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CY1117078T1 - Παραγωγα 1-((5-ετεροαρυλθειαζολ-2-υλ) αμινοκαρβονυλ) πυρρολιδινο-2-καρβοξαμιδης ως αναστολεις φωσφατιδυλινοσιτολ 3-κινασης (ρι3κ) χρησιμα στη θεραπεια πολλαπλασιαστικων νοσων - Google Patents

Παραγωγα 1-((5-ετεροαρυλθειαζολ-2-υλ) αμινοκαρβονυλ) πυρρολιδινο-2-καρβοξαμιδης ως αναστολεις φωσφατιδυλινοσιτολ 3-κινασης (ρι3κ) χρησιμα στη θεραπεια πολλαπλασιαστικων νοσων

Info

Publication number
CY1117078T1
CY1117078T1 CY20151101197T CY151101197T CY1117078T1 CY 1117078 T1 CY1117078 T1 CY 1117078T1 CY 20151101197 T CY20151101197 T CY 20151101197T CY 151101197 T CY151101197 T CY 151101197T CY 1117078 T1 CY1117078 T1 CY 1117078T1
Authority
CY
Cyprus
Prior art keywords
riskinisminal
phosphidrisilisnacilin
heterarylythesisol
carboxamidis
aminocarbonyl
Prior art date
Application number
CY20151101197T
Other languages
English (en)
Inventor
Giorgio Caravatti
Robin Alec Fairhurst
Pascal Furet
Vito Guagnano
Patricia Imbach
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40350060&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1117078(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY1117078T1 publication Critical patent/CY1117078T1/el

Links

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    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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Abstract

Η παρούσα εφεύρεση σχετίζεται με μια ένωση του χημικού τύπου (I) ή ενός άλατος αυτού, όπου οι υποκαταστάτες είναι όπως περιγράφηκαν στην περιγραφή, με συνθέσεις και με τη χρήση των ενώσεων στη θεραπεία νόσων οι οποίες βελτιώνονται από την αναστολή της φωσφατιδυλινοσιτολ 3-κινάσης.
CY20151101197T 2008-09-10 2015-12-29 Παραγωγα 1-((5-ετεροαρυλθειαζολ-2-υλ) αμινοκαρβονυλ) πυρρολιδινο-2-καρβοξαμιδης ως αναστολεις φωσφατιδυλινοσιτολ 3-κινασης (ρι3κ) χρησιμα στη θεραπεια πολλαπλασιαστικων νοσων CY1117078T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08164104 2008-09-10
US9667408P 2008-09-12 2008-09-12
EP09782777.8A EP2331537B1 (en) 2008-09-10 2009-09-08 1-((5-heteroarylthiazol-2-yl)aminocarbonyl)pyrrolidine-2-carboxamide derivatives as phosphatidylinositol 3-kinase (pi3k) inhibitors useful in the treatment of proliferative diseases

Publications (1)

Publication Number Publication Date
CY1117078T1 true CY1117078T1 (el) 2017-04-05

Family

ID=40350060

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20151101197T CY1117078T1 (el) 2008-09-10 2015-12-29 Παραγωγα 1-((5-ετεροαρυλθειαζολ-2-υλ) αμινοκαρβονυλ) πυρρολιδινο-2-καρβοξαμιδης ως αναστολεις φωσφατιδυλινοσιτολ 3-κινασης (ρι3κ) χρησιμα στη θεραπεια πολλαπλασιαστικων νοσων
CY2020037C CY2020037I2 (el) 2008-09-10 2020-11-24 Παραγωγα 1-((5-ετεροαρυλθειαζολ-2-υλ) αμινοκαρβονυλ) πυρρολιδινο-2-καρβοξαμιδης ως αναστολεις φωσφατιδυλινοσιτολ 3-κινασης (ρι3κ) χρησιμα στη θεραπεια πολλαπλασιαστικων νοσων

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY2020037C CY2020037I2 (el) 2008-09-10 2020-11-24 Παραγωγα 1-((5-ετεροαρυλθειαζολ-2-υλ) αμινοκαρβονυλ) πυρρολιδινο-2-καρβοξαμιδης ως αναστολεις φωσφατιδυλινοσιτολ 3-κινασης (ρι3κ) χρησιμα στη θεραπεια πολλαπλασιαστικων νοσων

Country Status (50)

Country Link
US (4) US8227462B2 (el)
EP (1) EP2331537B1 (el)
JP (1) JP5486601B2 (el)
KR (1) KR101290844B1 (el)
CN (1) CN102149711B (el)
AR (2) AR073369A1 (el)
AU (1) AU2009290904B2 (el)
BR (1) BRPI0918750B8 (el)
CA (1) CA2734819C (el)
CL (1) CL2011000504A1 (el)
CO (1) CO6351738A2 (el)
CR (1) CR20110059A (el)
CU (1) CU24000B1 (el)
CY (2) CY1117078T1 (el)
DK (1) DK2331537T3 (el)
DO (1) DOP2011000070A (el)
EA (1) EA018863B1 (el)
EC (1) ECSP11010880A (el)
ES (1) ES2560673T3 (el)
GE (1) GEP20135991B (el)
HK (1) HK1156305A1 (el)
HN (1) HN2011000699A (el)
HR (1) HRP20160014T1 (el)
HU (2) HUE025884T2 (el)
IL (1) IL210976A (el)
JO (1) JO3121B1 (el)
LT (1) LTC2331537I2 (el)
LU (1) LUC00186I2 (el)
MA (1) MA32604B1 (el)
ME (1) ME01284B (el)
MX (1) MX2011002597A (el)
MY (1) MY151556A (el)
NI (1) NI201100049A (el)
NL (1) NL301071I2 (el)
NO (1) NO2020037I1 (el)
NZ (1) NZ590754A (el)
PA (1) PA8841901A1 (el)
PE (1) PE20110796A1 (el)
PL (1) PL2331537T3 (el)
PT (1) PT2331537E (el)
RS (1) RS54476B1 (el)
SI (1) SI2331537T1 (el)
SM (1) SMP201100019B (el)
SV (1) SV2011003853A (el)
TN (1) TN2011000053A1 (el)
TW (1) TWI453206B (el)
UA (1) UA104147C2 (el)
UY (1) UY32096A (el)
WO (1) WO2010029082A1 (el)
ZA (1) ZA201100699B (el)

Families Citing this family (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200519106A (en) * 2003-05-02 2005-06-16 Novartis Ag Organic compounds
RU2508110C2 (ru) 2008-07-11 2014-02-27 Новартис Аг КОМБИНАЦИЯ (А) ИНГИБИТОРА ФОСФОИНОЗИТ-3-КИНАЗЫ И (Б) МОДУЛЯТОРА ПУТИ Ras/Raf/Mek
UA104147C2 (uk) * 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
US8293753B2 (en) * 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
AR082418A1 (es) 2010-08-02 2012-12-05 Novartis Ag Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
WO2012062694A1 (en) * 2010-11-08 2012-05-18 Novartis Ag Use of 2-carboxamide cycloamino urea derivatives in the treatment of egfr dependent diseases or diseases that have acquired resistance to agents that target egfr family members
AU2015203865B2 (en) * 2010-11-08 2016-11-03 Novartis Ag Use of 2-carboxamide cycloamino urea derivatives in the treatment of EGFR dependent diseases or diseases that have acquired resistance to agents that target EGFR family members
UA112539C2 (uk) 2011-03-03 2016-09-26 Новартіс Аг Спосіб одержання похідних 2-карбоксамідциклоаміносечовини
EP2701703A1 (en) * 2011-04-25 2014-03-05 Novartis AG Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor
CA2839621A1 (en) * 2011-06-21 2012-12-27 Novartis Ag Polymorphs of (s)-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}-amide
EP2726074B1 (en) 2011-07-01 2018-04-04 Novartis AG Combination therapy comprising a cdk4/6 inhibitor and a pi3k inhibitor for use in the treatment of cancer
CA2846454A1 (en) * 2011-08-31 2013-05-10 Novartis Ag Synergistic combinations of pi3k- and mek-inhibitors
US20140235630A1 (en) * 2011-09-30 2014-08-21 Beth Israel Deaconess Medical Center, Inc. Compositions and methods for the treatment of proliferative diseases
CN103857392A (zh) 2011-10-14 2014-06-11 诺华股份有限公司 用于治疗增生性疾病的2-甲酰胺环氨基尿素衍生物与Hsp90抑制剂的组合
CN103889422A (zh) * 2011-10-28 2014-06-25 诺华股份有限公司 治疗胃肠道间质瘤的方法
JP2014532684A (ja) * 2011-11-02 2014-12-08 ノバルティス アーゲー Ｖｅｇｆ依存性疾患の治療に使用する２−カルボキサミドシクロアミノウレア誘導体
BR112014020773A2 (pt) 2012-02-22 2020-10-27 Sanford-Burnham Medical Research Institute compostos de sulfonamida e seus usos como inibidores tnap
AR090544A1 (es) 2012-03-29 2014-11-19 Novarits Ag Metodo para tratar selectivamente a un sujeto que tenga cancer
KR20150002623A (ko) * 2012-03-30 2015-01-07 노파르티스 아게 신경모세포종, 유잉 육종 또는 횡문근육종의 치료에 사용하기 위한 화합물
KR20160027218A (ko) 2012-05-23 2016-03-09 에프. 호프만-라 로슈 아게 내배엽 및 간세포를 수득하고 사용하는 조성물 및 방법
US8980259B2 (en) 2012-07-20 2015-03-17 Novartis Ag Combination therapy
MX359403B (es) 2012-08-07 2018-09-26 Novartis Ag Combinaciones farmacéuticas que comprenden un inhibidor de b-raf, un inhibidor de egfr, y opcionalmente un inhibidor de pi3k-alfa.
KR102245985B1 (ko) * 2012-08-16 2021-04-30 노파르티스 아게 Pi3k 억제제와 c-met 억제제의 조합물
WO2014047109A1 (en) * 2012-09-20 2014-03-27 Novartis Ag Pharmaceutical combination comprising a phosphatidylinositol 3-kinase inhibitor|and an aromatase inhibitor
EP2920146B1 (en) * 2012-11-16 2016-09-28 Merck Patent GmbH 3-aminocyclopentane carboxamide derivatives
EP2742940B1 (en) 2012-12-13 2017-07-26 IP Gesellschaft für Management mbH Fumarate salt of (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-l-aza-bicyclo-[2.2.2]octane for adminstration once daily, twice daily or thrice daily
BR112015017331B1 (pt) * 2013-01-23 2022-01-11 Astrazeneca Ab Compostos de formula i, forma cristalina, uso dos compostos, combinação e composição
WO2014144850A1 (en) 2013-03-15 2014-09-18 Genentech, Inc. Methods of treating cancer and preventing cancer drug resistance
BR112015023483B8 (pt) * 2013-03-21 2023-01-31 Novartis Ag Uso de um inibidor de b-raf e um inibidor de mek 1/2"
US20160030440A1 (en) * 2013-04-05 2016-02-04 Sanofi Anti-tumoral composition comprising a pi3kbeta-selective inhibitor and a pi3kalpha-selective inhibitor
US20160095842A1 (en) 2013-05-31 2016-04-07 Christine Fritsch Combination therapy containing a pi3k-alpha inhibitor and fgfr kinase inhibitor for treating cancer
RU2015156221A (ru) * 2013-06-11 2017-07-17 Новартис Аг Фармацевтические комбинация ингибитора pi3k и средства, дестабилизирующего микротрубочки
JP2016522247A (ja) 2013-06-18 2016-07-28 ノバルティス アーゲー 組合せ医薬
WO2015019320A1 (en) 2013-08-08 2015-02-12 Novartis Ag Pim kinase inhibitor combinations
BR112016002465B1 (pt) 2013-08-14 2022-09-20 Novartis Ag Combinação farmacêutica e seu uso
WO2015048312A1 (en) 2013-09-26 2015-04-02 Costim Pharmaceuticals Inc. Methods for treating hematologic cancers
PL3076969T3 (pl) 2013-12-06 2022-01-17 Novartis Ag Schemat dawkowania selektywnego inhibitora 3-kinazy fosfatydynozytolu alfa-izoformy
KR20160101027A (ko) * 2014-01-15 2016-08-24 노파르티스 아게 제약 조합물
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
JOP20200096A1 (ar) 2014-01-31 2017-06-16 Children’S Medical Center Corp جزيئات جسم مضاد لـ tim-3 واستخداماتها
RU2016135413A (ru) 2014-02-11 2018-03-14 Новартис Аг Фармацевтические комбинации, включающие ингибитор pi3k, для лечения рака
WO2015138920A1 (en) 2014-03-14 2015-09-17 Novartis Ag Antibody molecules to lag-3 and uses thereof
MX2017003227A (es) 2014-09-13 2017-12-04 Novartis Ag Terapias de combinacion de inhibidores de alk.
US20170296523A1 (en) 2014-10-03 2017-10-19 Frantz ELBAZ Pharmaceutical Compositions Comprising Alpelisib
KR20170066546A (ko) 2014-10-03 2017-06-14 노파르티스 아게 조합 요법
MA41044A (fr) 2014-10-08 2017-08-15 Novartis Ag Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
TWI716362B (zh) 2014-10-14 2021-01-21 瑞士商諾華公司 針對ｐｄ－ｌ１之抗體分子及其用途
CN104844589B (zh) * 2014-12-26 2018-04-20 中国科学院合肥物质科学研究院 一种pi3k激酶抑制剂
PE20171448A1 (es) 2015-03-10 2017-10-02 Aduro Biotech Inc Composiciones y metodos para activar la senalizacion dependiente del estimulador del gen de interferon
CN107787226A (zh) * 2015-03-25 2018-03-09 诺华股份有限公司 药物组合
AU2016287189A1 (en) 2015-06-29 2017-10-12 F. Hoffmann-La Roche Ag Methods of treatment with taselisib
MY195002A (en) 2015-07-02 2022-12-30 Hoffmann La Roche Benzoxazepin oxazolidinone compounds and methods of use
EP3316902A1 (en) 2015-07-29 2018-05-09 Novartis AG Combination therapies comprising antibody molecules to tim-3
CN114272371A (zh) 2015-07-29 2022-04-05 诺华股份有限公司 包含抗pd-1抗体分子的联合疗法
PT3317301T (pt) 2015-07-29 2021-07-09 Novartis Ag Terapias de associação compreendendo moléculas de anticorpo contra lag-3
EP3340986A1 (en) 2015-08-28 2018-07-04 Novartis AG A pharmaceutical combination comprising the pi3k inhibitor alpelisib and the cdk4/6 inhibitor ribociclib, and the use thereof in the treatment/prevention of cancer
US20180250302A1 (en) 2015-08-28 2018-09-06 Giordano Caponigro Combination of ribociclib and dabrafenib for treating or preventing cancer
WO2017037574A1 (en) 2015-08-28 2017-03-09 Novartis Ag Combinations of the cdk4/6 inhibitor lee011 and the mek1/2 inhibitor trametinib, optionally further comprising the pi3k inhibitor byl719 to treat cancer
CN108348611A (zh) 2015-08-28 2018-07-31 诺华股份有限公司 使用pi3k抑制剂和mdm2抑制剂的联合疗法
US20180256557A1 (en) * 2015-08-28 2018-09-13 Giordano Caponigro Pharmaceutical combination comprising (a) the alpha-isoform specific pi3k inhibitor alpelisib (byl719) and (b) an akt inhibitor, preferably mk-2206, afuresertib or uprosertib, and the use thereof in the treatment/prevention of cancer
CA2992221C (en) 2015-08-28 2023-06-27 Novartis Ag Mdm2 inhibitors and combinations thereof
TW201726140A (zh) 2015-09-17 2017-08-01 瑞典商阿斯特捷利康公司 治療癌症之新型生物標記及方法
CN105294546B (zh) * 2015-10-29 2017-12-08 天津市斯芬克司药物研发有限公司 一种吡啶化合物及其制备方法
RU2018119085A (ru) 2015-11-02 2019-12-04 Новартис Аг Схема введения ингибитора фосфатидилинозитол-3-киназы
CR20180234A (es) 2015-11-03 2018-09-11 Janssen Biotech Inc Anticuerpos que se unen especificamente a pd-1 y sus usos
RU2018123524A (ru) 2015-12-03 2020-01-09 Новартис Аг Фармацевтическая диагностика
AU2016369537B2 (en) 2015-12-17 2024-03-14 Novartis Ag Antibody molecules to PD-1 and uses thereof
US11098077B2 (en) 2016-07-05 2021-08-24 Chinook Therapeutics, Inc. Locked nucleic acid cyclic dinucleotide compounds and uses thereof
WO2018060833A1 (en) 2016-09-27 2018-04-05 Novartis Ag Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
WO2018092064A1 (en) 2016-11-18 2018-05-24 Novartis Ag Combinations of mdm2 inhibitors and bcl-xl inhibitors
CN106674200B (zh) * 2016-12-21 2019-04-12 西安交通大学 一种含有l-脯氨酰胺片段的化合物及其制备方法和应用
UY37695A (es) 2017-04-28 2018-11-30 Novartis Ag Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
US20200172628A1 (en) 2017-06-22 2020-06-04 Novartis Ag Antibody molecules to cd73 and uses thereof
MA49457A (fr) 2017-06-22 2020-04-29 Novartis Ag Molécules d'anticorps se liant à cd73 et leurs utilisations
WO2019073031A1 (en) 2017-10-13 2019-04-18 INSERM (Institut National de la Santé et de la Recherche Médicale) POLYTHERAPY OF PANCREATIC CANCER
WO2019101871A1 (en) 2017-11-23 2019-05-31 Inserm (Institut National De La Sante Et De La Recherche Medicale) A new marker for predicting the sensitivity to pi3k inhibitors
US10695333B2 (en) 2017-12-01 2020-06-30 Novartis Ag Pharmaceutical combination comprising LSZ102 and alpelisib
MA51039A (fr) * 2017-12-08 2020-10-14 Vertex Pharma Procédés pour préparer des modulateurs du régulateur de la conductance transmembranaire de la mucoviscidose
CR20240101A (es) 2018-03-08 2024-05-24 Incyte Corp COMPUESTOS DIÓLICOS DE AMINOPIRAZINA COMO INHIBIDORES DE PI3K-y (DIVISIONAL 2020-464)
TW202015726A (zh) 2018-05-30 2020-05-01 瑞士商諾華公司 Ｅｎｔｐｄ２抗體、組合療法、及使用該等抗體和組合療法之方法
WO2019228341A1 (zh) 2018-05-30 2019-12-05 江苏豪森药业集团有限公司 含三并环类衍生物抑制剂、其制备方法和应用
WO2019232244A2 (en) 2018-05-31 2019-12-05 Novartis Ag Antibody molecules to cd73 and uses thereof
WO2020010003A1 (en) 2018-07-02 2020-01-09 Incyte Corporation AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS
EP3849545A1 (en) * 2018-09-10 2021-07-21 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods for the treatment of neurofibromatosis
AU2019355574A1 (en) * 2018-10-05 2021-05-06 Sloan-Kettering Institute For Cancer Research PI3K inhibitors and uses thereof
BR112021011894A2 (pt) 2018-12-21 2021-09-08 Daiichi Sankyo Company, Limited Composição farmacêutica
WO2020228729A1 (zh) 2019-05-13 2020-11-19 罗欣药业(上海)有限公司 喹唑啉酮类化合物的晶型及其制备方法
CN111995541A (zh) * 2019-05-27 2020-11-27 润佳（苏州）医药科技有限公司 含有稳定重同位素的酰胺官能团的化合物及其应用
WO2021001431A1 (en) 2019-07-02 2021-01-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of pi3ka-selective inhibitors for treating metastatic disease in patients suffering from pancreatic cancer
EP3993786A1 (en) 2019-07-02 2022-05-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the prophylactic treatment of cancer in patients suffering from pancreatitis
EP3993707A1 (en) 2019-07-02 2022-05-11 Institut National de la Santé et de la Recherche Médicale (INSERM) Use of ultrafast elasticity imaging for detecting pancreatic cancers
WO2021053559A1 (en) 2019-09-18 2021-03-25 Novartis Ag Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies
KR20220119610A (ko) 2019-11-25 2022-08-30 상하이 한서 바이오메디컬 컴퍼니 리미티드 3개의 융합된 고리 유도체-함유 염 또는 결정 형태 및 이의 약학 조성물
CN113045564B (zh) * 2019-12-27 2024-09-20 上海天慈国际药业有限公司 一种阿培利司的制备方法
CN115835888A (zh) 2020-03-25 2023-03-21 润佳（苏州）医药科技有限公司 酰胺官能团中的稳定重同位素及其用途
WO2022016420A1 (zh) * 2020-07-22 2022-01-27 罗欣药业(上海)有限公司 一种喹唑啉酮类化合物的晶型、其制备方法及应用
JP2024516006A (ja) 2021-05-03 2024-04-11 ノバルティス アーゲー アルペリシブ製剤
CN115611883A (zh) * 2021-07-13 2023-01-17 生物岛实验室 一种双环结构的PI3Kα抑制剂及其制备方法和用途
EP4431508A1 (en) * 2021-11-12 2024-09-18 Biopolar Youtang (Guangdong) Pharmaceutical Co., Ltd. Drak2 inhibitor, and preparation method therefor and use thereof
EP4230196A1 (en) 2022-02-21 2023-08-23 Som Innovation Biotech, S.A. Compounds for use in the treatment of dystrophinopathies
WO2024089272A1 (en) 2022-10-28 2024-05-02 Institut National De La Sante Et De La Recherche Medicale New inhibitors of phosphatidylinositol 3-kinase
WO2024100236A1 (en) 2022-11-11 2024-05-16 Astrazeneca Ab Combination therapies for the treatment of cancer
WO2024206147A1 (en) 2023-03-24 2024-10-03 Arvinas Operations, Inc. Dosage regimens of estrogen receptor degraders

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4649146A (en) 1983-01-31 1987-03-10 Fujisawa Pharmaceutical Co., Ltd. Thiazole derivatives and pharmaceutical composition comprising the same
DE3703435A1 (de) 1987-02-05 1988-08-18 Thomae Gmbh Dr K Neue thiazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
WO1989009767A1 (en) 1988-04-15 1989-10-19 Taiho Pharmaceutical Company, Limited Carbamoyl-2-pyrrolidinone compounds
US5028726A (en) * 1990-02-07 1991-07-02 The University Of Vermont And State Agricultural College Platinum amine sulfoxide complexes
US5780653A (en) * 1995-06-07 1998-07-14 Vivorx Pharmaceuticals, Inc. Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers
JP2001505585A (ja) 1996-12-16 2001-04-24 藤沢薬品工業株式会社 新規アミド化合物およびそれらの一酸化窒素シンターゼ阻害剤としての用途
US6187797B1 (en) 1996-12-23 2001-02-13 Dupont Pharmaceuticals Company Phenyl-isoxazoles as factor XA Inhibitors
JP4515542B2 (ja) * 1997-02-10 2010-08-04 ジェネンテック， インコーポレイテッド ヒレグリン変異体
JPH11193281A (ja) 1997-10-27 1999-07-21 Takeda Chem Ind Ltd アデノシンａ３受容体拮抗剤およびチアゾール化合物
DE69923681T2 (de) 1998-06-18 2006-01-12 Bristol-Myers Squibb Co. Kohlenstoff substituierte aminothiazole als inhibitoren von cyclin-abhängigen kinasen
EP1218376B1 (en) 1999-09-10 2005-11-09 Merck & Co., Inc. Tyrosine kinase inhibitors
GB0000313D0 (en) * 2000-01-10 2000-03-01 Astrazeneca Uk Ltd Formulation
NZ521068A (en) 2000-03-29 2005-04-29 Cyclacel Ltd 2-substituted 4-heteroaryl-pyrimidines and their use in the treatment of proliferative disorders
DK1415987T3 (da) 2000-10-20 2007-07-02 Eisai R&D Man Co Ltd Nitrogenholdige aromatiske ringforbindelser til anvendelse som midler mod cancer
ATE315555T1 (de) 2001-05-11 2006-02-15 Pfizer Prod Inc Thiazolderivate und ihre verwendung als cdk- inhibitoren
KR101034489B1 (ko) 2001-08-13 2011-05-17 얀센 파마슈티카 엔.브이. 2-아미노-4,5-삼치환 티아졸릴 유도체
WO2003015778A1 (en) 2001-08-17 2003-02-27 Merck & Co., Inc. Tyrosine kinase inhibitors
ATE349443T1 (de) 2001-09-28 2007-01-15 Cyclacel Ltd N-(4-(4-methylthiazol-5-yl)pyrimidin-2-yl)-n- phenylamine als antiproliferative verbindungen
TWI314928B (en) * 2002-02-28 2009-09-21 Novartis A 5-phenylthiazole derivatives and use as pi3 kinase inhibitors
WO2004041813A1 (en) 2002-10-30 2004-05-21 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of rock and other protein kinases
AU2003302084A1 (en) 2002-11-15 2004-06-15 Bristol-Myers Squibb Company Open chain prolyl urea-related modulators of androgen receptor function
CA2513399A1 (en) * 2003-01-10 2004-07-29 Threshold Pharmaceuticals, Inc. Treatment of cancer with 2-deoxyglucose
GB0305152D0 (en) 2003-03-06 2003-04-09 Novartis Ag Organic compounds
TW200519106A (en) * 2003-05-02 2005-06-16 Novartis Ag Organic compounds
GB0320197D0 (en) * 2003-08-28 2003-10-01 Novartis Ag Organic compounds
CN1898221A (zh) 2003-09-06 2007-01-17 沃泰克斯药物股份有限公司 Atp－结合弹夹转运蛋白的调控剂
WO2005068444A2 (en) 2004-01-12 2005-07-28 Applied Research Systems Ars Holding N.V. Thiazole derivatives and use thereof
US7358250B2 (en) * 2004-06-29 2008-04-15 Amgen Inc. Pyrrolo[2,3-d]pyrimidines that modulate ACK1 activity
SE0402735D0 (sv) 2004-11-09 2004-11-09 Astrazeneca Ab Novel compounds
ES2375828T3 (es) * 2005-02-18 2012-03-06 Abraxis Bioscience, Llc Combinaciones y modos de administración de agentes terapéuticos y terapia combinada.
DE102005024157A1 (de) 2005-05-23 2006-11-30 Amedo Gmbh Nadelpositioniersystem
AU2006251159B2 (en) 2005-05-24 2011-09-22 Merck Serono Sa Thiazole derivatives and use thereof
UA92489C2 (en) 2005-05-24 2010-11-10 Лаборатуар Сероно С.А. Thiazole derivatives and use thereof
DE102005024790A1 (de) 2005-05-26 2006-12-07 Eos Gmbh Electro Optical Systems Strahlungsheizung zum Heizen des Aufbaumaterials in einer Lasersintervorrichtung
US7655446B2 (en) 2005-06-28 2010-02-02 Vertex Pharmaceuticals Incorporated Crystal structure of Rho-kinase I kinase domain complexes and binding pockets thereof
DE102005048072A1 (de) 2005-09-24 2007-04-05 Bayer Cropscience Ag Thiazole als Fungizide
US7595398B2 (en) 2005-12-12 2009-09-29 Smithkline Beecham Corporation N-(5-membered aromatic ring)-amido anti-viral compounds
GB0525671D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
CA2635830A1 (en) * 2006-01-23 2007-07-26 Laboratoires Serono S.A. Thiazole derivatives and use thereof
US20070259855A1 (en) 2006-04-06 2007-11-08 Udo Maier Thiazolyl-dihydro-indazole
EP2016075A1 (en) * 2006-05-03 2009-01-21 AstraZeneca AB Thiazole derivatives and their use as anti-tumour agents
GB0610243D0 (en) 2006-05-23 2006-07-05 Novartis Ag Organic compounds
GB0612630D0 (en) * 2006-06-26 2006-08-02 Novartis Ag Organic compounds
FR2904190B1 (fr) 2006-07-25 2008-12-12 Inst Rech Pour Le Dev I R D Et Utilisation d'inocula fongiques pour l'amelioration de la production maraichere
EP2099778A2 (en) 2006-11-21 2009-09-16 Smithkline Beecham Corporation Amido anti-viral compounds
WO2008124000A2 (en) 2007-04-02 2008-10-16 Ligand Pharmaceuticals Incorporated Thiazole derivatives as androgen receptor modulator compounds
AU2008257559B2 (en) 2007-05-25 2013-10-10 AbbVie Deutschland GmbH & Co. KG Heterocyclic compounds as positive modulators of metabotropic glutamate receptor 2 (MGLU2 receptor)
US20090004140A1 (en) 2007-06-26 2009-01-01 Yao-Ling Qiu 4-substituted pyrrolidine as anti-infectives
PL2178865T3 (pl) 2007-07-19 2015-12-31 H Lundbeck As 5-członowe heterocykliczne amidy i związki pokrewne
ITMI20072396A1 (it) 2007-12-20 2009-06-21 Dachi S R L "apparato di chiusura di contenitori di materiale biologico"
PE20091523A1 (es) 2007-12-20 2009-10-29 Novartis Ag Derivados de tiazol como inhibidores de la enzima fosfatidilinositol 3-cinasa (pi3k)
CN101939319A (zh) 2007-12-20 2011-01-05 诺瓦提斯公司 联噻唑衍生物、它们的制备方法以及它们作为药物的用途
UA104147C2 (uk) * 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань

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US8476268B2 (en) 2013-07-02
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CA2734819A1 (en) 2010-03-18
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IL210976A0 (en) 2011-04-28
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