05-06 Fenofibrate suspension in a hydrophilic polymer solution
CY0600001A CY2547B1 (fr) 1997-01-17 2006-01-26 Composition pharmaceutique de fénofibrate présentant une biodisponibilité élévée et son procédé de préparation
CY0600016A CY2560B1 (fr) 1997-01-17 2006-07-11 Composition pharmaceutique de fénofibrate présentant une biodisponibilité élévée et son procédé de préparation

Family Applications After (3)

Application Number Title Priority Date Filing Date
CY0500028A CY2513B1 (en) 1997-01-17 2005-05-06 Fenofibrate suspension in a hydrophilic polymer solution
CY0600001A CY2547B1 (fr) 1997-01-17 2006-01-26 Composition pharmaceutique de fénofibrate présentant une biodisponibilité élévée et son procédé de préparation
CY0600016A CY2560B1 (fr) 1997-01-17 2006-07-11 Composition pharmaceutique de fénofibrate présentant une biodisponibilité élévée et son procédé de préparation

Country Status (36)

Country Link
US (18) US6074670A (xx)
EP (6) EP1468681A1 (xx)
JP (6) JP4219988B2 (xx)
KR (2) KR100391104B1 (xx)
CN (2) CN1496738B (xx)
AR (1) AR011411A1 (xx)
AT (4) ATE307576T1 (xx)
BR (1) BR9806738A (xx)
CA (5) CA2448623A1 (xx)
CY (4) CY2396B1 (xx)
CZ (1) CZ297251B6 (xx)
DE (5) DE69834437T2 (xx)
DK (5) DK1273294T3 (xx)
DZ (1) DZ2398A1 (xx)
EE (1) EE04042B1 (xx)
EG (1) EG23978A (xx)
ES (5) ES2241931T3 (xx)
FR (1) FR2758459B1 (xx)
HK (3) HK1023071A1 (xx)
HU (3) HU227758B1 (xx)
ID (1) ID22528A (xx)
IL (1) IL130790A0 (xx)
IN (1) IN187906B (xx)
IS (1) IS5097A (xx)
MA (1) MA26466A1 (xx)
NO (2) NO329200B1 (xx)
NZ (1) NZ336462A (xx)
PL (1) PL194802B1 (xx)
PT (4) PT1273293E (xx)
RU (3) RU2238089C2 (xx)
SK (1) SK285847B6 (xx)
TN (1) TNSN98009A1 (xx)
TR (1) TR199901660T2 (xx)
UA (1) UA61096C2 (xx)
WO (1) WO1998031361A1 (xx)
ZA (1) ZA98324B (xx)

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PT1273293E (pt) 2005-06-30
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DE69832108T2 (de) 2006-09-21
HU228849B1 (hu) 2013-06-28
EP1273294B1 (fr) 2005-10-26
EP2050445A3 (fr) 2009-09-09
DE69832108D1 (de) 2005-12-01
MA26466A1 (fr) 2004-12-20
FR2758459A1 (fr) 1998-07-24
HU0400409D0 (hu) 2004-04-28
US20040057997A1 (en) 2004-03-25
RU2002109746A (ru) 2004-03-20
TR199901660T2 (xx) 1999-09-21
JP4943975B2 (ja) 2012-05-30
DE69829591D1 (de) 2005-05-04
US20030104060A1 (en) 2003-06-05
EP2050445B1 (fr) 2013-06-26
AU5336798A (en) 1998-08-07
EP0952829A1 (fr) 1999-11-03
RU2236850C2 (ru) 2004-09-27
DE69834437T2 (de) 2006-11-16
DE69811855D1 (de) 2003-04-10
DE29825080U1 (de) 2004-11-04
US20020114839A1 (en) 2002-08-22
ATE233556T1 (de) 2003-03-15
HUP0000808A2 (hu) 2000-12-28
RU2238089C2 (ru) 2004-10-20
EP1273294A1 (fr) 2003-01-08
EP2050445B2 (fr) 2021-07-21
EP1273293B1 (fr) 2005-03-30
US6596317B2 (en) 2003-07-22
US6652881B2 (en) 2003-11-25
US20080063726A1 (en) 2008-03-13
US20040057999A1 (en) 2004-03-25
JP2011173927A (ja) 2011-09-08
CZ253599A3 (cs) 1999-11-17
KR100391104B1 (ko) 2003-07-12
HK1023071A1 (en) 2000-09-01
US20090035379A1 (en) 2009-02-05
CZ297251B6 (cs) 2006-10-11
DE69811855T2 (de) 2003-12-18
HUP0000808A3 (en) 2001-02-28
EP1273293A1 (fr) 2003-01-08
EE04042B1 (et) 2003-06-16
NZ336462A (en) 2000-09-29
US6589552B2 (en) 2003-07-08
DE69829591T2 (de) 2006-02-09
US20020009496A1 (en) 2002-01-24
AU731964B2 (en) 2001-04-05
NO993519L (no) 1999-09-16
TNSN98009A1 (fr) 2005-03-15
CY2547B1 (fr) 2008-07-02
ES2427252T3 (es) 2013-10-30
JP4365343B2 (ja) 2009-11-18
ES2263714T3 (es) 2006-12-16
CN1496738A (zh) 2004-05-19
CA2448630A1 (fr) 1998-07-17
ID22528A (id) 1999-10-28
US7041319B2 (en) 2006-05-09
EG23978A (fr) 2008-02-26
JP2009143967A (ja) 2009-07-02
KR100415897B1 (ko) 2004-01-24
DK1275387T3 (da) 2006-08-28
EP1468681A1 (fr) 2004-10-20
ATE291911T1 (de) 2005-04-15
ATE307576T1 (de) 2005-11-15
NO20100034L (no) 1999-09-16
US6074670A (en) 2000-06-13
US6277405B1 (en) 2001-08-21
CY2513B1 (en) 2005-12-23
CA2219475C (fr) 2002-07-09
CA2372576A1 (fr) 1998-07-17
ES2241931T3 (es) 2005-11-01
JP2007326878A (ja) 2007-12-20
US20030104051A1 (en) 2003-06-05
PT952829E (pt) 2003-07-31
US20020168413A1 (en) 2002-11-14
CN1243438A (zh) 2000-02-02
IN187906B (xx) 2002-07-20
EP1275387A1 (fr) 2003-01-15
CA2219475A1 (fr) 1998-07-17
BR9806738A (pt) 2000-02-29
FR2758459B1 (fr) 1999-05-07
DK0952829T3 (da) 2003-06-23
CA2372576C (fr) 2004-02-10
EP2050445A2 (fr) 2009-04-22
EE9900296A (et) 2000-02-15
HU230685B1 (en) 2017-08-28
HK1131051A1 (en) 2010-01-15
DK2050445T3 (da) 2013-09-08
US20080064759A1 (en) 2008-03-13
US8329214B2 (en) 2012-12-11
KR20000070021A (ko) 2000-11-25
NO329200B1 (no) 2010-09-13
ES2427252T5 (es) 2022-02-14
DK2050445T4 (da) 2021-10-18
DZ2398A1 (fr) 2003-06-04
US8343540B2 (en) 2013-01-01
IL130790A0 (en) 2001-01-28
SK285847B6 (sk) 2007-09-06
JP2001511156A (ja) 2001-08-07
WO1998031361A1 (fr) 1998-07-23

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