CY1112326T1 - Παραγωγα της 6-(πυριδινυλ)-4-πυριμιδονης ως αναστολεις της κινασης 1 tau πρωτεϊνης - Google Patents
Παραγωγα της 6-(πυριδινυλ)-4-πυριμιδονης ως αναστολεις της κινασης 1 tau πρωτεϊνηςInfo
- Publication number
- CY1112326T1 CY1112326T1 CY20111100427T CY111100427T CY1112326T1 CY 1112326 T1 CY1112326 T1 CY 1112326T1 CY 20111100427 T CY20111100427 T CY 20111100427T CY 111100427 T CY111100427 T CY 111100427T CY 1112326 T1 CY1112326 T1 CY 1112326T1
- Authority
- CY
- Cyprus
- Prior art keywords
- tau protein
- pyrimidone
- pyridinyl
- inhibitors
- derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Μια ένωση που αναπαριστάται από τον τύπο (I), ένα οπτικά δραστικό ισομερές της ή ένα φαρμακευτικά αποδεκτό άλας αυτής: όπου το R1 αναπαριστά ένα C1-C12 αλκύλιο• το R2 αναπαριστά ένα άτομο υδρογόνου ή παρόμοιο• το R3 αναπαριστά ένα αλογόνο ή παρόμοιο• το q αναπαριστά έναν ακέραιο από 1 έως 7• το R4 αναπαριστά ένα αλογόνο ή παρόμοιο• το p αναπαριστά 0 ή έναν ακέραιο από 1 έως 5• το R5 αναπαριστά ένα C6-C10 αρύλιο, μια ετεροκυκλική ομάδα ή παρόμοια• και το Χ αναπαριστά οξυγόνο, ΝΗ ή παρόμοια, που χρησιμοποιείται για την προληπτική και/ή θεραπευτική αντιμετώπιση μιας νόσου, η οποία προκαλείται από την υπερδραστηριότητα της κινάσης 1 της tau πρωτεΐνης, όπως οι νευροεκφυλιστικές νόσοι (π.χ. νόσος του Αλτσχάιμερ).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004313115 | 2004-09-29 | ||
| EP05790292A EP1805164B9 (en) | 2004-09-29 | 2005-09-29 | 6-(pyridinyl)-4-pyrimidone derivates as tau protein kinase 1 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1112326T1 true CY1112326T1 (el) | 2015-12-09 |
Family
ID=35848411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20111100427T CY1112326T1 (el) | 2004-09-29 | 2011-05-04 | Παραγωγα της 6-(πυριδινυλ)-4-πυριμιδονης ως αναστολεις της κινασης 1 tau πρωτεϊνης |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US8129377B2 (el) |
| EP (3) | EP2261224A3 (el) |
| JP (1) | JP5186213B2 (el) |
| KR (1) | KR20070057931A (el) |
| CN (1) | CN101048397A (el) |
| AR (1) | AR051823A1 (el) |
| AT (1) | ATE499356T1 (el) |
| AU (1) | AU2005288045B2 (el) |
| BR (1) | BRPI0515851A (el) |
| CA (1) | CA2581179A1 (el) |
| CY (1) | CY1112326T1 (el) |
| DE (1) | DE602005026546D1 (el) |
| DK (1) | DK1805164T3 (el) |
| EA (1) | EA013004B1 (el) |
| ES (1) | ES2359071T3 (el) |
| IL (1) | IL182223A0 (el) |
| MX (1) | MX2007003722A (el) |
| NO (1) | NO20072214L (el) |
| NZ (1) | NZ554722A (el) |
| PL (1) | PL1805164T3 (el) |
| PT (1) | PT1805164E (el) |
| SI (1) | SI1805164T1 (el) |
| TW (1) | TWI354669B (el) |
| WO (1) | WO2006036015A2 (el) |
| ZA (1) | ZA200703383B (el) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR050865A1 (es) * | 2004-09-09 | 2006-11-29 | Sanofi Aventis | Derivados de 2- morfolino-4-pirimidona |
| GB0510142D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds A1 |
| GB0510141D0 (en) | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds B3 |
| TW200740779A (en) | 2005-07-22 | 2007-11-01 | Mitsubishi Pharma Corp | Intermediate compound for synthesizing pharmaceutical agent and production method thereof |
| TW200813015A (en) * | 2006-03-15 | 2008-03-16 | Mitsubishi Pharma Corp | 2-(cyclic amino)-pyrimidone derivatives |
| CN101528729A (zh) * | 2006-08-23 | 2009-09-09 | 辉瑞产品公司 | 作为gsk-3抑制剂的嘧啶酮化合物 |
| WO2008026046A1 (en) * | 2006-08-30 | 2008-03-06 | Pfizer Products Inc. | Morpholine d3 dopamine antagonists |
| AR064660A1 (es) | 2006-12-26 | 2009-04-15 | Mitsubishi Tanabe Pharma Corp | Derivados de pirimidinona 6-heterociclica 2-sustituida, medicamentos que los contienen y usos para prevenir y/o tratar enfermedades neurodegenerativas entre otras |
| AU2008290329B2 (en) | 2007-08-22 | 2011-12-22 | Astrazeneca Ab | Cyclopropyl amide derivatives |
| US8198437B2 (en) | 2007-09-14 | 2012-06-12 | Mitsubishi Tanabe Pharma Corporation | 6-pyrimidinyl-pyrimid-4-one derivative |
| TW201039825A (en) | 2009-02-20 | 2010-11-16 | Astrazeneca Ab | Cyclopropyl amide derivatives 983 |
| JP5535310B2 (ja) | 2009-08-13 | 2014-07-02 | 田辺三菱製薬株式会社 | タウプロテインキナーゼ１阻害剤としてのピリミドン誘導体 |
| JPWO2011062194A1 (ja) | 2009-11-18 | 2013-04-04 | 武田薬品工業株式会社 | アミノピリジン誘導体 |
| US9452980B2 (en) * | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
| AU2011218491C1 (en) | 2010-02-18 | 2015-05-14 | Astrazeneca Ab | Processes for making cyclopropyl amide derivatives and intermediates associated therewith |
| EP2568812B1 (en) * | 2010-05-11 | 2016-10-26 | Merck Sharp & Dohme Corp. | Novel prolylcarboxypeptidase inhibitors |
| EP2928473B1 (en) | 2012-12-07 | 2017-06-28 | Merck Sharp & Dohme Corp. | Regioselective n-2 arylation of indazoles |
| JP7179014B2 (ja) | 2017-04-24 | 2022-11-28 | テサロ， インコーポレイテッド | ニラパリブの製造方法 |
| CN117143079A (zh) * | 2018-11-06 | 2023-12-01 | 上海奕拓医药科技有限责任公司 | 一种螺芳环化合物及其应用 |
| CN111704611B (zh) * | 2019-07-25 | 2022-01-14 | 上海凌达生物医药有限公司 | 一类芳基螺环类shp2抑制剂化合物、制备方法和用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR023052A1 (es) * | 1998-09-25 | 2002-09-04 | Mitsuharu Yoshimura Milton | Derivados de pirimidona |
| EP1136483A1 (en) * | 2000-03-23 | 2001-09-26 | Sanofi-Synthelabo | 2-[Piperazinyl]pyrimidone derivatives |
| EP1136482A1 (en) * | 2000-03-23 | 2001-09-26 | Sanofi-Synthelabo | 2-Amino-3-(alkyl)-pyrimidone derivatives as GSK3beta inhibitors |
| KR100754596B1 (ko) | 2001-09-21 | 2007-09-05 | 미쯔비시 웰 파마 가부시키가이샤 | 3-치환-4-피리미돈 유도체 |
| AU2002337499B2 (en) * | 2001-09-21 | 2007-08-23 | Mitsubishi Pharma Corporation | 3-substituted-4-pyrimidone derivatives |
| EP1454908B1 (en) * | 2003-03-07 | 2008-02-27 | Sanofi-Aventis | Substituted pyridinyl-2-(diaza-bicyclo-alkyl)-pyrimidinone derivatives |
| TWI357408B (en) | 2003-03-26 | 2012-02-01 | Mitsubishi Tanabe Pharma Corp | 3-substituted-4-pyrimidone derivatives |
-
2005
- 2005-09-29 PL PL05790292T patent/PL1805164T3/pl unknown
- 2005-09-29 DK DK05790292.6T patent/DK1805164T3/da active
- 2005-09-29 BR BRPI0515851-6A patent/BRPI0515851A/pt not_active IP Right Cessation
- 2005-09-29 NZ NZ554722A patent/NZ554722A/en not_active IP Right Cessation
- 2005-09-29 SI SI200531256T patent/SI1805164T1/sl unknown
- 2005-09-29 EP EP10010448A patent/EP2261224A3/en not_active Withdrawn
- 2005-09-29 AT AT05790292T patent/ATE499356T1/de active
- 2005-09-29 MX MX2007003722A patent/MX2007003722A/es active IP Right Grant
- 2005-09-29 TW TW094134059A patent/TWI354669B/zh not_active IP Right Cessation
- 2005-09-29 PT PT05790292T patent/PT1805164E/pt unknown
- 2005-09-29 DE DE602005026546T patent/DE602005026546D1/de active Active
- 2005-09-29 JP JP2007533116A patent/JP5186213B2/ja not_active Expired - Fee Related
- 2005-09-29 US US11/576,062 patent/US8129377B2/en not_active Expired - Fee Related
- 2005-09-29 CN CNA2005800330250A patent/CN101048397A/zh active Pending
- 2005-09-29 AU AU2005288045A patent/AU2005288045B2/en not_active Ceased
- 2005-09-29 EP EP05790292A patent/EP1805164B9/en not_active Not-in-force
- 2005-09-29 WO PCT/JP2005/018497 patent/WO2006036015A2/en active Application Filing
- 2005-09-29 ZA ZA200703383A patent/ZA200703383B/xx unknown
- 2005-09-29 CA CA002581179A patent/CA2581179A1/en not_active Abandoned
- 2005-09-29 KR KR1020077008236A patent/KR20070057931A/ko not_active Application Discontinuation
- 2005-09-29 AR ARP050104099A patent/AR051823A1/es not_active Application Discontinuation
- 2005-09-29 EA EA200700756A patent/EA013004B1/ru not_active IP Right Cessation
- 2005-09-29 EP EP10010450A patent/EP2266969A3/en not_active Withdrawn
- 2005-09-29 ES ES05790292T patent/ES2359071T3/es active Active
-
2007
- 2007-03-27 IL IL182223A patent/IL182223A0/en unknown
- 2007-04-27 NO NO20072214A patent/NO20072214L/no not_active Application Discontinuation
-
2011
- 2011-05-04 CY CY20111100427T patent/CY1112326T1/el unknown
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