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CY1110539T1 - Μεθοδος για παραγωγα φαινυλοξικου οξεος - Google Patents

Μεθοδος για παραγωγα φαινυλοξικου οξεος

Info

Publication number
CY1110539T1
CY1110539T1 CY20101100105T CY101100105T CY1110539T1 CY 1110539 T1 CY1110539 T1 CY 1110539T1 CY 20101100105 T CY20101100105 T CY 20101100105T CY 101100105 T CY101100105 T CY 101100105T CY 1110539 T1 CY1110539 T1 CY 1110539T1
Authority
CY
Cyprus
Prior art keywords
formula
phenyl acid
acid producers
precursors
pharmaceutically acceptable
Prior art date
Application number
CY20101100105T
Other languages
English (en)
Inventor
Murat Acemoglu
Thomas Allmendinger
John Vincent Calienni
Jacques Cercus
Olivier Loiseleur
Gottfried Sedelmeier
David Xu
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY1110539T1 publication Critical patent/CY1110539T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/52—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/54—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to two or three six-membered aromatic rings
    • C07C211/56—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to two or three six-membered aromatic rings the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C07C233/15—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
    • C07C235/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Μέθοδος για την παραγωγή μιας ένωσης του τύπου (I) ή ενός φαρμακευτικά αποδεκτού άλατος αυτής, ή ενός φαρμακευτικά αποδεκτού εστέρα προφαρμάκου αυτής, η οποία περιλαμβάνει τη διάσπαση μιας λακτάμης του τύπου (I)), όπου τα σύμβολα έχουν τις σημασίες που τους αποδίδονται, με μια βάση, και προδρόμους για το σκοπό αυτό και μεθόδους για την παρασκευή των προδρόμων. Οι ενώσεις του τύπου (I) είναι φαρμακευτικά δραστικές ενώσεις οι οποίες αποτελούν επιλεκτικούς αναστολείς της κυκλοοξυγενάσης (II).
CY20101100105T 1999-09-27 2010-02-03 Μεθοδος για παραγωγα φαινυλοξικου οξεος CY1110539T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9922830.6A GB9922830D0 (en) 1999-09-27 1999-09-27 Processes
EP00969292A EP1216226B1 (en) 1999-09-27 2000-09-25 Process for phenylacetic acid derivatives

Publications (1)

Publication Number Publication Date
CY1110539T1 true CY1110539T1 (el) 2015-04-29

Family

ID=10861676

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100105T CY1110539T1 (el) 1999-09-27 2010-02-03 Μεθοδος για παραγωγα φαινυλοξικου οξεος

Country Status (34)

Country Link
US (2) US20080249318A1 (el)
EP (2) EP1216226B1 (el)
JP (1) JP2003510303A (el)
KR (1) KR100745341B1 (el)
CN (1) CN100412053C (el)
AR (2) AR031529A1 (el)
AT (1) ATE447547T1 (el)
AU (1) AU775416B2 (el)
BR (1) BR0014314A (el)
CA (1) CA2379553C (el)
CO (1) CO5210865A1 (el)
CY (1) CY1110539T1 (el)
CZ (1) CZ20021027A3 (el)
DE (1) DE60043261D1 (el)
DK (1) DK1216226T3 (el)
EC (2) ECSP003680A (el)
ES (1) ES2338209T3 (el)
GB (1) GB9922830D0 (el)
HK (1) HK1047739A1 (el)
HU (1) HUP0202728A3 (el)
IL (2) IL148330A0 (el)
MY (1) MY125201A (el)
NO (1) NO327912B1 (el)
NZ (1) NZ517461A (el)
PE (1) PE20010644A1 (el)
PL (1) PL207777B1 (el)
PT (1) PT1216226E (el)
RU (1) RU2273628C2 (el)
SI (1) SI1216226T1 (el)
SK (1) SK287241B6 (el)
TR (1) TR200200745T2 (el)
TW (1) TWI270540B (el)
WO (1) WO2001023346A2 (el)
ZA (1) ZA200202367B (el)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0209257D0 (en) * 2002-04-23 2002-06-05 Novartis Ag Organic compounds
AU2003248642A1 (en) 2002-06-11 2003-12-22 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
GB0224198D0 (en) * 2002-10-17 2002-11-27 Novartis Ag Organic compounds
PE20040844A1 (es) 2002-11-26 2004-12-30 Novartis Ag Acidos fenilaceticos y derivados como inhibidores de la cox-2
US7161026B1 (en) 2005-07-08 2007-01-09 Property Development Corporation International, Ltd, Inc. Method of preparation of methyl-benzyl-ketone
AR061623A1 (es) 2006-06-26 2008-09-10 Novartis Ag Derivados de acido fenilacetico
WO2010056741A2 (en) 2008-11-12 2010-05-20 Auspex Pharmaceuticals, Inc. Phenylacetic acid inhibitors of cyclooxygenase
CN102311355B (zh) * 2011-09-26 2014-02-05 扬州天和药业有限公司 罗本考昔的一种制备方法
CN107721901A (zh) * 2017-11-12 2018-02-23 刘磊 一种2‑[2‑(2,3,5,6‑四氟苯胺基)苯基]乙酸的制备方法
EP3830072A1 (en) 2018-07-27 2021-06-09 KRKA, d.d., Novo mesto A process for the preparation of polymorphic form of robenacoxib
JP6708319B1 (ja) * 2018-08-03 2020-06-10 日産化学株式会社 フッ化芳香族第二級アミン化合物の製造方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558690A (en) * 1965-04-08 1971-01-26 Gelgy Chemical Corp Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation
IT1097265B (it) 1978-06-23 1985-08-31 Acraf Nouva sintesi di un acido fenilacetico
JPS5677246A (en) * 1980-11-27 1981-06-25 Nissan Chem Ind Ltd Production of substituted phenylacetic acid
DE3404401C2 (de) 1984-02-08 1994-02-10 Hoechst Ag Verwendung von Aryloxy-Verbindungen als Antidots
FR2578836B1 (fr) 1985-03-12 1987-04-17 Rhone Poulenc Spec Chim Procede de chloration selective de composes phenoliques
EP0380712B1 (de) * 1989-01-27 1995-01-04 HEUMANN PHARMA GMBH & CO Verfahren zur Herstellung von 2,6-Dichlordiphenylaminessigsäurederivaten
IT1248032B (it) * 1991-06-11 1995-01-05 Laboratorio Chimico Int Spa Procedimento per la preparazione della n- (2,6-diclorofenil) -n-fenil-n-(cloroacetil)-ammina.
CN1091420A (zh) * 1993-02-25 1994-08-31 永信药品工业股份有限公司 二苯胺衍生物的制备方法
JPH0789951A (ja) 1993-06-03 1995-04-04 Sterling Winthrop Inc インターロイキン−１β転換酵素阻害剤
US5475139A (en) 1993-10-22 1995-12-12 Yung Shin Pharm. Ind. Co., Ltd. Method for the preparation of substituted derivatives of diphenyl amine
CA2189036A1 (en) 1994-04-29 1995-11-09 Roland E. Dolle Halomethyl amides as il-1.beta. protease inhibitors
US5576460A (en) 1994-07-27 1996-11-19 Massachusetts Institute Of Technology Preparation of arylamines
JPH0977664A (ja) * 1995-09-13 1997-03-25 Yakult Honsha Co Ltd シクロオキシゲナーゼ−２特異的阻害剤及び抗炎症剤
US6355680B1 (en) 1996-02-20 2002-03-12 Exocell, Inc. Albumin-binding compounds that prevent nonenzymatic glycation and that may be used for treatment of glycation-related pathologies
US6034266A (en) 1996-03-11 2000-03-07 Fundacao Oswaldo Cruz-Fiocruz Gem-difluoro derivative of phenylacetamide and phenylacetic acid and their pharmaceutical uses
BR9600975A (pt) * 1996-03-11 1997-12-30 Fundacao Oswaldo Cruz Derivados do ácido gem-difluorfenilacético e de gem-difluorfenilacetamida processo de sua preparação e suas aplicações farmacêuticas
CA2208900C (en) 1996-07-18 2006-08-01 Lonza Ag Process for preparing 2-pyrimidinecarboxylates
US5817877A (en) 1996-09-23 1998-10-06 Yale University Metal-catalyzed amination of organic sulfonates to organic amines
CO4960662A1 (es) * 1997-08-28 2000-09-25 Novartis Ag Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados

Also Published As

Publication number Publication date
CZ20021027A3 (cs) 2002-07-17
NO20021368D0 (no) 2002-03-19
US7906677B2 (en) 2011-03-15
NO20021368L (no) 2002-05-27
CN100412053C (zh) 2008-08-20
AU7906700A (en) 2001-04-30
DE60043261D1 (de) 2009-12-17
GB9922830D0 (en) 1999-11-24
ES2338209T3 (es) 2010-05-05
AR031529A1 (es) 2003-09-24
NO327912B1 (no) 2009-10-19
JP2003510303A (ja) 2003-03-18
CN1377337A (zh) 2002-10-30
CA2379553A1 (en) 2001-04-05
KR20020030289A (ko) 2002-04-24
ATE447547T1 (de) 2009-11-15
RU2273628C2 (ru) 2006-04-10
SK287241B6 (sk) 2010-04-07
PT1216226E (pt) 2009-12-17
WO2001023346A2 (en) 2001-04-05
US20080249318A1 (en) 2008-10-09
PE20010644A1 (es) 2001-06-15
HK1047739A1 (en) 2003-03-07
SK4142002A3 (en) 2002-08-06
IL148330A0 (en) 2002-09-12
KR100745341B1 (ko) 2007-08-02
EP2275403A1 (en) 2011-01-19
AU775416B2 (en) 2004-07-29
PL207777B1 (pl) 2011-01-31
WO2001023346A3 (en) 2002-01-10
SI1216226T1 (sl) 2010-03-31
PL365994A1 (en) 2005-01-24
DK1216226T3 (da) 2010-02-01
EP1216226A2 (en) 2002-06-26
CO5210865A1 (es) 2002-10-30
TWI270540B (en) 2007-01-11
IL148330A (en) 2007-02-11
TR200200745T2 (tr) 2002-06-21
HUP0202728A2 (hu) 2002-12-28
NZ517461A (en) 2003-10-31
ZA200202367B (en) 2003-02-26
MY125201A (en) 2006-07-31
HUP0202728A3 (en) 2003-11-28
US20090275758A1 (en) 2009-11-05
ECSP093680A (es) 2009-02-27
AR042404A2 (es) 2005-06-22
CA2379553C (en) 2010-09-21
ECSP003680A (es) 2002-04-23
BR0014314A (pt) 2002-11-12
EP1216226B1 (en) 2009-11-04

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