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CY1124872T1 - Σχεδιασμος σταθερου ετεροδιμερικου αντισωματος με μεταλλαξεις στην επικρατεια fc - Google Patents

Σχεδιασμος σταθερου ετεροδιμερικου αντισωματος με μεταλλαξεις στην επικρατεια fc

Info

Publication number
CY1124872T1
CY1124872T1 CY20211101072T CY211101072T CY1124872T1 CY 1124872 T1 CY1124872 T1 CY 1124872T1 CY 20211101072 T CY20211101072 T CY 20211101072T CY 211101072 T CY211101072 T CY 211101072T CY 1124872 T1 CY1124872 T1 CY 1124872T1
Authority
CY
Cyprus
Prior art keywords
mutations
region
design
heterodimer antibody
stable heterodimer
Prior art date
Application number
CY20211101072T
Other languages
English (en)
Inventor
Thomas SPRETER VON KREUDENSTEIN
Eric Escobar-Cabrera
David Kai Yuen Poon
Paula Irene Lario
Surjit Bhimaro DIXIT
Original Assignee
Zymeworks Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymeworks Inc. filed Critical Zymeworks Inc.
Publication of CY1124872T1 publication Critical patent/CY1124872T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medical Informatics (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Physiology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Τα παρεχόμενα ικριώματα έχουν βαριές αλυσίδες οι οποίες είναι ασύμμετρες στις διάφορες επικράτειες (π.χ. CH2 και CH3) ώστε να επιτυγχάνουν εκλεκτικότητα μεταξύ των διαφόρων Fc υποδοχέων που εμπλέκονται στην τροποποίηση της λειτουργίας τελεστή, πέραν αυτών που επιτυγχάνονται με ένα φυσικό ομοδιμερικό (συμμετρικό) Fc μόριο και αυξανόμενη σταθερότητα και καθαρότητα των προκυπτόντων παραλλαγμένων Fc ετεροδιμερών. Αυτά τα νέα μόρια περιλαμβάνουν συμπλέγματα ετερογενών συστατικών που έχουν σχεδιασθεί ώστε να μεταβάλλουν τον φυσικό τρόπο με τον οποίο συμπεριφέρονται τα αντισώματα και που χρησιμοποιούνται σε θεραπευτικά μέσα.
CY20211101072T 2011-11-04 2021-12-07 Σχεδιασμος σταθερου ετεροδιμερικου αντισωματος με μεταλλαξεις στην επικρατεια fc CY1124872T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161556090P 2011-11-04 2011-11-04
US201161557262P 2011-11-08 2011-11-08
US201261645547P 2012-05-10 2012-05-10
PCT/CA2012/050780 WO2013063702A1 (en) 2011-11-04 2012-11-02 Stable heterodimeric antibody design with mutations in the fc domain

Publications (1)

Publication Number Publication Date
CY1124872T1 true CY1124872T1 (el) 2022-11-25

Family

ID=48191150

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20211101072T CY1124872T1 (el) 2011-11-04 2021-12-07 Σχεδιασμος σταθερου ετεροδιμερικου αντισωματος με μεταλλαξεις στην επικρατεια fc

Country Status (20)

Country Link
US (5) US9574010B2 (el)
EP (1) EP2773671B1 (el)
JP (1) JP6326371B2 (el)
KR (1) KR102052774B1 (el)
CN (2) CN104080811B (el)
AU (2) AU2012332021B8 (el)
BR (1) BR112014010580B1 (el)
CA (1) CA2854233C (el)
CY (1) CY1124872T1 (el)
DK (1) DK2773671T3 (el)
ES (1) ES2899956T3 (el)
HK (1) HK1200465A1 (el)
HR (1) HRP20211773T1 (el)
HU (1) HUE056462T2 (el)
MX (1) MX358862B (el)
PL (1) PL2773671T3 (el)
PT (1) PT2773671T (el)
RS (1) RS62689B1 (el)
RU (1) RU2675319C2 (el)
WO (1) WO2013063702A1 (el)

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