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MX2008008470A - Nuevos derivados pirrolicos con actividad inhibidora de desacetilasa de histonas. - Google Patents

Nuevos derivados pirrolicos con actividad inhibidora de desacetilasa de histonas.

Info

Publication number
MX2008008470A
MX2008008470A MX2008008470A MX2008008470A MX2008008470A MX 2008008470 A MX2008008470 A MX 2008008470A MX 2008008470 A MX2008008470 A MX 2008008470A MX 2008008470 A MX2008008470 A MX 2008008470A MX 2008008470 A MX2008008470 A MX 2008008470A
Authority
MX
Mexico
Prior art keywords
inhibitor activity
histone deacetylase
pyrrole derivatives
deacetylase inhibitor
novel pyrrole
Prior art date
Application number
MX2008008470A
Other languages
English (en)
Inventor
Fernando Pedro Cossio Mora
Aizpea Zubia Olascoaga
Dorleta Otaegui Ansa
Manuel Esteller Badosa
Original Assignee
Univ Pais Vasco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pais Vasco filed Critical Univ Pais Vasco
Publication of MX2008008470A publication Critical patent/MX2008008470A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/42—Nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención describe nuevos compuestos derivados de pirroles de formula 1, procedimientos para su obtención y su aplicación como fármacos para el tratamiento del cáncer en composiciones farmacéuticas gracias a la actividad inhibitoria de los mismos sobre ciertas desacetilasas de histonas.
MX2008008470A 2005-12-27 2005-12-27 Nuevos derivados pirrolicos con actividad inhibidora de desacetilasa de histonas. MX2008008470A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/ES2005/000708 WO2007074176A1 (es) 2005-12-27 2005-12-27 Nuevos derivados pirrólicos con actividad inhibidora de desacetilasas de histonas

Publications (1)

Publication Number Publication Date
MX2008008470A true MX2008008470A (es) 2008-09-26

Family

ID=38217700

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008008470A MX2008008470A (es) 2005-12-27 2005-12-27 Nuevos derivados pirrolicos con actividad inhibidora de desacetilasa de histonas.

Country Status (18)

Country Link
US (1) US7638550B2 (es)
EP (1) EP1975158B9 (es)
JP (1) JP4975758B2 (es)
CN (1) CN101351444B (es)
AT (1) ATE516268T1 (es)
AU (1) AU2005339535B2 (es)
BR (1) BRPI0520806A2 (es)
CA (1) CA2635392C (es)
CY (1) CY1111899T1 (es)
DK (1) DK1975158T3 (es)
ES (1) ES2369705T3 (es)
HK (1) HK1125926A1 (es)
MX (1) MX2008008470A (es)
PL (1) PL1975158T3 (es)
PT (1) PT1975158E (es)
RU (1) RU2416600C2 (es)
SI (1) SI1975158T1 (es)
WO (1) WO2007074176A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1874723A2 (en) * 2005-04-15 2008-01-09 Dominion Pharmakine S.L. New nitrogenated trans-stilbene analogs, method for the obtention and medical applications thereof
EP2305643A1 (en) * 2009-10-02 2011-04-06 Ikerchem, S.L. New histone deacetylase inhibitors based simultaneously on trisubstituted 1h-pyrroles and aromatic and heteroaromatic spacers
EP2508510A1 (en) 2011-04-06 2012-10-10 Ikerchem, S.L. Hydroxyphenyl pyrrole compounds containing an hydroxamic acid as hdac inhibitors and medicinal applications thereof
CN103373969B (zh) * 2012-04-27 2015-09-16 中国科学院上海有机化学研究所 苯基唑环取代酰胺类化合物及其制备方法和用途
AU2016267872B2 (en) 2015-05-22 2019-01-17 Chong Kun Dang Pharmaceutical Corp. Heterocyclicalkyl derivative compounds as selective histone deacetylase inhibitors and pharmaceutical compositions comprising the same
CN106565583A (zh) * 2016-11-15 2017-04-19 淮阴师范学院 多取代吡咯衍生物的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5377698A (en) * 1996-12-10 1998-07-03 G.D. Searle & Co. Substituted pyrrolyl compounds for the treatment of inflammation
JP4191825B2 (ja) * 1998-09-10 2008-12-03 あすか製薬株式会社 ５−アミノイソキサゾール誘導体
KR20020059393A (ko) * 1999-09-08 2002-07-12 제임스 에스. 쿼크 새로운 부류의 세포분화제 및 히스톤 데아세틸라아제, 및이의 사용 방법
ATE430567T1 (de) * 2000-09-29 2009-05-15 Topotarget Uk Ltd Carbaminsäurederivate enthaltend eine amidgruppe zur behandlung von malaria
US6576612B1 (en) * 2000-10-02 2003-06-10 Pharmacia Italia S.P.A. Antitumor therapy comprising distamycin derivatives
ES2351393T3 (es) * 2003-05-26 2011-02-03 Takeda Pharmaceutical Company Limited Sulfopirroles.
CA2547573A1 (en) 2003-12-05 2005-06-23 Warner-Lambert Company Llc N-alkyl pyrroles as hmg-coa reductase inhibitors
AU2005221834B2 (en) * 2004-03-11 2010-09-30 4Sc Ag Sulphonylpyrroles as HDAC inhibitors

Also Published As

Publication number Publication date
ATE516268T1 (de) 2011-07-15
CN101351444B (zh) 2011-07-13
PL1975158T3 (pl) 2011-12-30
EP1975158B1 (en) 2011-07-13
BRPI0520806A2 (pt) 2009-06-09
CY1111899T1 (el) 2015-11-04
PT1975158E (pt) 2011-09-23
JP2009521519A (ja) 2009-06-04
RU2416600C2 (ru) 2011-04-20
CN101351444A (zh) 2009-01-21
JP4975758B2 (ja) 2012-07-11
DK1975158T3 (da) 2011-10-24
CA2635392A1 (en) 2007-07-05
US20080262073A1 (en) 2008-10-23
CA2635392C (en) 2013-07-23
SI1975158T1 (sl) 2011-10-28
ES2369705T3 (es) 2011-12-05
AU2005339535A1 (en) 2007-07-05
US7638550B2 (en) 2009-12-29
EP1975158A1 (en) 2008-10-01
RU2008130876A (ru) 2010-02-10
AU2005339535B2 (en) 2012-02-23
EP1975158A4 (en) 2009-11-11
HK1125926A1 (en) 2009-08-21
EP1975158B9 (en) 2012-02-29
WO2007074176A1 (es) 2007-07-05

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Legal Events

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FG Grant or registration