[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

CY1111899T1 - Καινοφανη παραγωγα πυρρολης με δραστηριοτητα αναστολεα της απακετυλασης της ιστονης - Google Patents

Καινοφανη παραγωγα πυρρολης με δραστηριοτητα αναστολεα της απακετυλασης της ιστονης

Info

Publication number
CY1111899T1
CY1111899T1 CY20111100951T CY111100951T CY1111899T1 CY 1111899 T1 CY1111899 T1 CY 1111899T1 CY 20111100951 T CY20111100951 T CY 20111100951T CY 111100951 T CY111100951 T CY 111100951T CY 1111899 T1 CY1111899 T1 CY 1111899T1
Authority
CY
Cyprus
Prior art keywords
pyrolis
haston
producer
activator
destruction
Prior art date
Application number
CY20111100951T
Other languages
English (en)
Inventor
Mora Fernando Pedro Cossio
Badosa Manel Esteller
Olascoaga Aizpea Zubia
Ansa Dorleta Otaegui
Original Assignee
Universidad Del Pais Vasco-Euskal Herriko Unibersitatea
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad Del Pais Vasco-Euskal Herriko Unibersitatea filed Critical Universidad Del Pais Vasco-Euskal Herriko Unibersitatea
Publication of CY1111899T1 publication Critical patent/CY1111899T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/42—Nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Η εφεύρεση σχετίζεται με καινοφανή παράγωγα πυρρόλης έχοντας τον χημικό τύπο (I), με μεθόδους για την λήψη των ιδίων και με την χρήση εξ αυτών ως φαρμάκων για την αγωγή του καρκίνου σε φαρμακευτικές συνθέσεις ένεκα της ανασταλτικής δραστηριότητας των εν λόγω παραγώγων σε σχέση με συγκεκριμένες απακετυλάσες της ιστόνης.
CY20111100951T 2005-12-27 2011-10-05 Καινοφανη παραγωγα πυρρολης με δραστηριοτητα αναστολεα της απακετυλασης της ιστονης CY1111899T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/ES2005/000708 WO2007074176A1 (es) 2005-12-27 2005-12-27 Nuevos derivados pirrólicos con actividad inhibidora de desacetilasas de histonas
EP05850516A EP1975158B9 (en) 2005-12-27 2005-12-27 Novel pyrrole derivatives with histone deacetylase inhibitor activity

Publications (1)

Publication Number Publication Date
CY1111899T1 true CY1111899T1 (el) 2015-11-04

Family

ID=38217700

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100951T CY1111899T1 (el) 2005-12-27 2011-10-05 Καινοφανη παραγωγα πυρρολης με δραστηριοτητα αναστολεα της απακετυλασης της ιστονης

Country Status (18)

Country Link
US (1) US7638550B2 (el)
EP (1) EP1975158B9 (el)
JP (1) JP4975758B2 (el)
CN (1) CN101351444B (el)
AT (1) ATE516268T1 (el)
AU (1) AU2005339535B2 (el)
BR (1) BRPI0520806A2 (el)
CA (1) CA2635392C (el)
CY (1) CY1111899T1 (el)
DK (1) DK1975158T3 (el)
ES (1) ES2369705T3 (el)
HK (1) HK1125926A1 (el)
MX (1) MX2008008470A (el)
PL (1) PL1975158T3 (el)
PT (1) PT1975158E (el)
RU (1) RU2416600C2 (el)
SI (1) SI1975158T1 (el)
WO (1) WO2007074176A1 (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1874723A2 (en) * 2005-04-15 2008-01-09 Dominion Pharmakine S.L. New nitrogenated trans-stilbene analogs, method for the obtention and medical applications thereof
EP2305643A1 (en) * 2009-10-02 2011-04-06 Ikerchem, S.L. New histone deacetylase inhibitors based simultaneously on trisubstituted 1h-pyrroles and aromatic and heteroaromatic spacers
EP2508510A1 (en) 2011-04-06 2012-10-10 Ikerchem, S.L. Hydroxyphenyl pyrrole compounds containing an hydroxamic acid as hdac inhibitors and medicinal applications thereof
CN103373969B (zh) * 2012-04-27 2015-09-16 中国科学院上海有机化学研究所 苯基唑环取代酰胺类化合物及其制备方法和用途
AU2016267872B2 (en) 2015-05-22 2019-01-17 Chong Kun Dang Pharmaceutical Corp. Heterocyclicalkyl derivative compounds as selective histone deacetylase inhibitors and pharmaceutical compositions comprising the same
CN106565583A (zh) * 2016-11-15 2017-04-19 淮阴师范学院 多取代吡咯衍生物的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5377698A (en) * 1996-12-10 1998-07-03 G.D. Searle & Co. Substituted pyrrolyl compounds for the treatment of inflammation
JP4191825B2 (ja) * 1998-09-10 2008-12-03 あすか製薬株式会社 ５−アミノイソキサゾール誘導体
KR20020059393A (ko) * 1999-09-08 2002-07-12 제임스 에스. 쿼크 새로운 부류의 세포분화제 및 히스톤 데아세틸라아제, 및이의 사용 방법
ATE430567T1 (de) * 2000-09-29 2009-05-15 Topotarget Uk Ltd Carbaminsäurederivate enthaltend eine amidgruppe zur behandlung von malaria
US6576612B1 (en) * 2000-10-02 2003-06-10 Pharmacia Italia S.P.A. Antitumor therapy comprising distamycin derivatives
ES2351393T3 (es) * 2003-05-26 2011-02-03 Takeda Pharmaceutical Company Limited Sulfopirroles.
CA2547573A1 (en) 2003-12-05 2005-06-23 Warner-Lambert Company Llc N-alkyl pyrroles as hmg-coa reductase inhibitors
AU2005221834B2 (en) * 2004-03-11 2010-09-30 4Sc Ag Sulphonylpyrroles as HDAC inhibitors

Also Published As

Publication number Publication date
ATE516268T1 (de) 2011-07-15
MX2008008470A (es) 2008-09-26
CN101351444B (zh) 2011-07-13
PL1975158T3 (pl) 2011-12-30
EP1975158B1 (en) 2011-07-13
BRPI0520806A2 (pt) 2009-06-09
PT1975158E (pt) 2011-09-23
JP2009521519A (ja) 2009-06-04
RU2416600C2 (ru) 2011-04-20
CN101351444A (zh) 2009-01-21
JP4975758B2 (ja) 2012-07-11
DK1975158T3 (da) 2011-10-24
CA2635392A1 (en) 2007-07-05
US20080262073A1 (en) 2008-10-23
CA2635392C (en) 2013-07-23
SI1975158T1 (sl) 2011-10-28
ES2369705T3 (es) 2011-12-05
AU2005339535A1 (en) 2007-07-05
US7638550B2 (en) 2009-12-29
EP1975158A1 (en) 2008-10-01
RU2008130876A (ru) 2010-02-10
AU2005339535B2 (en) 2012-02-23
EP1975158A4 (en) 2009-11-11
HK1125926A1 (en) 2009-08-21
EP1975158B9 (en) 2012-02-29
WO2007074176A1 (es) 2007-07-05

Similar Documents

Publication Publication Date Title
MA32508B1 (fr) Composes organiques
EA201170531A1 (ru) Соединения на основе пиридина и пиримидина в качестве ингибиторов сигнального пути wnt для лечения рака
ATE482209T1 (de) Verbindungen und zusammensetzungen als modulatoren der gpr119-aktivität
EA201100136A1 (ru) 2,4'-бипиридинилы в качестве ингибиторов протеинкиназы d, применимые для лечения сердечной недостаточности и рака
CY1116754T1 (el) Παραγωγα νιτροκατεχολης ως αναστολεις της comt
EA201270215A1 (ru) Apaf-1 ингибиторные соединения
EA200970738A1 (ru) Ингибиторы активности akt
CY1123919T1 (el) 1η-βενζιμιδαζολο-4-καρβοξαμιδια υποκατεστημενα με τεταρτοταγη ανθρακα στην 2-θεση ειναι ισχυροι αναστολεις parp
CL2007003341A1 (es) Compuestos derivados de imidazotriazinas; composicion farmaceutica, util para el tratamiento del cancer, arteroesclerosis y enfermedades cardiovasculares entre otras.
EA200970447A1 (ru) Соединения и композиции в качестве ингибиторов протеинкиназы
BRPI0509172A (pt) pelo menos uma entidade quìmica, composição farmacêutica, métodos para tratar um paciente, para inibir pelo menos uma enzima que utiliza atp, e para tratar pelo menos uma doença, uso de pelo menos uma entidade quìmica, e, método para a fabricação de um medicamento
NO20092658L (no) New compounds
EA200900798A1 (ru) Производные индол-4-илпиримидинил-2-иламина и их применение в качестве ингибиторов циклинзависимой киназы
EA201300684A1 (ru) Производные 6-амино-2-фениламино-1н-бензимидазол-5-карбоксамида и их применение в качестве ингибиторов микросомной простагландин-е2-синтазы-1
MX2009000285A (es) Piperidinas sustituidas que incrementan la actividad de p53 y usos de las mismas.
DK1853602T3 (da) Kemiske forbindelser
DK1853588T3 (da) Kemiske forbindelser
UA111579C2 (uk) ГЕТЕРОЦИКЛІЧНІ ПОХІДНІ 2-АМІНОБЕНЗО[d]ОКСАЗОЛУ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ НА ЇХ ОСНОВІ ТА ЇХ ЗАСТОСУВАННЯ ДЛЯ ЛІКУВАННЯ ЗАХВОРЮВАННЯ, ПОВ'АНОГО З РІ3-КІНАЗОЮ
EA200901032A1 (ru) Соединения и композиции в качестве модуляторов активности gpr119
CY1111789T1 (el) Ετεροκυκλικες ενωσεις
TW200714604A (en) Substituted heterocycles and the uses thereof
ECSP066883A (es) Derivados de heteroarilaminopirazol utiles para el tratamiento de la diabetes
DE602006013191D1 (de) Substituierte 1h-benzimidazol-4-carbonsäureamide sind wirksame parp-inhibitoren
PA8719401A1 (es) Compuestos de tetrahidropiridotienopirimidina y metodos para su empleo
ATE478863T1 (de) Heterotetracyclische verbindungen als tpo- mimetica