CY2180B1 - 2-(2Amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative - Google Patents

2-(2Amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative

Info

Publication number: CY2180B1
Authority: CY; Cyprus
Prior art keywords: purin; dihydro; oxo; methoxy; 2amino
Prior art date: 1994-07-28

Application number

CY0000039A

Other languages

English (en)

Inventor

John J Nestor

Scott W Womble

Hans Maag

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-07-28

Filing date

2000-08-10

Publication date

2002-08-23

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23079211&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2180(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-08-10 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2002-08-23 Publication of CY2180B1 publication Critical patent/CY2180B1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)

CY0000039A 1994-07-28 2000-08-10 2-(2Amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative CY2180B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US28189394A	1994-07-28	1994-07-28

Publications (1)

Publication Number	Publication Date
CY2180B1 true CY2180B1 (en)	2002-08-23

Family

ID=23079211

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
CY0000039A CY2180B1 (en)	1994-07-28	2000-08-10	2-(2Amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
CY200400003C CY2004003I1 (el)	1994-07-28	2004-10-20	Παραγωγο 2-(2-αμινο-1,6-διυδρο-6-οξο-πυρινο-9-υλο)μεθοξυ-1,3-προπανεδιολης

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
CY200400003C CY2004003I1 (el)	1994-07-28	2004-10-20	Παραγωγο 2-(2-αμινο-1,6-διυδρο-6-οξο-πυρινο-9-υλο)μεθοξυ-1,3-προπανεδιολης

Country Status (32)

Country	Link
EP (1)	EP0694547B1 (ko)
JP (1)	JP3090305B2 (ko)
KR (1)	KR100358626B1 (ko)
CN (1)	CN1045089C (ko)
AT (1)	ATE179173T1 (ko)
AU (1)	AU697107B2 (ko)
BR (1)	BR9503468A (ko)
CA (1)	CA2154721C (ko)
CO (1)	CO4410181A1 (ko)
CY (2)	CY2180B1 (ko)
CZ (1)	CZ290511B6 (ko)
DE (3)	DE10299032I2 (ko)
DK (1)	DK0694547T3 (ko)
ES (1)	ES2083348T3 (ko)
FI (1)	FI112080B (ko)
GR (2)	GR960300021T1 (ko)
HU (1)	HU216867B (ko)
IL (1)	IL114735A (ko)
LU (1)	LU91136I2 (ko)
MA (1)	MA23631A1 (ko)
MY (1)	MY114393A (ko)
NL (1)	NL300071I2 (ko)
NO (2)	NO312899B1 (ko)
NZ (1)	NZ272652A (ko)
PE (1)	PE32296A1 (ko)
PL (1)	PL180609B1 (ko)
RU (1)	RU2133749C1 (ko)
SA (1)	SA95160158B1 (ko)
TR (1)	TR199500895A2 (ko)
TW (1)	TW434242B (ko)
UY (1)	UY24006A1 (ko)
ZA (1)	ZA956228B (ko)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6458772B1 (en)	1909-10-07	2002-10-01	Medivir Ab	Prodrugs
US5840890A (en) *	1996-01-26	1998-11-24	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
AU1592897A (en) *	1996-01-26	1997-08-20	F. Hoffmann-La Roche Ag	Process for preparing purine derivatives
JP4094667B2 (ja) *	1996-01-26	2008-06-04	エフ・ホフマン―ラロシュアーゲー	プリン誘導体の製造方法
US5700936A (en) *	1996-01-26	1997-12-23	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US5756736A (en) *	1996-01-26	1998-05-26	Syntex (U.S.A.) Inc.	Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US6703394B2 (en)	1996-02-16	2004-03-09	Medivir Ab	Acyclic nucleoside derivatives
US5869493A (en)	1996-02-16	1999-02-09	Medivir Ab	Acyclic nucleoside derivatives
US6184376B1 (en)	1997-02-10	2001-02-06	Mediver Ab	Synthesis of acyclic nucleoside derivatives
CA2277151C (en) *	1997-02-10	2007-04-17	Medivir Ab	Synthesis of acyclic nucleoside derivatives
SI0988304T1 (en) *	1997-08-15	2001-08-31	Medivir Ab	Nucleosides analogues, such as antivirals including inhibitors of retroviral reverse transcriptase and the dna polymerase of hepatitis b virus (hbv)
AU1711599A (en) *	1997-12-19	1999-07-12	Bristol-Myers Squibb Company	Prodrugs of lobucavir and methods of use
WO1999051613A1 (en) *	1998-04-03	1999-10-14	Medivir Ab	Prodrugs of phosphorous-containing pharmaceuticals
JP2000256359A (ja) *	1999-03-11	2000-09-19	Japan Science & Technology Corp	面性キラリティーを有する分子群の高選択的不斉変換法
KR20030015655A (ko) *	2001-08-17	2003-02-25	한미약품공업 주식회사	항암제의 경구흡수율을 증가시키는 인단계 화합물의결정성 산부가염, 이의 제조방법 및 이를 함유하는 약학적조성물
DE60313769T2 (de) *	2002-04-23	2008-03-06	Aventis Pharmaceuticals Inc.	3-(pyridinyl-amino)-1h-indol-2-carbonsäure-verbindungen als inhibitoren der interleukin-4 genexpression
AU2003273000A1 (en)	2002-10-16	2004-05-04	Takeda Pharmaceutical Company Limited	Stable solid preparations
WO2004064846A1 (en)	2003-01-14	2004-08-05	Gilead Sciences, Inc.	Compositions and methods for combination antiviral therapy
CA2537132A1 (en) *	2003-08-28	2005-03-10	Ranbaxy Laboratories Limited	Amorphous valganciclovir hydrochloride
US8461187B2 (en)	2004-06-16	2013-06-11	Takeda Pharmaceuticals U.S.A., Inc.	Multiple PPI dosage form
AU2005269753B2 (en) *	2004-07-19	2011-08-18	Biocon Limited	Insulin-oligomer conjugates, formulations and uses thereof
TWI375560B (en)	2005-06-13	2012-11-01	Gilead Sciences Inc	Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh)	2005-06-13	2015-02-01	Bristol Myers Squibb & Gilead Sciences Llc	單一式藥學劑量型
ZA200702234B (en) *	2006-03-21	2008-07-30	Cipla Ltd	Preparation of ester of purine derivatives
WO2009049160A1 (en)	2007-10-12	2009-04-16	Takeda Pharmaceuticals North America	Methods of treating gastrointestinal disorders independent of the intake of food
CN103562207B (zh) *	2011-05-31	2016-08-17	法尔玛赞公司	用于制备缬更昔洛韦的2-氨基-9-((2-苯基-1，3-二噁烷-5-基氧基)甲基)-1h-嘌呤-6(9h)-酮化合物的制备方法
KR102312533B1 (ko)	2021-02-24	2021-10-15	주식회사 이웅	자동 스패너

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL8202626A (nl) *	1982-06-29	1984-01-16	Stichting Rega V Z W	Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
US4897479A (en) *	1983-09-30	1990-01-30	Merck & Co., Inc.	Arylsulfonyloxy purine intermediates
IE842642L (en) *	1983-10-31	1985-04-30	Harvard College	Purine Derivatives
NZ214520A (en) *	1984-12-12	1989-08-29	Syntex Inc	Alkoxymethyl ether and ester derivatives in the production of guanine derivatives
AP160A (en) *	1987-08-15	1991-11-18	The Wellcome Foundation Ltd	Therapeutic acyclic nucleosides.
CA2005815C (en) *	1988-12-19	1999-08-03	Wellcome Foundation Limited (The)	Antiviral acyclic nucleoside derivatives

1995
- 1995-07-10 PE PE1995273436A patent/PE32296A1/es not_active IP Right Cessation
- 1995-07-19 DE DE2002199032 patent/DE10299032I2/de active Active
- 1995-07-19 EP EP95111319A patent/EP0694547B1/en not_active Expired - Lifetime
- 1995-07-19 DE DE69509173T patent/DE69509173T2/de not_active Expired - Lifetime
- 1995-07-19 DK DK95111319T patent/DK0694547T3/da active
- 1995-07-19 AT AT95111319T patent/ATE179173T1/de active
- 1995-07-19 ES ES95111319T patent/ES2083348T3/es not_active Expired - Lifetime
- 1995-07-19 DE DE0694547T patent/DE694547T1/de active Pending
- 1995-07-21 TR TR95/00895A patent/TR199500895A2/xx unknown
- 1995-07-26 CA CA002154721A patent/CA2154721C/en not_active Expired - Lifetime
- 1995-07-26 IL IL114735A patent/IL114735A/en not_active IP Right Cessation
- 1995-07-26 NZ NZ272652A patent/NZ272652A/en not_active IP Right Cessation
- 1995-07-26 MA MA23971A patent/MA23631A1/fr unknown
- 1995-07-26 HU HU9502238A patent/HU216867B/hu unknown
- 1995-07-26 ZA ZA956228A patent/ZA956228B/xx unknown
- 1995-07-26 AU AU27195/95A patent/AU697107B2/en not_active Expired
- 1995-07-27 CZ CZ19951939A patent/CZ290511B6/cs not_active IP Right Cessation
- 1995-07-27 MY MYPI95002156A patent/MY114393A/en unknown
- 1995-07-27 NO NO19952977A patent/NO312899B1/no not_active IP Right Cessation
- 1995-07-27 FI FI953592A patent/FI112080B/fi active Protection Beyond IP Right Term
- 1995-07-27 TW TW084107779A patent/TW434242B/zh not_active IP Right Cessation
- 1995-07-27 CO CO95033418A patent/CO4410181A1/es unknown
- 1995-07-27 JP JP07190953A patent/JP3090305B2/ja not_active Expired - Lifetime
- 1995-07-27 BR BR9503468A patent/BR9503468A/pt active Search and Examination
- 1995-07-27 RU RU95113148A patent/RU2133749C1/ru active
- 1995-07-27 UY UY24006A patent/UY24006A1/es not_active IP Right Cessation
- 1995-07-27 KR KR1019950022600A patent/KR100358626B1/ko not_active Expired - Lifetime
- 1995-07-27 PL PL95309812A patent/PL180609B1/pl unknown
- 1995-07-27 CN CN95109671A patent/CN1045089C/zh not_active Expired - Lifetime
- 1995-08-14 SA SA95160158A patent/SA95160158B1/ar unknown
1996
- 1996-04-30 GR GR960300021T patent/GR960300021T1/el unknown
1999
- 1999-07-02 GR GR990401760T patent/GR3030678T3/el unknown
2000
- 2000-08-10 CY CY0000039A patent/CY2180B1/xx unknown
2001
- 2001-11-23 NL NL300071C patent/NL300071I2/nl unknown
2003
- 2003-01-10 NO NO2003001C patent/NO2003001I2/no unknown
- 2003-05-21 LU LU91136C patent/LU91136I2/fr unknown
2004
- 2004-10-20 CY CY200400003C patent/CY2004003I1/el unknown

Also Published As

Publication number	Publication date
CN1045089C (zh)	1999-09-15
JP3090305B2 (ja)	2000-09-18
DE10299032I2 (de)	2006-06-14
EP0694547B1 (en)	1999-04-21
CZ290511B6 (cs)	2002-08-14
NO312899B1 (no)	2002-07-15
GR960300021T1 (en)	1996-04-30
AU2719595A (en)	1996-02-08
IL114735A (en)	1998-06-15
KR100358626B1 (ko)	2003-01-14
SA95160158B1 (ar)	2006-05-20
HUT73246A (en)	1996-07-29
FI953592L (fi)	1996-01-29
RU2133749C1 (ru)	1999-07-27
ES2083348T1 (es)	1996-04-16
PL309812A1 (en)	1996-02-05
CY2004003I2 (el)	2009-11-04
ATE179173T1 (de)	1999-05-15
CA2154721A1 (en)	1996-01-29
GR3030678T3 (en)	1999-11-30
NL300071I1 (nl)	2002-02-01
DE694547T1 (de)	1996-10-24
DE69509173D1 (de)	1999-05-27
UY24006A1 (es)	2001-07-31
FI953592A0 (fi)	1995-07-27
EP0694547A2 (en)	1996-01-31
PE32296A1 (es)	1996-08-07
TW434242B (en)	2001-05-16
MA23631A1 (fr)	1996-04-01
CN1122804A (zh)	1996-05-22
DE10299032I1 (de)	2003-01-23
DK0694547T3 (da)	2000-01-03
CO4410181A1 (es)	1997-01-09
NZ272652A (en)	1996-12-20
BR9503468A (pt)	1996-02-27
TR199500895A2 (tr)	1996-06-21
NO952977D0 (no)	1995-07-27
HU9502238D0 (en)	1995-09-28
AU697107B2 (en)	1998-09-24
ZA956228B (en)	1996-02-22
FI112080B (fi)	2003-10-31
IL114735A0 (en)	1995-11-27
LU91136I2 (fr)	2005-07-06
HU216867B (hu)	1999-09-28
KR960004345A (ko)	1996-02-23
CA2154721C (en)	2001-01-02
CY2004003I1 (el)	2009-11-04
ES2083348T3 (es)	1999-08-01
EP0694547A3 (en)	1996-06-05
JPH0841061A (ja)	1996-02-13
NO952977L (no)	1996-01-29
DE69509173T2 (de)	1999-10-21
RU95113148A (ru)	1997-06-27
NO2003001I2 (no)	2007-06-11
NL300071I2 (nl)	2002-03-01
CZ193995A3 (en)	1996-02-14
PL180609B1 (pl)	2001-03-30
MY114393A (en)	2002-10-31
HK1012339A1 (en)	1999-07-30

Publication	Publication Date	Title
GR960300021T1 (en)	1996-04-30	2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
EE9700275A (et)	1998-04-15	1,3-propaandiooli derivaadid bioaktiivsete ühenditena
AU7820491A (en)	1991-12-12	Substituted Phthalides and Heterocyclic Phthalides and derivatives thereof.
EP0563345A4 (en)	1994-09-28	Novel 4-arylpiperazines and 4-arylpiperidines
FI990207A0 (fi)	1999-02-03	Enantiomeeripuhtaat diatsabisyklo(4.3.0)nonaanijohdannaiset
AU8979191A (en)	1992-06-25	3,7-disubstituted indole derivatives
CA2244680A1 (en)	1997-07-31	Process for preparing purine derivatives
AU697679B2 (en)	1998-10-15	Treatment of tinnitis using neuroprotective agents
ATE172985T1 (de)	1998-11-15	Sulfonamidaminomethylenderivate als immunsuppressiva
DE69312776D1 (de)	1997-09-11	Fungizide 3,4-Diaryl-(5H)-Furan-2-Onederivate
DE69611148D1 (de)	2001-01-11	Pyrrolo(4,3,2-de)chinolin-Derivat
SG32424A1 (en)	1995-08-13	2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1, 3-propanediol derivative
LT2417B (lt)	1994-02-15	Mo budas vaiku astrios leukozes nepalankios eigos isaiskini
AU8803091A (en)	1992-05-28	Method for protecting the myocardium against ischemia
ITMI930017A0 (it)	1993-01-11	Composizione polimerizzabile per l'impreganzione di un supporto tessile, avente elevate caratteristiche tixotropiche
FI925488A0 (fi)	1992-12-03	Avlastningsanordning foer tonvaexlingshaevstaengerna i en med tonvaexlingsmekanism foersedd kantele